Tlr2 (NM_011905) Mouse Untagged Clone

CAT#: MC221571

Tlr2 (untagged) - Mouse toll-like receptor 2 (Tlr2), (10ug)



  "NM_011905" in other vectors (4)

CNY 5,752.00


货期*
现货

规格
    • 10 ug

Product images

经常一起买 (4)
Toll-Like Receptor 2 Rabbit monoclonal Antibody
    • 100 ul

CNY 1,999.00
CNY 3,280.00


TurboFectin Transfection Reagent (1 mL in 1 vial)
    • 1 ml in 1 vial

CNY 4,090.00


DH5α Chemically Competent Cells (≥10^8 cfu/μg of pUC19 DNA)
    • 5 x 200 ul

CNY 1,280.00


Forward sequencing primer VP1.5, Reverse sequencing primer XL39, 100pmoles each
    • 100 pmol

CNY 480.00

Specifications

Product Data
Type Mouse Untagged Clone
Tag Tag Free
Synonyms Ly105
Vector pCMV6-Entry
E. coli Selection Kanamycin (25 ug/mL)
Mammalian Cell Selection Neomycin
Sequence Data
>MC221571 representing NM_011905
Red=Cloning site Blue=ORF

TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
GCCGCGATCGCC

ATGCTACGAGCTCTTTGGCTCTTCTGGATCTTGGTGGCCATAACAGTCCTCTTCAGCAAACGCTGTTCTG
CTCAGGAGTCTCTGTCATGTGATGCTTCTGGGGTGTGTGATGGCCGCTCCAGGTCTTTCACCTCTATTCC
CTCCGGACTCACAGCAGCCATGAAAAGCCTTGACCTGTCTTTCAACAAGATCACCTACATTGGCCATGGT
GACCTCCGAGCGTGTGCGAACCTCCAGGTTCTGATTTTGAAGTCCAGCAGAATCAATACAATAGAGGGAG
ACGCCTTTTATTCTCTGGGCAGTCTTGAACATTTGGATTTGTCTGATAATCACCTATCTAGTTTATCTTC
CTCCTGGTTCGGGCCCCTTTCCTCTTTGAAATACTTAAACTTAATGGGAAATCCTTACCAGACACTGGGG
GTAACATCGCTTTTTCCCAATCTCACAAATTTACAAACCCTCAGGATAGGAAATGTAGAGACTTTCAGTG
AGATAAGGAGAATAGATTTTGCTGGGCTGACTTCTCTCAATGAACTTGAAATTAAGGCATTAAGTCTCCG
GAATTATCAGTCCCAAAGTCTAAAGTCGATCCGCGACATCCATCACCTGACTCTTCACTTAAGCGAGTCT
GCTTTCCTGCTGGAGATTTTTGCAGATATTCTGAGTTCTGTGAGATATTTAGAACTAAGAGATACTAACT
TGGCCAGGTTCCAGTTTTCACCACTGCCCGTAGATGAAGTCAGCTCACCGATGAAGAAGCTGGCATTCCG
AGGCTCGGTTCTCACTGATGAAAGCTTTAACGAGCTCCTGAAGCTGTTGCGTTACATCTTGGAACTGTCG
GAGGTAGAGTTCGACGACTGTACCCTCAATGGGCTCGGCGATTTCAACCCCTCGGAGTCAGACGTAGTGA
GCGAGCTGGGTAAAGTAGAAACAGTCACTATCCGGAGGTTGCATATCCCCCAGTTCTATTTGTTTTATGA
CCTGAGTACTGTCTATTCCCTCCTGGAGAAGGTGAAGCGAATCACAGTAGAGAACAGCAAGGTCTTCCTG
GTTCCCTGCTCGTTCTCCCAGCATTTAAAATCATTAGAATTCTTAGACCTCAGCGAAAATCTGATGGTTG
AAGAATATTTGAAGAACTCAGCCTGTAAGGGAGCCTGGCCTCCTCTACAAACCTTAGTTTTGAGCCAGAA
TCATTTGAGATCAATGCAAAAAACAGGAGAGATTTTGCTGACTCTGAAAAACCTGACCTCCCTTGACATC
AGCAGGAACACTTTTCATCCGATGCCCGACAGCTGTCAGTGGCCAGAAAAGATGCGCTTCCTGAATTTGT
CCAGTACAGGGATCCGGGTGGTAAAAACGTGCATTCCTCAGACGCTGGAGGTGTTGGATGTTAGTAACAA
CAATCTTGACTCATTTTCTTTGTTCTTGCCTCGGCTGCAAGAGCTCTATATTTCCAGAAATAAGCTGAAA
ACACTCCCAGATGCTTCGTTGTTCCCTGTGTTGCTGGTCATGAAAATCAGAGAGAATGCAGTAAGTACTT
TCTCTAAAGACCAACTTGGTTCTTTTCCCAAACTGGAGACTCTGGAAGCAGGCGACAACCACTTTGTTTG
CTCCTGCGAACTCCTATCCTTTACTATGGAGACGCCAGCTCTGGCTCAAATCCTGGTTGACTGGCCAGAC
AGCTACCTGTGTGACTCTCCGCCTCGCCTGCACGGCCACAGGCTTCAGGATGCCCGGCCCTCCGTCTTGG
AATGTCACCAGGCTGCACTGGTGTCTGGAGTCTGCTGTGCCCTTCTCCTGTTGATCTTGCTCGTAGGTGC
CCTGTGCCACCATTTCCACGGGCTGTGGTACCTGAGAATGATGTGGGCGTGGCTCCAGGCCAAGAGGAAG
CCCAAGAAAGCTCCCTGCAGGGACGTTTGCTATGATGCCTTTGTTTCCTACAGTGAGCAGGATTCCCATT
GGGTGGAGAACCTCATGGTCCAGCAGCTGGAGAACTCTGACCCGCCCTTTAAGCTGTGTCTCCACAAGCG
GGACTTCGTTCCGGGCAAATGGATCATTGACAACATCATCGATTCCATCGAAAAGAGCCACAAAACTGTG
TTCGTGCTTTCTGAGAACTTCGTACGGAGCGAGTGGTGCAAGTACGAACTGGACTTCTCCCACTTCAGGC
TCTTTGACGAGAACAACGACGCGGCCATCCTTGTTTTGCTGGAGCCCATTGAGAGGAAAGCCATTCCCCA
GCGCTTCTGCAAACTGCGCAAGATAATGAACACCAAGACCTACCTGGAGTGGCCCTTGGATGAAGGCCAG
CAGGAAGTGTTTTGGGTAAATCTGAGAACTGCAATAAAGTCCTAG


ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
ACAAGGATGACGACGATAAGGTTTAA
Restriction Sites SgfI-MluI     
ACCN NM_011905
Insert Size 2355 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Reference Data
RefSeq BC014693, AAH14693
RefSeq Size 3046 bp
RefSeq ORF 2355 bp
Locus ID 24088
UniProt ID Q9QUN7
Gene Summary Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity) (PubMed:15690042). May also promote apoptosis in response to lipoproteins (By similarity). Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Forms the cluster TLR2:TLR6:CD14:CD36 in response to diacylated lipopeptides and TLR2:TLR1:CD14 in response to triacylated lipopeptides (By similarity). Recognizes M.tuberculosis major T-antigen EsxA (ESAT-6) which inhibits downstream MYD88-dependent signaling (PubMed:17486091). Acts as the major receptor for M.tuberculosis lipoproteins LprA, LprG, LpqH and PhoS1 (pstS1), in conjunction with TLR1 and for some but not all lipoproteins CD14 and/or CD36. The lipoproteins act as agonists to modulate antigen presenting cell functions in response to the pathogen (PubMed:19362712). Recombinant MPT83 from M.tuberculosis stimulates secretion of cytokines (TNF-alpha, IL-6 and IL-12p40) by mouse macrophage cell lines in a TLR2-dependent fashion, which leads to increased host innate immunity responses against the bacterium (PubMed:22174456). Lung macrophages which express low levels of TLR2 respond poorly to stimulation by M.tuberculosis LpqH (PubMed:19362712). Required for normal uptake of M.tuberculosis, a process that is inhibited by M.tuberculosis LppM (PubMed:27220037). Interacts with TICAM2 (By similarity).[UniProtKB/Swiss-Prot Function]
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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