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Cfh (NM_009888) Mouse Untagged Clone
CAT＃: MC224056
Cfh (untagged) - Mouse complement component factor h (Cfh), (10ug)
CNY 16,060.00
Product images
Specifications
| Product Data | |
| Type | Mouse Untagged Clone |
| Tag | Tag Free |
| Synonyms | Mud-1; NOM; Sas-1; Sas1 |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>MC224056 representing NM_009888
Red=Cloning site Blue=ORF Orange=Stop codon TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGGTACAGCACAGATTTCTCTTGGAGTCAGTTGGTCCCAGAAAGATCCAAATTATGAGACTGTCAGCAA GAATTATTTGGCTTATATTATGGACTGTTTGTGCAGCAGAAGATTGTAAAGGTCCTCCTCCAAGAGAAAA TTCAGAAATTCTCTCAGGCTCGTGGTCAGAACAACTATATCCAGAAGGCACCCAGGCTACCTACAAATGC CGCCCTGGATACCGAACACTTGGCACTATTGTAAAAGTATGCAAGAATGGAAAATGGGTGGCGTCTAACC CATCCAGGATATGTCGGAAAAAGCCTTGTGGGCATCCCGGAGACACACCCTTTGGGTCCTTTAGGCTGGC AGTTGGATCTCAATTTGAGTTTGGTGCAAAGGTTGTTTATACCTGTGATGATGGGTATCAACTATTAGGT GAAATTGATTACCGTGAATGTGGTGCAGATGGGTGGATCAATGATATTCCACTATGTGAAGTTGTGAAGT GTCTACCTGTGACAGAACTCGAGAATGGAAGAATTGTGAGTGGTGCAGCAGAAACAGACCAGGAATACTA TTTTGGACAGGTGGTGCGGTTTGAATGCAATTCAGGCTTCAAGATTGAAGGACATAAGGAAATTCATTGC TCAGAAAATGGCCTTTGGAGCAATGAAAAGCCACGATGTGTGGAAATTCTCTGCACACCACCGCGAGTGG AAAATGGAGATGGTATAAATGTGAAACCAGTTTACAAGGAGAATGAAAGATACCACTATAAGTGTAAGCA TGGTTATGTGCCCAAAGAAAGAGGGGATGCCGTCTGCACAGGCTCTGGATGGAGTTCTCAGCCTTTCTGT GAAGAAAAGAGATGCTCACCTCCTTATATTCTAAATGGTATCTACACACCTCACAGGATTATACACAGAA GTGATGATGAAATCAGATATGAATGTAATTATGGCTTCTATCCTGTAACTGGATCAACTGTTTCAAAGTG TACACCCACTGGCTGGATCCCTGTTCCAAGATGTACCTTGAAACCATGTGAATTTCCACAATTCAAATAT GGACGTCTGTATTATGAAGAGAGCCTGAGACCCAACTTCCCAGTATCTATAGGAAATAAGTACAGCTATA AGTGTGACAACGGGTTTTCACCACCTTCTGGGTATTCCTGGGACTACCTTCGTTGCACAGCACAAGGGTG GGAGCCTGAAGTCCCATGCGTCAGGAAATGTGTTTTCCATTATGTGGAGAATGGAGACTCTGCATACTGG GAAAAAGTATATGTGCAGGGTCAGTCTTTAAAAGTCCAGTGTTACAATGGCTATAGTCTTCAAAATGGTC AAGACACAATGACATGTACAGAGAATGGCTGGTCCCCTCCTCCCAAATGCATCCGTATCAAGACATGTTC AGCATCAGATATACACATTGACAATGGATTTCTTTCTGAATCTTCTTCTATATATGCTCTAAATAGAGAA ACATCCTATAGATGTAAGCAGGGATATGTGACAAATACTGGAGAAATATCAGGATCAATAACTTGCCTTC AAAATGGATGGTCACCTCAACCCTCATGCATTAAGTCTTGTGATATGCCTGTATTTGAGAATTCTATAAC TAAGAATACTAGGACATGGTTTAAGCTCAATGACAAATTAGACTATGAATGTCTCGTTGGATTTGAAAAT GAATATAAACATACCAAAGGCTCTATAACATGTACTTATTATGGATGGTCTGATACACCCTCATGTTATG AAAGAGAATGCAGTGTTCCCACTCTAGACCGAAAACTAGTCGTTTCCCCCAGAAAAGAAAAATACAGAGT TGGAGATTTGTTGGAATTCTCCTGCCATTCAGGACACAGAGTTGGGCCAGATTCAGTGCAATGCTACCAC TTTGGATGGTCTCCTGGTTTCCCTACATGTAAAGGTCAAGTAGCATCATGTGCACCACCTCTTGAAATTC TTAATGGGGAAATTAATGGAGCAAAAAAAGTTGAATACAGCCATGGTGAAGTGGTGAAATATGATTGCAA ACCTAGATTCCTACTGAAGGGACCCAATAAAATCCAGTGTGTTGATGGGAATTGGACAACCTTGCCTGTA TGTATTGAGGAGGAGAGAACATGTGGAGACATTCCTGAACTTGAACATGGCTCTGCCAAGTGTTCTGTTC CTCCCTACCACCATGGAGATTCAGTGGAGTTCATTTGTGAAGAAAACTTCACAATGATTGGACATGGGTC AGTTTCTTGCATTAGTGGAAAATGGACCCAGCTTCCTAAATGTGTTGCAACAGACCAACTGGAGAAGTGT AGAGTGCTGAAGTCAACTGGCATAGAAGCAATAAAACCAAAATTGACTGAATTTACGCATAACTCCACCA TGGATTACAAATGTAGAGACAAGCAGGAGTACGAACGCTCAATCTGTATCAATGGAAAATGGGATCCTGA ACCAAACTGTACAAGCAAAACATCCTGCCCTCCTCCACCGCAGATTCCAAATACCCAAGTGATTGAAACC ACCGTGAAATACTTGGATGGAGAAAAATTATCTGTTCTTTGCCAAGACAATTACCTAACTCAGGACTCAG AAGAAATGGTGTGCAAAGATGGAAGGTGGCAGTCATTACCTCGCTGCATTGAAAAAATTCCATGTTCCCA GCCCCCTACAATAGAACATGGATCTATTAATTTACCCAGATCTTCAGAAGAAAGGAGAGATTCCATTGAG TCCAGCAGTCATGAACATGGAACTACATTCAGCTATGTCTGTGATGATGGTTTCAGGATACCTGAAGAAA ATAGGATAACCTGCTACATGGGAAAATGGAGCACTCCACCTCGCTGTGTTGGACTTCCTTGTGGACCTCC ACCTTCAATTCCTCTTGGTACTGTTTCTCTTGAGCTAGAGAGTTACCAACATGGGGAAGAGGTTACATAC CATTGTTCTACAGGCTTTGGAATTGATGGACCAGCATTTATTATATGCGAAGGAGGAAAGTGGTCTGACC CACCAAAATGCATAAAAACGGATTGTGACGTTTTACCCACAGTTAAAAATGCCATAATAAGAGGAAAGAG CAAAAAATCATATAGGACAGGAGAACAAGTGACATTCAGATGTCAATCTCCTTATCAAATGAATGGCTCA GACACTGTGACATGTGTTAATAGTCGGTGGATTGGACAGCCAGTATGCAAAGATAATTCCTGTGTGGATC CACCACATGTGCCAAATGCTACTATAGTAACAAGGACCAAGAATAAATATCTACATGGTGACAGAGTACG TTATGAATGTAATAAACCTTTGGAACTATTTGGGCAAGTGGAAGTGATGTGTGAAAATGGGATATGGACA GAAAAACCAAAGTGCCGAGACTCAACAGGGAAATGTGGGCCTCCTCCACCTATTGACAATGGAGACATCA CCTCCTTGTCATTACCAGTATATGAACCATTATCATCAGTTGAATATCAATGCCAGAAGTATTATCTCCT TAAGGGAAAGAAGACAATAACATGTAGAAATGGAAAGTGGTCTGAGCCACCAACATGCTTACATGCATGT GTAATACCAGAAAACATTATGGAATCACACAATATAATTCTCAAATGGAGACACACTGAAAAGATTTATT CCCATTCAGGGGAGGATATTGAATTTGGATGTAAATATGGATATTATAAAGCAAGAGATTCACCGCCATT TCGTACAAAGTGCATTAATGGCACCATCAATTATCCCACTTGTGTATAA ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA |
| Restriction Sites | SgfI-MluI |
| ACCN | NM_009888 |
| Insert Size | 3759 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_009888.3, NP_034018.2 |
| RefSeq Size | 4365 bp |
| RefSeq ORF | 3759 bp |
| Locus ID | 12628 |
| UniProt ID | P06909 |
| Gene Summary | Glycoprotein that plays an essential role in maintaining a well-balanced immune response by modulating complement activation. Acts as a soluble inhibitor of complement, where its binding to self markers such as glycan structures prevents complement activation and amplification on cell surfaces. Accelerates the decay of the complement alternative pathway (AP) C3 convertase C3bBb, thus preventing local formation of more C3b, the central player of the complement amplification loop. As a cofactor of the serine protease factor I, CFH also regulates proteolytic degradation of already-deposited C3b. In addition, mediates several cellular responses through interaction with specific receptors. For example, interacts with CR3/ITGAM receptor and thereby mediates the adhesion of human neutrophils to different pathogens. In turn, these pathogens are phagocytosed and destroyed.[UniProtKB/Swiss-Prot Function] |
Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| MG218690 | Cfh (tGFP-tagged) - Mouse complement component factor h (Cfh), (10ug) |
CNY 12,070.00 |
|
| MR218690 | Cfh (Myc-DDK-tagged) - Mouse complement component factor h (Cfh) |
CNY 8,720.00 |
|
| MR218690L3 | Lenti ORF clone of Cfh (Myc-DDK-tagged) - Mouse complement component factor h (Cfh) |
CNY 12,830.00 |
|
| MR218690L4 | Lenti ORF clone of Cfh (mGFP-tagged) - Mouse complement component factor h (Cfh) |
CNY 12,830.00 |
