HMGCR (NM_000859) Human 3' UTR Clone

CAT#: SC216360

3' UTR clone of 3-hydroxy-3-methylglutaryl-Coenzyme A reductase (HMGCR) transcript variant 1 for miRNA target validation



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CNY 5,795.00


货期*
3周

规格
    • 10 ug

Cited in 1 publication.

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经常一起买 (2)
Firefly luciferase assay kit, 150 assays
    • 1 kit

CNY 1,520.00


DH5α Chemically Competent Cells (≥10^8 cfu/μg of pUC19 DNA)
    • 5 x 200 ul

CNY 1,280.00

Specifications

Product Data
Product Name HMGCR (NM_000859) Human 3' UTR Clone
Vector pMirTarget
Synonyms LDLCQ3
ACCN NM_000859
Insert Size 1792 bp
Sequence Data
>SC216360 3' UTR clone of NM_000859
The sequence shown below is from the reference sequence of NM_000859. The complete sequence of this clone may contain minor differences, such as SNPs. Red=Cloning site Blue=Stop Codon


CAATTGGCAGAGCTCAGAATTCAAGCGATCGC

ACAAGACCTCCAAGGAGCTTGCACCAAGAAGACAGCCTGAATAGCCCGACAGTTCTGAACTGGAACATGG
GCATTGGGTTCTAAAGGACTAACATAAAATCTGTGAATTAAAAAAGCTCAATGCATTGTCTTGTGGAGGA
TGAATAGATGTGATCACTGAGACAGCCACTTGGTTTTTGGCTCTTTCAGAGAGGTCTCAGGTTCTTTCCA
TGCAGACTCCTCAGATCTGAACACAGTTTAGTGCTTTACATGCTGTGCTCTTTGAAGAGATTTCAACAAG
AATATTGTATGTTAAAGCATCAGAGATGGTAATCTACAGCTCACCTCTGAAGGCAAATATAAGCTGGGAA
AAAAGTTTTGATGAAATTCTTGAAGTTCATGGTGATCAGTGCAATTGACCTTCTCCCTCACTCCTGCCAG
TTGAAAATGGATTTTTAAATTATACTGTAGCTGATGAAACTCCTGATTTTGTAGTTAATTTATTAAGTCT
GGGATGTAGAACTTCAAGAAGTAAGAGCTAAGTTCTAAGTTCATGTTTGTAAATTAATACTTCATTTGGT
GCTGGTCTATTTTGATTTTGGGGGGTAATCAGCATTATTCTTCAGAAGGGGACCTGTTTTCTTCAAGGGA
AGAAACACTCTTATTCCCAAACTACAGAATAATGTGTTAAACATGCTAAATAGTTCTATCAGGAAAACAA
ATCACTGTATTTATCTCCGCAGGCTATTTGTTCAGAGAGGCCTTTTGTTTAAATATAAATGTTTAAATAT
AAATGTTTGTCTGGATTGGCTATAACATGTCTTTCAGCATTAGGCTTTTAAGAAACACAGGGTTTTGTAT
TCTTTACTAAAGATATCAGAGCTCTTAATGTTGCTTAGATGAGGGTGACTGTCAAGTACAAGCAAGACTG
GGACCTTAGAAATCATTGTAGAAACACAGTTTTGAAAGAAAAATACCATGTCTCTAAGCCAACTTTAATT
GCTTAAAAGACATTTTTATTTAGTTGAAAAATCTAGTTTTTTTTGTAAACTGTATCAAATCTGTATATGT
TGTAATAAAACTTATGCTAGTTTATTGGAAGTGTTCAAGAAATAAAAATCAACTTGTGTACTGATAAAAT
ACTCTAGCCTGGGCCAGAGAAGATAATGTTCTTTAATGTTGTCCAGGAAACCCTGGCTTGCTTGCCGAGC
CTAATGAAAGGGAAAGTCAGCTTTCAGAGCCAGTGAAGGAGCCACGTGAATGGCCCTAGAACTGTGCCTA
GTTCCTGTGGCCAGGAGGTTGGTGACTGAAACATTCACACAGGGCTCTTTGATGGACCCACGAACGCTCT
TAGCTTTCTCAGGGGGTCAGCAGAGTTATTGAATCTTAATTTTTTTTAATGTACAAGTTTTGTATAAATA
ATAAAGAACTCCTTATTTTGTATTACATCTAATGCTTCAAGTGTTGCTCTTGGAAAGCTGATGATGTCTC
TTGTAGAAGATGGACTCTGAAAAACATTCCAGGAAACCATGGCAGCATGGAGAGCCTCTTAGTGATTGTG
TCTGCATTGTTATTGTGGAAGATTTACCTTTTCTGTTGTACGTAAAGCTTAAATTGCTTTTGTTGTGACT
TTTTAGCCAGTGACTTTTTCTGAGCTTTTCATGGAAGTGGCAGTGAAAAATATGTTGAGTGTTCATTTTA
GTGACTGTAATTAATATCTTGCTGGATTAATGTTTTGTACAATTACTAAATTGTATACATTTTGTTATAG
AATACTTTTTTCTAGTTTCAGTAAATAATGAAAAGGAAGTTA

ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCG
Restriction Sites SgfI-MluI     
OTI Disclaimer Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq NM_000859.2
Synonyms LDLCQ3
Summary HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Locus ID 3156
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Citations (1)

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