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Mul1 (NM_026689) Mouse Untagged Clone
CAT＃: MC207664
Mul1 (untagged) - Mouse mitochondrial ubiquitin ligase activator of NFKB 1 (Mul1), nuclear gene encoding mitochondrial protein, (10ug)
CNY 3,990.00
Product images
Specifications
| Product Data | |
| Type | Mouse Untagged Clone |
| Tag | Tag Free |
| Synonyms | 0610009K11Rik; AV000801; Gide |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>MC207664 representing NM_026689
Red=Cloning site Blue=ORF Orange=Stop codon TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGGAGAGCGGTTCGCGACCGTCGCTCGGCCAGGTCATCCTGCTGGGCACCAGTTCGATGGTCACCGCCG TACTGTACTCCATATACCGGCAGAAGGCCCAGGTCGCGCAGGAACTCAAGGGAGCTAAGAAGATTCATCT GGGTGAAGATTTAAAGGGCATTCTTTCAGAAGCACCGGGGAAGTGTGTGCCTTATGCTGTCATCGAAGGA GCTGTGCGGTCTGTTAAAGAAACACTCAACAGCCAGTTCGTGGAAAACTGCAAGGGGGTGATCCAGCGGC TGTCGCTTCAGGAGCATAAGATGGTGTGGAACCGAACTACCCACCTTTGGAATGACTATTCCAAGATCAT TCACCAGAGGACTAACACTGTGCCCTTTGACCTCGTGCCCCACGAGGACGGCGTGGCTGTGTCCGTGCGA GTGCTGAAGCCCCTGGATTCAGTGGATCTGGGCCTAGAGACCGTGTACGAGAAGTTCCACCCCTCTGTGC AGTCCTTCACCGATGCCATCGGCCACTACATCAGTGGCGAGAGGCCCAAAGGCATCCAGGAGACAGAGGA GATGCTGAAGGTGGGAGCCACCCTCACGGGGATCGGTGAACTGGTCCTGGACAACAACGCTGTCCGCCTG CAGCCCCCCAAGCAGGGCATGCAGTACTACCTGAGCAGCCAGGACTTTGACAGCCTGCTGCACAGGCAGG AGTCTAGTGTCCGGCTCTGGAAGATTCTGGTCCTGGTGTTCGGCTTTGCTACCTGTGCCACCCTCTTCTT CATCCTGAGGAAGCAGTACCTTCATCGGCAGGAGCGCCTGCGCCAGCAGCAGCTCCAGGAAGAGTTCCTT GAACACGAGGCCCAGCTGCTGAGTCAAGCCTCGCCTGAGGACAGGGAGAGTCTGAAGAGCGCCTGTGTTG TGTGTCTGAGCAACTTCAAGTCCTGTGTCTTCCTCGAGTGCGGGCATGTGTGTTCCTGCCGCCAGTGTTA CCTTGCCTTGCCAGAGCCCAAGAGGTGCCCGATCTGTCGGCGGGAGATCACCAGGGTGATACCCTTGTAT AACAGCTAG ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA |
| Restriction Sites | SgfI-MluI |
| ACCN | NM_026689 |
| Insert Size | 1059 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_026689.3, NP_080965.2 |
| RefSeq Size | 3732 bp |
| RefSeq ORF | 1059 bp |
| Locus ID | 68350 |
| UniProt ID | Q8VCM5 |
| Gene Summary | Exhibits weak E3 ubiquitin-protein ligase activity (By similarity). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (By similarity). Can ubiquitinate AKT1 preferentially at 'Lys-284' involving 'Lys-48'-linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting phosphorylated Akt to proteosomal degradation (By similarity). Proposed to preferentially act as a SUMO E3 ligase at physiological concentrations (By similarity). Plays a role in the control of mitochondrial morphology by promoting mitochondrial fragmentation, and influences mitochondrial localization (By similarity). Likely to promote mitochondrial fission through negatively regulating the mitochondrial fusion proteins MFN1 and MFN2, acting in a pathway that is parallel to the PRKN/PINK1 regulatory pathway (PubMed:24898855). May also be involved in the sumoylation of the membrane fission protein DNM1L (By similarity). Inhibits cell growth (By similarity). When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis (By similarity). Involved in the modulation of innate immune defense against viruses by inhibiting DDX58-dependent antiviral response (By similarity). Can mediate DDX58 sumoylation and disrupt its polyubiquitination (By similarity).[UniProtKB/Swiss-Prot Function] |
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Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| MG205346 | Mul1 (tGFP-tagged) - Mouse RIKEN cDNA 0610009K11 gene (0610009K11Rik) |
CNY 5,256.00 |
|
| MR205346 | Mul1 (Myc-DDK-tagged) - Mouse mitochondrial ubiquitin ligase activator of NFKB 1 (Mul1), nuclear gene encoding mitochondrial protein |
CNY 3,656.00 |
|
| MR205346L1 | Lenti ORF clone of Mul1 (Myc-DDK-tagged) - Mouse mitochondrial ubiquitin ligase activator of NFKB 1 (Mul1), nuclear gene encoding mitochondrial protein |
CNY 4,750.00 |
|
| MR205346L2 | Lenti ORF clone of Mul1 (mGFP-tagged) - Mouse mitochondrial ubiquitin ligase activator of NFKB 1 (Mul1), nuclear gene encoding mitochondrial protein |
CNY 6,056.00 |
|
| MR205346L3 | Lenti ORF clone of Mul1 (Myc-DDK-tagged) - Mouse mitochondrial ubiquitin ligase activator of NFKB 1 (Mul1), nuclear gene encoding mitochondrial protein |
CNY 6,056.00 |
|
| MR205346L4 | Lenti ORF clone of Mul1 (mGFP-tagged) - Mouse mitochondrial ubiquitin ligase activator of NFKB 1 (Mul1), nuclear gene encoding mitochondrial protein |
CNY 6,056.00 |
