SHC (SHC1) (NM_001130040) Human 3' UTR Clone

Specifications

Product Data
Product Name	SHC (SHC1) (NM_001130040) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	SHC; SHCA
ACCN	NM_001130040
Insert Size	1535 bp
Sequence Data	Insert Sequence (showhide) >SC215055 3’UTR clone of NM_001130040 The sequence shown below is from the reference sequence of NM_001130040. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC CTACAGCAACCTGTGGAGCGGAAACTGTGATCTGCCCTAGCGCTCTCTTCCAGAAGATGCCCTCCAATC CTTTCCACCCTATTCCCTAACTCTCGGGACCTCGTTTGGGAGTGTTCTGTGGGCTTGGCCTTGTGTCAG AGCTGGGAGTAGCATGGACTCTGGGTTTCATATCCAGCTGAGTGAGAGGGTTTGAGTCAAAAGCCTGGG TGAGAATCCTGCCTCTCCCCAAACATTAATCACCAAAGTATTAATGTACAGAGTGGCCCCTCACCTGGG CCTTTCCTGTGCCAACCTGATGCCCCTTCCCCAAGAAGGTGAGTGCTTGTCATGGAAAATGTCCTGTGG TGACAGGCCCAGTGGAACAGTCACCCTTCTGGGCAAGGGGGAACAAATCACACCTCTGGGCTTCAGGGT ATCCCAGACCCCTCTCAACACCCGCCCCCCCCATGTTTAAACTTTGTGCCTTTGACCATCTCTTAGGTC TAATGATATTTTATGCAAACAGTTCTTGGACCCCTGAATTCAATGACAGGGATGCCAACACCTTCTTGG CTTCTGGGACCTGTGTTCTTGCTGAGCACCCTCTCCGGTTTGGGTTGGGATAACAGAGGCAGGAGTGGC AGCTGTCCCCTCTCCCTGGGGATATGCAACCCTTAGAGATTGCCCCAGAGCCCCACTCCCGGCCAGGCG GGAGATGGACCCCTCCCTTGCTCAGTGCCTCCTGGCCGGGGCCCCTCACCCCAAGGGGTCTGTATATAC ATTTCATAAGGCCTGCCCTCCCATGTTGCATGCCTATGTACTCTACGCCAAAGTGCAGCCCTTCCTCCT GAAGCCTCTGCCCTGCCTCCCTTTCTGGGAGGGCGGGGTGGGGGTGACTGAATTTGGGCCTCTTGTACA GTTAACTCTCCCAGGTGGATTTTGTGGAGGTGAGAAAAGGGGCATTGAGACTATAAAGCAGTAGACAAT CCCCACATACCATCTGTAGAGTTGGAACTGCATTCTTTTAAAGTTTTATATGCATATATTTTAGGGCTG TAGACTTACTTTCCTATTTTCTTTTCCATTGCTTATTCTTGAGCACAAAATGATAATCAATTATTACAT TTATACATCACCTTTTTGACTTTTCCAAGCCCTTTTACAGCTCTTGGCATTTTCCTCGCCTAGGCCTGT GAGGTAACTGGGATCGCACCTTTTATACCAGAGACCTGAGGCAGATGAAATTTATTTCCATCTAGGACT AGAAAAACTTGGGTCTCTTACCGCGAGACTGAGAGGCAGAAGTCAGCCCGAATGCCTGTCAGTTTCATG GAGGGGAAACGCAAAACCTGCAGTTCCTGAGTACCTTCTACAGGCCCGGCCCAGCCTAGGCCCGGGGTG GCCACACCACAGCAAGCCGGCCCCCCCTCTTTTGGCCTTGTGGATAAGGGAGAGTTGACCGTTTTCATC CTGGCCTCCTTTTGCTGTTTGGATGTTTCCACGGGTCTCACTTATACCAAAGGGAAAACTCTTCATTAA AGTCCGTATTTCTTCTA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_001130040.2
Synonyms	SHC; SHCA
Summary	This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
Locus ID	6464
MW	55.5

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