GRP78 (HSPA5) (NM_005347) Human 3' UTR Clone

Specifications

Product Data
Product Name	GRP78 (HSPA5) (NM_005347) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	BIP; GRP78; HEL-S-89n
ACCN	NM_005347
Insert Size	1754 bp
Sequence Data	Insert Sequence (showhide) >SC216266 3' UTR clone of NM_005347 The sequence shown below is from the reference sequence of NM_005347. The complete sequence of this clone may contain minor differences, such as SNPs. Red=Cloning site Blue=Stop Codon CAATTGGCAGAGCTCAGAATTCAAGCGATCGC CTGGTGAAGAGGATACAGCAGAAAAAGATGAGTTGTAGACACTGATCTGCTAGTGCTGTAATATTGTAAA TACTGGACTCAGGAACTTTTGTTAGGAAAAAATTGAAAGAACTTAAGTCTCGAATGTAATTGGAATCTTC ACCTCAGAGTGGAGTTGAAACTGCTATAGCCTAAGCGGCTGTTTACTGCTTTTCATTAGCAGTTGCTCAC ATGTCTTTGGGTGGGGGGGAGAAGAAGAATTGGCCATCTTAAAAAGCGGGTAAAAAACCTGGGTTAGGGT GTGTGTTCACCTTCAAAATGTTCTATTTAACAACTGGGTCATGTGCATCTGGTGTAGGAAGTTTTTTCTA CCATAAGTGACACCAATAAATGTTTGTTATTTACACTGGTCTAATGTTTGTGAGAAGCTTCTAATTAGAT CAATTACTTATTTTAGGAAATTTAAGACTAGATACTCGTGTGTGGGGTGAGGGGAGGGAGTATTTGGTAT GTTGGGATAAGGAAACACTTCTATTTAATGCTTCCAGGGATTTTTTTTTTTTTTTTTAACCCTCCTGGGC CCAAGTGATCCTTCCACCTCAGTCTCCCAGCTAATTGAGACCACAGGCTTGTTACCACCATGCTCGGCTT TTGCATTAATCTAAGAAAAGGGGAGAGAAGTTAATCCACATCTTTACTCAGGCAAGGGGCATTTCACAGT GCCCAAGAGTGGGGTTTTCTTGAACATACTTGGTTTCCTATTTCCCCTTATCTTTCTAAAACTGCCTTTC TGGTGGCTTTTTTTAAAATTATTACTAATGATGCTTTTATAGCTGCTTGGATTCTCTGAGAAATGATGGG GAGTGAGTGATCACTGGTATTAACTTTATACACTTGGATTTCATTTGTAACTTTAGGATGTAAAGGTATA TTGTGAACCCTAGCTGTGTCAGAATCTCCATCCCTGAAATTTCTCATTAGTGGTACTGGGGTGGGATCTT GGATGGTGACATTGAAACTACACTAAATCCCCTCACTATGAATGGGTTGTTAAAGGCAATGGTTTGTGTC AAAACTGGTTTAGGATTACTTAGATTGTGTTCCTGAAGAAAAGAGTCCAGGTAAATGGTATGATCAATAA AGGACAGGCTGGTGCTAACATAAAATCCAATATTGTAATCCTAGCACTTTGGGAGGCCAAGGCGGGTGGA TCACAAGGTCAAGAGATAGAGACCATCTTTGCCAACATGGTGAAACTCCATCTCTACTGAAAATACAAAA ATTAGCTGGGCGTGGTAGTGCAAGCTGAAGGCTGAGGCAGGAGAATCACTCGAACCCGGGAGGCAGAGGT TGCAGTGAGCCGAGATCACACCACTGTACTCCAGCCCGGCACTCCAGCCTGGCGACAAGAGTGAGACTCC ACCTCAAAAAAAAAAAAAAGAATCCAATACTGCCCAAGGATAGGTATTTTATAGATGGGCAACTGGCTGA AAGGTTAATTCTCTAGGGCTAGTAGAACTGGATCCCAACACCAAACTCTTAATTAGACCTAGGCCTCAGC TGCACTGCCCGAAAAGCATTTGGGCAGACCCTGAGCAGAATACTGGTCTCAGGCCAAGCCCAATACAGCC ATTAAAGATGACCTACAGTGCTGTGTACCCTGGGGCAATAGGGTTAAATGGTAGTTAGCAACTAGGGCTA GTCTTCCCTTACCTCAAAGGCTCTCACTACCGTGGACCACCTAGTCTGTAACTCTTTCTGAGGAGCTGTT ACTG ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_005347.3
Synonyms	BIP; GRP78; HEL-S-89n
Summary	The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. This protein localizes to the lumen of the endoplasmic reticulum (ER) where it operates as a typical HSP70 chaperone involved in the folding and assembly of proteins in the ER and is a master regulator of ER homeostasis. During cellular stress, as during viral infection or tumorogenesis, this protein interacts with the transmembrane stress sensor proteins PERK (protein kinase R-like endoplasmic reticulum kinase), IRE1 (inositol-requiring kinase 1), and ATF6 (activating transcription factor 6) where it acts as a repressor of the unfolded protein response (UPR) and also plays a role in cellular apoptosis and senescence. Elevated expression and atypical translocation of this protein to the cell surface has been reported in viral infections and some types of cancer cells. At the cell surface this protein may facilitate viral attachment and entry to host cells. This gene is a therapeutic target for the treatment of coronavirus diseases and chemoresistant cancers. [provided by RefSeq, Jul 2020]
Locus ID	3309

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