HMGA2 (NM_003483) Human Tagged ORF Clone

CAT＃: RC214629

HMGA2 (Myc-DDK-tagged)-Human high mobility group AT-hook 2 (HMGA2), transcript variant 1

ORF Plasmid: DDK tGFP

Datasheet
SDS
Plasmid Map

  "NM_003483" in other vectors (6)

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CNY 1,200.00

CNY 3,705.00

货期*
现货
规格
    • 10 ug
Cited in 8 publications.

Product images

经常一起买 (5)
PS100001
pCMV6-Entry, mammalian vector with C-terminal Myc- DDK Tag, 10ug
    • 10 ug

CNY 5,420.00

添加到购物车
CC100003
DH5α Chemically Competent Cells (≥10^8 cfu/μg of pUC19 DNA)
    • 5 x 200 ul

CNY 1,280.00

暂停销售
PRIMER
Forward sequencing primer VP1.5, Reverse sequencing primer XL39, 100pmoles each
    • 100 pmol

CNY 480.00

添加到购物车
TA592569S
DDK Rabbit monoclonal antibody, recognizing both N- and C-terminal tags
    • 30 ul

CNY 300.00

添加到购物车

【特别福利】购一抗正装产品（≥50ul或≥50ug），免费领10ul抗体试用装

TA308757
Rabbit polyclonal antibody to HMGA2 (high mobility group AT-hook 2)
    • 100 ul

CNY 6,281.00

添加到购物车

Specifications

Product Data
Type Human Tagged ORF Clone
Tag Myc-DDK
Synonyms BABL; HMGI-C; HMGIC; LIPO; SRS5; STQTL9
Vector pCMV6-Entry
E. coli Selection Kanamycin (25 ug/mL)
Mammalian Cell Selection Neomycin
Sequence Data
>RC214629 representing NM_003483
Red=Cloning site Blue=ORF Green=Tags(s)

TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
GCCGCGATCGCC

ATGAGCGCACGCGGTGAGGGCGCGGGGCAGCCGTCCACTTCAGCCCAGGGACAACCTGCCGCCCCAGCGC
CTCAGAAGAGAGGACGCGGCCGCCCCAGGAAGCAGCAGCAAGAACCAACCGGTGAGCCCTCTCCTAAGAG
ACCCAGGGGAAGACCCAAAGGCAGCAAAAACAAGAGTCCCTCTAAAGCAGCTCAAAAGAAAGCAGAAGCC
ACTGGAGAAAAACGGCCAAGAGGCAGACCTAGGAAATGGCCACAACAAGTTGTTCAGAAGAAGCCTGCTC
AGGAGGAAACTGAAGAGACATCCTCACAAGAGTCTGCCGAAGAGGAC

ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
ACAAGGATGACGACGATAAGGTTTAA
>RC214629 representing NM_003483
Red=Cloning site Green=Tags(s)

MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEA
TGEKRPRGRPRKWPQQVVQKKPAQEETEETSSQESAEED

TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Chromatograms CHROMATOGRAMS
Sequencher program is needed, download here.
Restriction Sites SgfI-MluI      Cloning Scheme for this gene      Plasmid Map     
ACCN NM_003483
ORF Size 327 bp
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Product Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Reference Data
RefSeq NM_003483.6
RefSeq Size 4150 bp
RefSeq ORF 330 bp
Locus ID 8091
UniProt ID P52926
Protein Families Druggable Genome
MW 11.7 kDa
Gene Summary This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

Citations (8)

The use of this cDNA Clones has been cited in the following citations:
Overexpression of Replication-Dependent Histone Signifies a Subset of Dedifferentiated Liposarcoma with Increased Aggressiveness ,null, Cancers ,PubMed ID 34206586 [HMGA2]
HMGA2-mediated tumorigenesis through angiogenesis in leiomyoma ,Li, Y;Qiang, W;Griffin, BB;Gao, T;Chakravarti, D;Bulun, S;Kim, JJ;Wei, JJ;, Fertil. Steril. ,PubMed ID 32868105 [HMGA2]
Overexpression of HMGA2 in breast cancer promotes cell proliferation, migration, invasion and stemness ,Mansoori, B;Duijf, PHG;Mohammadi, A;Najafi, S;Roshani, E;Shanehbandi, D;Hajiasgharzadeh, K;Shirjang, S;Ditzel, HJ;Kazemi, T;Mokhtarzadeh, A;Gjerstorff, MF;Baradaran, B;, Expert Opin. Ther. Targets ,PubMed ID 32172636 [HMGA2]
Ca2+ and CACNA1H mediate targeted suppression of breast cancer brain metastasis by AM RF EMF ,null, EBioMedicine ,PubMed ID 31129098 [HMGA2]
MicroRNA-599 targets high-mobility group AT-hook 2 to inhibit cell proliferation and invasion in clear cell renal carcinoma ,Zhao, H;Zhao, H;Xia, X;Liu, X;, Mol Med Rep ,PubMed ID 29568870 [HMGA2]
Let-7c inhibits migration and epithelial-mesenchymal transition in head and neck squamous cell carcinoma by targeting IGF1R and HMGA2 ,Hou, B;Ishinaga, H;Midorikawa, K;Nakamura, S;Hiraku, Y;Oikawa, S;Ma, N;Takeuchi, K;Murata, M;, Oncotarget ,PubMed ID 29507664 [HMGA2]
Let-7a suppresses glioma cell proliferation and invasion through TGF-ß/Smad3 signaling pathway by targeting HMGA2 ,Li, Y;Zhang, X;Chen, D;Ma, C;, Tumour Biol. ,PubMed ID 26715270 [HMGA2]
MicroRNA-33b, upregulated by EF24, a curcumin analog, suppresses the epithelial-to-mesenchymal transition (EMT) and migratory potential of melanoma cells by targeting HMGA2 ,Zhang, P;Bai, H;Liu, G;Wang, H;Chen, F;Zhang, B;Zeng, P;Wu, C;Peng, C;Huang, C;Song, Y;Song, E;, Toxicol. Lett. ,PubMed ID 25725129 [HMGA2]

Other Versions

SKU Description Size Price
RC214629L1 Lenti ORF clone of Human high mobility group AT-hook 2 (HMGA2), transcript variant 1, Myc-DDK-tagged
    • 10 ug

CNY 3,600.00
CNY 5,890.00

RC214629L2 Lenti ORF clone of Human high mobility group AT-hook 2 (HMGA2), transcript variant 1, mGFP tagged
    • 10 ug

CNY 3,600.00
CNY 5,890.00

RC214629L3 Lenti ORF clone of Human high mobility group AT-hook 2 (HMGA2), transcript variant 1, Myc-DDK-tagged
    • 10 ug

CNY 5,890.00

RC214629L4 Lenti ORF clone of Human high mobility group AT-hook 2 (HMGA2), transcript variant 1, mGFP tagged
    • 10 ug

CNY 3,600.00
CNY 5,890.00

RG214629 HMGA2 (tGFP-tagged) - Human high mobility group AT-hook 2 (HMGA2), transcript variant 1
    • 10 ug

CNY 2,800.00
CNY 4,370.00

SC303313 HMGA2 (untagged)-Human high mobility group AT-hook 2 (HMGA2), transcript variant 1
    • 10 ug

CNY 1,200.00
CNY 3,990.00

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