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Itga4 (NM_010576) Mouse Untagged Clone
CAT＃: MC223264
Itga4 (untagged) - Mouse integrin alpha 4 (Itga4), (10ug)
CNY 13,300.00
Product images
Specifications
| Product Data | |
| Type | Mouse Untagged Clone |
| Tag | Tag Free |
| Synonyms | CD49D; Itga4B |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>MC223264 representing NM_010576
Red=Cloning site Blue=ORF Orange=Stop codon TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGGCTGCGGAAGCGAGGTGCAGACCGAGGTCCCGAGGGATCGCCCTCCGGGAAGCGGTGATGCTGTTGT TGTACTTCGGGGTGCCAACCGGGCACTCCTACAACCTGGACCCGGAGAATGCACTGCTGTACCAGGGCCC CTCCGGCACGCTGTTTGGCTACTCGGTGGTGCTGCACAGCCACGGGTCGAAGCGCTGGCTCATCGTGGGG GCTCCCACTGCCAGCTGGCTCTCTAATGCCTCAGTGGTCAATCCTGGGGCGATTTACAGATGCGGGATCA GAAAGAATCCAAACCAGACCTGCGAACAGCTCCAGCTGGGTAGCCCCAGTGGAGAGCCTTGTGGGAAGAC ATGCCTGGAGGAGAGGGATAACCAGTGGCTGGGGGTCACCCTTTCCAGACAGCCTGGAGAAAATGGCTCT ATCGTGACTTGTGGGCACAGGTGGAAAAATATTTTTTACATGAAGAGCGATAACAAACTCCCCACTGGCA TTTGCTACGTCATGCCTTCTGATTTGCGGACAGAACTGAGTAAAAGGATGGCCCCGTGTTACAAAGATTA TACGAGAAAATTTGGAGAAAATTTTGCATCATGTCAAGCTGGAATATCTAGTTTTTACACACAGGATTTA ATTGTGATGGGGGCCCCGGGATCATCGTACTGGACTGGCACCGTCTTTGTCTACAATATAACTACAAACC AATACAAAGCATTTGTAGACAGACAGAACCAAGTAAAATTTGGAAGCTACTTAGGCTACTCAGTTGGAGC TGGACATTTTCGAAGTCCACATACTACCGAAGTCGTGGGAGGAGCCCCTCAACACGAACAGATAGGAAAA GCATATATATTTAGCATTGATGAAAACGAACTGAACATCGTATATGAAATGAAAGGTAAAAAGCTTGGCT CATACTTTGGAGCTTCTGTCTGCGCTGTGGACCTCAATGCAGATGGCTTCTCAGATCTCCTTGTTGGAGC TCCCATGCAGAGCACCATCAGGGAGGAAGGAAGAGTATTCGTGTACATCAACTCTGGCATGGGAGCTGTG ATGGTTGAAATGGAAAGGGTCCTTGTCGGAAGTGACAAATATGCTGCAAGATTTGGGGAGTCTATAGCGA ATCTTGGCGACATTGACAATGACGGCTTTGAAGATATTGCTATTGGTGCACCACAAGAAGACGACTTGAG AGGTGCTGTCTACATTTACAATGGCCGAGTCGATGGAATCTCCTCCACCTACTCACAGAGAATTGAAGGA CAGCAAATCAGCAAATCATTAAGGATGTTTGGACAATCTATCTCAGGACAAATTGATGCAGACAACAATG GATATGTTGATGTAGCCGTTGGTGCATTTCAATCTGATTCTGCAGTGTTGCTAAGGACAAGGCCTGTAGT GATTGTTGAAGCATCTTTAAGCCATCCTGAGTCTGTAAATAGGACAAAGTTTGACTGTACTGAAAATGGA CTTCCATCTGTGTGCATGCATCTTACACTGTGTTTCTCATATAAAGGCAAAGAGGTCCCAGGCTACATCG TTTTGTTTTACAATGTGAGCTTGGATGTGCACAGGAAGGCAGAGTCTCCGTCAAGATTTTATTTCTTCTC TAATGGGACTTCTGACGTGATTACAGGAAGCATACGAGTTTCAAGCAGTGGAGAGAAATGTAGGACACAC CAGGCATTCATGCGGAAAGACGTGCGAGACATCCTTACCCCCATTCATGTAGAGGCCACATACCACCTTG GGCATCATGTGATCACCAAACGAAACACTGAGGAATTTCCACCACTCCAGCCGATCCTTCAGCAGAAGAA AGAAAAAGACGTTATTAGAAAAATGATAAACTTTGCAAGGTTTTGTGCCTATGAAAATTGCTCTGCTGAT CTCCAAGTTTCTGCAAAAGTTGGATTTTTGAAGCCATATGAAAATAAAACCTATCTTGCTGTTGGGAGCA TGAAGACCATAATGCTAAACGTGTCCTTGTTCAACGCTGGCGATGATGCTTACGAAACCACTCTGAATGT CCAACTCCCCACAGGCCTTTATTTCATTAAGATCTTAGACCTGGAAGAGAAACAAATAAACTGCGAAGTG ACTGAGAGCTCAGGCATAGTGAAGCTTGCCTGCAGCCTAGGTTACATATATGTGGATCGCCTCTCAAGGA TAGACATTAGCTTTCTCCTGGATGTGAGCTCACTCAGCAGGGCACATGAGGACCTCAGCATCAGTGTGCA TGCCTCCTGTGAAAACGAGGGCGAATTGGACCAAGTGAGGGACAACAGAGTGACCTTAACGATACCTCTA AGGTATGAGGTTATGCTGACTGTTCATGGGCTTGTGAACCCAACTTCATTTGTGTATGGATCTAGCGAAG AAAACGAGCCAGAAACATGCATGGCCGAGAAGCTGAACCTCACTTTCCATGTTATAAACACTGGGATTAG CATGGCTCCAAATGTTAGTGTGAAAATAATGGTACCAAATTCTTTTCTCCCTCAAGATGATAAGTTGTTC AACGTTTTGGATGTCCAGACAACTACAGGGCAATGCCATTTTAAACACTATGGAAGAGAGTGTACATTTG CACAGCAAAAAGGCATAGCGGGGACGTTGACCGATATAGTCAAATTCCTATCAAAGACTGATAAGAGACT CCTGTATTGCATGAAAGCTGATCAACACTGTTTAGATTTCTTATGCAATTTCGGAAAAATGGAAAGTGGG AAGGAAGCCAGCGTTCATATTCAGCTGGAGGGCAGGCCATCCATCTTGGAAATGGATGAGACCTCATCAC TCAAGTTTGAAATAAAAGCAACAGCTTTTCCAGAGCCACACCCAAAAGTTATTGAACTAAATAAAGATGA GAACGTGGCCCATGTTTTCTTGGAAGGGCTCCATCATCAAAGACCCAAACGACATTTCACCATCATTATT ATTACCATCAGCTTGCTACTTGGACTTATTGTACTTTTATTAATTTCATGTGTTATGTGGAAGGCTGGAT TCTTTAAAAGACAGTACAAATCTATCCTACAAGAAGAAAACAGGAGAGACAGCTGGAGTTATGTCAACAG CAAAAGCAATGATGACTGA ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA |
| Restriction Sites | SgfI-MluI |
| ACCN | NM_010576 |
| Insert Size | 3099 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_010576.3, NP_034706.3 |
| RefSeq Size | 9833 bp |
| RefSeq ORF | 3099 bp |
| Locus ID | 16401 |
| UniProt ID | Q00651 |
| Gene Summary | Integrins alpha-4/beta-1 (VLA-4 or LPAM-2) and alpha-4/beta-7 (LPAM-1) are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling. ITGA4:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1.[UniProtKB/Swiss-Prot Function] |
Documents
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| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| MG211489 | Itga4 (tGFP-tagged) - Mouse integrin alpha 4 (Itga4) |
CNY 12,376.00 |
|
| MR211489 | Itga4 (Myc-DDK-tagged) - Mouse integrin alpha 4 (Itga4) |
CNY 10,776.00 |
|
| MR211489L1 | Lenti ORF clone of Itga4 (Myc-DDK-tagged) - Mouse integrin alpha 4 (Itga4) |
CNY 13,176.00 |
|
| MR211489L2 | Lenti ORF clone of Itga4 (mGFP-tagged) - Mouse integrin alpha 4 (Itga4) |
CNY 10,260.00 |
|
| MR211489L3 | Lenti ORF clone of Itga4 (Myc-DDK-tagged) - Mouse integrin alpha 4 (Itga4) |
CNY 10,260.00 |
|
| MR211489L4 | Lenti ORF clone of Itga4 (mGFP-tagged) - Mouse integrin alpha 4 (Itga4) |
CNY 10,260.00 |
