Plat (BC061508) Mouse Untagged Clone

Specifications

Product Data
Type	Mouse Untagged Clone
Tag	Tag Free
Synonyms	tPA, t-PA, MGC18508
Vector	PCMV6-Kan/Neo
E. coli Selection	Kanamycin (25 ug/mL)
Mammalian Cell Selection	Neomycin
Sequence Data	Fully Sequenced ORF (showhide) >BC061508 AGGAACTCAAGAGCTCAGCGTCAAGGAGAGGCCCCTGCAAGAGTGGGAAAGAAGCAAGCACTCTCGGGAC ACAGAAGAAACGGGGAGCAAAATGAAGAGAGAGCTGCTGTGTGTACTGCTGCTTTGTGGACTGGCTTTCC CATTGCCTGACCAGGGAATACATGGGAGGTTCAGAAGAGGAGCCCGGTCCTACAGAGCGACCTGCAGAGA TGAGCCAACGCAGACAACTTACCAACAGCACCAGTCGTGGCTCCGACCCATGCTCAGAAGCAGCCGGGTG GAATATTGCCGGTGCAACAGCGGCCTGGTACAATGCCACTCAGTGCCTGTCCGAAGTTGCAGCGAACCAA GATGCTTCAATGGGGGGACGTGTCAGCAGGCCCTGTATTTCTCTGACTTTGTCTGCCAGTGCCCTGATGG ATTTGTAGGGAAACGCTGTGACATAGATACCAGAGCAACATGCTTTGAGGAGCAGGGCATCACCTACAGA GGCACGTGGAGCACAGCAGAAAGTGGGGCTGAGTGCATCAACTGGAATAGCAGTGTTCTGTCGCTGAAGC CCTACAATGCAAGGAGGCCAAATGCCATCAAGCTGGGCCTTGGGAATCACAATTACTGCAGAAACCCAGA CCGAGACTTGAAGCCCTGGTGCTATGTCTTTAAGGCAGGGAAGTATACCACGGAGTTCTGTAGCACACCA GCTTGCCCTAAGGGAAAAAGCGAGGACTGCTATGTTGGGAAAGGTGTGACTTACCGTGGCACCCACAGCC TCACCACATCCCAGGCCTCCTGCCTCCCCTGGAATTCCATAGTCCTCATGGGCAAGAGTTACACAGCGTG GAGGACCAACTCCCAGGCACTCGGCCTGGGCAGACACAATTATTGTCGGAATCCAGATGGTGATGCCAGA CCTTGGTGCCATGTGATGAAGGACCGAAAGCTGACGTGGGAATACTGTGACATGTCCCCATGCTCCACCT GTGGCCTGAGGCAGTACAAACGGCCTCAGTTTAGAATTAAAGGAGGACTCTACACAGACATCACCTCACA CCCTTGGCAGGCTGCCATCTTTGTCAAGAACAAGAGGTCTCCTGGAGAGAGATTCCTTTGTGGAGGGGTG CTGATCAGTTCCTGCTGGGTGCTGTCAGCTGCCCACTGCTTTCTAGAGAGGTTCCCCCCCAATCATCTTA AAGTGGTCTTGGGCAGAACATACAGGGTGGTCCCCGGAGAGGAAGAACAGACATTTGAGATTGAAAAATA CATAGTCCATGAGGAATTTGATGACGATACTTATGACAACGACATCGCATTACTGCAGCTGAGGTCACAG TCCAAGCAATGTGCCCAAGAGAGCAGCTCTGTTGGCACTGCCTGCCTCCCTGACCCCAACCTGCAGCTCC CTGACTGGACAGAGTGTGAGCTTTCTGGCTACGGCAAGCATGAGGCATCGTCTCCATTCTTCTCTGACCG GCTGAAGGAGGCTCACGTCAGACTGTACCCGTCCAGCCGCTGCACCTCACAGCATCTGTTTAATAAAACC GTCACGAACAACATGCTGTGCGCTGGAGACACCCGGAGCGGAGGCAACCAAGACCTCCACGATGCATGCC AGGGTGACTCGGGAGGCCCTCTGGTGTGCATGATCAATAAACAGATGACATTGACTGGCATTATCAGCTG GGGCCTCGGCTGTGGGCAGAAGGATGTGCCTGGGGTCTACACAAAGGTTACGAATTACCTAGACTGGATT CACGACAACATGAAGCAATGACAAAGAAAGCCCAGCTCCTTCAATCCAGAGGAGGACCTGCCTTCCTCTT CCTCTTCTACAGAAGATGCGCCTAAAAGGCCAAGCATTCTTTACACCATCATCTTCGTGAGCTGCCACTC GGGAGAGGGGAGGGGGGTCTTTGGGAGCAGATGTAGCATTTACCTGTGACAGGTACTTCACAACTTGTAA GTTTTAAGGATGAAGGTCTGGCTTTAGAATAAATCCTGTCAGATGAGATGACAGGGAGATGCCAACCTTC CTATAACTCTAGGATTTTAAAAAGAGAGGTAGACCAAAGTCTGCCCTCCTGGTCCACTATGTTGTACACT GAACCACAAGATCATGTCTCAACAGCAAAAAAATACAACTTGATCTTTCAGGAGTGAAAGTTTGCACTGG GGACAAGAATGTGTTTTTATAGTTACACAGGGGGCCCCACAGGGCCTCCACGAGAAGGAAGGGGTATCTG GCCGAATCACAGCACCATAAAATCCTTGAGATCATGCACTCCCCATCCCTCCACACTCCTCAACTCTTGG GACATATCCCTTTGTATACAGTGTAAATGTCTTTTTCTTTATAAACTCTATAGATGGTTGGGAGAACTGT ATGATTTTAATAATTGATGAATAACACTAGTATATTTATATTTTAATCTATTTTAGTTTTTACTTTGTTA CTATAACTTTGTATTATACTGTACTTAAATAATAAATTCAGAGGTATTTTTCACAAAAAAAAAAAAAAAA
Restriction Sites	RsrII-NotI
ACCN	BC061508
Insert Size	1680 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	BC061508, AAH61508
RefSeq Size	2520 bp
RefSeq ORF	1680 bp
Locus ID	18791
Gene Summary	This gene encodes a key enzyme of the fibrinolytic pathway. The encoded protein undergoes proteolytic processing by plasmin to generate a heterodimeric serine protease that cleaves the proenzyme plasminogen to produce plasmin, a protease that is required to break down fibrin clots. Additionally, the encoded protein is involved in other biological processes such as synaptic plasticity, cell migration and tissue remodeling. Mice lacking the encoded protein display a reduction in long-term potentiation in hippocampus and conversely, transgenic mice overexpressing the encoded protein have increased and prolonged long-term potentiation. [provided by RefSeq, Jul 2015]

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