Cmtm6 (NM_026036) Mouse Tagged ORF Clone
CAT#: MG201673
- TrueORF®
Cmtm6 (tGFP-tagged) - Mouse CKLF-like MARVEL transmembrane domain containing 6 (Cmtm6)
ORF Plasmid: DDK
"NM_026036" in other vectors (4)
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CNY 2,850.00
Specifications
Product Data | |
Type | Mouse Tagged ORF Clone |
Tag | TurboGFP |
Synonyms | 2810051A14Rik; AA536733; Cklfsf6 |
Vector | pCMV6-AC-GFP |
E. coli Selection | Ampicillin (100 ug/mL) |
Mammalian Cell Selection | Neomycin |
Sequence Data |
>MG201673 representing NM_026036
Red=Cloning site Blue=ORF Green=Tags(s) TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGGAGAACGGAGCGGTCTACAGTCCCACCACCGAGGCGGCCCCGGGCACTGGCAGGGGTGCGCGCAGCG GCCTGGCCGCCTACTTCGTCCTGGGCAGGCTCCCTTGGCATCGGCGCATCCTCAAAGGCTTGCAGCTGCT GCTGTCTCTCCTGGCCTTCATCTGTGAAGAGGTTGTGTCCGAGTGTGGGTTGTGTGGAGGCCTCTACTTC TTTGAATTTGTGAGCTGTAGCGCCTTTCTCCTGAGCCTCCTCCTGCTGATCGTGTACTGCACCCCAGTGC ACGACAGAGTGGATACTGGAAAAGTCAAGTCATCGGATTTTTACATCACCCTGGGAACTGGGTGTGTGTT CCTGCTGGCATCTATCATTTTTGTCTCCACCCATTCTGGGACCTCAGCTGAAATTGCTGCAATTGTGTTT GGCTTCTTGGCAAGCTCCATGTTCCTACTGGACTTCGTTGTCATGCTGTGTGAGAAGCTGCGGGAGAGCC CGCTGAGAAAGCCCGAGAACAACGCAAAGGTGGAAGCCCTCACCGAACCACTGAACGCT ACGCGTACGCGGCCGCTCGAG - GFP Tag - GTTTAA >MG201673 representing NM_026036
Red=Cloning site Green=Tags(s) MENGAVYSPTTEAAPGTGRGARSGLAAYFVLGRLPWHRRILKGLQLLLSLLAFICEEVVSECGLCGGLYF FEFVSCSAFLLSLLLLIVYCTPVHDRVDTGKVKSSDFYITLGTGCVFLLASIIFVSTHSGTSAEIAAIVF GFLASSMFLLDFVVMLCEKLRESPLRKPENNAKVEALTEPLNA TRTRPLE - GFP Tag - V |
Restriction Sites | SgfI-MluI Cloning Scheme for this gene Plasmid Map |
ACCN | NM_026036 |
ORF Size | 549 bp |
OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
Reference Data | |
RefSeq | NM_026036.3 |
RefSeq Size | 3356 bp |
RefSeq ORF | 552 bp |
Locus ID | 67213 |
UniProt ID | Q9CZ69 |
Gene Summary | Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately triggering T-cell anergy.[UniProtKB/Swiss-Prot Function] |
Documents
Product Manuals |
FAQs |
SDS |
Resources
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
MC201503 | Cmtm6 (untagged) - Mouse CKLF-like MARVEL transmembrane domain containing 6 (Cmtm6), (10ug) |
CNY 2,400.00 |
|
MR201673 | Cmtm6 (Myc-DDK-tagged) - Mouse CKLF-like MARVEL transmembrane domain containing 6 (Cmtm6) |
CNY 2,400.00 |
|
MR201673L3 | Lenti ORF clone of Cmtm6 (Myc-DDK-tagged) - Mouse CKLF-like MARVEL transmembrane domain containing 6 (Cmtm6) |
CNY 4,750.00 |
|
MR201673L4 | Lenti ORF clone of Cmtm6 (mGFP-tagged) - Mouse CKLF-like MARVEL transmembrane domain containing 6 (Cmtm6) |
CNY 4,750.00 |