MRP5 (ABCC5) (AK090667) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	ABC33; EST277145; MOAT-C; MOATC; MRP5; pABC11; SMRP
Vector	pCMV6-XL5
E. coli Selection	Ampicillin (100 ug/mL)
Mammalian Cell Selection	None
Sequence Data	Fully Sequenced ORF (showhide) >NCBI ORF sequence for AK090667, the custom clone sequence may differ by one or more nucleotides CATTCCTCTGGGTAGCACCATATGCAGGCTTTGCGAATAAAGTGATCATGGGCTTTCTTGATTCCATTTG GCCAATGCAAGAACTTCATTGGCTCCCCTCTAAAAAAAATTCCATGGATTGCTGGGATTTTTATTTTTTA TTTTTTGAAAAAAATGGTACCTATCCGTATTCAGCTTGGTGGCTTCACAGTCCCTCCCCTGAACATCCGT ATATTCCTTATTCTCTCATTTATGGTGCAGAACACTGGGGTACTAACCTCTAGGAAACTGTTCTAGCTGC CAGGGAAAGCTAAGAGCCCTCCTTTAACAGGAAAGCAGCAGCATGCTTTTTCTTCTCTCTGCCGTTTCAG GGAAGAGCACCTTAAGGCCAGTGTTATTTCATGGGATTCTGTCCTAGAGCTGAGAAAGTAATGGACTCAT CCATAATCTCTTTTATAGATTTGAAAGTGTAAACAATACACACTTCCTTTTTTGGAACTCCAATTCTAAT ATGTTTCTTTTTCATTGGAAATTGAAAAACCAGGCTGGTTTTGAGATTAGTACTAGCAGTGAGTAAACCT CCTGTCTGTGGACTTAAATCCTTTTGAGGAACATTTCGTTTTAGATTTTTACAAGTTTTCTAATCTGGCA CGACTTTCAAACTAGCTTAATCTGTTCTTACAGAAACCTGTGTAAGGACAGACTGCCCACATACGGGCTC CCCAAACAAAACGGCATTTTTATTTCTTGTCCCTGCTCGGGTTTCACCGAACCTTGGTAGCCATAATCAG AACAAATGAAACACAGTCAAGTTGTTGTGTTCTGTTTGTTTTTACCTGCCAGCCAGCTGATGCTGACATT TATACACCAAGATGATCCAAGGTTTTGGTGACGCCGGTGGGGACTGCCGCTATATGTGCAGGGTGCCCGG GGGTCATAGTAATGTTAATGGAGTACCAGAATCTCTAACAGTGTGGTCCTGTGTAGCCACATTGCTACAC TTACAGAGATGCTTTGGGGCCTTTTTGGATTAAGACAGTTCTAAAAGACCAGGCCTCACCTATGATCTGT GTATAAAGAATTAGCATCGCACTGTAGATCTGCAAGAGAAGGCCGCCTCCTGCAGTGCTCTCTCTTGGTG AATGCTAACTCTGCTCGAGGGCCTTTTGGGGAAAGGACAGTGCAAAACCCTTAGAGAGGTAAGTTTCCCA CCCTTCCAACCTCTCTCCACCTGCAGCTTGCTTGGTGCTGTCAGGATCTGGATTTGGGGGGAGTCTCTCT GTAGTGGAACCAGTGACAGAAGCTGTTCTTTAGAATTTTCAGGATGGCTGTATTCTGCGGTCAGAATGAG AGAGTCAAGCTGGGCAGAATCTCTCGCCAAGAGTTCAGGTAAGGTAATGTTTATTCACTGGGAATGCTTT CCACAGCCAGACAGCTATGCTAACAGTCTCAAGTTTTCTTCCAGTTTGTTTAGATTTAAATGATACATTT GTAACTTTTTAAAAACTAAATTTTGGTTGGATTTTTCATGAAAACCTCTTTTTTCTTTATCCCCTAAAAA ATGGTTTGAAATGTCATTGTTATTTAAAAACCCGATGTGTTGGAACTTCTTTAATCTGCTGTTTCCTCTT TTTCCCCCCCTTTGAAAGTTTCGCATAGTGTAAACATTCACTATGTCTTTTACCTTCCCTGCTCCTCCCA TCTGGGAGGCGCTGATGCTATTACCCAGTGCTGAAAAATGGCACTCTAAAGGTATGGGAAGGAAGGAGCC CAAGGCAACCACCTGCTGTCCTTTCAGCCTTCCTTTGGAGACTGCTCCATCAGTGCCGAGGTGTGTGGGA ACAGGCTTCACTGCACCGCCATCTTACTGAGTTGCTTCACGTGAGGAAAAGGGGGCTTTGGCCCTGTGAC TCAGTTCCACATTTTGGATTGCATACTGGAAAAGAAGCCAATCTTCTTGCTAGTAAACCAGCAACCCGGC TGTATACAGTGGTGACCCAAGCAATGGATATAAACCTAAAAATCTGAGGGAGGGGAGAGGTGGAATACAG TAGTTCTTGGAATCTGAAGTCTCCTATTTGATCAGGTTATTTCCTGGGACTTGGCAAAAATCTGATTGGT GGGGATCTCCTAGGACCTAGTGGACATCTGGTATTAATTTAATCTCAGGAAAAACAAGAAATTAACCCAG AGAGAGTCTGGGTTCTGGAATTCAGCGTAGCTACCTCCAGACCGTGGTGTCTGGCCTCCATTTTTGTCTG TCATTCAGCTCTGACTTACAGCTGCAATCACCTTTGCTATAAGGCACCTGGGTAGAAGGGTGGATGGGCT TCACATCAATTTTTTTCTTCCTTTAGGGTGGGGGATTGGTTTGGCTTTCTTTTGTTGTGGCTTTTTGTTT TATTTTTGTCAAGATTGATTTTTAGATGCAAGGACTTGAAAAGACCCAGAAGGATGCCACCAGTTTTTCC TTGAGGCCTAGGATTTTTTATTCTGTCCCGAGCAGAGGTAATTCCTCACAACTTAGTGCACCAGTAGCAC CAGCCGTTTTGAGCAGAGTACCTCTTTGGGGAGCTTTTCGTTTTGTTTTGTTTTTAATTCTCTTTCCTTA GCAGCAAGGTCTTTTTTCCTAGAGAATCTACTCCGTTGCAGAATCATTGCAACCTCAGGAGCCCTCACTG ATTGAGTGCTGTCAGCCTGATATACTACTTTGGACTCTGGAAACAGATATGGGTTCTATTCTCTATTTCT ACTGTGTGTCGTTAAACAACCGTCGGAGACCAGATGACCTGTTAGATGGCTAGTCCTGTATAACTCGACT CTGTATGTTTCAATGTATGTTACTGCAATGCTTCACCTGCTGTACAGTGTTTGTGAGATGCTCTTTGAAG ATGGTACTTTTATATTTTTTCATTTTCAATAAAAGTACATTCCTTCCC 5' Read Nucleotide Sequence (showhide) >OriGene 5' read for AK090667 unedited NGGTCAAATATTGTATACGACTCATATAGGCGGCCGCGNAATTCGCACGAGGATGAAACA CAGTCAAGTTGTTGTGTTCTGTTTGTTTTTACCTGCCAGCCAGCTGATGCTGACATTTAT ACACCAAGATGATCCAAGGTTTTGGTGACGCCGGTGGGGACTGCCGCTATATGTGCAGGG TGCCCGGGGGTCATAGTAATGTTAATGGAGTACCAGAATCTCTAACAGTGTGGTCCTGTG TAGCCACATTGCTACACTTACAGAGATGCTTTGGGGCCTTTTTGGATTAAGACAGTTCTA AAAGACCAGGCCTCACCTATGATCTGTGTATAAAGAATTAGCATCGCACTGTAGATCTGC AAGAGAAGGCCGCCTCCTGCAGTGCTCTCTCTTGGTGAATGCTAACTCTGCTCGAGGGCC TTTTGGGGAAAGGACAGTGTAAAACCCTTAGAGAGGTAAGTTTCCCACCCTTCCAACCTC TCTCCACCTGCAGCTTGCTTGGTGCTGTCAGGATCTGGATTTGGGGGGGAGTCTCTCTGT AGTGGAACCAGTGAAGAAAGCTGTTCTTTAGAATTTTCAGGATGGCTGTATNCTGCGGTC AGAATGAGAGAGTCAAGCTGGGCAGAATCTCTGCCAAGAGTTCAAGTAAGGTAATGTTTA TTCACTGNGAATGCTTTCCACAGCCAGACAGCTATGCTAACAGTCTCAAGTTTTCTTCNC AGTTTGTTTAGATTTAAATGATACATTTGTAACTTTTTAAAATAAATTTTGNTTTGGATT TTTCATGAAAACCTCTTTTTTCTTTATCCCTANAAAATGGTTNGAATGTCATTGNTATTT AAAAACCGATGTGTTGGAAACTCTTAATCTGCTGTTNCCTCTTTTCCCCCTTTTGAAAGT TCGCATATGGTAACATCACTATGNCTTTTACTTCCTGCTCTCATATNNGNAA 3' Read Nucleotide Sequence (showhide) >OriGene 3' read for AK090667 unedited NGGGGGAATACTGTGNNACGCGGNCCGCTTNCNANGATCGAGTTTTTTTTTTTTTTTTTT GGGGAAGGAATGTACTTTTATTGAAAATGAAAAAAATAAAAGTACCATCTTCAAAGAGCA TCTCACAAACACTGTACAGCAGGTGAAGCATTGCAGTAACATACATTTGAAACATACAGA GGTCGAGTTATACAGGACTAGCCATCTAACAGGTCATCTGGTCTCCGACGGTTGTTTAAC GACACACAGTAGAAATAGAGAATAGAACCCATATCTGTTTCCAGAGTCCAAAGTAGTATA TCAGGCTGACAGCACTCAATCAGTGAGGGCTCCTGAGGTTGCAATGATTCTGCAACGGAG TAGATTCTCTAGGAAAAAAGACCTTGCTGCTAAGGAAAGAGAATTAAAAACAAAACAAAA CGAAAAGCTCCCCAAAGAGGTACTCTGCTCAAAATGGCTGGTGCTACTGGTGCACTAAGT TGTGAGGAATTACCTCTGCTCGGGACAGAATAAAAAATCCTAGGCCTCAAGGAAAAACTG GTGGCATCCTTCTGGGTCTTTTCAAGTCCTTGCATCTAAAAATCAATCTTGACAAAAATA AAACAAAAAACCACAACAAAAGAAAGCCAAACCAATCCCCCACCCTAAAGGAAGAAAAAA ATTGATGTGAAGCCCATCCACCCTTCTACCCANGTGCCTTATAGCAAAGGTGACTGCAGC TGTTAGTCAGAGCTGAATGACAGACAAAAATGGAGGCCAGACACCACGGTCTGGAGGTAG CTACGCCTGATTCCAGAACCCAGACTCTCTCTGGGGGTAATTTTCTGGTTTTCCCTGAGA TTAATTAATTACAGATGTCCACTAAGTCCTAGGAGATCCCACCCATCAGATTTTTGCCCA GTCCCG
Restriction Sites	NotI-NotI
ACCN	AK090667
Insert Size	2500 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note	Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Reference Data
RefSeq	AK090667.1
RefSeq Size	2918 bp
RefSeq ORF	2918 bp
Locus ID	10057
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	ABC transporters
Gene Summary	The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

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