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Mfn2 (NM_133201) Mouse Untagged Clone
CAT＃: MC205980
Mfn2 (untagged) - Mouse mitofusin 2 (Mfn2), nuclear gene encoding mitochondrial protein, (10ug)
CNY 5,552.00
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热销推荐Specifications
| Product Data | |
| Type | Mouse Untagged Clone |
| Tag | Tag Free |
| Synonyms | D630023P19Rik; Fzo |
| Vector | PCMV6-Kan/Neo |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>BC046503
GATGGCCGCCGCGAGGCCGGGAAGGTGAAGAAGCTTGGACAGGTGGAGTCAACACCATCAGGGGCCAACC TGGACCTGAATCAGCACAGAGGAGACCTCGAGTCCTTTTCATCTTTCTGACTCCAGCCATGTCCACGATG CCCAACCTGTGAAGGTCTCTTACCAGCTAGAAACGAGATGTCCCTGCTCTTTTCTCGATGCAACTCCATC GTCACCGTCAAGAAGGATAAGCGACACATGGCTGAAGTGAATGCTTCCCCTCTCAAGCACTTTGTCACTG CCAAGAAAAAGATCAATGGAATCTTTGAGCAGCTGGGGGCCTACATCCAAGAGAGCGCCAGCTTCCTTGA AGACACCCACAGGAACACAGAACTGGACCCGGTTACCACGGAAGAGCAGGTCCTGGACGTCAAAGGGTAC CTGTCCAAGGTCAGGGGTATCAGCGAAGTGCTGGCCAGGCGGCACATGAAGGTGGCTTTTTTTGGCCGGA CGAGCAATGGGAAGAGCACCGTGATCAATGCCATGCTCTGGGACAAAGTTCTGCTATCTGGGATTGGTCA TACCACCAATTGCTTCCTGCGGGTTGGGGGCACAGATGGCCATGAGGCCTTCCTCCTCACAGAGGGCTCA GAAGAGAAGAAGAGTGTCAAGACTGTGAACCAACTGGCCCATGCCCTCCATCAGGACGAGCAGTTGCATG CAGGCAGCATGGTGAGTGTGATGTGGCCCAACTCCAAGTGTCCGCTCCTGAAGGATGACCTCGTGCTGAT GGACAGCCCTGGGATCGATGTTACCACGGAGCTGGACAGCTGGATTGATAAGTTTTGCCTGGATGCTGAT GTGTTTGTGCTGGTGGCCAACTCAGAGTCCACGCTGATGCAGACGGAGAAGCAGTTCTTCCACAAAGTGA GTGAACGTCTCTCCCGGCCCAACATCTTCATCCTGAACAACCGCTGGGATGCGTCTGCCTCGGAGCCTGA GTACATGGAGGAGGTGCGGCGGCAGCACATGGAGCGCTGCACCAGCTTTCTGGTGGATGAGCTGGGCGTG GTGGATCGAGCTCAGGCTGGGGACCGGATCTTCTTCGTGTCTGCCAAGGAGGTTCTCAGCGCCAGGGTCC AGAAAGCCCAGGGCATGCCAGAAGGAGGCGGCGCTCTCGCAGAAGGTTTTCAAGTGAGGATGTTTGAGTT TCAGAATTTCGAGAGGCAGTTTGAGGAGTGCATTTCCCAGTCTGCAGTAAAGACCAAATTTGAGCAGCAC ACAGTCCGGGCCAAGCAGATTGCAGAGGCCGTTCGTCTCATCATGGATTCCCTGCACATCGCAGCTCAGG AGCAGCGGGTTTATTGCCTAGAAATGCGGGAAGAGCGGCAAGACCGGCTGAGGTTTATTGACAAGCAGCT GGAGCTCCTGGCTCAAGACTACAAGCTGCGAATTAAGCAGATTACGGAGGAAGTGGAAAGGCAGGTGTCC ACAGCCATGGCTGAAGAGATCAGGCGCCTCTCTGTGCTAGTTGACGAGTACCAGATGGACTTCCACCCAT CCCCAGTTGTCCTCAAGGTTTATAAGAACGAGCTGCACCGCCATATAGAGGAAGGTCTGGGCCGGAACCT GTCTGACCGCTGCTCCACTGCCATTGCCAGTTCACTGCAGACTATGCAGCAGGACATGATAGACGGCTTG AAGCCCCTTCTTCCTGTATCTATGCGGAATCAGATAGACATGCTGGTCCCTCGACAGTGTTTCTCCCTCA GCTATGACCTGAATTGTGACAAGCTGTGTGCTGACTTTCAGGAGGACATCGAGTTCCACTTCTCCCTTGG ATGGACTATGCTAGTGAACAGGTTCCTGGGCCCCAAGAATAGCCGCCGGGCCTTGCTAGGCTACAGTGAT CAGGTTCAGCGTCCTCTCCCTCTGACACCTGCCAACCCCAGCATGCCCCCCTTGCCACAGAGCTCCCTCA CCCAGGAGGAGCTCATGGTCTCCATGGTTACTGGCCTGGCCTCTCTGACGTCTAGGACCTCCATGGGCAT TCTTGTGGTCGGAGGAGTGGTGTGGAAGGCAGTGGGCTGGAGACTCATCGCCCTCTCCTTTGGACTGTAT GGCCTCCTGTACGTCTATGAGCGACTGACCTGGACCACCAAAGCCAAAGAGAGGGCCTTCAAGCGCCAGT TTGTGGAATACGCCAGTGAGAAGCTACAGCTCATCATCAGTTACACCGGCTCTAACTGCAGCCACCAAGT CCAGCAGGAATTGTCTGGGACATTTGCTCATCTGTGCCAGCAAGTTGACATCACCCGAGATAATCTGGAG CAGGAAATTGCTGCCATGAACAAGAAAGTCGAGGCTCTGGATTCACTTCAGAGCAGAGCCAAACTGCTCA GGAATAAAGCTGGCTGGTTGGACAGCGAACTCAACATGTTCACACACCAGTACCTGCAGCCCAGCAGATA GTGGGCAGCCAGGGCGGACCTGCACGAAGAAGAGGCAGGGCCGCACCTCCCATCAGCTCTAGTCCTTGGC CGCTGCAGAGAGAAGGAAAGCACCCAGTCTTGTACCAGTTACTCCCTACCCCCTGCAGGAAGACCCCTGG CTCATACCCTAATGGAGACCAACAAGGACTGGACAGCTCGGCTCCAAGGAGTTATGCATGTGTCTGTGTC TGCTCCTCACGCTCACCCGGTTGAAAGTCACTGTGCATTTGATAAAGTTTTCCTCAGAATGGCACCCTGC AGAATGACTGATGGGCGCCTTCACAGGCATCAGGCAGCCACTCCTACTTTCTCCAGCCTGAGCACACCTA CAGAGAGACAGTGTTGGGGGTGACAGGATGCCCCAGAAAAATTCAGGATACTTCTGAAATTGCCATGTTT GTCTCAGAACTTGTATCTTGCGTTTGGCCCTCAGCTTTAGCACTTTTTCCCACTTGCAGAGTCTTTCAGT TGTGCTTGGTAGCCAGGCTCAACACACCGGGGCTTTAGACTCAAGCAGCTTATATGGGAAGCTGGAGACC CCTGCCAGCCAGAGCACAGTAAGGGCTCGGAGAAGGTATGTGAACTAGGGTATCTGATGTGGTAGTGCAG TTGGTGTCTGGCATTGTGACGACAAGGGACTTGCCTCCCTTCTTGCCACTGAGGCCCTTGCTTTTCCTTC AGCTCTTGGCCTGTTGGTCCGGTTTATTAGTGAGAGCTAGTTTGCTCCAGGTGGTTAAAGGATGTAGCAG GAGGAATGGTGGAAGATGGGAGCTGCCCGGGTTAGTACAGAAGAGGTCTGTCTATCTGACCTAGCACTGA GGGGTTCACAAACCTGTGAGGTGCACCTCACTAATTTTGGCTCATCCCTGCCTTGCTACAAGCTCCCTGT GGCCACCATTCTCTGGACTGTACCGTGCTGATGACTGCAGCTGGCTACAAAACAGCATGAGAACCTGGCC GCTGTTCTCCTACTGCCTCCACCCTCAGGCAGGCCTCCTCCTCTTCTGCCCCTGAAGCCTCCTGCTGCTT GCTCCTCCTGCCTCCACCCTCAGGCAGGCCTCCTCCTCTTCTGCCCCTGAAGCCTCCTGCTGCTGCTCCT CCACCTCAGTCAGTGCTGAACTTCTCACTGTTGAGTGTTGAAATTGTTAATGGTCAAAGCAGGGAGGATG CCAGTCACCAAGGTTGATTGTCTTGGGAAAGCAGTTTTAGAGTGATGAATCCTTTGTAGGACAGGTAGAG AGTATCTTAGAGATAAAAAAATGGGCTATGTCCTCTCCTGCCCATGTCTTGTGCTCACTCGCCCCTCAGT CTACCCTTTTTGCTGGGACAGTGATGGTCTTGGCCAAGGTCAGCATGTAATGGAAAGACAGTGTATTGCC AGGCTGGATAGATGGGGTCATCTCACAGTGGGTCACGTGAAAATCAGTGTCACGTAGTCCCAGTGAATGT TGTGTTCTTTCTGGGGGGAGGGGGGAATAGAATAAACTCAAATTCTTTTTCAGTATAGCCCCTGAGTAAT GAATGAAAATTTGAGCTTATGTAAGTAAAGATTCATTTATGCCACCAGGGAGAGCCTGTATCTGAGAGAC ATTTAGCAGAGAGCACTTTAGTTTTTTGCTGCTAACTGTTGTGTGATCCTTTGCTGGGGTGCAAAAGGCA CCGGACACAGTGTGTTTGCTTCTGGTATATTTAGGTGATGCATCCGCCTGGGTTACCTGTATCTCTGCTG ATCATATTGGAAACTAAAATAAAGCCCCATTTGTGACCCTGAAAAAAAAAAAAAAAAA |
| Restriction Sites | RsrII-NotI |
| ACCN | NM_133201 |
| Insert Size | 2274 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | BC046503, AAH46503 |
| RefSeq Size | 4258 bp |
| RefSeq ORF | 2274 bp |
| Locus ID | 170731 |
| UniProt ID | Q80U63 |
| Gene Summary | Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:12527753, PubMed:23921378, PubMed:23620051). Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events. Overexpression induces the formation of mitochondrial networks. Membrane clustering requires GTPase activity and may involve a major rearrangement of the coiled coil domains (By similarity). Plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Plays an important role in the regulation of vascular smooth muscle cell proliferation (By similarity). Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). Is required for PRKN recruitment to dysfunctional mitochondria (PubMed:23620051). Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress (PubMed:23921556). Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions (PubMed:23921556).[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All variants (1 through 7) encode the same protein. |
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Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| MG210494 | Mfn2 (tGFP-tagged) - Mouse mitofusin 2 (Mfn2) |
CNY 7,152.00 |
|
| MR210494 | Mfn2 (Myc-DDK-tagged) - Mouse mitofusin 2 (Mfn2), nuclear gene encoding mitochondrial protein |
CNY 5,552.00 |
|
| MR210494L3 | Lenti ORF clone of Mfn2 (Myc-DDK-tagged) - Mouse mitofusin 2 (Mfn2), nuclear gene encoding mitochondrial protein |
CNY 7,952.00 |
|
| MR210494L4 | Lenti ORF clone of Mfn2 (mGFP-tagged) - Mouse mitofusin 2 (Mfn2), nuclear gene encoding mitochondrial protein |
CNY 7,700.00 |
