Aurkc (BC064780) Mouse Tagged ORF Clone
CAT#: MG203721
- TrueORF®
Aurkc (tGFP-tagged) - Mouse aurora kinase C (cDNA clone MGC:76648 IMAGE:30476803)
"BC064780" in other vectors (1)
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CNY 2,850.00
Specifications
Product Data | |
Type | Mouse Tagged ORF Clone |
Tag | TurboGFP |
Synonyms | AIK3, AIE1 |
Vector | pCMV6-AC-GFP |
E. coli Selection | Ampicillin (100 ug/mL) |
Mammalian Cell Selection | Neomycin |
Sequence Data |
>MG203721 representing BC064780
Red=Cloning site Blue=ORF Green=Tags(s) TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGGAGCCCAGCACCTCAACCAGGAAGCATTTCACCATCAATGACTTTGAAATCGGGCGTCCTCTGGGCA GGGGGAAATTTGGGCGTGTGTACTTGGCTCGGCTCAAGGAAAATCATTTCATCGTGGCCCTGAAGGTCCT CTTCAAGTCTGAGATAGAGAAGGAGGGATTGGAGCACCAACTTCGCAGGGAAGTGGAGATCCAGGCACAC CTACAACACCGGAACATCCTTCGCCTGTACAACTACTTCTATGATGACACTCGGATATACTTAATTCTGG AGTATGCTCCAGGAGGAGAGCTCTATAAGGAGCTTCAGAGACATCAGAAGTTGGACCAGCAGCGTACAGC CACGATAATACAGGAGTTGTCAGATGCCCTGACCTACTGCCATGAGAAGAAGGTGATTCACAGGGACATC AAGCCAGAGAATCTCCTGCTGGGCCTCAATGGTGAGGTGAAGATCTCAGACTTTGGGTGGTCTGTGCATA CCCCCTCTCTCAGGAGAAAGACAATGTGTGGGACTCTGGACTACTTGCCCCCGGAAATGATAGCGCAGAA ACCGTACAATGAGATGGTTGATCTGTGGTGCATTGGGGTGCTCTGCTATGAGCTGCTGGTGGGGAAGCCA CCCTTTGAGAGCAGCACCTCCAGTGAGACATACAGACGCATCCGCCAGGTGGATTTTAAGTTTCCTTCAT CAGTACCTGCAGGAGCCCAGGACTTGATCTCCAAGCTTCTTAGGTACCATCCTTCAGAGCGGCTGAGCCT GGCCCAGGTCCTGAAGCACCCCTGGGTCAGGGAACACTCTCGAAGGGTGCTTCCTTGC ACGCGTACGCGGCCGCTCGAG - GFP Tag - GTTTAA >MG203721 representing BC064780
Red=Cloning site Green=Tags(s) MEPSTSTRKHFTINDFEIGRPLGRGKFGRVYLARLKENHFIVALKVLFKSEIEKEGLEHQLRREVEIQAH LQHRNILRLYNYFYDDTRIYLILEYAPGGELYKELQRHQKLDQQRTATIIQELSDALTYCHEKKVIHRDI KPENLLLGLNGEVKISDFGWSVHTPSLRRKTMCGTLDYLPPEMIAQKPYNEMVDLWCIGVLCYELLVGKP PFESSTSSETYRRIRQVDFKFPSSVPAGAQDLISKLLRYHPSERLSLAQVLKHPWVREHSRRVLPC TRTRPLE - GFP Tag - V |
Restriction Sites |
SgfI-MluI
Cloning Scheme for this gene
Plasmid Map
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ACCN | BC064780 |
ORF Size | 830 bp |
OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
Reference Data | |
RefSeq | BC064780, AAH64780 |
RefSeq Size | 1358 bp |
RefSeq ORF | 830 bp |
Locus ID | 20871 |
Gene Summary | Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'.[UniProtKB/Swiss-Prot Function] |
Documents
Product Manuals |
FAQs |
SDS |
Resources
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
MC206733 | Aurkc (untagged) - Mouse aurora kinase C (cDNA clone MGC:76648 IMAGE:30476803), (10ug) |
CNY 2,400.00 |