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PTPRB (NM_002837) Human Tagged ORF Clone
CAT＃: RG214228
- TrueORF®
PTPRB (tGFP-tagged) - Human protein tyrosine phosphatase, receptor type, B (PTPRB), transcript variant 2
ORF Plasmid: DDK
"NM_002837" in other vectors (2)
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CNY 20,900.00
货期*
3周
规格
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经常一起买 (5)
Specifications
| Product Data | |
| Type | Human Tagged ORF Clone |
| Tag | TurboGFP |
| Synonyms | HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP |
| Vector | pCMV6-AC-GFP |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>RG214228 representing NM_002837
Red=Cloning site Blue=ORF Green=Tags(s) TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGCTGAGCCATGGAGCCGGGTTGGCCTTGTGGATCACACTGAGCCTGCTGCAGACTGGACTGGCGGAGC CAGAGAGATGTAACTTCACCCTGGCGGAGTCCAAGGCCTCCAGCCATTCTGTGTCTATCCAGTGGAGAAT TTTGGGCTCACCCTGTAACTTTAGCCTCATCTATAGCAGTGACACCCTGGGGGCCGCGTTGTGCCCTACC TTTCGGATAGACAACACCACATACGGATGTAACCTTCAAGATTTACAAGCAGGAACCATCTATAACTTCA GGATTATTTCTCTGGATGAAGAGAGAACAGTGGTCTTGCAAACAGATCCTTTACCTCCTGCTAGGTTTGG AGTCAGTAAAGAGAAGACGACTTCAACCAGCTTGCATGTTTGGTGGACTCCTTCTTCCGGAAAAGTCACC TCATATGAGGTGCAATTATTTGATGAAAATAACCAAAAGATACAGGGGGTTCAAATTCAAGAAAGTACTT CATGGAATGAATACACTTTTTTCAATCTCACTGCTGGTAGTAAATACAATATTGCCATCACAGCTGTTTC TGGAGGAAAACGTTCTTTTTCAGTTTATACCAATGGATCAACAGTGCCATCTCCAGTGAAAGATATTGGT ATTTCCACAAAAGCCAATTCTCTCCTGATTTCCTGGTCCCATGGTTCTGGGAATGTGGAACGATACCGGC TGATGCTAATGGATAAAGGGATCCTAGTTCATGGCGGTGTTGTGGACAAACATGCTACTTCCTATGCTTT TCACGGGCTGACCCCTGGCTACCTCTACAACCTCACTGTTATGACTGAGGCTGCAGGGCTGCAAAACTAC AGGTGGAAACTAGTCAGGACAGCCCCCATGGAAGTCTCAAATCTGAAGGTGACAAATGATGGCAGTTTGA CCTCTCTAAAAGTCAAATGGCAAAGACCTCCTGGAAATGTGGATTCTTACAATATCACCCTGTCTCACAA AGGGACCATCAAGGAATCCAGAGTATTAGCACCTTGGATTACTGAAACTCACTTTAAAGAGTTAGTCCCC GGTCGACTTTATCAAGTTACTGTCAGCTGTGTCTCTGGTGAACTGTCTGCTCAGAAGATGGCAGTGGGCA GAACATTTCCAGACAAAGTTGCAAACCTGGAGGCAAACAATAATGGCAGGATGAGGTCTCTTGTAGTGAG CTGGTCGCCCCCTGCTGGAGACTGGGAGCAGTATCGGATCCTACTCTTCAATGATTCTGTGGTGCTGCTC AACATCACTGTGGGAAAGGAAGAAACACAGTATGTCATGGATGACACGGGGCTCGTACCGGGAAGACAGT ATGAGGTGGAAGTCATTGTTGAGAGTGGAAATTTGAAGAATTCTGAGCGTTGCCAAGGCAGGACAGTCCC CCTGGCTGTCCTCCAGCTTCGTGTCAAACATGCCAATGAAACCTCACTGAGTATCATGTGGCAGACCCCT GTAGCAGAATGGGAGAAATACATCATTTCCCTAGCTGACAGAGACCTCTTACTGATCCACAAGTCACTCT CCAAAGATGCCAAAGAATTCACTTTTACTGACCTGGTGCCTGGACGAAAATACATGGCTACAGTCACCAG TATTAGTGGAGACTTAAAAAATTCCTCTTCAGTAAAAGGAAGAACAGTGCCTGCCCAAGTGACTGACTTG CATGTGGCCAACCAAGGAATGACCAGTAGTCTGTTTACTAACTGGACCCAGGCACAAGGAGACGTAGAAT TTTACCAAGTCTTACTGATCCATGAAAATGTGGTCATTAAAAATGAAAGCATCTCCAGTGAGACCAGCAG ATACAGCTTCCACTCTCTCAAGTCCGGCAGCCTGTACTCCGTGGTGGTAACAACAGTGAGTGGAGGGATC TCTTCCCGACAAGTGGTTGTGGAGGGAAGAACAGTCCCTTCCAGTGTGAGTGGAGTAACGGTGAACAATT CCGGTCGTAATGACTACCTCAGCGTTTCCTGGCTGCTGGCGCCCGGAGATGTGGATAACTATGAGGTAAC ATTGTCTCATGACGGCAAGGTGGTTCAGTCCCTTGTCATTGCCAAGTCTGTCAGAGAATGTTCCTTCAGC TCCCTCACCCCAGGCCGCCTCTACACCGTGACCATAACTACAAGGAGTGGCAAGTATGAAAATCACTCCT TCAGCCAAGAGCGGACAGTGCCTGACAAAGTCCAGGGAGTCAGTGTTAGCAACTCAGCCAGGAGTGACTA TTTAAGGGTATCCTGGGTGCATGCCACTGGAGACTTTGATCACTATGAAGTCACCATTAAAAACAAAAAC AACTTCATTCAAACTAAAAGCATTCCCAAGTCAGAAAACGAATGTGTATTTGTTCAGCTAGTCCCTGGAC GGTTGTACAGTGTCACTGTTACTACAAAAAGTGGACAATATGAAGCCAATGAACAAGGGAATGGGAGAAC AATTCCAGAGCCTGTTAAGGATCTAACATTGCGCAACAGGAGCACTGAGGACTTGCATGTGACTTGGTCA GGAGCTAATGGGGATGTCGACCAATATGAGATCCAGCTGCTCTTCAATGACATGAAAGTATTTCCTCCTT TTCACCTTGTAAATACCGCAACCGAGTATCGATTTACTTCCCTAACACCAGGCCGCCAATACAAAATTCT TGTCTTGACGATTAGCGGGGATGTACAGCAGTCAGCCTTCATTGAGGGCTTCACAGTTCCTAGTGCTGTC AAAAATATTCACATTTCTCCCAATGGAGCAACAGATAGCCTGACGGTGAACTGGACTCCTGGTGGGGGAG ACGTTGATTCCTACACGGTGTCGGCATTCAGGCACAGTCAAAAGGTTGACTCTCAGACTATTCCCAAGCA CGTCTTTGAGCACACGTTCCACAGACTGGAGGCCGGGGAGCAGTACCAGATCATGATTGCCTCAGTCAGC GGGTCCCTGAAGAATCAGATAAATGTGGTTGGGCGGACAGTTCCAGCATCTGTCCAAGGAGTAATTGCAG ACAATGCATACAGCAGTTATTCCTTAATAGTAAGTTGGCAAAAAGCTGCTGGTGTGGCAGAAAGATATGA TATCCTGCTTCTAACTGAAAATGGAATCCTTCTGCGCAACACATCAGAGCCAGCCACCACTAAGCAACAC AAATTTGAAGATCTAACACCAGGCAAGAAATACAAGATACAGATCCTAACTGTCAGTGGAGGCCTCTTTA GCAAGGAAGCCCAGACTGAAGGCCGAACAGTCCCAGCAGCTGTCACCGACCTGAGGATCACAGAGAACTC CACCAGGCACCTGTCCTTCCGCTGGACCGCCTCAGAGGGGGAGCTCAGCTGGTACAACATCTTTTTGTAC AACCCAGATGGGAATCTCCAGGAGAGAGCTCAAGTTGACCCACTAGTCCAGAGCTTCTCTTTCCAGAACT TGCTACAAGGCAGAATGTACAAGATGGTGATTGTAACTCACAGTGGGGAGCTGTCTAATGAGTCTTTCAT ATTTGGTAGAACAGTCCCAGCCTCTGTGAGTCATCTCAGGGGGTCCAATCGGAACACGACAGACAGCCTT TGGTTCAACTGGAGTCCAGCCTCTGGGGACTTTGACTTTTATGAGCTGATTCTCTATAATCCCAATGGCA CAAAGAAGGAAAACTGGAAAGACAAGGACCTGACGGAGTGGCGGTTTCAAGGCCTTGTTCCTGGAAGGAA GTACGTGCTGTGGGTGGTAACTCACAGTGGAGATCTCAGCAATAAAGTCACAGCGGAGAGCAGAACAGCT CCAAGTCCTCCCAGTCTTATGTCATTTGCTGACATTGCAAACACATCCTTGGCCATCACGTGGAAAGGGC CCCCAGACTGGACAGACTACAACGACTTTGAGCTGCAGTGGTTGCCCAGAGATGCACTTACTGTCTTCAA CCCCTACAACAACAGAAAATCAGAAGGACGCATTGTGTATGGTCTTCGTCCAGGGAGATCCTATCAATTC AACGTCAAGACTGTCAGTGGTGATTCCTGGAAAACTTACAGCAAACCAATTTTTGGATCTGTGAGGACAA AGCCTGACAAGATACAAAACCTGCATTGCCGGCCTCAGAACTCCACGGCCATTGCCTGTTCTTGGATCCC TCCTGATTCTGACTTTGATGGTTATAGTATTGAATGCCGGAAAATGGACACCCAAGAAGTTGAGTTTTCC AGAAAGCTGGAGAAAGAAAAATCTCTGCTCAACATCATGATGCTAGTGCCCCATAAGAGGTACCTGGTGT CCATCAAAGTGCAGTCGGCCGGCATGACCAGCGAGGTGGTTGAAGACAGCACTATCACAATGATAGACCG CCCCCCTCCTCCACCCCCACACATTCGTGTGAATGAAAAGGATGTGCTAATTAGCAAGTCTTCCATCAAC TTTACTGTCAACTGCAGCTGGTTCAGCGACACCAATGGAGCTGTGAAATACTTCACAGTGGTGGTGAGAG AGGCTGATGGCAGTGATGAGCTGAAGCCAGAACAGCAGCACCCTCTCCCTTCCTACCTGGAGTACAGGCA CAATGCCTCCATTCGGGTGTATCAGACTAATTATTTTGCCAGCAAATGTGCCGAAAATCCTAACAGCAAC TCCAAGAGTTTTAACATTAAGCTTGGAGCAGAGATGGAGAGCCTAGGTGGAAAATGCGATCCCACTCAGC AAAAATTCTGTGATGGACCACTGAAGCCACACACTGCCTACAGAATCAGCATTCGAGCTTTTACACAGCT CTTTGATGAGGACCTGAAGGAATTCACAAAGCCACTCTATTCAGACACATTTTTTTCTTTACCCATCACT ACTGAATCAGAGCCCTTGTTTGGAGCTATTGAAGGTGTGAGTGCTGGTCTGTTTTTAATTGGCATGCTAG TGGCTGTTGTTGCCTTATTGATCTGCAGACAGAAAGTGAGCCATGGTCGAGAAAGACCCTCTGCCCGTCT GAGCATTCGTAGGGATCGACCATTATCTGTCCACTTAAACCTGGGCCAGAAAGGTAACCGGAAAACTTCT TGTCCAATAAAAATAAATCAGTTTGAAGGGCATTTCATGAAGCTACAGGCTGACTCCAACTACCTTCTAT CCAAGGAATACGAGGAGTTAAAAGACGTGGGCCGAAACCAGTCATGTGACATTGCACTCTTGCCGGAGAA TAGAGGGAAAAATCGATACAACAATATATTGCCCTATGATGCCACGCGAGTGAAGCTCTCCAATGTAGAT GATGATCCTTGCTCTGACTACATCAATGCCAGCTACATCCCTGGCAACAACTTCAGAAGAGAATACATTG TCACTCAGGGACCGCTTCCTGGCACCAAGGATGACTTCTGGAAAATGGTGTGGGAACAAAACGTTCACAA CATCGTCATGGTGACCCAGTGTGTTGAGAAGGGCCGAGTAAAGTGTGACCATTACTGGCCAGCGGACCAG GATTCCCTCTACTATGGGGACCTCATCCTGCAGATGCTCTCAGAGTCCGTCCTGCCTGAGTGGACCATCC GGGAGTTTAAGATATGCGGTGAGGAACAGCTTGATGCACACAGACTCATCCGCCACTTTCACTATACGGT GTGGCCAGACCATGGAGTCCCAGAAACCACCCAGTCTCTGATCCAGTTTGTGAGAACTGTCAGGGACTAC ATCAACAGAAGCCCGGGTGCTGGGCCCACTGTGGTGCACTGCAGTGCTGGTGTGGGTAGGACTGGAACCT TTATTGCATTGGACCGAATCCTCCAGCAGTTAGACTCCAAAGACTCTGTGGACATTTATGGAGCAGTGCA CGACCTAAGACTTCACAGGGTTCACATGGTCCAGACTGAGTGTCAGTATGTCTACCTACATCAGTGTGTA AGAGATGTCCTCAGAGCAAGAAAGCTACGGAGTGAACAAGAAAACCCCTTGTTTCCAATCTATGAAAATG TGAATCCAGAGTATCACAGAGATCCAGTCTATTCAAGGCAT ACGCGTACGCGGCCGCTCGAG - GFP Tag - GTTTAA >RG214228 representing NM_002837
Red=Cloning site Green=Tags(s) MLSHGAGLALWITLSLLQTGLAEPERCNFTLAESKASSHSVSIQWRILGSPCNFSLIYSSDTLGAALCPT FRIDNTTYGCNLQDLQAGTIYNFRIISLDEERTVVLQTDPLPPARFGVSKEKTTSTSLHVWWTPSSGKVT SYEVQLFDENNQKIQGVQIQESTSWNEYTFFNLTAGSKYNIAITAVSGGKRSFSVYTNGSTVPSPVKDIG ISTKANSLLISWSHGSGNVERYRLMLMDKGILVHGGVVDKHATSYAFHGLTPGYLYNLTVMTEAAGLQNY RWKLVRTAPMEVSNLKVTNDGSLTSLKVKWQRPPGNVDSYNITLSHKGTIKESRVLAPWITETHFKELVP GRLYQVTVSCVSGELSAQKMAVGRTFPDKVANLEANNNGRMRSLVVSWSPPAGDWEQYRILLFNDSVVLL NITVGKEETQYVMDDTGLVPGRQYEVEVIVESGNLKNSERCQGRTVPLAVLQLRVKHANETSLSIMWQTP VAEWEKYIISLADRDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTSISGDLKNSSSVKGRTVPAQVTDL HVANQGMTSSLFTNWTQAQGDVEFYQVLLIHENVVIKNESISSETSRYSFHSLKSGSLYSVVVTTVSGGI SSRQVVVEGRTVPSSVSGVTVNNSGRNDYLSVSWLLAPGDVDNYEVTLSHDGKVVQSLVIAKSVRECSFS SLTPGRLYTVTITTRSGKYENHSFSQERTVPDKVQGVSVSNSARSDYLRVSWVHATGDFDHYEVTIKNKN NFIQTKSIPKSENECVFVQLVPGRLYSVTVTTKSGQYEANEQGNGRTIPEPVKDLTLRNRSTEDLHVTWS GANGDVDQYEIQLLFNDMKVFPPFHLVNTATEYRFTSLTPGRQYKILVLTISGDVQQSAFIEGFTVPSAV KNIHISPNGATDSLTVNWTPGGGDVDSYTVSAFRHSQKVDSQTIPKHVFEHTFHRLEAGEQYQIMIASVS GSLKNQINVVGRTVPASVQGVIADNAYSSYSLIVSWQKAAGVAERYDILLLTENGILLRNTSEPATTKQH KFEDLTPGKKYKIQILTVSGGLFSKEAQTEGRTVPAAVTDLRITENSTRHLSFRWTASEGELSWYNIFLY NPDGNLQERAQVDPLVQSFSFQNLLQGRMYKMVIVTHSGELSNESFIFGRTVPASVSHLRGSNRNTTDSL WFNWSPASGDFDFYELILYNPNGTKKENWKDKDLTEWRFQGLVPGRKYVLWVVTHSGDLSNKVTAESRTA PSPPSLMSFADIANTSLAITWKGPPDWTDYNDFELQWLPRDALTVFNPYNNRKSEGRIVYGLRPGRSYQF NVKTVSGDSWKTYSKPIFGSVRTKPDKIQNLHCRPQNSTAIACSWIPPDSDFDGYSIECRKMDTQEVEFS RKLEKEKSLLNIMMLVPHKRYLVSIKVQSAGMTSEVVEDSTITMIDRPPPPPPHIRVNEKDVLISKSSIN FTVNCSWFSDTNGAVKYFTVVVREADGSDELKPEQQHPLPSYLEYRHNASIRVYQTNYFASKCAENPNSN SKSFNIKLGAEMESLGGKCDPTQQKFCDGPLKPHTAYRISIRAFTQLFDEDLKEFTKPLYSDTFFSLPIT TESEPLFGAIEGVSAGLFLIGMLVAVVALLICRQKVSHGRERPSARLSIRRDRPLSVHLNLGQKGNRKTS CPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDATRVKLSNVD DDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQ DSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDY INRSPGAGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCV RDVLRARKLRSEQENPLFPIYENVNPEYHRDPVYSRH TRTRPLE - GFP Tag - V |
| Restriction Sites |
SgfI-MluI
Cloning Scheme for this gene
Plasmid Map
|
| ACCN | NM_002837 |
| ORF Size | 5991 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_002837.4, NP_002828.3 |
| RefSeq Size | 10663 bp |
| RefSeq ORF | 5994 bp |
| Locus ID | 5787 |
| UniProt ID | P23467 |
| Protein Families | Druggable Genome, Phosphatase |
| Protein Pathways | Adherens junction |
| Gene Summary | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and one intracytoplasmic catalytic domain, thus belongs to receptor type PTP. The extracellular region of this PTP is composed of multiple fibronectin type_III repeats, which was shown to interact with neuronal receptor and cell adhesion molecules, such as contactin and tenascin C. This protein was also found to interact with sodium channels, and thus may regulate sodium channels by altering tyrosine phosphorylation status. The functions of the interaction partners of this protein implicate the roles of this PTP in cell adhesion, neurite growth, and neuronal differentiation. Alternate transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011] |
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