Thimet Oligopeptidase (THOP1) (AK093392) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	EP24.15; MEPD_HUMAN; MP78; TOP
Vector	pCMV6-XL5
E. coli Selection	Ampicillin (100 ug/mL)
Mammalian Cell Selection	None
Sequence Data	Fully Sequenced ORF (showhide) >NCBI ORF sequence for AK093392, the custom clone sequence may differ by one or more nucleotides ATGTTCAGCGGGACCCACGTGGAGCGGGACTTTGTGGAGGCGCCGTCGCAGATGCTGGAGAACTGGGTGT GGGAGCAGGAGCCGCTGCTGCGGATGTCGCGGCACTACCGCACAGGCAGCGCCGTGCCCCGGGAGCTCCT GGAGAAGCTCATTGAGTCCCGGCAGGCCAACACAGGCCTCTTCAACCTGCGCCAGATCGTCCTCGCCAAG GTGGACCAGGCCCTGCACACGCAGACGGACGCAGACCCCGCCGAGGAGTATGCGCGGCTCTGCCAGGAGA TCCTCGGGGTCCCGGCCACGCCAGGAACCAACATGCCTGCAACCTTCGGCCATCTGGCAGGTGGCTACGA CGCCCAGTACTACGGGTACCTGTGGAGCGAGGTGTATTCCATGGACATGTTCCACACGCGCTTCAAGCAG GAGGGTGTCCTGAACAGCAAGTTTCCTCACTATGAAGTGCGGCCGTTACGCCATGTGAGCCTGTGCCTCC CGCTGACTTGGTGTGACCCAGGCTCGGGACAGCCGCCAGAGTCCCTCACAAGGAACAGGTGGCTACCAGC TTTGAGGGCCGGCCCTGCCCTGCCTGGGTGCAACATTGCACTGGGCAGCCTGCAGGTTGGCATGGATTAC AGAAGCTGCATCCTGAGACCCGGCGGTTCCGAGGATGCCAGCGCCATGCTGAGGCGCTTCCTGGGCCGTG ACCCCAAGCAGGACGCCTTCCTCCTGAGCAAGGGGCTGCAGGTCGGGGGCTGCGAGCCCGAGCCGCAGGT CTGCTGA 5' Read Nucleotide Sequence (showhide) >OriGene 5' read for AK093392 unedited TTGTAATACGATCTCACTATAGGGCGGCCGCGAATCGGCACGAGGCCTCGTGCCGAATTC GGCACGAGGGAGCGCCGGGGCCTGCCCTTCGACGGCCGCATCCGTGCCTGGGACATGCGC TACTACATGAACCAGGTGGAGGAGACGCGCTACTGCGTGGACCAGAACCTGCTCAAGGAG TACTTCCCCGTGCAGGTGGTCACGCACGGGCTGCTGGGCATCTACCAGGAGCTCCTGGGG CTGGCCTTCCACCACGAGGAGGGCGCCAGTGCCTGGCATGAGGACGTGCGGCTCTACACC GCGAGGGACGCGGCCTCGGGGGAGGTGGTCGGCAAGTTCTACCTGGACCTGTACCCGCGG GAAGGAAAGTACGGGCACGCGGCCTGCTTTGGCCTGCAGCCCGGCTGCCTGCGGCAGGAT GGGAGCCGCCAGATCGCCATCGCGGCCATGGTGGCCAACTTCACCAAGCCCACAGCCGAC GCGCCCTCGCTGCTGCAGCATGACGAGGTGGAGACCTACTTCCATGAGTTTGGCCACGTG ATGCACCAGCTCTGCTCCCAGGCGGAGTTCGCCATGTTCAGCGGGACCCACGTGGAGCGG GACTTTGTGGAGGCGCCGTCGCAGATGCTGGAGAACTGGGTGTGGGAGCAGGAGCCGCTG CTGCGGATGTCGCGGCACTACCGCACAGGCAGCGCCGTGCCCCGGGAGCTCCTGGAGAAG CTCATTGAGTCCCGGCAGGCCAACACAGGCCTCTTNCACCTGCGCCAGATCGTNCTCGCC AAGGTGACCANGCCCTGCACACGCAGACGGACGCANACCCCGNCGAGGAGTATGCGCGGC TCTGCCAGGAGATCCTCGGGGTCCCGGCCCGCCAGGACAACATGCCTGCACCTTCGCCAT TTGGAGTGGCTAGACGCCCATN 3' Read Nucleotide Sequence (showhide) >OriGene 3' read for AK093392 unedited AAAAATTGGGGGTTNAGAAAGCGTAATCNAGGATTTANCCGTACAAATGNACAAGGGNNN ACGTTTCCCAGAATATTATACGTGTTAGTGCAACAAAGACCAGCCCTGGCAGCCACGAAA GCCCTCCAGATGCCTTGAGGACGCCGTCTCTAGCCGGGTGGGCCACGACCGGGTGGGGAC AGACAATGACAAGAGGCAAGACAGCCGCTCAGCCACCCTGCCTTACCTAGCTCTGTGCCA GAGCCTGCCCCATCCTGTGCCGGGGGCTAATGCACCAGGGCGGCGGGAGCGCAGGCCAGA CTGGGCAGTCGCAGTGCCAGGCCTCAGCAGACCTGCGGCTCGGGCTCGCAGCCCCCGACC TGCAGCCCCTTGCTCAGGAGGAAGGCGTCCTGCTTGGGGTCACGGCCCAAGAAGCGCCTC AGCATGGCGCTGGCATCCTCGGAACCGCCGGGTCTCAGGATGCAGCTTCTGTAATCCATG CCAACCTTGCTGTTCAGGACACCCTCCTGCTTGAAGCGCGTGTGGAACATGTCCATGGAA TACACCTCGCTCCACAGGTACCCGTAGTACTGGGCGTCGTAGCCACCTGCCAAATGGCCG NAAGTTGCAGGCATGTTGGTTCCTGGCGTGGCCGGGACCCCGAGGATCTCCTGGCAAAGC CGCGCATACTCCTCGGCGGAGTCTGCGTCCGTCTGCGTGTGCAGGGCCTGGTCCACCTTG GCGAGGACGATCTTGGCGCATGTTTGAAAGAGGCCCTGTGATAGGCCTTGCCTGGGACTC AATGAGCTTCTTCAGGAGCTTCCGGGGCACGCGCTGCCTGTGCGGTAGTGCCGCGAAATT CAGCAAAAACGGGCTCCTGGTTCCACAACCAGTTTTCCAGCATCTGGGAGGCGCCCTCCA CAAATTCCAGCTCCACGTGGGTTCCCGCTGAACATGGA
Restriction Sites	NotI-NotI
ACCN	AK093392
Insert Size	1500 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note	Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Reference Data
RefSeq	AK093392.1, BAG52704.1
RefSeq Size	1887 bp
RefSeq ORF	1887 bp
Locus ID	7064
Protein Families	Druggable Genome, Protease
Protein Pathways	Renin-angiotensin system
Gene Summary	The protein encoded by this gene is a kininase that uses zinc as a cofactor. The encoded oligopeptidase cleaves cytosolic peptides, making them unavailable for display on antigen-presenting cells. This protein also cleaves neuropeptides under 20 aa in length and can degrade beta-amyloid precursor protein to amyloidogenic peptides. [provided by RefSeq, Nov 2015]

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