Hivep3 (NM_010657) Mouse Untagged Clone

Specifications

Product Data
Type	Mouse Untagged Clone
Tag	Tag Free
Synonyms	2900056N03Rik; A130075N07; AI848000; E030045D18Rik; KBP-1; KBP1; Krc; Rc; Schnurri-3; Shn3
Vector	pCMV6-Entry
E. coli Selection	Kanamycin (25 ug/mL)
Mammalian Cell Selection	Neomycin
Sequence Data	Fully Sequenced ORF (showhide) >MC225284 representing NM_010657 Red=Cloning site Blue=ORF Orange=Stop codon TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGGATCCTGACCAAAGCATCAAGGGCACCAAGAAGGCTGATGGAAGTCCCCGGAAGCGGCTGACCAAAG GAGAGGCCATTCAGACGAGTGTTTCTTCCAGTGCTCCATACCCAGGCAGCGGCACTACTGCTCCCTCAGA GAGTGCCACCCAGGAGCTCCTAGCCACGCAGCCTTTCTCAGGCCCCTCTCAGGAGAAAACGGGCCAGCAG CAGAAGCCTGCCCGGAGGCCTTCCATCGAGGCCTCGGTCCACATCTCTCAGCTTCCGCAGCACCCTCTGA CACCAGCATTCATGTCCCCGGGCAAGCCAGAGCATCTCCTCGAGGGGTCCACGTGGCAGCTGGTTGACCC CATGAGACCTGGACCCTCGGGCTCCTTTGTGGCCCCCGGGCTGCATCCGCAGAGCCAGCTCCTCCCATCC CATGCTTCTATCCTTCCTCCTGAGGAGCTGCCTGGCATCCCTAAGGTCTTTGTGCCTCGTCCCTCACAGG TCTCCCTGAAACCTGCAGAAGAGGCACACAAGAAAGAGAGGAAACCGCAGAAGCCAGGCAAGTATATATG TCAATACTGCAGCCGACCCTGCGCCAAGCCCAGTGTGCTCCAGAAACACATTCGCTCACACACAGGTGAG AGGCCCTACCCCTGCGGCCCCTGCGGCTTCTCCTTCAAGACCAAGAGTAACCTCTACAAGCACAGGAAGT CCCATGCCCACCGTATCAAAGCTGGCCTGGCCTCGGGCTCCAGCAGTGAGATGTACCCCCCTGGGCTGGA GATGGAGAGGATCCCCGGGGAAGAGTTTGAGGAACCCACCGAGGGAGAAAGCACAGACTCTGAGGAGGAA ACGGGTGCCGCATCAGGTCCCTCCACAGATGTTCTCCCCAAACCCAAGCACCCCCTGCTCTCAAGTAGTT TGTACAGCTCCGGGAGCCACGGTTCCAGCCAGGAACGCTGCTCCCTCTCCCAGTCAAGCACTGGCCCATC ACTAGAGGACCCCGCCCCATTTGCAGAAGCCTCATCGGAACATCCCCTGAGCCATAAACCGGAAGACACG CACACCATCAAGCAGAAGCTGGCACTCCGCCTGAGTGAGAGGAAGAAGCTGATCGAAGAGCAGACATTCC TGAGCCCAGGGAGCAAAGGCAGCACAGAGTCCGGGTACTTCTCACGCTCTGAGAGCGCTGAGCAGCAGGT CAGCCCCCCCAACACCAACGCAAAGTCCTACGCAGAGATCATCTTCGGCAAGTGTGGACGGATTGGGCAG CGGACCTCCATGCTGGCATCCACCTCTACCCAGCCCCTACTGCCTCTATCCTCGGAAGACAAGCCCAGCT TGGTACCTTTGTCTGTGCCCAGGACACAAGTGATCGAACATATCACCAAGCTCATCACCATCAATGAAGC CGTGGTGGACACCAGTGAGATCGACAGTGTGAAGCCCAGGAGGAGCTCTCTAACCAGGCGCAGCAGCGTG GAGTCCCCGAAGTCCAGCCTCTACCGGGACTCACTATCGTCCCATGGGGAGAAGACTAAGCAGGAGCAAT CACTGCTGAGCCTCCAGCACCCACCCAGCTCCACGCACCCTGTGCCTCTCCTGAGAAGTCACTCAATGCC TTCTGCCGCCTGCACCATCAGCACCCACCACCACACCTTCCGTGGTAGCTACTCCTTTGATGACCACGTC GCTGACCCCGAGGTCCCCAGCCGCAACACTCCCGTGTTTACCTCCCACCCACGGATGCTAAAGCGCCAGC CAGCCATTGAATTACCTTTGGGGGGTGAGTACAGTTCCGAGGAGCCTGGACCGAGCAGCAAGGACCCCAC CTCCAAGCCCTCCGATGAACCAGAACCCAAGGAAAGCGACCTTACCAAAAAGACCAAGAAGGGGTTCAAA ACAAAAGGCGCGAACTATGAATGTACCATCTGCGGTGCTCGGTACAAAAAGAGAGATAATTACGAAGCTC ATAAGAAGTACTACTGCTCTGAGCTCCAGATCACAAAAGCCCACTCTGTAGGTGCTCATGAAGTGGAAAA GACTCAGGCTGAGCCTGAGCCTTGGTCCCAGATGATGCATTATAAACTGGGGGCCACCTTGGAACTCACT CCGCTGAGAAAAAGACGGAAAGAAAAGAGCCTTGGAGATGAGGAAGAGCCACCTGCCTTTGGCAGCCCAG GCCCTTCAGAAACAGCTCATAACCGTCCCCTGGGGTCCACCAAGTCACCAGCAGAAGCAAGCAAATCAGC GCCCTCTCTAGAGGGACCCACGAGCTTCCAGCCCAGGACTCCCAAGCCAGGAGCTGGGTCAGAACCAGGG AAGGAGAGGAGAACAATGTCCAAAGAAATTTCCGTCATCCAGCACACCAGCTCCTTTGAGAAGTCTGACC CACCGGAGCAGCCCAGTGGCCTGGAGGAAGACAAGCCCCCGGCCCAGTTCTCATCCCCACCACCTGCCCC GCACGGACGCTCCGCTCACTCCCTGCAGCCAAGGTTGGTCCGGCAGCCCAACATTCAGGTTCCAGAGATC CTCGTGACAGAAGAACCGGACAGGCCTGACACAGAGCCTGAGCCGCCCCCCAAGGAGCCTGAGAAGACAG AAGAATTCCAGTGGCCCCAGCGCAGCCAGACACTGGCACAACTCCCAGCGGAGAAGCTGCCACCCAAGAA AAAGAGACTCCGCCTGGCTGAGATGGCGCAGTCCTCGGGGGAGTCCAGCTTTGAGTCCTCCGTGCCTCTG TCTCGAAGCCCAAGCCAGGAGAGCAGCATTTCTCTGAGTGGCTCCAGCCGCTCGGCTTCATTCGACAGGG AAGACCATGGAAAAGCTGAGGCCCCTGGACCCTTCTCAGACACACGCTCCAAAACCTTGGGCTCCCACAT GCTGACTGTCCCCAGCCACCACCCACATGCCCGAGAGATGAGACGGTCAGCCTCAGAGCAGAGCCCCAAT GTGCCCCATTCCTCACACATGACTGAGACCCGAAGCAAATCCTTTGACTACGGCAGCTTGTCCCCTACAG GACCATCCTTAGCAGTGCCTGCTGCTCCGCCACCCCCAGCCGCCCCGCCAGAAAGAAGAAAATGCTTTCT GGTACGTCAGGCCTCCCTGAACAGACCTCCAGAAGCCGAGCTGGAGGCTGTGCCCAAGGGAAAACAAGAG AGCAGTGAGGAGCCCGCAGCCAGCAAGCCTTCCACAAAAAGCTCTGTGCCCCAGATCTCTGTGGGCACTA CGCAAGGTGGGCCTTCAGGGGGCAAAAGCCAGATGCAGGACAGGCCCCCACTGGGATCCAGCCCACCCTA CACAGAAGCTCTGCAAGTGTTCCAACCTCTCGGCACCCAGCTGCCCCCTCCAGCCTCTCTCTTCTCCTTG CAACAGCTCTTGCCTCAGGAGCAAGAACAATCCTCTGAGTTCTTCCCCACACAAGCAATGGCCGGCCTCC TCTCCTCCCCATACTCCATGCCCCCGCTCCCACCTTCCTTGTTCCAAGCCCCACCACTTCCTCTACAGCC TACTGTGCTACACCCCAGCCAGCTCCATCTCCCCCAGCTCCTGCCTCACGCTGCAGATATCCCCTTCCAG CAGCCCCCTTCCTTTCTCCCCATGCCATGCCCTGCCCCTTCAACCCTCTCCGGATATTTCCTCCCTCTGC AATCCCAGTTTGCACTGCAGCTCCCTGGTGAAATAGAAAGCCACTTGCCCCCAGTCAAAACCAGCCTGCC CCCTCTGGCCACAGGACCTCCTGGCCCCTCCAGCAGCACAGAATACAGCAGTGACATCCAGCTGCCTCCT GTGACTCCCCAAGCCACCTCCCCAGCTCCCACATCAGCCCCACCACTGGCCCTTCCTGCCTGTCCAGATG CCATGGTGTCACTGGTTGTTCCTGTCCGAATCCAGACCCATATGCCATCCTATGGAAGTGCCATGTACAC CACTTTGTCTCAGATCTTGGTCACACAGTCTCCGGGTAGCCCAGCAAGCACGGCCCTTACCAAGTACGAG GAACCCTCCTCCAAAAGTATGACTGTTTGTGAGGCTGATGTATATGAGGCTGAGCCTGGGCCATCGAGCA TAAGCAAGGAACAAAACAGAGGTTACCAGACACCATATCTGAGAGTACCTGAAAGGAAAGGCACTTCACT GTCTTCTGAGGGTATCCTGAGCCTGGAGGGGTGCTCATCCACAGCCAGTGGAAGCAAGCGCGTCCTTTCC CCAGCTGGCAGTCTTGAACTTACCATGGAAACCCAGCAGCAGAAAAGGGTAAAGGAGGAAGAAGCTTCCA AGGCAGATGAAAAACTGGAGCTTGTGAGTACCTGTAGTGTCGTGCTGACAAGTACAGAGGATAGGAAGAA GACAGAGAAACCCCATGTGGGTGGCCAGGGCCGGAGCAGGAGGGAGGCAGAAACACTGTCCAGCTTGTCT TCAGATGTATCCGACCCAAAAGAACTTTCTCCCCTCTCTCATTCCACATTGTCCCATGGGACAGCCCCAG GCTCAGAAGCTTTGAAGGAATATGCCCAACCATCTAGCAAAGCTCACCGAAGAGGTCTGCCTCCAATGAG TGTAAAGAAAGAAGATCCAAAGGAACAGACTGACCTCCCTCCCCTGGCACCCCCTAGTTCTCTGCCTCTG TCAGATACTTCCCCTAAACCAGCCAAATTGCAAGAAGGTACGGACTCAAAGAAGGTACTGCAGTTCCCCA GCCTCCACACAACCACTAATGTCAGTTGGTGCTATTTAAACTACATTAAGCCAAATCACATCCAGCATGC AGATAGGAGGTCCTCTGTTTACGCTGGTTGGTGCATAAGTTTGTACAACCCCAACCTTCCAGGGGTTTCC ACTAAAGCTGCTTTGTCCCTCCTGCGATCTAAGCAGAAGGTGAGCAAAGAGACATATACCATGGCCACAG CTCCGCATCCTGAGGCAGGAAGGCTGGTTCCATCCAACTCCCGAAAGCCCCGCATGACAGAGGTGCACCT CCCGTCGCTGGTTTCCCCAGAGAGCCAGAAAGACCCAGCTAGAGTGGAAAAGGAAGAAAAGCAAGGGAAG GCGGAGGAAGGTACTCCCACTTCCAAGAGAGGCGAGCCGGCGAGGGTCAAGATCTTCGAAGGAGGGTACA AATCAAACGAAGAGTATATATATGTGCGAGGCCGCGGCCGAGGGAGATATGTTTGTGAGGAATGTGGAAT TCGCTGCAAGAAGCCCAGCATGCTGAAGAAACACATCCGCACCCACACTGACGTCCGGCCCTATGTGTGC AAGCACTGTCACTTTGCTTTTAAAACCAAAGGGAATCTGACTAAGCACATGAAGTCGAAAGCCCACAGCA AAAAGTGCCAAGAGACGGGGGTGCTGGAGGAGCTGGAAGCCGAAGAAGGAACCAGTGATGACCTGCACCA GGACTCAGAGGGGCAAGAGGGCGCCGAGGCTGTGGAGGAGCACCAGTTCTCAGACCTGGAGGACTCTGAC TCAGACTCAGACCTGGATGAAGATGAGGAGGAGGAAGAGGAGGAGGAAGAGAGCCAGGATGAGCTGTCTG GGCCATGCTCGGAGGCAGCTCCGCCTTGCCTGCCCCCCACACTACAGGAGAACTCCTCACCCGTTGAGGG CCCTCAGGCTCCAGATAGCACTTCTGACGAGGTCCCGCAAGGCAGCTCCATCTCAGAAGCCACGCATTTG ACCGCCAGCAGTTGTTCCACACCTAGCCGGGGTACCCAAGGCCTTCCCAGGCTGGGACTGGCCCCACTGG AGAAGGACATGAGCTCAGCCCCGAGTCCCAAGGCCACGTCCCCTAGGAGGCCGTGGTCCCCAAGCAAAGA AGCAGGCAGCCGCCCCTCACTCACTCGCAAACATTCACTCACCAAAAATGACTCGTCTCCCCAGCAATGT TCACCGGCCCGAGAAGCTCAGGCCTCAGTAACGAGCACACCTGGTCCCCAGATGGGCCCAGGAAGGGACC TGGGCCCTCACCTTTGTGGGTCTCCAAGACTGGAGCTGTCCTGTCTCACTCCCTACCCCATAGGAAGAGA AGCGCCCGCTGGACTCGAGCGTGCCACAGACACAGGCACCCCCAGATATTCACCCACCAGGAGATGGTCT CTGGGTCAGGCCGAGTCACCGCCACAGACAGTGCTGCCAGGGAAATGGGCCCTGGCTGGGCCCTGCAGCC CCTCAGCGGACAAGAGTGGCCTGGGCTTGGGGCCGGTTCCACGGGCCCTCCTCCAGCCCGTGCCTCTACC TCACACACTTCTCAGCAGAAGCCCTGAAACGTGCACCTCTGCATGGCGGAAGACTGAGTCCCGAAGTCCA TCAGCTGGCCCTGCTCCTCTCTTCCCCCGACCATTCTCCGCCCCTCATGACTTCCATGGCCACCTCCCTA GCCGAAGTGAGGAGAACCTCTTCAGCCACCTGCCTCTGCATTCCCAGCTCCTGAGCCGCGCCCCCTGCCC CCTCATTCCCATCGGTGGGATCCAGATGGTACAGGCCCGGCCAGGAGCCCAGCCCACCGTGCTTCCTGGA CCCTGCGCGGCCTGGGTCAGTGGCTTCTCAGGGGGCGGCAGTGACCTAACTGGGGCCCGAGAGGCCCAGG AGCGCAGCCGCTGGAGTCCCACAGAGAGCCCTTCAGCATCGGTGTCCCCTGTGGCCAAGGTCTCCAAGTT TACACTCTCGTCAGAGCTGGAAGAGGAAAGGACCGGCAGAGGCCCAGGAAGACCTCCTGACTGGGAACCT CACAGGGCTGAAGCCCCTCCAGGACCCATGGGCACACACAGCCCCTGCTCCCCACAGCTGCCCCAAGGCC ACCAGGTGGCACCTTCCTGGAGGGGCCTCTTGGGGTCACCACACACACTGGCCAACCTAAAGGCCTCAAG CTTCCCACCACTGGATCGCAGCAGCTCCATGGACTGCCTGGCAGAGACCTCCACTTACTCTCCACCCCGG AGCAGGAACCTCTCTGGAGAACCCAGGACCCGTCAAGGCTCCCCTGAGCTCTTAGGTAGAGGGGAGCTCA GGACACCTCTATTCCTGCCCAAGGGTAGTGGCCCCCCAAGCATCTAG ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA
Restriction Sites	SgfI-MluI
ACCN	NM_010657
Insert Size	7047 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note	Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Reference Data
RefSeq	NM_010657.3, NP_034787.2
RefSeq Size	9021 bp
RefSeq ORF	7047 bp
Locus ID	16656
UniProt ID	A2A884
Gene Summary	Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Binds also to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and proinflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation.[UniProtKB/Swiss-Prot Function]

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