PTCH1 (NM_000264) Human 3' UTR Clone

Specifications

Product Data
Product Name	PTCH1 (NM_000264) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	BCNS; NBCCS; PTC; PTC1; PTCH
ACCN	NM_000264
Insert Size	2000 bp
Sequence Data	Insert Sequence (showhide) >SC220803 3’UTR clone of NM_000264 The sequence shown below is from the reference sequence of NM_000264. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GAGAGGCCCCGGGGAAGCAGCTCCAACTGAGGGTGATTAAAATCTGAAGCAAAGAGGCCAAAGATTGGA AACCCCCCACCCCCACCTCTTTCCAGAACTGCTTGAAGAGAACTGGTTGGAGTTATGGAAAAGATGCCC TGTGCCAGGACAGCAGTTCATTGTTACTGTAACCGATTGTATTATTTTGTTAAATATTTCTATAAATAT TTAAGAGATGTACACATGTGTAATATAGGAAGGAAGGATGTAAAGTGGTATGATCTGGGGCTTCTCCAC TCCTGCCCCAGAGTGTGGAGGCCACAGTGGGGCCTCTCCGTATTTGTGCATTGGGCTCCGTGCCACAAC CAAGCTTCATTAGTCTTAAATTTCAGCATATGTTGCTGCTGCTTAAATATTGTATAATTTACTTGTATA ATTCTATGCAAATATTGCTTATGTAATAGGATTATTTTGTAAAGGTTTCTGTTTAAAATATTTTAAATT TGCATATCACAACCCTGTGGTAGTATGAAATGTTACTGTTAACTTTCAAACACGCTATGCGTGATAATT TTTTTGTTTAATGAGCAGATATGAAGAAAGCACGTTAATCCTGGTGGCTTCTCTAGGTGTCGTTGTGTG CGGTCCTCTTGTTTGGCTGTGCGTGTGAACACGTGTGTGAGTTCACCATGTACTGTACTGTGATTTTTT TTTTGTCTTGTTTTGTTTCTCTACACTGTCTGTAACCTGTAGTAGGCTCTGACCTAGTCAGGCTGGAAG CGTCAGGATATCTTTTCTTCGTGCTGGTGAGGGCTGGCCCTAAACATCCACCTAATCCTTTCAAATCAG CCCGGCAAAAGCTAGACTCTCCTCGTGTCTACGGCATCTCTTATGATCATTGGCTGCCATCCAGGACCC CAATTTGTGCTTCAGGGGGATAATCTCCTTCTCTCGGATCATTGTGATGGATGCTGGAACCTCAGGGTA TGGAGCTCACATCAGTTCATCATGGTGGGTGTTAGAGAATTCGGTGACATGCCTAGTGCTGAGCCTTGG CTGGGCCATGAGAGTCTGTATACTCTAAAAAGCATGCAGCATGGTGCCCCTCTTCTGACCAACACACAC ACGACCCCTCCCCCAACACCCCCAAATTCAAGAGTGGATGTGGCCCTGTCACAGGTAGAAAAACCTATT TAGTTAATTCTTTCTTGGCCCACAGTCTCCCAGAAATGATGTTTTGAGTCCCTATAGTTTAAACTCCCT CTCTTAAATGGAGCAGCTGGTTGAGGCTTTCTAGATCTGTTTGCATCTTCTTTAAAACTAAGTGGTGAG CATGCATTGTGGTGTAGAGGCAGGCATTATGTAGGATAAGAGCTCCGGGGGGATTCTTCATGCACCAGT GTTTAGGGTACGTGCTTCCTAAGTAAATCCAAACATTGTCTCCATCCTCCCCGTCATTAGTGCTCTTTC AATGTGATGTGGGAAAGCAGGAGGATGGACACACCCCACTGAAAGATGTAGGCAGGGGCAGGTCTCTCA ACCAGGCATATTTTTAAAAGTTGCTTCTGTACTGGTTCTCTTCTTTTGCTCTGAGGTGTGGGCTCCCTC ATCTCGTAACCAGAGACCAGCACATGTCAGGGAAGCACCCAGTGTCGGCTCCCCATCCAAATCCACACC AGCACCTTGTTACAGACAAGAAGTCAGAGGAAAGGGCGGGGTCCCTGCAGGGCTGAAGCCTAAGCTACT GTGAGGCGCTCACGAGTGGCAGCTCCTGTTACTCCCTTTTAAATTACCTGGGAAATCTTAACAGAAAGG TAATGGGCCCCCAGAAATACCCACAGCATAGTGACCTCAGACCCTGATACTCACCACAAAACTTTTAAG ATGCTGATTGGGAGCCGCTTGTGGCTGCTGGGTGTGTGTGTGTGTGTGTGCGTGCGTGCGTGTGTGTGT GTCTCTGCTGGGGACCCTGGCCACCCCCCTGCTGCTGTCTTGGTGCCTGTCACCCACATGGTCTGCCA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_000264.5
Synonyms	BCNS; NBCCS; PTC; PTC1; PTCH
Summary	This gene encodes a member of the patched family of proteins and a component of the hedgehog signaling pathway. Hedgehog signaling is important in embryonic development and tumorigenesis. The encoded protein is the receptor for the secreted hedgehog ligands, which include sonic hedgehog, indian hedgehog and desert hedgehog. Following binding by one of the hedgehog ligands, the encoded protein is trafficked away from the primary cilium, relieving inhibition of the G-protein-coupled receptor smoothened, which results in activation of downstream signaling. Mutations of this gene have been associated with basal cell nevus syndrome and holoprosencephaly. [provided by RefSeq, Aug 2017]
Locus ID	5727
MW	74.5

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