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Ddr2 (NM_022563) Mouse Untagged Clone
CAT＃: MC222147
Ddr2 (untagged) - Mouse discoidin domain receptor family, member 2 (Ddr2), (10ug)
CNY 9,392.00
| Cited in 1 publication. |
Product images
Specifications
| Product Data | |
| Type | Mouse Untagged Clone |
| Tag | Tag Free |
| Synonyms | AW495251; Ntrkr3; tyro10 |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>MC222147 representing NM_022563
Red=Cloning site Blue=ORF Orange=Stop codon TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGATCCCGATTCCCAGAATGCCCCTGGTGCTGCTCCTGCTCTTGCTCATCCTGGGTTCTGCAAAAGCTC AGGTTAATCCAGCCATATGCCGCTATCCTCTGGGCATGTCAGGAGGCCACATTCCAGATGAGGACATCAC AGCCTCAAGTCAGTGGTCAGAATCCACGGCTGCCAAATATGGGAGGCTGGACTCTGAAGAAGGAGATGGA GCCTGGTGTCCTGAGATTCCAGTGCAACCCGATGACCTGAAGGAATTTCTGCAGATTGACTTGCGAACCC TACACTTTATCACTCTTGTGGGGACCCAGGGGCGCCATGCAGGGGGTCATGGCATTGAATTTGCACCCAT GTACAAGATCAACTACAGTCGGGATGGCAGTCGCTGGATCTCCTGGCGTAACCGGCATGGGAAGCAGGTG CTTGATGGAAACAGTAACCCTTATGATGTATTCCTGAAGGACTTGGAGCCACCCATCGTCGCCAGATTTG TTCGCCTTATCCCAGTCACTGACCACTCCATGAACGTGTGCATGAGGGTTGAGCTTTATGGTTGTGTCTG GCTAGATGGCTTGGTATCCTACAATGCTCCAGCTGGACAGCAGTTTGTACTCCCTGGAGGCTCCATCATT TATCTGAATGATTCTGTCTATGATGGAGCTGTTGGGTACAGCATGACTGAAGGGCTAGGCCAGTTGACTG ATGGAGTATCCGGCCTGGATGATTTTACCCAGACCCATGAATACCACGTGTGGCCTGGCTATGACTACGT GGGATGGCGGAACGAAAGTGCTACCAACGGTTTCATTGAGATCATGTTTGAATTTGACCGAATCAGGAAT TTTACTACCATGAAGGTCCACTGCAACAACATGTTTGCTAAAGGTGTGAAGATTTTTAAGGAGGTCCAGT GCTACTTTCGCTCGGAAGCCAGCGAGTGGGAACCCACTGCTGTCTACTTTCCCCTGGTCCTGGACGATGT GAACCCCAGTGCCCGGTTTGTCACGGTGCCCCTCCACCACCGAATGGCCAGTGCCATCAAGTGCCAATAC CATTTTGCCGACACGTGGATGATGTTCAGCGAGATCACTTTCCAATCAGATGCTGCAATGTATAACAACT CTGGAGCCCTTCCCACCTCTCCTATGGCACCCACCACCTATGATCCCATGCTTAAAGTTGATGATAGCAA CACTCGGATCCTGATTGGTTGCTTGGTGGCCATCATCTTCATCCTGCTGGCTATCATCGTCATCATCCTG TGGAGGCAGTTCTGGCAGAAGATGCTAGAAAAGGCTTCACGGAGGATGCTGGATGATGAAATGACAGTCA GCCTTTCCCTGCCCAGCGAGTCCAGCATGTTCAATAACAACCGCTCCTCATCACCAAGTGAACAGGAGTC CAACTCTACTTATGATCGAATCTTCCCCCTTCGCCCTGACTACCAGGAGCCATCCAGACTGATCCGAAAG CTTCCAGAGTTTGCTCCAGGAGAGGAGGAGTCAGGGTGCAGTGGTGTTGTGAAGCCGGCCCAGCCCAATG GACCTGAGGGCGTGCCCCACTATGCAGAAGCCGACATAGTGAATCTCCAGGGAGTGACAGGTGGCAACAC CTACTGTGTGCCTGCTGTAACCATGGATCTGCTATCGGGGAAAGATGTGGCTGTGGAAGAGTTCCCCAGG AAACTGTTGGCCTTCAAGGAGAAGCTGGGAGAAGGCCAGTTTGGGGAGGTTCATCTCTGTGAAGTGGAGG GAATGGAAAAATTCAAAGACAAAGATTTTGCACTAGATGTCAGTGCCAACCAGCCTGTCCTGGTGGCCGT GAAAATGCTCCGAGCAGATGCCAACAAGAATGCCAGGAATGATTTTCTTAAGGAGATCAAGATCATGTCT CGGCTCAAGGACCCAAACATCATCCGTCTCTTAGCTGTGTGCATCACTGAGGACCCGCTCTGCATGATCA CGGAATACATGGAGAATGGAGATCTTAATCAGTTTCTTTCTCGCCACGAGCCTCTGAGTTCCTGTTCTAG TGATGCCACAGTCAGTTACGCCAACCTGAAGTTTATGGCAACCCAGATTGCCTCTGGTATGAAGTACCTT TCGTCTCTCAACTTTGTCCACCGAGATCTGGCCACACGAAACTGTTTAGTGGGCAAGAATTACACCATCA AGATAGCTGATTTTGGCATGAGCAGAAACCTGTACAGTGGTGATTACTACCGGATCCAGGGCCGGGCGGT GCTCCCCATTCGCTGGATGTCCTGGGAAAGCATCTTGCTGGGCAAATTCACCACGGCAAGTGATGTGTGG GCCTTTGGGGTGACTCTGTGGGAGACCTTCACCTTTTGCCAGGAGCAGCCCTATTCCCAGCTGTCGGATG AGCAGGTTATCGAGAACACTGGAGAGTTCTTCCGAGACCAAGGGAGGCAGATCTATCTCCCTCAACCAGC CCTTTGCCCCGACTCTGTGTATAAGCTGATGCTCAGCTGCTGGAGAAGAGAAACCAAGCACCGGCCATCC TTCCAGGAAATACACCTCCTGCTTCTTCAGCAAGGAGCCGAGTGA ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA |
| Chromatograms |
CHROMATOGRAMS
 Sequencher program is needed, download here. |
| Restriction Sites | SgfI-MluI |
| ACCN | NM_022563 |
| Insert Size | 2565 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | BC138826, AAI38827 |
| RefSeq Size | 8306 bp |
| RefSeq ORF | 2565 bp |
| Locus ID | 18214 |
| UniProt ID | Q62371 |
| Gene Summary | Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing.[UniProtKB/Swiss-Prot Function] |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
NSCLC Driven by DDR2 Mutation is Sensitive to Dasatinib and JQ1 Combination Therapy
,Xu, C;Buczkowski, KA;Zhang, Y;Asahina, H;Beauchamp, EM;Terai, H;Li, YY;Meyerson, M;Wong, KK;Hammerman, PS;,
Mol. Cancer Ther.
,PubMed ID 26206333
[DDR2]
|
Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| MG222870 | Ddr2 (tGFP-tagged) - Mouse discoidin domain receptor family member 2 (Ddr2), (10ug) |
CNY 10,984.00 |
|
| MR222870 | Ddr2 (Myc-DDK-tagged) - Mouse discoidin domain receptor family, member 2 (Ddr2) |
CNY 9,384.00 |
|
| MR222870L3 | Lenti ORF clone of Ddr2 (Myc-DDK-tagged) - Mouse discoidin domain receptor family, member 2 (Ddr2) |
CNY 10,450.00 |
|
| MR222870L4 | Lenti ORF clone of Ddr2 (mGFP-tagged) - Mouse discoidin domain receptor family, member 2 (Ddr2) |
CNY 10,450.00 |
