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Cops3 (NM_011991) Mouse Tagged ORF Clone
CAT＃: MR206727
- TrueORF®
Cops3 (Myc-DDK-tagged) - Mouse COP9 (constitutive photomorphogenic) homolog, subunit 3 (Arabidopsis thaliana) (Cops3)
ORF Plasmid: tGFP
"NM_011991" in other vectors (4)
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CNY 3,656.00
| Cited in 1 publication. |
Product images
CNY 300.00
Specifications
| Product Data | |
| Type | Mouse Tagged ORF Clone |
| Tag | Myc-DDK |
| Synonyms | Csn3; Sgn3 |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>MR206727 ORF sequence
Red=Cloning site Blue=ORF Green=Tags(s) TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGGCGTCTGCTCTGGAGCAGTTCGTGAACAGTGTCCGACAGCTCTCAGCTCAAGGGCAAATGACTCAGC TTTGTGAACTCATCAACAAGAGTGGAGAACTCCTTGCGAAGAACTTGTCCCATCTGGACACTGTGCTTGG GGCTTTAGATGTTCAAGAACACTCTTTGGGTGTCCTTGCTGTTCTGTTTGTGAAGTTCTCAATGCCCAGT GTTCCTGACTTCGAAACACTATTCTCACAGGTTCAGCTTTTCATCAGTACATGTAATGGCGAGCACATTC GATATGCAACAGATACGTTTGCTGGGCTTTGCCATCAGCTAACAAATGCACTTGTGGAAAGAAAACAGCC CCTTCGAGGAATTGGCATCCTTAAGCAAGCCATAGACAAGATGCAGATGAATACCAACCAACTGACCTCA GTACATGCCGATCTCTGCCAGCTTTGTTTACTAGCGAAGTGCTTTAAACCTGCCCTTCCATATCTTGATG TGGATATGATGGATATCTGTAAAGAGAATGGAGCCTATGATGCAAAACACTTTCTGTGCTACTACTATTA TGGAGGAATGATCTATACGGGGCTGAAGAACTTTGAAAGAGCGCTGTACTTTTATGAGCAGGCTATAACT ACTCCTGCCATGGCCGTCAGCCATATCATGTTGGAATCATATAAAAAGTATATTCTAGTGTCTTTGATAT TACTTGGCAAAGTACAACAGCTGCCTAAATACACCTCTCAAATAGTGGGTAGATTTATTAAGCCTCTCAG CAATGCTTACCATGAGTTAGCACAAGTTTATTCAACCAACAACCCGTCTGAGCTGCGGAACCTGGTGAGC AAGCACAGCGAGACCTTCACTCGAGACAACAACATGGGCCTGGTGAAGCAGTGCCTGTCGTCTCTTTATA AGAAGAACATTCAGAGGCTGACAAAGACTTTTTTAACACTATCATTACAAGATATGGCAAGCCGTGTACA GTTATCTGGACCACAGGAGGCAGAAAAATATGTTCTACACATGATAGAAGATGGAGAAATTTTTGCAAGT ATTAACCAGAAGGATGGAATGGTCAGTTTCCATGATAACCCTGAGAAGTATAATAACCCAGCCATGCTTC ATAACATCGACCAAGAGATGCTAAAATGCATAGAGCTGGATGAGCGACTGAAGGCTATGGACCAGGAGAT CACGGTGAACCCCCAGTTTGTTCAAAAGAGCATGGGCTCACAAGAAGATGACTCAGGAAACAAGCCCTCC AGCTACTCT ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA >MR206727 protein sequence
Red=Cloning site Green=Tags(s) MASALEQFVNSVRQLSAQGQMTQLCELINKSGELLAKNLSHLDTVLGALDVQEHSLGVLAVLFVKFSMPS VPDFETLFSQVQLFISTCNGEHIRYATDTFAGLCHQLTNALVERKQPLRGIGILKQAIDKMQMNTNQLTS VHADLCQLCLLAKCFKPALPYLDVDMMDICKENGAYDAKHFLCYYYYGGMIYTGLKNFERALYFYEQAIT TPAMAVSHIMLESYKKYILVSLILLGKVQQLPKYTSQIVGRFIKPLSNAYHELAQVYSTNNPSELRNLVS KHSETFTRDNNMGLVKQCLSSLYKKNIQRLTKTFLTLSLQDMASRVQLSGPQEAEKYVLHMIEDGEIFAS INQKDGMVSFHDNPEKYNNPAMLHNIDQEMLKCIELDERLKAMDQEITVNPQFVQKSMGSQEDDSGNKPS SYS TRTRPLEQKLISEEDLAANDILDYKDDDDKV |
| Restriction Sites |
SgfI-MluI
Cloning Scheme for this gene
Plasmid Map
|
| ACCN | NM_011991 |
| ORF Size | 1272 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_011991.1, NP_036121.1 |
| RefSeq Size | 1583 bp |
| RefSeq ORF | 1272 bp |
| Locus ID | 26572 |
| UniProt ID | O88543 |
| MW | 47.8 kDa |
| Gene Summary | Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Essential to maintain the survival of epiblast cells and thus the development of the postimplantation embryo.[UniProtKB/Swiss-Prot Function] |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Thrombin-Par1 signaling axis disrupts COP9 signalosome subunit 3-mediated ABCA1 stabilization in inducing foam cell formation and atherogenesis
,Boro, M;Govatati, S;Kumar, R;Singh, NK;Pichavaram, P;Traylor, JG;Wayne Orr, A;Rao, GN;,
Cell Death Differ.
,PubMed ID 32968199
[COPS3]
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Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| MC203437 | Cops3 (untagged) - Mouse COP9 (constitutive photomorphogenic) homolog, subunit 3 (Arabidopsis thaliana) (Cops3), (10ug) |
CNY 3,656.00 |
|
| MG206727 | Cops3 (tGFP-tagged) - Mouse COP9 (constitutive photomorphogenic) homolog, subunit 3 (Arabidopsis thaliana) (Cops3) |
CNY 3,710.00 |
|
| MR206727L3 | Lenti ORF clone of Cops3 (Myc-DDK-tagged) - Mouse COP9 (constitutive photomorphogenic) homolog, subunit 3 (Arabidopsis thaliana) (Cops3) |
CNY 5,230.00 |
|
| MR206727L4 | Lenti ORF clone of Cops3 (mGFP-tagged) - Mouse COP9 (constitutive photomorphogenic) homolog, subunit 3 (Arabidopsis thaliana) (Cops3) |
CNY 5,230.00 |
