RTN3 (NM_006054) Human 3' UTR Clone

Specifications

Product Data
Product Name	RTN3 (NM_006054) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	ASYIP; HAP; NSPL2; NSPLII; RTN3-A1
ACCN	NM_006054
Insert Size	1711 bp
Sequence Data	Insert Sequence (showhide) >SC215994 3’UTR clone of NM_006054 The sequence shown below is from the reference sequence of NM_006054. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC CCTGGAATCGCCAAAAAAAAGGCAGAATAAGTACATGGAAACCAGAAATGCAACAGTTACTAAAACACC ATTTAATAGTTATAACGTCGTTACTTGTACTATGAAGGAAAATACTCAGTGTCAGCTTGAGCCTGCATT CCAAGCTTTTTTTTTAATTTGGTGTTTTCTCCCATCCTTTCCCTTTAACCCTCAGTATCAAGCACAAAA ATTGATGGACTGATAAAAGAACTATCTTAGAACTCAGAAGAAGAAAGAATCAAATTCATAGGATAAGTC AATACCTTAATGGTGGTAGAGCCTTTACCTGTAGCTTGAAAGGGGAAAGATTGGAGGTAAGAGAGAAAA TGAAAGAACACCTCTGGGTCCTTCTGTCCAGTTTTCAGCACTAGTCTTACTCAGCTATCCATTATAGTT TTGCCCTTAAGAAGTCATGATTAACTTATGAAAAAATTATTTGGGGACAGGAGTGTGATACCTTCCTTG GTTTTTTTTTGCAGCCCTCAAATCCTATCTTCCTGCCCCACAATGTGAGCAGCTACCCCTGATACTCCT TTTCTTTAATGATTTAACTATCAACTTGATAAATAACTTATAGGTGATAGTGATAATTCCTGATTCCAA GAATGCCATCTGATAAAAAAGAATAGAAATGGAAAGTGGGACTGAGAGGGAGTCAGCAGGCATGCTGCG GTGGCGGTCACTCCCTCTGCCACTATCCCCAGGGAAGGAAAGGCTCCGCCATTTGGGAAAGTGGTTTCT ACGTCACTGGACACCGGTTCTGAGCATTAGTTTGAGAACTCGTTCCCGAATGTGCTTTCCTCCCTCTCC CCTGCCCACCTCAAGTTTAATAAATAAGGTTGTACTTTTCTTACTATAAAATAAATGTCTGTAACTGCT GTGCACTGCTGTAAACTTGTTAGAGAAAAAAATAACCTGCATGTGGGCTCCTCAGTTATTGAGTTTTTG TGATCCTATCTCAGTCTGGGGGGGAACATTCTCAAGAGGTGAAATACAGAAAGCCTTTTTTTCTTGATC TTTTCCCGAGATTCAAATCTCCGATTCCCATTTGGGGGCAAGTTTTTTTCTTCACCTTCAATATGAGAA TTCAGCGAACTTGAAAGAAAAATCATCTGTGAGTTCCTTCAGGTTCTCACTCATAGTCATGATCCTTCA GAGGGAATATGCACTGGCGAGTTTAAAGTAAGGGCTATGATATTTGATGGTCCCAAAGTACGGCAGCTG CAAAAAGTAGTGGAAGGAAATTGTCTACGTGTCTTGGAAAAATTAGTTAGGAATTTGGATGGGTAAAAG GTACCCTTGCCTTACTCCATCTTATTTTCTTAGCCCCCTTTGAGTGTTTTAACTGGTTTCATGTCCTAG TAGGAAGTGCATTCTCCATCCTCATCCTCTGCCCTCCCAGGAAGTCAGTGATTGTCTTTTTGGGCTTCC CCTCCAAAGGACCTTCTGCAGTGGAAGTGCCACATCCAGTTCTTTTCTTTTGTTGCTGCTGTGTTTAGA TAATTGAAGAGATCTTTGTGCCACACAGGATTTTTTTTTTTTTTTAAGAAAAACCTATAGATGAAAAAT TACTAATGAAACTGTGTGTACGTGTCTGTGCGTGCAACATAAAAATACAGTAGCACCTAAGGAGCTTGA ATCTTGGTTCCTGTAAAATTTCAAATTGATGTGGTATTAATAAAAAAAAAAAAAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_006054.4
Synonyms	ASYIP; HAP; NSPL2; NSPLII; RTN3-A1
Summary	This gene belongs to the reticulon family of highly conserved genes that are preferentially expressed in neuroendocrine tissues. This family of proteins interact with, and modulate the activity of beta-amyloid converting enzyme 1 (BACE1), and the production of amyloid-beta. An increase in the expression of any reticulon protein substantially reduces the production of amyloid-beta, suggesting that reticulon proteins are negative modulators of BACE1 in cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, and pseudogenes of this gene are located on chromosomes 4 and 12. [provided by RefSeq, May 2012]
Locus ID	10313
MW	64

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