cGKI (PRKG1) (NM_006258) Human 3' UTR Clone

Specifications

Product Data
Product Name	cGKI (PRKG1) (NM_006258) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	AAT8; cGK; cGK 1; cGK1; cGKI; cGKI-alpha; cGKI-BETA; PKG; PKG1; PRKG1B; PRKGR1B
ACCN	NM_006258
Insert Size	2000 bp
Sequence Data	Insert Sequence (showhide) >SC215614 3’UTR clone of NM_006258 The sequence shown below is from the reference sequence of NM_006258. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GACAACTCAGGATGGGATATAGACTTCTAATGTATTTCTCTTACCTGCTTCTGCCTTGCTGAAGACAGC TTTTTCTGAGACACAGCTGCCAGCAAACCTGAGGGAAAGAGAGAAGATTAGTGCTCGGGGTCACCATGA TGCCTTTGATCGATGCTGCTCCAGTAACTACAGTGGCATTAGGACTTACCGCTTAGATGACAATAGTGC TCTTTACATGTTTTCTGTTTGAACCTAAAATAGCAGTTGACATGGTGGTCCTGAAGCAAAGCCTTTCAC CAGTAAAAGATGTTTTCTATTGTTGCAATGACCTTGCTTTGCTCTGATTATAATTTGAAAGACTGTAGG AAACACTTCAATGTAGTATAAGAGTCTGTACCTTGCTGGAATATTCAAGAAGATGAAAGAATAATATAT TGGGTACAATAGATTACTATGGTACAGAAACTGGGCTATTCCCTTTCTTCAAGTGAAGGCTGTGGGATC TATTACTGCAGGCCGGTGTATATACCATACAAAAGAGGACCACACATCTGTTGGTCACAGAGTTCATGT CACACCAGTGCTAGAAGTTTCATGATTTTATTTCCCAGCAGTGCTGATGACAAGACTGAATGTTACCTT TTCTTTCTGACAGATTTTAAAAATTGATATGATAAAAGCACAACTGCTATAGATTCTGCTGAGACCTCT CATAGTAGGTATATATGAGTTTTCACAGAAGACTGAAAAATAATGCATGATATTTGTTTGTTTTTTTTG ATAAATTGGCATGACAGAGTGGGGAAAAAAAGCAATTCACAAAACCATTTCATATTTTTTAAAATATTG TGCTTAAAGATGGTCCTGGAAGTAAATGACTAGCAGCCAATTGGTTTTACTTAACATACCCTCAAACTG AGGCTTAAAGTATTCCCTTTTATAAAAATAAATGCTTGGGGTAGGGTGGAGTGGGGAGGGATTAAAACC CATCCAAAAAATAAATAAAAACTATATAGGTGCTATGTATATCTTTCATCTGTAAATGTCAGTGTCTGA ACAGACAACACAAATTCAAATCATTATACGTGTAGCCAGAAACTCAAGCATTTTCACTAAAGTTATTAA ACCAAACTCCTGTCCAATTTCACTTATACAACATAGTCAGTCTAGAGTTGAGAGACAAAGGTAATTATA AACCTATTTGAACTAGCTTCTTGTCTTAGGCCTGAACCAAAAAACAACAAACAAACAAAAAACAAGAAT GAAAAACAGAAATAAAAGAAGTAGAAAAGACAAAGAAAGAAAGCCCAAAGTCAAAGTTGTTAATATTTA CAGGTTTACCAGATCTGGAACATTACTTATTTGAGGTCAGAGAACAAAACAAGAACCTGGCCAGGTGTT GATTACCTTTTAGTGAATAAGCTGAGTCCATATACTTGTCTAACTAAGAAAGCAGTACAGAGGAAAACA GGAACCTGATTTTTTTAAAATAAATTTTAAATAAAATAGAATTACTACAATTCTGCAATTTCATACTAC CTAAAAAAGACTAGATTTGAAAATGTCAAGCTGATTTACTTTATTCACATGGAGAAAAGAATCCACAAA TTAAACTGAGTCCTTCACTGGCATGCCAGTTGACTATTATTAGCTGTCATAAGTAACTCAGCCATTTGG AAGCATTTCCTGGACAAAATTACATTATACCTGTGAAGAAAAATATAGAAGCTTTCAAGCTGTCATTCT GTTTTGGCCCTGTGTGAATTTGGTATATTAAATTGACGCTTGCTTTTTTTTTCAGTAGAGTTTTCTTTT TAATCAATCAAACGCCTACATTTCTGGAAGAAAAAGTCCAATTAGATCATTACACCTTAACTAAGAAGG CAAATCTTATAAATTTTGCTTGAATTGTTCTTACTCAAAACTACCTTAGAATATGGTATCTTATGAAAA TATAATATTCTTAAAATTTTGGAGGATAAAATGAAAAGGGTATAAACTTCAATTAGAACTTTAATCCT ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_006258.4
Synonyms	AAT8; cGK; cGK 1; cGK1; cGKI; cGKI-alpha; cGKI-BETA; PKG; PKG1; PRKG1B; PRKGR1B
Summary	Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity. [provided by RefSeq, Sep 2011]
Locus ID	5592
MW	78.5

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