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Nuak1 (BC082328) Mouse Untagged Clone
CAT＃: MC206680
Nuak1 (untagged) - Mouse NUAK family, SNF1-like kinase, 1 (cDNA clone MGC:90816 IMAGE:30355405), (10ug)
CNY 4,904.00
货期*
现货
规格
Product images
经常一起买 (3)
Specifications
| Product Data | |
| Type | Mouse Untagged Clone |
| Tag | Tag Free |
| Synonyms | AU014801; AW494241; B230104P22Rik; Omphk1 |
| Vector | PCMV6-Kan/Neo |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>BC082328
CAATGCTGCTGCGGGGGCGACCTTGAACGCACCCCGGTTTCCCTCGGTGGGGACCACCCCGAGCCCCTGT GCCGGGACCTGCCCTCTCCAACTCGGCTCGCCCTGCGCTTGGTCATGGAAGGGGCGGCAGTGTCCGCGGC AGGGGATGGCCCTGCTGTAGAGACCGGCTTGCCGGGCTCTCCGCTGGAGGCGGTGGCCGGGGCGACTGCA GCCCCAGTGGAGCCCAGGAAGCCGCACGGGGTGAAGCGACATCACCACAAACACAACTTGAAGCATCGCT ATGAGCTGCAAGAGACCCTGGGCAAAGGTACCTACGGCAAAGTCAAGAGAGCCACCGAGAGGTTTTCAGG CCGAGTGGTTGCTATAAAATCCATCCGTAAGGACAAAATTAAGGACGAGCTAGACATGGTTCACATCAGA CGAGAGATTGAGATCATGTCATCCCTCAACCATCCTCATATCATCAGTATTTATGAAGTGTTTGAGAACA AAGATAAGATTGTGATCATCATGGAATATGCCAGCAAAGGAGAGCTGTATGATTACATCAGTGAGCGCAG GCGCCTCAGCGAGAGGGAGACCAGACACTTCTTCCGGCAGATTGTGTCTGCCGTGCATTACTGTCACAAG AATGGTGTGGTCCACCGGGACTTGAAGCTGGAGAACATACTGCTTGATGACAACTGCAACATTAAGATTG CTGACTTTGGGCTCTCCAACCTGTACCAGAAGGACAAGTTCTTGCAAACATTTTGTGGGAGCCCACTCTA TGCGTCGCCCGAGATTGTCAACGGCAGGCCTTACCGAGGGCCAGAGGTGGACAGCTGGGCCCTGGGTGTC TTGCTTTACACTCTCATTTATGGAACGATGCCCTTCGATGGCTTTGATCACAAAAACCTCATCCGGCAGA TCAGCAGCGGAGAGTACCGGGAGCCCACACAACCCTCAGATGCTCGGGGACTCATCCGGTGGATGCTGAT GGTGAATCCCGATCGCAGAGCCACCATCGAGGACATCGCCAACCATTGGTGGGTGAACTGGGGCTACAAG AGCAGCGTCTGTGACTGTGATGCCCTTCCTGACTCTGAGTCTCCACTCTTGGCACGGATCATCGATTGGC ATCACCGTTCCACGGGGCTGCAGGCTGAGGCTGAAGCCAAGATGAAGGGTCTGGCCAAACCCGGGGCCTC TGAGGTTGTGTTGGAGCGGCAGCGGTCACTGAAGAAGTCCAAGAAAGAGAACGACTTTCCCCAGTCTGGC CAGGACTCCGTACCTGAAAGCCCATCCAAGCTGAGTTCCAAGAGGCCCAAGGGCATCCTGAAGAAACGGA GCAACAGCGAACACCGCTCCCACAGCACTGGCTTTATCGAAGGCATTGTGAGCCCTGCCTTACCATCCCC TTTCAAAATGGAGCAAGATTTGTGCCGGACTGCCATCCCCCTCCCCAGCTCCCCCGAGGCAGATATGTCA GGGAAGCTCAGCCTCAAACAGTCTGCCACGATGCCCAAGAAAGGCATCTTGAAAAAGACCCAGCAGAGAG AATCTGGCTACTATTCATCCCCAGAGCGCAGCGAGTCCTCGGAACTGCTGGACAGCAACGATGTGGTCAT CAGTGGTGGCCTCTCGTCCCCTCCCCCAGACCCAGCCAGGGGAACTTCCCACAGCCTGTCCTGCCGGAGG AAGGGCATCTTAAAACATAGTAGCAGGTACTCAGATGGTGGCACAGACCCTGCCCTCACCCGCCCTGAAA TGCCCACACTGGAATCCTTGTCACCTCCCGGTGTCCCCTCCGATGGCATCTCTCGGAGCTACAGTCGCCC GTCCAGTATCATCAGTGATGACAGTGTCCTGTCCAGCGACTCTTTCGACTTGTTAGAGCTTCAAGAGAAC CGGCCAGCCCGCCAGCGCATCCGCAGCTGCGTCTCTGCTGAAAACTTCCTCCAGCTTCAGGACTTTGAGA CACCACACAACCGGCCCCGGCCCCAGTACCTGAAGCGGCTGGCAGACAGTAGCTTCTCCCTTCTCACTGA TATGGACGATGTGACTCAGGTGTATAAGAAAGCGCTGGAGATCTGCAGCAAGCTCAACTAGCCCTTCAGG GCACAGAGGATGGGATGGGTGGGTGGGTGAGGCCAAGGGAGAAGGGGAACAGAACTCAGCCTGAAGGCTG GTTACCTCTTTGCTGGTCAAGGCAACGGATTGGGAAAGGACTAGTAATGTCTGGCCTGGCCAGTTTACAC AGCCTTGAGTCAGCACCTAAAAGGGATAGAAACCATTCTTTACCAGTTCTGCCTGTGCCAGTTAGAATGG GGGTCCTAACTGGCATTCCCAGGTGACATCTCACGGGGGAGGTGGTGTTGGCCAGCAAGAAATGGGAAGC GGCATTATGGGGAAGGGTGTGTTTCCTAGAAGTCATCTAGATGTTTCTGGAGGAGGGGAAGAAAGACTGA GACCATCTGCTTTGGATGGATCCATTAGCAAGCCTGGTCTGACTACACAGGGGCTAGCAAGACTCCAGCA ACCTGAGTGTGAATTGGTGATCAATTGGTAATGTCTGTACTGTGGTCTGAGTTTAGTAGACTAGGCACAC CAGGGAGCATTGAGTGAGTACCAATAACTGCCAGGGAATCAGGACCGGAGGCAACAGCATACCTGCCCTG GCTAAGCCCTGGGAGTTAGGTTAAAGCAGGCTGTTTTAAAGAAAAACAGTTAACTCTTTCATGGCACAGC ATGACATGTGTTAATTTGCTCCTGGACCTTGAGTAGAAGACAGGGCTTGCTTAGAGAGTGAATATGCTGA ACTCTGCTACCGAAATAAGTCTGGTGGTGGTGACTTTCTGGTTTTCTGGGATCTGCCTCTTCTTTCTCCT CTCTCTTGCCTTGTTCTTCTTTAGTGGGATCTTCTGAAGGTGAGCAGGAATAAAGATGGCAGTGTGAGAG CCCAGGGCTTTGTGTGTAATGGGGCACAGAGCTGCTGGGGCCTTTGCTCAGTGAATGGACTGACGGTGAA GCATGCCAGCAAGGGGCGACTTAACACTTTCTTAAATATCTCAGTATTAACTGGAACCCCGCCTCTTGGC TTCTCACCTGCACAAGGACAGGATGCTACTCTGAGTCTCCAAAGCATCACTGGCTCAGCCATAGGCCCCA TTCACCCCAAGTGTGGAATCTTGACTGTAGAAGAGTTGCTTCTAGGGAGTTAGTATGTAGGTGAAATATG TGGCCGAGGGAAAGCCCAGTTTGACAGAAGGTTCTTGTCTCGCCAGGCCTTAGTATTCTGCCTCGTGGTT TTGATCTCCCTCATTTTGGGGGAATAAACAAGTTCCATTCATCCATCCTTCCATCCATCCATCCATCCAT CCATCCATCCATCCACAGAATAAGATGTTGAGAGAGCAGAGTGTGGGGGGAGGAGGCTTAGGGACGTTTC CTCGGGAGCCATCCAGATGGCTCTGGAGGAGGCAGAAAGGAGGTGTATGGGGTGACAGGATGCTTAAAAA TGTTCCAGCTAGTTATCTAATCTCTGAACACTAAGATTACAGGTGATGTCATCCCCTCAGAGGGGACCCT GGGGACACTGGGGGCGGGGGTGGGGGGGATTGAAGTGGTCTTTCTGGGCTGACCACGGAATCCACTGGCT TAGTCAAATTAGAATCCTTCTTCTAAGGTGGCTGCCTTGTGGGAGCCTCTCAGACAGGGTTGGGGGAGGA TGCATCCGTCACTGCACTGAGGACAGTTGTCAGGGAGATGCTGCTCTATACAGCAGAAGGCTGCTTTGCA TCACTGTGTTTGGGCCCCGCGCTTTCCTTTGGGCTGAAGTGAGCAGGATGTAGTGGGAAGCTGCTTCGAT TCTTTTCCTTCAGTTTCACCTCCTACCTGAACTGTGGCAGGGGCTAAAAGGGAGGAAAATCTATAGGTAG AGAAGTGGCTCTGGCGCTTGGAGGTGTATAGACGGCAGCATGTAACCTCTGAATCCTCCCGCTCCCTGCC TCCTCTCGTGAACAACCCCGCCTGCTGCTACACTGCTGGCCCCTGAGCAGGCAGCTGGTCTCGGGTGTAG CAGCCATTGCTGGTTGATGGAATTTTTCCCTTTTGCCAGCTGATTGTGTCTGTTTAGTATTCCCCACCAT GCAGTTGACTCCATTAGGAAAACCACGCCCTTCGGCTTTCTCCCCTTCTCGATCACCAGGGTCACCAGTG TGTTCTCTTTTGGCGGGACTCTCAAAGACAAGGGGTTGGGGAGGGGAAACCAAATGTTTCACACCAAGAA CAGAGGCTCTCGGGTGTGGGGTGTGTCCTCCGTTCCAGGGCTGACACTGAGTTGAGTCCAGGTCTGCCTT GATCTGGAGGTCTCAGGCACCTGCAGTGGCTATGAGGGCTGCTTCCCACGGGTGGAGGCTGGAGACGTGG CTGAGTGGTTTCCCAAGGCCCTCCCCGCCCCCCTCAGTTCTGATACCTGCTTCTAGCTGAGATGCTGACT GTCCCTGCAGGAAATGAGTTAGATCAGAGAATAAAGCCCTAAAAAAAGCAGTTTCCCAATGGAGCCCTGT TATCCCTGCCAGTCAGTCCCCAGCCAAAGAAGGGATGCCTGACTCATTTCCGCGGAGTCCCCAGTGAGAG ACACAGATGACCCCATGGGCAGAGTGGGAAAGTCGCTGCGTGAGCTGTCCTCGTCCTTCCTTTGCTTCTA GGGCACTTCTATTCTTCGTTTACACATCTGCCAAAGGGGGTGGAGTTGTACTTCGTTTTACAGGTAAATT TCAAGGCACAGTCAGTTTTTAAGAAAGTGCTCCAAGACCCTAGGCAACGTGACAGTTCTCAGTTCCCTCT GAATTTTAGTCTCTGCTACCTGGTGCTCTTTACCAAAGGAGCTCGCTGCAGGGTGAAATTCAGGCGTGTT CTGCCCAGGCCTGCTGTCTTGAGTACAAATGTGAATGATGGACTGACTGCTTGTTGCCAAACTGGAAATG TTTTGTAGGGATTTACTGGCATGGTATCATTCCTAGGAAGAAGAAGAAAAAAAAAAAAAAAA |
| Restriction Sites | EcoRI-NotI |
| ACCN | BC082328 |
| Insert Size | 1977 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | BC082328, AAH82328 |
| RefSeq Size | 5032 bp |
| RefSeq ORF | 1977 bp |
| Locus ID | 77976 |
| Gene Summary | Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1. May be involved in DNA damage response: phosphorylates p53/TP53 at 'Ser-15' and 'Ser-392' and is recruited to the CDKN1A/WAF1 promoter to participate to transcription activation by p53/TP53. May also act as a tumor malignancy-associated factor by promoting tumor invasion and metastasis under regulation and phosphorylation by AKT1. Suppresses Fas-induced apoptosis by mediating phosphorylation of CASP6, thereby suppressing the activation of the caspase and the subsequent cleavage of CFLAR. Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with STK11, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair.[UniProtKB/Swiss-Prot Function] |
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