United States
Germany
Japan
United Kingdom
China
Myt1l (NM_001093775) Mouse Untagged Clone
CAT＃: MC223883
Myt1l (untagged) - Mouse myelin transcription factor 1-like (Myt1l), transcript variant 1, (10ug)
CNY 15,300.00
Product images
Specifications
| Product Data | |
| Type | Mouse Untagged Clone |
| Tag | Tag Free |
| Synonyms | 2900046C06Rik; 2900093J19Rik; C630034G21Rik; mKIAA1106; Nztf1; Pmng1; Png-1 |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>MC223883 representing NM_001093775
Red=Cloning site Blue=ORF Orange=Stop codon TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGGACGTGGACTCTGAGGAGAAGCGCCATCGCACACGGTCCAAAGGGGTTCGAGTTCCTGTGGAGCCAG CCATACAAGAGCTGTTCAGCTGTCCCACTCCAGGCTGCGACGGCAGTGGTCACGTCAGTGGCAAATATGC ACGACACAGAAGTGTATATGGTTGTCCCTTGGCTAAAAAAAGAAAAACGCAAGATAAACAGCCCCAAGAA CCTGCTCCCAAGCGAAAACCATTTGCAGTAAAAGCAGATAGTTCCTCAGTAGACGAATGTTATGAGAGTG ATGGTACTGAAGACATGGATGATAAGGAGGAAGATGATGATGAGGAGTTCTCTGAAGACAATGATGAGCA AGGGGATGATGACGACGAAGATGAGGTGGATCGGGAAGACGAGGAGGAGATCGAGGAGGAAGATGATGAA GAAGATGATGATGATGAAGATGGTGACGATGTAGAAGAGGAAGAAGAGGATGATGATGAAGAGGAGGAAG AAGAGGAAGAGGAAGAAGAAAATGAAGACCATCAAATGAGTTGTACTCGAATAATGCAGGACACAGACAA GGATGATAACAACAATGATGAGTATGATAACTATGATGAACTGGTAGCTAAGTCGCTATTAAATCTTGGC AAAATTGCTGAGGATGCAGCATACCGAGCCAGGACTGAATCAGAGATGAACAGCAATACCTCCAATAGTC TGGAGGACGATAGTGACAAAAACGAAAACCTCGGTCGGAAAAGCGAACTGAGTCTAGACTTAGACAGTGA TGTTGTTAGAGAAACAGTGGACTCCCTTAAGCTGTTAGCACAAGGACATGGTGTTGTGCTATCAGAGAAT ATCAGTGACAGAAGTTATGCTGAGGGGATGTCACAGCAGGACAGTAGAAATATGAACTATGTCATGCTAG GGAAGCCCATGAACAATGGACTCATGGAGAAGATGGTGGAGGAGAGTGATGAGGAAGTGTGTCTAAGTAG TCTAGAGTGCCTGAGGAACCAGTGCTTTGACCTGGCCAGGAAACTCAGCGAGACCAACCCACAGGACAGG AGTCAGCCACCCAACATGAGTGTGCGCCAACATGTCCGGCAAGAGGACGACTTCCCTGGGAGGACGCCAG ACAGGAGCTACTCGGATATGATGAACCTTATGCGGCTGGAGGAGCAGCTCAGTCCCAGGTCTAGAACGTT CTCCAGCTGTGCCAAGGAGGATGGGTGTCATGAGAGGGATGATGACACCACCTCAGTGAACTCAGACAGG TCTGAGGAAGTGTTTGACATGACCAAGGGCAACCTGACTCTGCTAGAGAAAGCCATTGCCTTGGAGACAG AGAGAGCCAAGGCCATGCGGGAGAAGATGGCCATGGATGCTGGGAGAAGGGATAACCTGAGATCCTATGA GGACCAGTCTCCAAGACAGCTGGCTGGGGAAGACAGAAAATCCAAATCCAGTGACAGCCATGTCAAAAAG CCATACTATGGTAAAGATCCCTCAAGAACAGAAAAGAGAGAGAGCAAGTGTCCAACCCCCGGGTGTGATG GAACCGGCCACGTAACTGGGCTTTACCCGCATCACCGCAGTCTGTCTGGATGCCCGCACAAAGATAGGGT CCCTCCAGAAATTCTTGCCATGCATGAAAATGTTCTCAAGTGTCCCACTCCAGGCTGCACAGGGCGAGGG CATGTGAATAGCAACAGGAACTCGCACAGAAGCCTCTCTGGATGCCCCATTGCTGCTGCAGAAAAACTGG CAAAGGCCCAAGAGAAACACCAGAGCTGTGATGTGTCCAAATCCAACCAGGCCTCAGACCGAGTCCTCAG GCCAATGTGCTTTGTCAAACAGCTTGAGATTCCTCAGTATGGCTACAGAAACAATGTTCCCACAACCACA CCACGCTCCAACCTGGCCAAGGAGCTTGAGAAATACTCCAAGACTTCGTTTGAGTACAACAGTTACGACA ACCATACTTATGGCAAAAGAGCCATAGCTCCCAAGGTGCAAACCAGGGACATATCCCCCAAAGGATATGA CGATGCCAAGCGGTACTGCAAGAATGCCAGCCCCAGCAGCAGCACCACCAGCAGCTATGCACCTAGCAGC AGCAGCAACCTCAGCTGTGGTGGTGGCAGCAGCGCCAGTAGCACGTGTAGCAAGAGCAGCTTTGACTACA CACATGACATGGAGGCCGCACACATGGCAGCCACAGCCATTCTCAACCTGTCCACACGTTGTCGTGAAAT GCCACAGAACCTGTCCACCAAGCCACAGGACCTGTGTACTGCCCGGAACCCAGACATGGAGGTGGATGAG AATGGCACCCTGGACCTGAGCATGAACAAGCAGAGGCCTCGAGACAGCTGCTGCCCAGTCCTGACACCCC TGGAACCCATGTCTCCGCAGCAGCAGGCCGTGATGAGCAGCCGATGCTTCCAGCTGAGCGAGGGGGATTG CTGGGACTTGCCTGTAGACTACACCAAAATGAAGCCTCGGAGGGTAGATGAGGATGAGCCCAAAGAGATT ACCCCAGAAGACTTGGACCCATTCCAGGAGGCTCTGGAAGAAAGACGGTATCCAGGGGAGGTGACCATCC CAAGCCCCAAACCCAAGTACCCTCAGTGCAAGGAAAGCAAAAAGGACTTAATAACTCTGTCTGGCTGCCC CCTGGCGGACAAAAGCATTCGAAGTATGCTGGCCACCAGTTCCCAAGAGCTCAAGTGCCCCACCCCTGGC TGTGACGGTTCTGGACACATCACTGGCAATTACGCTTCTCATCGAAGCCTTTCTGGGTGCCCGAGAGCAA AGAAGAGTGGCATCCGGATAGCACAGAGCAAAGAGGACAAGGAAGACCAGGAGCCAATCAGGTGTCCGGT ACCTGGCTGTGACGGTCAGGGACACATCACTGGGAAGTATGCATCCCACCGCAGCGCCTCCGGGTGTCCC TTGGCAGCCAAGAGGCAGAAAGATGGGTACCTTAATGGCTCCCAGTTCTCCTGGAAGTCGGTCAAGACGG AGGGCATGTCCTGCCCTACCCCCGGGTGTGATGGGTCAGGACACGTCAGTGGCAGCTTCCTCACACACCG CAGCTTGTCAGGATGTCCAAGAGCCACATCAGCAATGAAGAAAGCAAAGCTGTCTGGAGAACAGATGTTG ACTATCAAGCAGCGAGCCAGCAACGGTATAGAAAATGATGAAGAAATCAAGCAGTTAGATGAAGAGATCA AGGAGCTTAATGAGTCCAATTCCCAGATGGAGGCTGACATGATCAAACTCAGAACTCAGATCACCACAAT GGAGAGCAACCTGAAGACGATTGAGGAGGAGAACAAAGTCATTGAACAGCAGAATGAGTCGCTCTTGCAC GAGTTGGCCAACCTGAGCCAGTCCCTGATCCACAGCCTCGCCAACATCCAGCTGCCTCACATGGATCCAA TCAATGAACAAAATTTTGATGCTTACGTGACTACTTTGACGGAAATGTATACAAATCAAGATCGTTATCA GAGTCCAGAAAATAAAGCCCTACTGGAAAATATAAAGCAGGCTGTGAGAGGAATTCAGGTCTGA ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA |
| Restriction Sites | SgfI-MluI |
| ACCN | NM_001093775 |
| Insert Size | 3564 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_001093775.1, NP_001087244.1 |
| RefSeq Size | 7198 bp |
| RefSeq ORF | 3564 bp |
| Locus ID | 17933 |
| UniProt ID | P97500 |
| Gene Summary | Transcription factor that plays a key role in neuronal differentiation by specifically repressing expression of non-neuronal genes during neuron differentiation (PubMed:28379941). In contrast to other transcription repressors that inhibit specific lineages, mediates repression of multiple differentiation programs (PubMed:28379941). Also represses expression of negative regulators of neurogenesis, such as members of the Notch signaling pathway, including HES1 (PubMed:28379941). The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro (PubMed:20107439, PubMed:24243019, PubMed:27281220). Directly binds the 5'-AAGTT-3' core motif present on the promoter of target genes and represses transcription by recruiting a multiprotein complex containing SIN3B (PubMed:28379941). The 5'-AAGTT-3' core motif is absent from the promoter of neural genes (PubMed:28379941).[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| MG224643 | Myt1l (tGFP-tagged) - Mouse myelin transcription factor 1-like (Myt1l) transcript variant 1, (10ug) |
CNY 12,920.00 |
|
| MR224643 | Myt1l (Myc-DDK-tagged) - Mouse myelin transcription factor 1-like (Myt1l), transcript variant 1 |
CNY 12,376.00 |
|
| MR224643L1 | Lenti ORF clone of Myt1l (Myc-DDK-tagged) - Mouse myelin transcription factor 1-like (Myt1l), transcript variant 1 |
CNY 14,776.00 |
|
| MR224643L2 | Lenti ORF clone of Myt1l (mGFP-tagged) - Mouse myelin transcription factor 1-like (Myt1l), transcript variant 1 |
CNY 13,680.00 |
|
| MR224643L3 | Lenti ORF clone of Myt1l (Myc-DDK-tagged) - Mouse myelin transcription factor 1-like (Myt1l), transcript variant 1 |
CNY 13,680.00 |
|
| MR224643L4 | Lenti ORF clone of Myt1l (mGFP-tagged) - Mouse myelin transcription factor 1-like (Myt1l), transcript variant 1 |
CNY 13,680.00 |
