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Ercc6 (NM_001081221) Mouse Untagged Clone
CAT＃: MC224549
Ercc6 (untagged) - Mouse excision repair cross-complementing rodent repair deficiency, complementation group 6 (Ercc6), (10ug)
CNY 19,000.00
货期*
8周
规格
Product images
经常一起买 (3)
Specifications
| Product Data | |
| Type | Mouse Untagged Clone |
| Tag | Tag Free |
| Synonyms | 4732403I04; C130058G22Rik; CSB |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>MC224549 representing NM_001081221
Red=Cloning site Blue=ORF Orange=Stop codon TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGTTCCACGAGGAAGTTCCCAACTCCACTCACCCTCAGGAGCAAGACTGTTTACCAAGTCAGCATGCCA ATGCTTACAAAGACATGCCAGTTGGGCAGGAGAATGGTGGGGTCTCAGAGGCCGGGGAGTGCCTCTCCTC TACTTCCTGTGAGTATGGGCCATCCACATCTGCTGAAGCTTGTGTGTTGGCAGCCACAAGGCGTGGGCCG ACCCTGCTACACATTGATCGGCATCAGATCCCTGCAGTTGAGCCCAGTGCTCAGGCCCTGGAGCTGCAGG GCCTGGGTGTGGACGTCTATGACCAGGCTGTCCTGGAACAAGGCGTGCTTCAGCAGGTGGACAGTGCGAT GCATGAGGCCAGCTGTGTGGCCCAGCTTGCTGATGCGGAGAAGGAGTATCAGTCAGTCCTGGATGACCTC ATGTCATGTACAACATCCCTGAGGCAAATCAATAAAATTATAGAGCAACTTAGCCCTCAAGCTGCCAGCA ACAGAGACATCAACAGGAAACTAGATTCCGTGAAGCGACAGAAGTATAACAAGGAACAACAGCTAAAGAA GATAACTGCAAAACAGAAACGTCTCCAGGCCATTCTCGGAGGGGCTGGGGTCCAAGTGGAACTGGATCAT GCCAGCCTAGAGGAGGACGATGCAGAGCCAGGGCCATCATGTCTTGGCAGTATGCTCATGCCTGCCCAGG AGACCGCCTGGGAGGAGCTTATCCGCACTGGCCAGATGACACCGTTTGGTACCCCAGCCCCTCAGAAACA GGAGAAAAAGCCCAGAAAAATAATGCTGAATGAAGCATCAGGCTTTGAAAAATATTTGGCAGAGCAAGCA CAACTTTCGTTTGAAAGGAAGAAACAAGCTGCTACTAAAAGAACAGCTAAAAAAGCTATAGTCATATCCG AGTCAAGCCGAGCAGCAATTGAAACCAAGGCAGACCAGAGAAGCCAAGTGCTCTCTCAGACAGACAAGCG CCTGAAGAAGCACAGCAGGAAACTCCAGAGGAGGGCGCTGCAGTTCCAGGGCAAAGTGGGATTGCCGAGC GGGAAGAAACCTTTGGAGCCTGAGGTGAGGCCAGAGGCCGAGGGAGACACTGAGGGTGAGGAGTCTGGGT CCTCTCCCACCGATGGGGAGGAGGAGGAAGAACAAGAGGAGGAGGAAGGGGTAGCCAGCCTGTCTTCTGA TGACGTTAGCTATGAGCTGAAGCCTCTTCGGAAGAGGCAGAAATACCAGAAGAAAGTCCCAGTTCAGGAG ATCGACGATGACTTCTTTCCAAGTTCTGAGGAGGAAGATGAAGCTATGGAAGGAAGAGGAGGAGGCCGAA AGGTAGCCAGGCGCCAAGACGATGGAGATGAGGATTATTATAAGCAGCGGTTAAGGAGGTGGAACAGGCT GAGGCTGCAGGACAAAGAGAAACGCCTGAAGCTTGAAGATGATTCTGAGGAGAGCGATGCCGAATTTGAC GAAGGTTTCAAAGTGCCGGGTTTTCTGTTCAAAAAGCTCTTTAAGTATCAGCAGACAGGTGTTAGGTGGC TGTGGGAATTGCACTGCCAGCAGGCAGGAGGAATTCTGGGAGACGAAATGGGATTGGGCAAGACCATCCA GATAATTGCCTTCTTGGCAGGTCTGAGCTACAGCAAGATCAGGACTCGCGGTTCAAATTACAGGTTCGAG GGACTAGGCCCCACTATAATTGTCTGCCCAACGACAGTGATGCATCAGTGGGTGAAGGAATTCCACACGT GGTGGCCTCCATTCAGAGTGGCAGTTCTGCATGAAACAGGTTCCTACACCCACAAAAAGGAGAGGCTGAT TCGAGATATTGTTTATTGTCATGGAGTTTTGATAACTTCATATTCATACATCCGACTGATGCAAGATGAC ATTAGCAGACATGACTGGCACTACGTCATCTTAGATGAAGGACACAAAATTCGAAATCCAAATGCTGCAG TCACCCTTGCTTGCAAACAGTTCCGGACACCTCATCGGATTATCTTGTCTGGCTCACCGATGCAGAATAA CCTCCGAGAGCTGTGGTCACTCTTCGACTTCATCTTCCCAGGAAAGCTGGGCACATTGCCTGTGTTTATG GAGCAGTTCTCTGTCCCCATCACCATGGGAGGCTATTCCAATGCTTCCCCAGTACAGGTTAAAACTGCTT ATAAGTGTGCATGTGTCTTAAGAGACACGATAAACCCGTACTTACTGCGGAGAATGAAATCAGATGTCAA GATGAGCCTTTCGTTGCCAGATAAAAATGAGCAGGTCTTATTTTGCCGTCTAACTGATGAGCAGCATAAA GTCTACCAGAATTTCATTGATTCTAAAGCAGTCTACAGGATTCTCAATGGAGAAAATCAGATTTTCTCTG GACTTGTAGCGCTGAGGAAGATCTGCAACCACCCTGACCTCTTTTCTGGCGGCCCCAAGAACGCCAGTGG TCCTCCAGAGGATGAGCTGGAAGAAGAGCAGTTTGGACACTGGAGACGCTCTGGGAAAATGATTGTTGTT GAGTCTTTGCTGAAAATATGGCACAGGCAGGGTCAGCGGGTGCTGCTGTTTTCCCAGTCCAGGCAGATGC TACACATACTGGAAGTGTTCCTGAGAGCCCATAAGTATTCCTATCTCAAGATGGATGGGACCACCACCAT AGCGTCAAGACAGCCGCTGATTACAAAATACAATGAGGACACGTCCATCTTTGTCTTTCTTCTGACCACA CGGGTGGGTGGCTTAGGAGTGAACCTGACCGGTGCCAACAGAGTCATCATCTACGACCCAGACTGGAATC CAAGCACCGACACACAGGCCCGGGAGCGAGCATGGAGGATAGGTCAGAAGAAGCAGGTGACTGTCTACAG GCTTCTGACGGCTGGCACCATTGAGGAAAAGATCTACCACCGACAAATCTTCAAGCAATTTTTGACAAAC AGAGTGCTAAAAGACCCAAAACAAAGGCGCTTTTTCAAATCCAACGATCTCTATGAGCTGTTCACTCTGA CCAGTCCTGACGCCTCCCAGGGCACTGAGACAAGTGCTATTTTTGCAGGAACGGGCTCCAGTATTCAGAC ACCCAAATGCCAGTTAAAAAAAAGGACTTCCACAGTCCTGGGAACAGATCCCAAATGCAAGAAGCCCCCT GTTTCTGACACACCTGCAAATGCTGCCACCCTGATTGGAGAAAAACCTAAGGCGGCGGGAGCTACAGGAA GAAGTGTCACTTCTGGAGAAAGTGGTCCTTTCAAAGGCGACCATGACACAAATGGGAACAGAGCTAGCAG TGTTGCTTTTGGAGAAGAGACAGATGCAGGGTCCACACTGGAGCATCTCTCAGTGATGAGTGGAGATGGG AAGCATTCAGATTCTCCAACAGTTGACCACACATCCAGGCCACCAGTGGAGGCAAGCACCAGTGAGAAGC AGGGTTCTTCCTATGCAGGGGCGCGCTGCCAGGCTCAGACAGAACCTGTTCCCATGAGTGAACAAATGGA AGGTCAGTTTTCTAAGTACAAATCCAAAAGGAAGCATGATGCATCTGAGGAAGAGACCACAGAGAAACGT CCACAGCCCAAGCAAAAGGCCAAGAACTCCAAGCATTGCAGAGATGCTAAGTTTGAGGGAACTCGAGTCC CGCACCTGGTGAAGAAAAGACGGTACCGCCAGCAAACCAGTGAGCAGGAGGGCGGAGCCAAGGACCGGAG CAGCGATGATTATGTGTTGGAAAAGCTTTTCAAAAAATCAGTGGGCGTGCACAGCGTCGTGAGGCATGAT GCCATCATAGATGGGTCCAGTCCAGATTATGTGCTGGTGGAAGCAGAAGCCAACCGAGTGGCTCAGGACG CCTTGAAAGCTCTGAGGCTCTCTCGTCAGCAATGCCTGGGGGCAGCATCTGGTGTTCCCACCTGGACTGG CCACAGGGGGATTTCTGGTGCACCAACAGGAGTAAAGAATAGGTTCGGTCAGAAAAGGGACTCCAGCCTC CCTGTGCAGCATCCTTCATCACTAACAGAAAAGACTCAGAACAACATGAAAAAGGAGGGAAAAGCTCACA CCCCTGAGCACTTCAGTGGCAAAGAAGATGGAGCATCTGTGTCTGGAGCGCCCAGTTCCTCCTCCCTCTT GGCCAGAATGCGAGCAAGAAACCACATGATTTTGCCGGAGCGCTTAGAGAGTGACAGTGAACATCTTGCT GAGGCTGCTGCCGTGCCTCCCTGCGGCACCGAACACGACGACCTTCTGGTGGACATGAGGAACTTCATTG CTTTCCAGGCCCAGGTGGATGGCCAGGCCAGCACTCAGGAAATCCTGCAGGAGTTTGAGTCCAAGCTGTC CGTGGCACAGTCCTGTGTCTTCCGAGAACTGCTGAGAAATCTGTGCAATTTCCATAGAACTCCTGGTGGG GAAGGGATTTGGAAGCTGAAGCCAGAATACTGCTAA ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA |
| Restriction Sites | SgfI-MluI |
| ACCN | NM_001081221 |
| Insert Size | 4446 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_001081221.1, NP_001074690.1 |
| RefSeq Size | 8422 bp |
| RefSeq ORF | 4446 bp |
| Locus ID | 319955 |
| UniProt ID | F8VPZ5 |
| Gene Summary | Essential factor involved in transcription-coupled nucleotide excision repair which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes (By similarity). Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA (By similarity). It is required for transcription-coupled repair complex formation. It recruits the CSA complex (DCX(ERCC8) complex), nucleotide excision repair proteins and EP300 to the sites of RNA polymerase II-blocking lesions (By similarity). Plays an important role in regulating the choice of the DNA double-strand breaks (DSBs) repair pathway and G2/M checkpoint activation; DNA-dependent ATPase activity is essential for this function (By similarity). Regulates the DNA repair pathway choice by inhibiting non-homologous end joining (NHEJ), thereby promoting the homologous recombination (HR)-mediated repair of DSBs during the S/G2 phases of the cell cycle (By similarity). Mediates the activation of the ATM- and CHEK2-dependent DNA damage responses thus preventing the premature exit from the G2/M checkpoint (By similarity). Acts as a chromatin remodeler at DSBs; DNA-dependent ATPase-dependent activity is essential for this function (By similarity). Remodels chromatin by evicting histones from chromatin flanking DSBs, limiting RIF1 accumulation at DSBs thereby promoting BRCA1-mediated HR (By similarity). Required for stable recruitment of ELOA and CUL5 to DNA damage sites (By similarity). Involved in UV-induced translocation of ERCC8 to the nuclear matrix (By similarity). Essential for neuronal differentiation and neuritogenesis; regulates transcription and chromatin remodeling activities required during neurogenesis (By similarity).[UniProtKB/Swiss-Prot Function] |
Documents
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| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| MG222310 | Ercc6 (tGFP-tagged) - Mouse excision repair cross-complementing rodent repair deficiency complementation group 6 (Ercc6), (10ug) |
CNY 11,880.00 |
|
| MR222310 | Ercc6 (Myc-DDK-tagged) - Mouse excision repair cross-complementing rodent repair deficiency, complementation group 6 (Ercc6) |
CNY 10,136.00 |
|
| MR222310L3 | Lenti ORF clone of Ercc6 (Myc-DDK-tagged) - Mouse excision repair cross-complementing rodent repair deficiency, complementation group 6 (Ercc6) |
CNY 12,730.00 |
|
| MR222310L4 | Lenti ORF clone of Ercc6 (mGFP-tagged) - Mouse excision repair cross-complementing rodent repair deficiency, complementation group 6 (Ercc6) |
CNY 12,730.00 |
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