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Terf2ip (BC017641) Mouse Tagged ORF Clone
CAT＃: MR206145
- TrueORF®
Terf2ip (Myc-DDK-tagged) - Mouse telomeric repeat binding factor 2, interacting protein (cDNA clone MGC:28971 IMAGE:4483320)
ORF Plasmid: tGFP
"BC017641" in other vectors (6)
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CNY 5,488.00
| Cited in 1 publication. |
Product images
CNY 300.00
Specifications
| Product Data | |
| Type | Mouse Tagged ORF Clone |
| Tag | Myc-DDK |
| Synonyms | Rap1 |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>MR206145 ORF sequence
Red=Cloning site Blue=ORF Green=Tags(s) TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGGCGGAGGCGATGGATCTGGGTAAAGACCCCAATGGGCCCACTCACTCCTCCACTCTGTTCGTGAGAG AAGACGGCAGCGCCATGTCGTTTTACGTGCGGCCCAGCTCGGCCAAGCGCCGGCTGTCGACGCTCATCCT GCACGGCGGCGGCACCGTGTGTCGGGTGCAGGAACCCGGAGCCGTGCTTCTCGCCCAGCCCGGGGAGGCG CTGGCCGAGGCTTCGGGCGACTTCATCTCCACGCAGTACATCCTAGACTGCGTGGATCGCAACGAGAAGC TGGACCTGGAGGCCTATCGGCTGGGCCTGACGGAGCAGGCGTCCGATCCGAAGCCCGGGGCTTCCACCGA GGGCTCCACGGAACCGGAGCCGCAGCCCCTGACCGGGCGCATCGCCTACACCGACGCGGAAGATGTGGCC ATCCTGACCTACGTGAAGGAGAACGCCCGTTCGCCCAGCTCGGTCACAGGCAATGCCTTGTGGAAAGCGA TGGAGAAGAGCTCGCTCACGCAGCACTCCTGGCAGTCGCTCAAGGACCGCTACCTCAAGCACCTACGGGG TCAGGAGCACAAGTACCTGCTCGGGAACGCCCCGGTCAGCCCGTCCTCCCAGAAGCTCAAACGGAAGGCG GAGCAGGACCCCGAGGCCGCGGATAGCGGAGAGCCACAGAACAAGAGAGCGCCAGACTTGCCTGAGGAGG AGTGTGTGAAAGGAGAGATCAAGGAGAATGGAGAGGCAGACAACAAGCTGTTTGAGGAAGCCGCTCCGGA GTTCGGAGAAGCCGTGGTGGATGAGAGCCCTGACTTTGAAATACATATAACGATGTGTGATGGTGATCCA CCCACACCCGAGGAAGACTCAGAAACACAGCCAGACGAGGAGGAAGAAGAACCAAAAGTTTCTACGCAAG AAGTGGGAACTGCCATTAAGGTGATCCGGCAGCTAATGGAGAAGTTCAACTTGGATCTATCAACAGTTAC ACAGGCCTTGCTGAAGAACAGTGGTGAGCTGGAGGCCACGTCCTCCTTCTTAGAGTCGGGGCGGAGACCC GACGGTTATCCCATTTGGTGCAGACAAGATGACTTAGATTTGCAGAAGGACGATGACGACACGAAAAATG CACTGGTCAAAAAGTTTGGAGCTCAGAACGTTGCTCGGAGGATTGAATTCCGAAAGAAA ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA >MR206145 protein sequence
Red=Cloning site Green=Tags(s) MAEAMDLGKDPNGPTHSSTLFVREDGSAMSFYVRPSSAKRRLSTLILHGGGTVCRVQEPGAVLLAQPGEA LAEASGDFISTQYILDCVDRNEKLDLEAYRLGLTEQASDPKPGASTEGSTEPEPQPLTGRIAYTDAEDVA ILTYVKENARSPSSVTGNALWKAMEKSSLTQHSWQSLKDRYLKHLRGQEHKYLLGNAPVSPSSQKLKRKA EQDPEAADSGEPQNKRAPDLPEEECVKGEIKENGEADNKLFEEAAPEFGEAVVDESPDFEIHITMCDGDP PTPEEDSETQPDEEEEEPKVSTQEVGTAIKVIRQLMEKFNLDLSTVTQALLKNSGELEATSSFLESGRRP DGYPIWCRQDDLDLQKDDDDTKNALVKKFGAQNVARRIEFRKK TRTRPLEQKLISEEDLAANDILDYKDDDDKV |
| Restriction Sites |
SgfI-MluI
Cloning Scheme for this gene
Plasmid Map
|
| ACCN | BC017641 |
| ORF Size | 1179 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | BC017641, AAH17641 |
| RefSeq Size | 2122 bp |
| RefSeq ORF | 1181 bp |
| Locus ID | 57321 |
| MW | 43.4 kDa |
| Gene Summary | Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes.[UniProtKB/Swiss-Prot Function] |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
NLRP3 Inflammasome Induced Liver Graft Injury through Activation of Telomere-independent RAP1/KC Axis
,Liu, H;Yeung, OW;Li, CX;Liu, XB;Qi, X;Ng, KT;Liu, J;Ma, YY;Lam, YF;Lian, Q;Chan, SC;Lo, CM;Man, K;,
J. Pathol.
,PubMed ID 28378341
[TERF2IP]
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Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| MC218340 | Terf2ip (untagged) - Mouse telomeric repeat binding factor 2, interacting protein (cDNA clone MGC:28971 IMAGE:4483320), (10ug) |
CNY 6,940.00 |
|
| MG206145 | Terf2ip (tGFP-tagged) - Mouse telomeric repeat binding factor 2, interacting protein (cDNA clone MGC:28971 IMAGE:4483320) |
CNY 2,470.00 |
|
| MR206145L1 | Lenti ORF clone of Terf2ip (Myc-DDK-tagged) - Mouse telomeric repeat binding factor 2, interacting protein (cDNA clone MGC:28971 IMAGE:4483320) |
CNY 4,180.00 |
|
| MR206145L2 | Lenti ORF clone of Terf2ip (mGFP-tagged) - Mouse telomeric repeat binding factor 2, interacting protein (cDNA clone MGC:28971 IMAGE:4483320) |
CNY 7,888.00 |
|
| MR206145L3 | Lenti ORF clone of Terf2ip (Myc-DDK-tagged) - Mouse telomeric repeat binding factor 2, interacting protein (cDNA clone MGC:28971 IMAGE:4483320) |
CNY 4,180.00 |
|
| MR206145L4 | Lenti ORF clone of Terf2ip (mGFP-tagged) - Mouse telomeric repeat binding factor 2, interacting protein (cDNA clone MGC:28971 IMAGE:4483320) |
CNY 4,180.00 |
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