HMGCR (NM_000859) Human 3' UTR Clone
CAT#: SC216360
3' UTR clone of 3-hydroxy-3-methylglutaryl-Coenzyme A reductase (HMGCR) transcript variant 1 for miRNA target validation
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CNY 5,795.00
货期*
3周
规格
Cited in 1 publication. |
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经常一起买 (2)
Specifications
Product Data | |
Product Name | HMGCR (NM_000859) Human 3' UTR Clone |
Vector | pMirTarget |
Synonyms | LDLCQ3 |
ACCN | NM_000859 |
Insert Size | 1792 bp |
Sequence Data |
>SC216360 3' UTR clone of NM_000859
The sequence shown below is from the reference sequence of NM_000859. The complete sequence of this clone may contain minor differences, such as SNPs. Red=Cloning site Blue=Stop Codon CAATTGGCAGAGCTCAGAATTCAAGCGATCGC ACAAGACCTCCAAGGAGCTTGCACCAAGAAGACAGCCTGAATAGCCCGACAGTTCTGAACTGGAACATGG GCATTGGGTTCTAAAGGACTAACATAAAATCTGTGAATTAAAAAAGCTCAATGCATTGTCTTGTGGAGGA TGAATAGATGTGATCACTGAGACAGCCACTTGGTTTTTGGCTCTTTCAGAGAGGTCTCAGGTTCTTTCCA TGCAGACTCCTCAGATCTGAACACAGTTTAGTGCTTTACATGCTGTGCTCTTTGAAGAGATTTCAACAAG AATATTGTATGTTAAAGCATCAGAGATGGTAATCTACAGCTCACCTCTGAAGGCAAATATAAGCTGGGAA AAAAGTTTTGATGAAATTCTTGAAGTTCATGGTGATCAGTGCAATTGACCTTCTCCCTCACTCCTGCCAG TTGAAAATGGATTTTTAAATTATACTGTAGCTGATGAAACTCCTGATTTTGTAGTTAATTTATTAAGTCT GGGATGTAGAACTTCAAGAAGTAAGAGCTAAGTTCTAAGTTCATGTTTGTAAATTAATACTTCATTTGGT GCTGGTCTATTTTGATTTTGGGGGGTAATCAGCATTATTCTTCAGAAGGGGACCTGTTTTCTTCAAGGGA AGAAACACTCTTATTCCCAAACTACAGAATAATGTGTTAAACATGCTAAATAGTTCTATCAGGAAAACAA ATCACTGTATTTATCTCCGCAGGCTATTTGTTCAGAGAGGCCTTTTGTTTAAATATAAATGTTTAAATAT AAATGTTTGTCTGGATTGGCTATAACATGTCTTTCAGCATTAGGCTTTTAAGAAACACAGGGTTTTGTAT TCTTTACTAAAGATATCAGAGCTCTTAATGTTGCTTAGATGAGGGTGACTGTCAAGTACAAGCAAGACTG GGACCTTAGAAATCATTGTAGAAACACAGTTTTGAAAGAAAAATACCATGTCTCTAAGCCAACTTTAATT GCTTAAAAGACATTTTTATTTAGTTGAAAAATCTAGTTTTTTTTGTAAACTGTATCAAATCTGTATATGT TGTAATAAAACTTATGCTAGTTTATTGGAAGTGTTCAAGAAATAAAAATCAACTTGTGTACTGATAAAAT ACTCTAGCCTGGGCCAGAGAAGATAATGTTCTTTAATGTTGTCCAGGAAACCCTGGCTTGCTTGCCGAGC CTAATGAAAGGGAAAGTCAGCTTTCAGAGCCAGTGAAGGAGCCACGTGAATGGCCCTAGAACTGTGCCTA GTTCCTGTGGCCAGGAGGTTGGTGACTGAAACATTCACACAGGGCTCTTTGATGGACCCACGAACGCTCT TAGCTTTCTCAGGGGGTCAGCAGAGTTATTGAATCTTAATTTTTTTTAATGTACAAGTTTTGTATAAATA ATAAAGAACTCCTTATTTTGTATTACATCTAATGCTTCAAGTGTTGCTCTTGGAAAGCTGATGATGTCTC TTGTAGAAGATGGACTCTGAAAAACATTCCAGGAAACCATGGCAGCATGGAGAGCCTCTTAGTGATTGTG TCTGCATTGTTATTGTGGAAGATTTACCTTTTCTGTTGTACGTAAAGCTTAAATTGCTTTTGTTGTGACT TTTTAGCCAGTGACTTTTTCTGAGCTTTTCATGGAAGTGGCAGTGAAAAATATGTTGAGTGTTCATTTTA GTGACTGTAATTAATATCTTGCTGGATTAATGTTTTGTACAATTACTAAATTGTATACATTTTGTTATAG AATACTTTTTTCTAGTTTCAGTAAATAATGAAAAGGAAGTTA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCG |
Restriction Sites | SgfI-MluI |
OTI Disclaimer | Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs). |
Reference Data | |
RefSeq | NM_000859.2 |
Synonyms | LDLCQ3 |
Summary | HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008] |
Locus ID | 3156 |
Citations (1)
The use of this cDNA Clones has been cited in the following citations: |
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MicroRNA-195 inhibits proliferation, invasion and metastasis in breast cancer cells by targeting FASN, HMGCR, ACACA and CYP27B1
,Singh, R;Yadav, V;Kumar, S;Saini, N;,
Sci Rep
,PubMed ID 26632252
[HMGCR]
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