Irs4 (NM_010572) Mouse Untagged Clone

CAT#: MC223965

Irs4 (untagged) - Mouse insulin receptor substrate 4 (Irs4), (10ug)



  "NM_010572" in other vectors (2)

CNY 15,580.00


货期*
14周

规格
    • 10 ug

Product images

经常一起买 (4)
Goat Anti-Irs4 (mouse aa633-647) Antibody
    • 100 ug

CNY 5,371.00


TurboFectin Transfection Reagent (1 mL in 1 vial)
    • 1 ml in 1 vial

CNY 4,090.00


DH5α Chemically Competent Cells (≥10^8 cfu/μg of pUC19 DNA)
    • 5 x 200 ul

CNY 1,280.00


Forward sequencing primer VP1.5, Reverse sequencing primer XL39, 100pmoles each
    • 100 pmol

CNY 480.00

Specifications

Product Data
Type Mouse Untagged Clone
Tag Tag Free
Synonyms IRS-4
Vector pCMV6-Entry
E. coli Selection Kanamycin (25 ug/mL)
Mammalian Cell Selection Neomycin
Sequence Data
>MC223965 representing NM_010572
Red=Cloning site Blue=ORF Orange=Stop codon

TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
GCCGCGATCGCC

ATGGCGAGTTGCTCCTTCTCTGGCCACCAAGCGCTTAGGAGACTGAGAGCCTCAGCAGCAGCAGCAGCCT
CCGCAGCTCTAGCAGCAGTGGCGACCACCCCGCTCCTTTCCTCGGGAACCCGGACCGCACTCATTGGGAC
CGGGTCGTCCTGTCCGGGAGCCATGTGGCTCTCCACAGCCACTGGCTCCCGGTCAGACTCGGAATCCGAA
GAGGAGGACCTCCCCGTCGGGGATGAAGTCTGCAAACGCGGCTACCTGAGGAAGCAGAAGCATGGGCATA
GGCGTTACTTCGTGCTCAAACTCGAGACCGCAGACGCTCCAGCTCGACTCGAATACTACCGAAATGCCAG
GAAGTTCCGGCACAGTGTCCGCGCCGCGGCGGCTGCAGCAGAGGCGGCCGCCTCCGGTGCTGCGGTCCCC
GCGCTCATCCCACCACGGCGCGTGATCATCCTGTACCAATGCTTCTCCGTGAGCCAGCGCGCCGATGCCA
GGTACCGACACCTCATTGCCCTTTTTACCCAGGACGAATACTTCGCGATGGTGGCCGAGAACGAGTCGGA
ACAAGAAAGCTGGTACTTGCTCCTCAGCCGCCTCATCCTCGAGAGCAAGCGCCGCCGCTGCGGCACGCTA
GGCGCACTGCCGGACGGAGAGCCGGCAGCCCTGGCGGCCGCAGCGGCGGCGGAGCCACCCTTCTACAAAG
ATGTGTGGCAGGTAGTAGTGAAACCCAGGGGGCTGGGGCACAGAAAAGAGCTGAGCGGCGTGTTCCGGCT
GTGTCTTACCGACGAAGAGGTAGTGTTTGTAAGGCTCAATACCGAAGTGGCCAGTGTGGTCGTCCAGCTG
CTGAGCATTCGTCGCTGTGGGCACTCGGAGCAGTACTTCTTCTTGGAAGTCGGCAGATCCACTGTCATAG
GTCCGGGGGAGCTGTGGATGCAAGTGGATGACTCCGTGGTGGCCCAAAATATGCATGAGCTGTTTCTGGA
GAAGATGAGAGCCTTGTGCGCAGATGAATACAGAGCCCGATGCCGCAGCTACAGCATCAGTATTGGCGCC
CACCTGTTAACCCTGCTGTCCACTAGGAGGCACCTGGGCTTGCTCCCGCTGGAGCCTGGTGGCTGGCTCA
GAAGATACGGCTTGGAGCAGTTTTGCCGCCTCAGAGCTATCCGTGAGAGGGAAGAGATGCTATTCACCAG
GCGCTTCATCTCACCCAGAGAGCCTCCGCCTCCCTTTAGGCGAGGAAGAGGGCACCTGCCCAGAGCCCGC
AGGTCCAGGAGAGCCGCGTCAGTACCACCCAGCCTTTTCCGACGCTCAGCACCTAGCCCGGGAAGGATCC
CACAGCCTGAAGATGTCCCCAACGACAGAGCCCGTGAAGCCTCCGGTTCCAGCTCTGGCAACACTGAAGA
AAAAGACAAGGAGGGTGAGGAAGGAAACCGAGGTGATTGCATACCTATGAACAACTGGGGCTCAGGAAAT
GGCCGGGGCTCAGGAGGTGGACGGGGCTCAAGTGGCCAAGGTTCCAGTAGCCAGGGCTCAGGTGGGAGAC
AGGGATCTGGAGGTGGCCAGGGCTCAGGAGGCCAGGGTGCCGGAGGAAACCAGTGTTCAGGAAATGGCCA
GGGCACAGCAGGTGGCCATGGCTCAGGTGGAGGTGGCCATGGCTCAGGCGGTGGCCAGAGACCTGGAGAT
GGTCATGGCTCAGGTGGTGGCAAGAACTCAGGAAGTGGGAAAAATTCTGACGATGGTGACCGTGGAAAAT
CTGTGAAGAAAAGATCCTACTTTGGTAAATTCACTCAAAGCAAGCAGCAGCAAACACTGCCTCCACCCCC
ACCGCCACCGCCAGCAGCTGGAGCAACTGGTGGCAAAGGGAAGTCTGGAGGAAGATTCCGACTTTATTTT
TGCGCAGACAGAGGCACAAAAGAACGCAAAGAAGCCAAAGAGGTAAGAGATATGGAGACCTCAGGAGGTG
CTACCCGGGGGCCTTACAGAGCCAGAGCTTTCGATGAAGATGAGGATGACCCGTATGTGCCAATGAGACC
AGGGGTGGCTGCCCCTCTTGCGTGTTCCAGTGATTATATGCCAATGGCTCCTCAAAATTCCTCTGCTTCA
ACAAAACGCCACTCTAGGTCACCCTTTGAAGACTCCAGAGGGTACATGATGATGTTTCCCAGAGTGAGCC
CCCCACCACCTGTGCCAAGTGCTCCGAAAGCACCGGACACCAATAAAGGGGATGACTCAAAGGACAATGA
CAGTGACAGTGATTACATGTTTATGGCTCCCGGAGCAGGTGCGATTCCTAAAAATCCTCCCAATGCGCAG
GGAGGCTCTTCCTCCAAAAGCTGGAGCTCGTATTTCTCTCTGCCAAGTCCTTTTCAGAGTTCACCTTTGG
GACAGAGTGACCACAGTGAGTATGTTCCTATGTTACCTGGAAAATTCCTGGGGAGCGGTCTACACAAAGA
AGCCTCCTTTAGCCAGGGCACCAAAAATGTGTCTTCAAAGCCTTCAACTGAGGCGTCATTCTCAAAACCC
GAAGATAAAGGGTCATCTGCAAAGCCTTCAGATGATGTGCCCCCAATGAACAAGGCTAAGGAACCTAACC
ACCTTTCTTTTATTGCAAAAGGAACTCAAGTAAAGCCCAAACCGCTAAACCCCACACAGGAGCGGAGAGA
AGCTGCTGGCTCCCGTGACTATATCAACATTGACTTTATTAAGAGAGAGCGCCTTGTGCTACCTTCCTCT
GCTCAAGGACTGCCAGACATGCGGGGCGTAGTTACTGACCCCGCACCCACAGCTTTTTCTGGCTACCTGA
ATGTTGAATTCGGGGTGCCCTTCCCAAATCCAACAATCCGCCTCTCAGATCTTTTAAGAGTTCTACCAGG
TGCCAACTCCATCCCTCTGGCCGGTACTAGGTGGCCCTTCCCAGGCAGTGCTATAGGTAGCATTGTGGAA
GCGGGAGAATACATTGAAGTTATTTTCAACCCGGCTATGACACCAGCCATGTCTTTTGCTGACAGTGCCA
TTTGCTATGATGCTCAAACAGGTCAAATCTATGTCGTCGACCCATTTTCTGAGTGCTGTATGGACGTTTC
TCTCTCTCCTGGTCGATGCTCTGAACCGCCACCTGTAGCTAGGCTGCGGCGGGAGGAAGCGCAGGAGAGA
AGACGCCCACAAAGCCGCTCCCAAAGTTTATTTGCCAGCACTCGAGCCGCGGTCTCGGCTTTCCCGACTG
ACAGCTTGGACAGAGACTTTCCCGCCGCTTCTGCGGTGATTGCTGCTCCAGCTGAGGCGCCTCTCTTGGC
AGTGAGCCGGGCTTTAGCCGTGGTCTCTGCGCTCGCAGCGGCCCCCAGCATAGGCGACGTCTTTGCAGGC
TTCCGCGCTGCGGCAGGAGTTGACTCCGCCTCCGCTCGCGGGTTCCAACCTGTTGCGGGTGCCCAGGCTG
TAAGAGAATTCCAGGACCTTGCCGCAGGCTGGAATCCTGGAGCCCTTAACCACAGGGCCCGAGGTGAGGA
CCTGGCCGCCGGCGCAGCGGCTCCCCCGCCGCCACCTCGCCAGATTTGGGTGCTGAGACCCCAAGAGAGA
GCGGATTCTGAGGACGACGACGATGATGACGACGACATTTACGTGAGAATGGACTTTGCCAGACGAGACT
ACAGGAAGTGA


ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
ACAAGGATGACGACGATAAGGTTTAA
Restriction Sites SgfI-MluI     
ACCN NM_010572
Insert Size 3651 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Reference Data
RefSeq NM_010572.2, NP_034702.2
RefSeq Size 6269 bp
RefSeq ORF 3651 bp
Locus ID 16370
UniProt ID Q9Z0Y7
Gene Summary Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2.[UniProtKB/Swiss-Prot Function]
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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