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Ptpn22 (NM_008979) Mouse Untagged Clone
CAT＃: MC201915
Ptpn22 (untagged) - Mouse protein tyrosine phosphatase, non-receptor type 22 (lymphoid) (Ptpn22), (10ug)
CNY 8,824.00
Product images
Specifications
| Product Data | |
| Type | Mouse Untagged Clone |
| Tag | Tag Free |
| Synonyms | 70zpep; PEP; Ptpn8 |
| Vector | PCMV6-Kan/Neo |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>BC055377 sequence for NM_008979
AAGAGGTAATCCCCTCCCTTAACCTACTCACAGACTCTTGCTCTGCGGCATGGACCAAAGAGAAATTCTG CAGCAACTACTGAAAGAAGCCCAGAAAAAGAAACTCAACAGTGAGGAGTTTGCCAGTGAATTTCTGAAGC TGAAAAGGCAATCCACCAAGTACAAGGCCGACAAAATCTATCCTACAACTGTGGCTCAGAGGCCCAAGAA TATCAAGAAAAACAGATACAAGGATATTTTGCCCTATGATCACAGCCTGGTAGAGCTGTCTTTGTTAACT TCCGATGAGGATTCCAGTTACATCAATGCCAGCTTTATTCAGGGTGTCTATGGACCCAAGGCTTATATTG CTACCCAGGGTCCTTTATCTACAACTCTCCTGGACTTCTGGAGGATGATTTGGGAGTACCGCATCTTGGT CATTGTCATGGCATGTATGGAGTTTGAAATGGGAAAGAAAAAATGTGAGCATTATTGGGCCGAACCAGGA GAAACGCAGCTGCAATTTGGCCCCTTTTCTATATCCTGTGAAGCTGAGAAAAAGAAATCTGATTATAAAA TCAGGACTCTGAAGGCCAAGTTCAATAATGAAACTCGAATTATTTACCAGTTTCATTATAAGAATTGGCC AGACCATGATGTGCCTTCATCTATAGACCCTATTCTTCAGCTCATCTGGGATATGCGTTGTTACCAAGAA GATGACTGTGTTCCTATATGCATTCACTGCAGTGCCGGCTGCGGAAGGACAGGTGTCATTTGTGCTGTTG ATTATACATGGATGCTGCTGAAAGATGGGATAATTCCTAAGAACTTCAGTGTTTTTAATTTGATTCAGGA GATGCGAACACAGAGGCCTTCGCTAGTTCAAACTCAGGAACAGTACGAACTGGTCTACAGTGCTGTGTTA GAGCTGTTTAAGAGGCACATGGATGTTATCTCTGATAATCACCTTGGAAGAGAGATTCAAGCACAATGCT CAATTCCTGAACAAAGCCTCACGGTAGAAGCTGACTCTTGTCCTCTGGATTTACCAAAAAACGCCATGAG GGATGTGAAAACGACAAACCAGCATAGCAAACAAGGGGCTGAAGCGGAGAGCACTGGAGGGTCTTCCCTT GGCCTTAGGACTTCTACGATGAATGCCGAGGAAGAGTTGGTTTTGCACTCGGCTAAATCAAGCCCTTCTT TTAACTGTTTAGAGCTAAACTGCGGGTGTAACAACAAGGCTGTCATAACCAGGAACGGGCAGGCAAGGGC TTCTCCAGTCGTGGGAGAGCCCCTTCAGAAGTATCAAAGTCTGGATTTTGGTTCCATGTTGTTTGGGTCG TGTCCTAGTGCTCTGCCCATAAACACAGCGGACAGGTATCACAATTCAAAGGGGCCGGTAAAACGGACCA AATCAACTCCCTTTGAACTGATTCAGCAGAGAAAAACAAATGACTTGGCCGTGGGAGACGGTTTTTCATG CCTGGAATCTCAGCTGCATGAGCATTACAGTCTCAGGGAGTTGCAGGTGCAAAGAGTGGCCCATGTTTCT TCAGAAGAGCTGAATTATTCACTGCCTGGTGCCTGTGATGCGTCGTGTGTGCCCCGGCACAGCCCCGGCG CTTTGAGAGTGCATCTGTACACATCTTTAGCGGAAGATCCTTATTTTTCATCATCCCCTCCGAATAGTGC TGATTCGAAGATGTCTTTTGATCTGCCTGAGAAACAGGATGGAGCCACTTCCCCTGGCGCTCTATTGCCA GCCTCTTCTACAACCTCCTTCTTTTATAGCAACCCACACGACTCCCTAGTGATGAACACTCTGACCAGCT TTTCCCCACCGTTAAACCAAGAGACAGCTGTAGAAGCTCCTTCTCGGAGGACAGATGATGAAATCCCCCC GCCACTCCCTGAACGGACACCCGAGTCTTTTATTGTGGTTGAGGAAGCCGGAGAGCCCTCACCACGTGTT ACCGAATCCTTACCTCTGGTGGTAACATTTGGAGCATCACCAGAATGCAGTGGGACATCTGAAATGAAGA GCCATGACTCTGTAGGGTTTACACCAAGCAAGAATGTGAAACTCCGAAGTCCCAAATCAGATCGACATCA GGATGGTTCTCCTCCACCTCCTCTCCCAGAAAGAACTCTAGAGTCCTTCTTTCTTGCTGATGAGGACTGT ATACAGGCCCAAGCCGTGCAAACTTCTTCTACTAGCTATCCTGAAACCACAGAGAACTCCACATCTTCTA AACAAACATTGAGGACCCCTGGAAAAAGTTTCACAAGGAGTAAGAGTTTGAAGATTTTTCGAAATATGAA AAAAAGTGTCTGTAATTCTTCCTCACCAAGCAAGCCTACAGAACGTGTTCAGCCAAAAAATTCCAGCTCC TTTCTGAATTTTGGTTTCGGAAATCGTTTTTCAAAACCCAAAGGACCAAGGAACCCGCCATCAGCTTGGA ATATGTAACGCACCTCTGGATTTATAAGAATATTTGTTAAAATTGTACCTGCAGATAAAGCTACTTGAAT ACTGCTATAATAATAATATCAGTAATGAGGATATATTTTGTCAATAGTCTTGAAAAGGAAAGCAATATGT GACAAACTTCCAGCAAACTTGTATTTTCATATTCCTTATATTTCACTGGGAACTGCCAATAAAGTTTGTA CTTCAAAAAAAAAAA |
| Restriction Sites | RsrII-NotI |
| ACCN | NM_008979 |
| Insert Size | 2409 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | BC055377, AAH55377 |
| RefSeq Size | 2675 bp |
| RefSeq ORF | 2409 bp |
| Locus ID | 19260 |
| UniProt ID | P29352 |
| Gene Summary | Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules (By similarity). Associates with and probably dephosphorylates CBL (By similarity). Dephosphorylates LCK at its activating 'Tyr-394' residue (By similarity). Dephosphorylates ZAP70 at its activating 'Tyr-492' residue (By similarity). Dephosphorylates the immune system activator SKAP2 (By similarity). Positively regulates toll-like receptor (TLR)-induced type 1 interferon production (PubMed:23871208). Promotes host antiviral responses mediated by type 1 interferon (PubMed:23871208). Regulates NOD2-induced pro-inflammatory cytokine secretion and autophagy (PubMed:23991106).[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (1) represents the longer transcript and encodes a protein. |
Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| MG210734 | Ptpn22 (tGFP-tagged) - Mouse protein tyrosine phosphatase, non-receptor type 22 (lymphoid) (Ptpn22) |
CNY 10,408.00 |
|
| MR210734 | Ptpn22 (Myc-DDK-tagged) - Mouse protein tyrosine phosphatase, non-receptor type 22 (lymphoid) (Ptpn22) |
CNY 8,808.00 |
|
| MR210734L3 | Lenti ORF clone of Ptpn22 (Myc-DDK-tagged) - Mouse protein tyrosine phosphatase, non-receptor type 22 (lymphoid) (Ptpn22) |
CNY 9,880.00 |
|
| MR210734L4 | Lenti ORF clone of Ptpn22 (mGFP-tagged) - Mouse protein tyrosine phosphatase, non-receptor type 22 (lymphoid) (Ptpn22) |
CNY 9,880.00 |
