Bag6 (NM_001033968) Rat Untagged Clone

CAT#: RN200239

Bag6 (untagged ORF) - Rat HLA-B-associated transcript 3 (Bat3), transcript variant 1, (10 ug)



  "NM_001033968" in other vectors (3)

CNY 18,430.00


货期*
7周

规格
    • 10 ug

Product images

经常一起买 (3)
TurboFectin Transfection Reagent (1 mL in 1 vial)
    • 1 ml in 1 vial

CNY 4,090.00


DH5α Chemically Competent Cells (≥10^8 cfu/μg of pUC19 DNA)
    • 5 x 200 ul

CNY 1,280.00


Forward sequencing primer VP1.5, Reverse sequencing primer XL39, 100pmoles each
    • 100 pmol

CNY 480.00

Specifications

Product Data
Type Rat Untagged Clone
Tag Tag Free
Synonyms Bat3
Vector pCMV6-Entry
E. coli Selection Kanamycin (25 ug/mL)
Mammalian Cell Selection Neomycin
Sequence Data
>RN200239 representing NM_001033968
Red=Cloning site Blue=ORF Orange=Stop codon

TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
GCCGCGATCGCC

ATGGAGCCGAGTGATAGTACCAGTACCGCTATGGAGGAGCCTGACAGCCTGGAGGTACTGGTGAAGACCC
TGGACTCTCAGACTCGGACTTTTATTGTGGGGGCCCAGATGAATGTAAAGGAGTTTAAGGAACACATAGC
TGCCTCTGTCAGCATCCCTTCCGAGAAACAGCGGCTCATCTACCAGGGCCGGGTTCTACAAGATGACAAG
AAGCTCCAGGACTACAATGTTGGGGGAAAGGTTATCCACCTGGTGGAACGGGCTCCTCCTCAGACTCAGC
TACCTTCTGGAGCATCTTCTGGGACAGGCTCTGCCTCAGCTACTCATGGTGGGGGCCCCCTGCCTGGCAC
TCGGGGCCCTGGGGCCTCTGGTCATGACCGGAATGCCAACAGTTATGTCATGGTTGGAACCTTCAATCTT
CCTAGTGACGGCTCTGCTGTGGACGTTCACATCAACATGGAACAGGCCCCAATTCAGAGTGAGCCCCGGG
TACGGCTGGTGATGGCTCAGCACATGATTAGGGATATACAGACCTTACTGTCCCGGATGGAGTGTCGAGG
GGGAACCCAAGCACAGGCCAGTCAGCCACCCCCGCAGACTCCGACTGTGGCCTCAGAGACAGTAGCTTTG
AACTCACAAACATCAGAGCCAGTTGAAAGTGAAGCTCCTCCTCGAGAGCCCATGGAGTCAGAAGAAATGG
AGGAACGTCCCCCAACCCAGACTCCAGAGCTTCCACCCTCTGGCCCAGCTCCAGCAGGCCCAGCACCCGC
ACCAGAGACAAATGCACCCAACCACCCTTCCCCTGCAGAGCACGTGGAGGTGCTCCAGGAGCTTCAGCGC
TTGCAACGCCGTCTTCAGCCCTTCCTGCAGCGCTACTGTGAGGTCCTGGGTGCTGCTGCCACTACAGACT
ACAATAACAATCATGAGGGCCGAGAAGAGGACCAGAGGTTGATTAACTTGGTGGGGGAGAGCCTGCGGCT
ACTGGGCAACACTTTCGTGGCATTGTCTGATCTGCGCTGTAATCTAGCCTGTGCACCCCCACGGCACCTG
CATGTGGTACGGCCTATGTCTCACTACACGACTCCCATGGTGCTCCAGCAGGCAGCCATTCCCATTCAGA
TCAATGTGGGGACTACTGTGACCATGACAGGCAATGGGGCTCGGCCTCCACCAGCTCCCGGTGCAGAGGC
AGCATCCCCAGGTTCTGGCCAGGCCTCATCCCTTCCTCCATCTTCTGCCACTGTTGATTCATCAACGGAA
GGAGCTCCCCCACCAGGGCCAGCACCACCACCAGCCACCAGCCATCCACGGGTCATCCGGATTTCCCACC
AGAGTGTGGAACCTGTGGTCATGATGCACATGAACATTCAAGACTCCGGAGCACAGCCTGGAGGTGTGCC
CAGTGCTCCCACTGGCCCCCTGGGACCTCCTGGTCATGGACAGAGCCTGGGACAGCAGGTGCCCGGCTTC
CCAACAGCACCAACTCGGGTGGTGATTGCCCGACCCACTCCTCCACAGGCTCGGCCTTCCCATCCTGGGG
GCCCTCCAGTCTCTGGAGCTCTACAGGGTGCTGGGCTGGGTACAAACACTTCATTGGCCCAGATGGTGAG
CGGCCTTGTGGGGCAACTTCTCATGCAGCCTGTTCTTGTGGCTCAGGGGACTCCAGGAATGGCTCCGGCT
TCTGCTTCAGCTCCGGCTACGGCCCAGGCACAGGCCCCGGCCCCAGCCCCAGCTCCGGCCCCAGCTCCGG
CCACTGCTTCAGCTAGTGCTGGCACTACCAACACAGCCACCACAGCCGGCCCTGCTCCTGGGGGTCCCGC
CCAGCCTCCACCTCCTCAGCCCTCTGCGGCTGATCTTCAGTTCTCTCAGCTCCTGGGAAATCTGCTGGGG
CCTGCAGGGCCAGGGGCTGGGGGCCCAAGCCTGGCTTCTCCCACCATCACTGTGGCAGTGCCTGGAGTTC
CTGCTTTTCTCCAGGGCATGACTGAGTTTTTGCAGGCATCACAGGCTGCCCCTCCACCCCCTCCACCTCC
TCCACCCCCACCTCCTGCTCCAGAGCAGCAGACCACACCGCCTCCAGGATCCCCTTCTGGTGGGACAGCG
AGTCCTGGGGGCTTAGGTCCTGAGAGCCTGCCACCAGAGTTTTTCACCTCAGTGGTGCAGGGCGTGTTGA
GCTCTCTCCTGGGCTCCTTGGGGGCTCGTGCTGGCAGCAGCGAGAGTATTGCTGCCTTCATCCAACGCCT
CAGTGGATCCAGCAACATCTTTGAGCCTGGGGCTGATGGCGCCCTTGGATTCTTTGGAGCTCTGCTCTCT
CTTCTGTGCCAGAATTTCTCCATGGTGGATGTGGTGATGCTTCTCCATGGCCATTTCCAGCCACTACAGC
GGCTCCAGCCACAGCTACGATCTTTCTTCCACCAGCACTACCTGGGTGGCCAGGAGCCCACGTCCAGCAA
CATCCGGATGGCAACCCACACGTTGATCACGGGGCTGGAAGAGTATGTACGGGAGAGTTTCTCTTTGGTG
CAGGTTCAGCCAGGTGTGGATATCATCCGGACAAATTTAGAATTTCTCCAGGAGCAATTTAACAGCATTG
CTGCTCACGTGCTGCACTGTACAGACAGTGGATTTGGAGCCCGGCTGCTGGAGCTATGTAACCAGGGCCT
GTTTGAATGCTTGGCCCTGAACCTGCACTGCTTGGGGGGCCAGCAAATGGAGCTTGCTGCTGTCATCAAT
GGCCGAATTCGCCGCATGTCTCGTGGGGTGAATCCATCCTTGGTGAGCTGGCTGACAACTATGATGGGAC
TCAGGCTTCAGGTGGTCTTAGAGCACATGCCCGTGGGTCCCGACGCCATCCTCAGATATGTGCGCAGGAT
TGGTGATCCTCCTCAGGCACTTCCTGAAGAGCCAATGGAAGTTCAGGGAGCAGAAAGAACTTCCCCTGAG
CCTCAGAGAGAGGATGCTTCCCCAGCCCCCGGAACAACAGCAGAAGAAGCCATGTCCCGAGGTCCACCCC
CTGCTCCTGAAGGAGGTTCCCGAGACGAACAGGATGGAGCTTCAGCCGATGCAGAGCCCTGGGCAGCTGC
AGTCCCCCCTGAATGGGTACCTATTATCCAGCAGGACATTCAGAGCCAGCGGAAGGTGAAACCTCAGCCG
CCCCTGAGTGATGCCTACCTCAGTGGCATGCCTGCCAAGAGACGAAAGACAATGCAGGGTGAGGGCCCCC
AGCTGCTACTCTCAGAGGCAGTGAGCCGGGCAGCTAAGGCAGCCGGAGCTCGGCCCCTGACAAGCCCCGA
GAGCCTGAGCCGGGACCTGGAGGCACCAGAGGTTCAGGAGAGCTACAGGCAGCAGCTCCGGTCTGATATT
CAAAAACGACTGCAGGAAGATCCCAACTACAGCCCCCAGCGCTTCCCTAATGCCCACCGGGCATTTGCTG
ATGACCCCTAG


ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
ACAAGGATGACGACGATAAGGTTTAA
Restriction Sites SgfI-MluI     
ACCN NM_001033968
Insert Size 3441 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_001033968.1, NP_001029140.1
RefSeq Size 3651 bp
RefSeq ORF 3441 bp
Locus ID 94342
UniProt ID Q6MG49
Gene Summary ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins. Functions as part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, which maintains these client proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum. Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated by RNF126, an E3 ubiquitin-protein ligase associated with BAG6 and are sorted to the proteasome. SGTA which prevents the recruitment of RNF126 to BAG6 may negatively regulate the ubiquitination and the proteasomal degradation of client proteins. Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum. The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome. BAG6 is also required for selective ubiquitin-mediated degradation of defective nascent chain polypeptides by the proteasome. In this context, it may participate to the production of antigenic peptides and play a role in antigen presentation in immune response. BAG6 is also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. BAG6 may ensure the proper degradation of these proteins and thereby protects the endoplasmic reticulum from protein overload upon stress. By inhibiting the polyubiquitination and subsequent proteasomal degradation of HSPA2 it may also play a role in the assembly of the synaptonemal complex during spermatogenesis. Also positively regulates apoptosis by interacting with and stabilizing the proapoptotic factor AIFM1. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway.[UniProtKB/Swiss-Prot Function]
Transcript Variant: This variant (1) encodes the longer isoform (1).
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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