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Metabotropic Glutamate Receptor 6 (GRM6) (NM_000843) Human Tagged ORF Clone
CAT＃: RG221195
- TrueORF®
GRM6 (tGFP-tagged) - Human glutamate receptor, metabotropic 6 (GRM6)
ORF Plasmid: DDK
"NM_000843" in other vectors (4)
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CNY 10,170.00
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Specifications
| Product Data | |
| Type | Human Tagged ORF Clone |
| Tag | TurboGFP |
| Synonyms | CSNB1B; GPRC1F; mGlu6; MGLUR6 |
| Vector | pCMV6-AC-GFP |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>RG221195 representing NM_000843
Red=Cloning site Blue=ORF Green=Tags(s) TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGGCGCGGCCCCGGAGAGCCCGGGAGCCGCTGCTCGTGGCGCTGCTGCCGCTGGCGTGGCTGGCGCAGG CGGGCCTGGCGCGCGCGGCGGGCTCTGTGCGCCTGGCGGGCGGCCTGACGCTGGGCGGCCTGTTCCCGGT GCACGCGCGGGGCGCGGCGGGCCGGGCGTGCGGGCAGCTGAAGAAGGAGCAGGGCGTGCACCGGCTGGAG GCCATGCTGTACGCGCTGGACCGCGTCAACGCCGACCCCGAGCTGCTGCCCGGCGTGCGCCTGGGCGCGC GGCTGCTGGACACCTGCTCGCGGGACACCTACGCGCTGGAGCAGGCGCTGAGCTTCGTGCAGGCGCTGAT CCGCGGCCGCGGCGACGGCGACGAGGTGGGCGTGCGCTGCCCGGGAGGCGTCCCTCCGCTGCGCCCCGCG CCCCCCGAGCGCGTCGTGGCCGTCGTGGGCGCCTCGGCCAGCTCCGTCTCCATCATGGTCGCCAACGTGC TGCGCCTGTTTGCGATACCCCAGATCAGCTATGCCTCCACAGCCCCGGAGCTCAGCGACTCCACACGCTA TGACTTCTTCTCCCGGGTGGTGCCACCCGACTCCTACCAGGCGCAGGCCATGGTGGACATCGTGAGGGCA CTGGGATGGAACTATGTGTCCACGCTGGCCTCCGAGGGCAACTATGGCGAAAGTGGGGTTGAGGCCTTCG TTCAGATCTCCCGAGAGGCTGGGGGGGTCTGTATTGCCCAGTCTATCAAGATTCCCAGGGAACCAAAGCC AGGAGAGTTCAGCAAGGTGATCAGGAGACTCATGGAGACGCCCAACGCCCGGGGCATCATCATCTTTGCC AATGAGGATGACATCAGGCGGGTCCTGGAGGCAGCTCGCCAGGCCAACCTGACCGGCCACTTCCTGTGGG TCGGCTCAGACAGCTGGGGAGCCAAGACCTCACCCATCTTGAGCCTGGAGGACGTGGCCGTTGGGGCCAT CACCATCCTGCCCAAAAGGGCCTCCATCGACGGATTTGACCAGTACTTCATGACTCGATCCCTGGAGAAC AACCGCAGGAACATCTGGTTCGCCGAGTTCTGGGAAGAGAATTTTAACTGCAAACTGACCAGCTCAGGTA CCCAGTCAGACGATTCCACCCGCAAATGCACAGGCGAGGAACGCATCGGCCGGGACTCCACCTACGAGCA GGAGGGCAAGGTGCAGTTTGTGATTGATGCGGTGTACGCCATTGCCCACGCCCTCCACAGCATGCACCAG GCGCTCTGCCCTGGGCACACAGGCCTGTGCCCGGCGATGGAACCCACTGATGGGCGGATGCTTCTGCAGT ACATTCGAGCTGTCCGCTTCAATGGCAGCGCAGGAACCCCTGTGATGTTCAACGAGAACGGAGATGCGCC CGGGCGGTACGACATCTTCCAGTACCAGGCGACCAATGGCAGTGCCAGCAGTGGCGGGTACCAGGCAGTG GGCCAGTGGGCAGAGACCCTCAGACTGGATGTGGAGGCCCTGCAGTGGTCTGGCGACCCCCACGAGGTGC CCTCGTCTCTGTGCAGCCTGCCCTGCGGGCCGGGGGAGCGGAAGAAGATGGTGAAGGGCGTCCCCTGCTG TTGGCACTGCGAGGCCTGTGACGGGTACCGCTTCCAGGTGGACGAGTTCACATGCGAGGCCTGTCCTGGG GACATGAGGCCCACGCCCAACCACACGGGCTGCCGCCCCACACCTGTGGTGCGCCTGAGCTGGTCCTCCC CCTGGGCAGCCCCGCCGCTCCTCCTGGCCGTGCTGGGCATCGTGGCCACTACCACGGTGGTGGCCACCTT CGTGCGGTACAACAACACGCCCATCGTCCGGGCCTCGGGCCGAGAGCTCAGCTACGTCCTCCTCACCGGC ATCTTCCTCATCTACGCCATCACCTTCCTCATGGTGGCTGAGCCTGGGGCCGCGGTCTGTGCCGCCCGCA GGCTCTTCCTGGGCCTGGGCACGACCCTCAGCTACTCTGCCCTGCTCACCAAGACCAACCGTATCTACCG CATCTTTGAGCAGGGCAAGCGCTCGGTCACACCCCCTCCCTTCATCAGCCCCACCTCACAGCTGGTCATC ACCTTCAGCCTCACCTCCCTGCAGGTGGTGGGGATGATAGCATGGCTGGGGGCCCGGCCCCCACACAGCG TGATTGACTATGAGGAACAGCGGACGGTGGACCCCGAGCAGGCCAGAGGGGTGCTCAAGTGCGACATGTC GGATCTGTCTCTCATCGGCTGCCTGGGCTACAGCCTCCTGCTCATGGTCACGTGCACAGTGTACGCCATC AAGGCCCGTGGCGTGCCCGAGACCTTCAACGAGGCCAAGCCCATCGGCTTCACCATGTACACCACCTGCA TCATCTGGCTGGCATTCGTGCCCATCTTCTTTGGCACTGCCCAGTCAGCTGAAAAGATCTACATCCAGAC AACCACGCTAACCGTGTCCTTGAGCCTGAGTGCCTCGGTGTCCCTCGGCATGCTCTACGTACCCAAAACC TACGTCATCCTCTTCCATCCAGAGCAGAATGTGCAGAAGCGAAAGCGGAGCCTCAAGGCCACCTCCACGG TGGCAGCCCCACCCAAGGGCGAGGATGCAGAGGCCCACAAG ACGCGTACGCGGCCGCTCGAG - GFP Tag - GTTTAA >RG221195 representing NM_000843
Red=Cloning site Green=Tags(s) MARPRRAREPLLVALLPLAWLAQAGLARAAGSVRLAGGLTLGGLFPVHARGAAGRACGQLKKEQGVHRLE AMLYALDRVNADPELLPGVRLGARLLDTCSRDTYALEQALSFVQALIRGRGDGDEVGVRCPGGVPPLRPA PPERVVAVVGASASSVSIMVANVLRLFAIPQISYASTAPELSDSTRYDFFSRVVPPDSYQAQAMVDIVRA LGWNYVSTLASEGNYGESGVEAFVQISREAGGVCIAQSIKIPREPKPGEFSKVIRRLMETPNARGIIIFA NEDDIRRVLEAARQANLTGHFLWVGSDSWGAKTSPILSLEDVAVGAITILPKRASIDGFDQYFMTRSLEN NRRNIWFAEFWEENFNCKLTSSGTQSDDSTRKCTGEERIGRDSTYEQEGKVQFVIDAVYAIAHALHSMHQ ALCPGHTGLCPAMEPTDGRMLLQYIRAVRFNGSAGTPVMFNENGDAPGRYDIFQYQATNGSASSGGYQAV GQWAETLRLDVEALQWSGDPHEVPSSLCSLPCGPGERKKMVKGVPCCWHCEACDGYRFQVDEFTCEACPG DMRPTPNHTGCRPTPVVRLSWSSPWAAPPLLLAVLGIVATTTVVATFVRYNNTPIVRASGRELSYVLLTG IFLIYAITFLMVAEPGAAVCAARRLFLGLGTTLSYSALLTKTNRIYRIFEQGKRSVTPPPFISPTSQLVI TFSLTSLQVVGMIAWLGARPPHSVIDYEEQRTVDPEQARGVLKCDMSDLSLIGCLGYSLLLMVTCTVYAI KARGVPETFNEAKPIGFTMYTTCIIWLAFVPIFFGTAQSAEKIYIQTTTLTVSLSLSASVSLGMLYVPKT YVILFHPEQNVQKRKRSLKATSTVAAPPKGEDAEAHK TRTRPLE - GFP Tag - V |
| Restriction Sites |
SgfI-MluI
Cloning Scheme for this gene
Plasmid Map
|
| ACCN | NM_000843 |
| ORF Size | 2631 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_000843.4 |
| RefSeq Size | 6122 bp |
| RefSeq ORF | 2634 bp |
| Locus ID | 2916 |
| UniProt ID | O15303 |
| Protein Families | Druggable Genome, Transmembrane |
| Protein Pathways | Neuroactive ligand-receptor interaction |
| Gene Summary | L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Mutations in this gene result in congenital stationary night blindness type 1B. [provided by RefSeq, May 2018] |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC221195 | GRM6 (Myc-DDK-tagged)-Human glutamate receptor, metabotropic 6 (GRM6) |
CNY 6,424.00 |
|
| RC221195L3 | Lenti ORF clone of Human glutamate receptor, metabotropic 6 (GRM6), Myc-DDK-tagged |
CNY 11,120.00 |
|
| RC221195L4 | Lenti ORF clone of Human glutamate receptor, metabotropic 6 (GRM6), mGFP tagged |
CNY 11,120.00 |
|
| SC300141 | GRM6 (untagged)-Human glutamate receptor, metabotropic 6 (GRM6) |
CNY 6,432.00 |
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