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ITM2C (NM_001287240) Human Tagged ORF Clone
CAT＃: RG236551
- TrueORF®
ITM2C (tGFP-tagged) - Human integral membrane protein 2C (ITM2C), transcript variant 4
ORF Plasmid: DDK
"NM_001287240" in other vectors (2)
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CNY 4,370.00
Product images
Specifications
| Product Data | |
| Type | Human Tagged ORF Clone |
| Tag | TurboGFP |
| Synonyms | BRI3; BRICD2C; E25; E25C; ITM3 |
| Vector | pCMV6-AC-GFP |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>RG236551 representing NM_001287240.
Blue=ORF Red=Cloning site Green=Tag(s) GCTCGTTTAGTGAACCGTCAGAATTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTG GATCCGGTACCGAGGAGATCTGCCGCCGCGATCGCC ATGGGCATGGTCGTGCTGCTCATGGGCCTCGTGTTCGCCTCTGTCTACATCTACAGATACTTCTTCCTT GCGCAGCTGGCCCGAGATAACTTCTTCCGCTGTGGTGTGCTGTATGAGGACTCCCTGTCCTCCCAGGTC CGGACTCAGATGGAGCTGGAAGAGGATGTGAAAATCTACCTCGACGAGAACTACGAGCGCATCAACGTG CCTGTGCCCCAGTTTGGCGGCGGTGACCCTGCAGACATCATCCATGACTTCCAGCGGGGTCTGACTGCG TACCATGATATCTCCCTGGACAAGTGCTATGTCATCGAACTCAACACCACCATTGTGCTGCCCCCTCGC AACTTCTGGGAGCTCCTCATGAACGTGAAGAGGGGGACCTACCTGCCGCAGACGTACATCATCCAGGAG GAGATGGTGGTCACGGAGCATGTCAGTGACAAGGAGGCCCTGGGGTCCTTCATCTACCACCTGTGCAAC GGGAAAGACACCTACCGGCTCCGGCGCCGGGCAACGCGGAGGCGGATCAACAAGCGTGGGGCCAAGAAC TGCAATGCCATCCGCCACTTCGAGAACACCTTCGTGGTGGAGACGCTCATCTGCGGGGTGGTG ACGCGTACGCGGCCGCTCGAG - GFP Tag - GTTTAAAC >Peptide sequence encoded by RG236551
Blue=ORF Red=Cloning site Green=Tag(s) MGMVVLLMGLVFASVYIYRYFFLAQLARDNFFRCGVLYEDSLSSQVRTQMELEEDVKIYLDENYERINV PVPQFGGGDPADIIHDFQRGLTAYHDISLDKCYVIELNTTIVLPPRNFWELLMNVKRGTYLPQTYIIQE EMVVTEHVSDKEALGSFIYHLCNGKDTYRLRRRATRRRINKRGAKNCNAIRHFENTFVVETLICGVV TRTRPLEMESDESGLPAMEIECRITGTLNGVEFELVGGGEGTPEQGRMTNKMKSTKGALTFSPYLLSHV MGYGFYHFGTYPSGYENPFLHAINNGGYTNTRIEKYEDGGVLHVSFSYRYEAGRVIGDFKVMGTGFPED SVIFTDKIIRSNATVEHLHPMGDNDLDGSFTRTFSLRDGGYYSSVVDSHMHFKSAIHPSILQNGGPMFA FRRVEEDHSNTELGIVEYQHAFKTPDADAGEERV |
| Restriction Sites |
SgfI-MluI
Cloning Scheme for this gene
Plasmid Map
|
| ACCN | NM_001287240 |
| ORF Size | 615 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reference Data | |
| RefSeq | NM_001287240.2 |
| RefSeq Size | 2051 bp |
| RefSeq ORF | 618 bp |
| Locus ID | 81618 |
| UniProt ID | Q9NQX7 |
| Protein Families | Transmembrane |
| MW | 24.4 kDa |
| Gene Summary | Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity).[UniProtKB/Swiss-Prot Function] |
Documents
| Product Manuals |
| FAQs |
| SDS |
