KIDINS220 (AK022873) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	ARMS
Vector	pCMV6-XL5
E. coli Selection	Ampicillin (100 ug/mL)
Mammalian Cell Selection	None
Sequence Data	Fully Sequenced ORF (showhide) >OriGene ORF within SC102707 sequence for AK022873 edited (data generated by NextGen Sequencing) ATGCTGCCTCAGTATTGTACCACGATCAAAAAGGCAAACATAAATGGCCGTGTGTTAGCT CAGTGTAACATTGATGAGCTGAAGAAAGAGATGAATATGAATTTTGGAGACTGGCACCTT TTCAGAAGCACAGTACTAGAAATGAGAAACGCAGAAAGCCACGTGGTCCCTGAAGACCCA CGTTTCCTCAGTGAGAGCAGCAGTGGCCCAGCCCCGCACGGTGAGCCTGCTCGCCGCGCT TCCCACAACGAGCTGCCTCACACCGAGCTCTCCAGCCAGACGCCCTACACACTCAACTTC AGCTTCGAAGAGCTGAACACGCTTGGCCTGGATGAAGGTGCCCCTCGTCACAGTAATCTA AGTTGGCAGTCACAAACTCGCAGAACCCCAAGTCTTTCGAGTCTCAATTCCCAGGATTCC AGTATTGAAATTTCAAAGCTTACTGATAAGGTGCAGGCCGAGTATAGAGATGCCTATAGA GAATACATTGCTCAGATGTCCCAGTTAGAAGGGGGCCCCGGGTCTACAACCATTAGTGGC AGATCTTCTCCACATAGCACATATTACATGGGTCAGAGTTCATCAGGGGGCTCTATTCAT TCAAACCTAGAGCAAGAAAAGGGGAAGGATAGTGAACCAAAGCCCGATGATGGGAGGAAG TCCTTTCTAATGAAGAGGGGAGATGTTATCGATTATTCATCATCAGGGGTTTCCACCAAC GATGCTTCCCCCCTGGATCCTATCACTGAAGAAGATGAAAAATCAGATCAGTCAGGCAGT AAGCTTCTCCCAGGCAAGAAATCTTCCGAAAGGTCAAGCCTCTTCCAGACAGATTTGAAG CTTAAGGGAAGTGGGCTGCGCTATCAAAAACTCCCAAGTGACGAGGATGAATCTGGCACA GAAGAATCAGATAACACTCCACTGCTCAAAGATGACAAAGACAGAAAAGCCGAAGGGAAA GTAGAGAGAGTGCCGAAGTCTCCAGAACACAGTGCTGAGCCGATCAGAACCTTCATTAAA GCCAAAGAGTATTTATCGGATGCGCTCCTTGACAAAAAGGATTCATCGGATTCAGGAGTG AGATCCAGTGAAAGTTCTCCCAATCACTCTCTGCACAATGAAGTGGCGGATGACTCCCAG CTTGAAAAGGCAAATCTCATAGAGCTGGAAGATGACAGTCACAGCGGAAAGCGGGGAATC CCACATAGCCTGAGTGGCCTGCAAGATCCAATTATAGCTCGGATGTCCATTTGTTCAGAA GACAAGAAAAGCCCTTCCGAATGCAGCTTGATAGCCAGCAGCCCTGAAGAAAACTGGCCT GCATGCCAGAAAGCCTACAACCTGAACCGAACTCCCAGCACCGTGACTCTGAACAACAAT AGTGCTCCAGCCAACAGAGCCAATCAAAATTTCGATGAGATGGAGGGAATTAGGGAGACT TCTCAAGTCATTTTGAGGCCTAGTTCCAGTCCCAACCCAACCACTATTCAGAATGAGAAT CTAAAAAGCATGACACATAAGCGAAGCCAACGTTCAAGTTACACAAGGCTCTCCAAAGAT CCTCCGGAGCTCCATGCAGCAGCCTCTTCTGAGAGCACAGGCTTTGGAGAAGAAAGAGAA AGCATTCTTTGA Clone variation with respect to AK022873.1 1140 t=>g;1153 g=>a 5' Read Nucleotide Sequence (showhide) >OriGene 5' read for AK022873 unedited ATTTGTAATACGACTCACTATAGGGCGGCCGCGAATTCGGCACGAGGCGCAGGTGGAGTG GTGTNCACCACAGCCTCACAGCAGCTATTACAGCGGCATGACGGGCCCTCAGCATCCCTT CTACAACAGGCCATTCTTTGCCCCATACCTTTACACGCCAAGGTATTACCCTGGCGGCTC CCAACATCTCATCTCACGTCCATCAGTAAAAACGAGTTTGCCCAGAGATCAGAACAATGG CCTAGGGTCAGGCCCAGCCCCAGGCCCAGTGGTATTACTGAATTCACTGAATGTGGATGC AGTATGTGAGAAGCTGAAACAAATAGAAGGGCTGGACCAGAGTATGCTGCCTCAGTATTG TACCACGATCAAAAAGGCAAACATAAATGGCCGTGTGTTAGCTCAGTGTAACATTGATGA GCTGAAGAAAGAGATGAATATGAATTTTGGAGACTGGCACCTTTTCAGAAGCACAGTACT AGAAATGAGAAACGCAGAAAGCCACGTGGTCCCTGAAGACCCACGTTTCCTCAGTGAGAG CAGCAGTGGCCCAGCCCCGCACGGTGAGCCTGCTCGCCGCGCTTCCCACAACGAGCTGCC TCACACCGAGCTCTCCAGCCAGACGCCCTACACACTCAACTTCAGCTTCGAAGAGCTGAA CACGCTTGGCCTGGATGAAGGTGCCCCTCGTCACAGTAATCTAAGTTGGCAGTCACAAAC TCGCAGAACCCCCAGTCTTTCGAGTCTCAATTCCCAGGATTCCAGTATTGAAATTTCAAA GCCTACCTGATAAGTGCANGCCGAGTATAGAGATGCTATAGAGATACATTGCTCAGATGT CCATTAGAAGGGGCCCCGGGTCTACACCATTATGGCAGATCTCTCCCATAGACATATTAC ATGGTCAG 3' Read Nucleotide Sequence (showhide) >OriGene 3' read for AK022873 unedited NCGGTATATCTATGNACGCGGCCGCATTCTANGATCGAGTTTTTTTTTTTTTTTTTTGCT AAGCTCACTTAGAAAAGTTGGGCACCATTTAAAAGATTGGAGAACAGACCAGGGTGGCTT CTTGGGCACAGCTGGATGGTGCTGGAAGCCAGGCCTGGGATTTGGAGAGAAGAGTTTCCG ACATATAAACCCACGGAGGTCACCAGCCCTCCCCGCATCTACTCTCCTAACAGCTCAGGA CAGCCCCGTCACACTACTGCCAGCCCTGGTGACTCACTTTGTTGGCAATTTTTAAAGCCC TCTTCATTATGTACTTCCTACTCTTCAGAACCTCTGTGATAAGCAATACCCCTGCCATAC AGAACGCTGGATCTCGGTTTACTCAGCCTCTCCCTGTAGCGTCACAGGCTGTGCACTCAC CTAGGTGAGCCCCTAAGAGCAGGGTTTGCTTCTGCTTCACCTAACGCCACGTCTTCCCTC AAATGTGTGGTCACCAAATGTTTGCAAAAAGGGTCTCTAGCTTTTTTTCTTTTTGGCACA TTAAGCCCTTTAAAATACTTCTGACCTATCTTTATACTCAGATCTCACCTCGTCTCAAAA AGTTTTATGGGGTAATGCGCCAATGAAAGGTACAGTAGTATTAGTGAGTTCTGAAGCTTC NTATTACAAAGACCACAGAGGCTGGCTGGTGAGCCATGCTTCTCATGCTNCCTTCTGTCA CACTGCAGATGTCTCTTTTACCCTCGCCTCATCATCGGTTAGTTATCTGTCAGCAAAATG TAAAAAGGTGATGGGGCGTGGATGGAGTCAAAATCCAGACAATTTCTGTCATAAGGGGTA CAGTACACCTCTTCTCCTTGGCTTGGTTTTCTCAAAGAAGGCTTCTCTTTCTTTCTCCAA GCC
Restriction Sites	NotI-NotI
ACCN	AK022873
Insert Size	3000 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note	Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Reference Data
RefSeq	AK022873.1, BAB14285.1
RefSeq Size	2564 bp
RefSeq ORF	1632 bp
Locus ID	57498
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Neurotrophin signaling pathway
Gene Summary	This gene encodes a transmembrane protein that is preferentially expressed in the nervous system where it controls neuronal cell survival, differentiation into exons and dendrites, and synaptic plasticity. The encoded protein interacts with membrane receptors, cytosolic signaling components, and cytoskeletal proteins, serving as a scaffold that mediates crosstalk between the neurotrophin pathway and several other intracellular signaling pathways. Aberrant expression of this gene is associated with the onset of various neuropsychiatric disorders and neurodegenerative diseases, including Alzheimer's disease. Naturally occurring mutations in this gene are associated with a syndrome characterized by spastic paraplegia, intellectual disability, nystagmus and obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]

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