CNOT8 (NM_004779) Human 3' UTR Clone

Specifications

Product Data
Product Name	CNOT8 (NM_004779) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	CAF1; Caf1b; CALIF; hCAF1; POP2
ACCN	NM_004779
Insert Size	1383 bp
Sequence Data	Insert Sequence (showhide) >SC214486 3’UTR clone of NM_004779 The sequence shown below is from the reference sequence of NM_004779. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC CTGGCGATTATCAACAACATGCAGCAGTGATGGCGCCAGGCTCTGCAGGGTGGGCCTGATCCCAGAGTG GTGCTTACTGTGCTGACTGTGTACTTATCTTCCCCAAGAGAAAATGCTTCTTTTGAGCACACTGTACCT ACCATCTGCATTGAGCAGAAAGACTTTTGTTTTACTGAAGACAAAAGATGTTTTTATTTTAGACCCAGA AGAGAGGAGTTTGCTCTGAATTTGTAAATAAGTCTTCCCCATTCCTCATACTCGAGCCTCTCCTCTCTG GTTGCCTCCTGCCACCAGCATCCATGGCTCATTTGACACCTTTTTAAATATCAGGACAAGTCTGAAACA AAGTAGTAAAATGTATATAACTCTTACCTGTTGTCATTCTTTTTCTTTTAAATTTGTTGCTAATCTCTG ATAATGAAGATTCTTACTCTGATTCTCAGCTGAGCTGTGAGGGCTTCCAGGGAAAATGGAACAAAATGG TGTTCTTAGGTAATGGGTTGTAGATACTGAGTCTTCCTTTCCTTTTCTGACCCTTCTCGAGGACATTTG CTTTCCTCACACTTTTGTAGTCTCTCTTTACATATTACTATATGGAAATGAATTGCTCTGTGCTGAAAT TTGAAGACCAGATAATGAAACTGAAAAGCAAACAATTTTACTGAATCTGTCTACCCTTCATTCATGAGA ACTCCAGAATGAGTGTTGACCACTGAAGCATCTTTTAAGTCTGTGTTCCATTGTGCCATTCAGGTTTGC TGTCACATATGCATCATCTGAAATCATTTGAAATTTTTGTACAATAAAATATCCTGGATTTGATCCTGA AGGAAACTAGTAAGATCAGATTTTTGGGTCATGTCTGTTGTATTTTCAGTAATGTGATTTCAGATGGTC ATCTGGATTCTCCCACTTCTCTACTCCATTATTTCTCTACTTTTCCTTCCAGCAAACCTGAAACGTGAG GGAGATGGATTAATGTGAGTAACAGGAATGTGTCTTTAAAAAGCTAGAGTGGTTACATTTAATCAGGCA GTAAGATAATTTGGGTTCTTGAGTTGTTTTGGAGTAATATCCCACAACTGGGGTAGGAAGCTCAGGACT TTTTTCTTTAAAGCTAGTCATTTCAAAAGCATATTGTATTTTTTTGAATGACTACAGTATGGACAATTT CAAAAACCAAAACCCACTTTGGATTGGTGGAAGTAAAAACTGGTAACTCACTCAAGTGAATGAATGGTC TTGCATTTTAAAAGCTTATGGGAAACTCAATTTGAAATGATTAGAAAATGTCAAGTATTATAAGCTGGT ATTTAAGATGCTTGTAAATACTATTTATGTTTTTAATTTTGTAAAATAAAGATTTCTTTTTAACCACTG GCA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_004779.6
Synonyms	CAF1; Caf1b; CALIF; hCAF1; POP2
Summary	Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.[UniProtKB/Swiss-Prot Function]
Locus ID	9337
MW	53.9

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