Proteasome Activator Subunit 4 (PSME4) (NM_014614) Human 3' UTR Clone

Specifications

Product Data
Product Name	Proteasome Activator Subunit 4 (PSME4) (NM_014614) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	PA200
ACCN	NM_014614
Insert Size	1539 bp
Sequence Data	Insert Sequence (showhide) >SC215018 3’UTR clone of NM_014614 The sequence shown below is from the reference sequence of NM_014614. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC CTTCTTGTGTCACCATGCTATTATGCATAGAAAGATGACTAGTCCTCACTTCAGGCTCTTTTCATCAAA AATTCCACACCCTCAGGTACCATCTGTGGTGGCTCTCTGCAAGTTTTAAAACTGCCTCTGCTGAGCTCT CATCATTTTGGTGGTTTCTGTGTTAGATCTCGTTAGTCTGCATTCCACAGCTTCTCAGTTGCCATTTGA TTTCCCAACTTGTCCGGAAGTGTTTCCAGAATACTGATCACTTTTTTTTTTTGAGGCATCTGACAAAGT CACAAAGTCTCAGACTAGAAATAATTACCCAGTATGATCATGGCATCCAAGACCAGAGTCTCAGAACTC ATTAAGAAACAGTTTACTTGGAATGGAGAATACCCATCTGTAATACAGGTCCTGTCATTTCATTCATCT CAAATTATTTTGAATTCTTCCCAAATGGCTGCTGGATTTAGGTGGTAATAGGGGCTGTGGGCCATAAAT CTGAAGCCTTGAGAACCTTGGGTCTGGAGAGCCATGAAGAGGGAAGGAAAAGAGGGCAAGTCCTGAACC TAACCAATGACCTGATGGATTGCTCGACCAAGACACAGAAGTGAAGTCTGTGTCTGTGCACTTCCCACA GACTGGAGTTTTTGGTGCTGAATAGAGCCAGTTGCTAAAAAATTGGGGGTTTGGTGAAGAAATCTGATT GTTGTGTGTATTCAATGTGTGATTTTAAAAATAAACAGCAACAACAATAAAAACCCTGACTGGCTGTTT TTTCCCTGTATTCTTTACAACTATTTTTTGACCCTCTGAAAATTATTATACTTCACCTAAATGGAAGAC TGCTGTGTTTGTGGAAATTTTGTAATTTTTTAATTTATTTTATTCTCTCTCCCTTTTTATTTTGCCTGC AGAATCGTTGAGAGACTAATAAGGCTTAATATTTAATTGATTTGTTTAATATGTTATATAAATGTAAAA GAGTGTATAAACTGTAGAGATAGCATTGGCAAGACATTGTACAGATGCAACCTTTTACACAACATCATT GTGTAATTTGTAAAGATTCACGTGTAGTTCTTTATTATAGTGATTTTGGGCTTTGTACCCACTGAATGC CATTTTTTGTGTTTTTAAATTATTTTCTTTATCTTGTTACAAAAACTGAGATGTGGGGTTTTTTTTTTT TCAGTTCACTTATCATTAGAATGTCTGAACTTTTATGTAACATTTTTGTGTGCATCTCTCAATGCTAAC ACCACATGTTTGCCTATGACAAGTTTATAGAGTGAAAGGTATCTTCTGGGTTGAAATAATTCACAAATT GGTGAATGTCATCTTGCAACACACCCTGTACAGTCTTCCTTAAAGGAACACTACAGTATATTTTTAGTA TCTACATGCTGAATGACTGAATACAGACCTAAGCACAGCAGTGGTCCTGGTACAGTATTTAAGTGTCGG CATACACAGGCGTAATCCCTGTATAAAGTAGTGCCAAACTGATTTCAGTTGTGTAACTAGTTTAAAACC CAATAAATGGATTCTTTTTAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_014614.3
Synonyms	PA200
Summary	Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks.[UniProtKB/Swiss-Prot Function]
Locus ID	23198
MW	58.8

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