SRPK2 (NM_182692) Human 3' UTR Clone

Specifications

Product Data
Product Name	SRPK2 (NM_182692) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	SFRSK2
ACCN	NM_182692
Insert Size	1494 bp
Sequence Data	Insert Sequence (showhide) >SC214824 3’UTR clone of NM_182692 The sequence shown below is from the reference sequence of NM_182692. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC TGCCTTCGGCATCCTTGGTTGAATTCTTAGCAAATTCTACCAATATTGCATTCTGAGCTAGCAAATGTT CCCAGTACATTGGACCTAAACGGTGACTCTCATTCTTTAACAGGATTACAAGTGAGCTGGCTTCATCCT CAGACCTTTATTTTGCTTTGAGGTACTGTTGTTTGACATTTTGCTTTTTGTGCACTGTGATCCTGGGGA AGGGTAGTCTTTTGTCTTCAGCTAAGTAGTTTACTGACCATTTTCTTCTGGAAACAATAACATGTCTCT AAGCATTGTTTCTTGTGTTGTGTGACATTCAAATGTCATTTTTTTGAATGAAAAATACTTTCCCCTTTG TGTTTTGGCAGGTTTTGTAACTATTTATGAAGAAATATTTTAGCTGAGTACTATATAATTTACAATCTT AAGAAATTATCAAGTTGGAACCAAGAAATAGCAAGGAAATGTACAATTTTATCTTCTGGCAAAGGGACA TCATTCCTGTATTATAGTGTATGTAAATGCACCCTGTAAATGTTACTTTCCATTAAATATGGGAGGGGG ACTCAAATTTCAGAAAAGCTACCAAGTCTTGAGTGCTTTGTAGCCTATGTTGCATGTAGCGGACTTTAA CTGCTCCAAGGAGTTGTGCAAACTTTTCATTCCATAACAGTCTTTTCACATTGGATTTTAAACAAAGTG GCTCTGGGTTATAAGATGTCATTCTCTATATGGCACTTTAAAGGAAGAAAAGATATGTTTCTCATTCTA AAATATGCATTATAATTTAGCAGTCCCATTTGTGATTTTGCATATTTTTAAAAGTACTTTTAAAGAAGA GCAATTTCCCTTTAAAAATGTGATGGCTCAGTACCATGTCATGTTGCCTCCTCTGGGCGCTGTAAGTTA AGCTCTACATAGATTAAATTGGAGAAACGTGTTAATTGTGTGGAATGAAAAAATACATATATTTTTGGA AAAGCATGATCATGCTTGTCTAGAACACAAGGTATGGTATATACAATTTGCAGTGCAGTGGGCAGAATA CTTCTCACAGCTCAAAGATAACAGTGATCACATTCATTCCATAGGTAGCTTTACGTGTGGCTACAACAA ATTTTACTAGCTTTTTCATTGTCTTTCCATGAAACGAAGTTGAGAAAATGATTTTCCCTTTGCAGGTTG CACACAGTTTTGTTTATGCATTTCCTTAAAATTAATTGTAGACTCCAGGATACAAACCATAGTAGGCAA TACAATTTTAGAATGTAATATATAGAGGTATATTTAGCCTCTTTTAGAAGTCAGTGGATTGAATGTCTT TTTATTTTAAATTTTACATTCATTAAGGTGCCTCGTTTTTGACTTTGTCCATTAACATTTATCCATATG CCTTTGCAATAACTAGATTGTGAAAAGCTAACAAGTGTTGTAACAATAATCCATTGTTTGAGGTGCTTG CAGTTGTCTTAAAAATTAAAGTGTTTTGGTTTTTTTTTTTCCAGA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_182692.3
Synonyms	SFRSK2
Summary	Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up-regulation. Plays an essential role in spliceosomal B complex formation via the phosphorylation of DDX23/PRP28. Can mediate hepatitis B virus (HBV) core protein phosphorylation. Plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles.[UniProtKB/Swiss-Prot Function]
Locus ID	6733
MW	57.9

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