ZBTB48 (AF318381) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	HKR3; pp9964; ZNF855
Vector	pCMV6-XL5
E. coli Selection	Ampicillin (100 ug/mL)
Mammalian Cell Selection	None
Sequence Data	Fully Sequenced ORF (showhide) >NCBI ORF sequence for AF318381, the custom clone sequence may differ by one or more nucleotides ATGGAGCTGCGGGTGCACATGGTGTCTCACACAGGGGAGATGCCCTACAAGGTCAGGCTTGGCCTGTCTC CAGGGCCAGGGTTGGGTGGCCCCAGGATCCTTCCTGCTGAGCCCTTTACGTGGGGTGCTGTCAGGCACCT CCCTCACAGTAGCTGTCAGGGAGCCTGCCTTCCCTGCCTTCCCTGCCTTTCCAGTGCCCCCTTATCTAGG CAAGGGCTACTGTCTGCAGCCTCACCTCCAAGGTCCTTATTAGGCCCTTGTTTCTTTCCATGGAGGACAG GCTTGGCATCCTCTGGGCAGCTGAGCCCTGAGGCCCTCCTTTGCACCATCCTTCACACCAGATCAGGGGT CCTCCCAGAATCATCTCACCGGGGCCTCCCTCTAGTTCCTGCCCTATAG 5' Read Nucleotide Sequence (showhide) >OriGene 5' read for AF318381 unedited CAGATTTTGTATACGACTCATATAGGCGGCCGCGAATTCGGCACGAGGGAGAGATGGGAA ACCCTCTCAGCCCCCCCACCCCTGTGGCTTCTCCTGGCAGGAAACATACTGGGGAGAAAC CCTTTGAGTGTCCCAAATGTGGGAAGTGTTACTTTCGGAAGGAGAACCTCCTGGAGCATG AAGCCCGGAATTGCATGAACCGCTCGGAACAGGTACTTGGGAGCTGGCCCAGGTACTTGT GGGCAGGGCACACTGGCCTCTCTGTCTTCGTGCCATCCGGGAAGGGCCCCAGGAGACTGT CTGAGAGGGGTACTGTAAACTCAGGAAAGCTGTGGGGTCCTTGGATGTCATGAGGTCCAT GCCCTGGTACAGGTGGGGACACAGGTCCTGAGGGCGGAAGGGACAGGCATAGGAGGGACT CTGTGGGAGGCATTTGGGGTTGGCTTTCCTAGGCCCCTGGCCCACCTCCACCTTGGCTTT GGAGAAGGGGAGCCGCTACAGGGGATGGCAGCTGGGAAAGGCCCCCTGGCCACCCCCAGC AACCCCACTGCTGGCTTCTGTGTCAGGGCCCGCCGAAACCCAGGCCCACTCTTCCTAGAG GCCTGTCAGCAGCCACTAGGGCCAGGGACTGTGGGTGAGGCCACTCGGACCCTGCCCCCA GTCTGTCTGGGCCTGAGAGGGCCTGGTGTGCGGTGGGCTTGCAGCACTCAGTGATGGTCA GGCCAGGCAGGTTATGTGTTGNCCTCTNCCACCCTTAGCGTCCCACCCTCCCCAGGCAGA CTCTTCCAGCAGCAAGCGGAAGCCCGGGCAGAGGCTGCTGTCATANGCAGAAGCCCCCGC TGATGCCGGCCCTGCTTGCCCCTACACTGCCAGGTCTCACGTGCTCTGTGTGCCANGAGA CATTNCGNCGAAGATGNAGCTGCGGNTGCACATGGTGTCTACACAGGGGAGATGCCCTAC ANNGTCAGCTTGNCTGTCTCAGGCCAN 3' Read Nucleotide Sequence (showhide) >OriGene 3' read for AF318381 unedited ATTATGNACCGCGCCGCAATCTANGATCGATTTTTTTTTTTTTTTTTTTTTTTTTTTTTT TTTTTTTTTTTTTTTTTTGAAAATCCCAAACCCACCGTTTATTGAGGGGTGGGGCCAAAT GGGCTCTGGTGGCCCAAATGGGCTATTTGTCACAATCCTCGGGGACAACAACTTTGATGA TGAAGGAGGGCTCCAGGACACCTGGGCCGGTGAAACTCTCCTTTGCACACAATCTTTGGC CGGGGAACTGGGAGGCCAAGCCCCCCTGGGCCAAGGACTCCACAATGACCTCCGCCGAAC CCACCTCCAGCTTTGCAGGCGGGTGCAGCGCCACCACCACCATCTTTTCGTCCTCGATGA TCAAGTTGCGGAACTTGCGCTGCCCCGGGTTGTAATTCTCTACCCGGGCGTGGATCTCCA TGTGCCTCCCCAAGTGGGCCTGGCGGGGAAGGTGAGCTCAAAACTTTGGGGGATCCTAAG GTAGGGGAAAGGGCCCAAGCCCTGGCCTAACTGTCGGGTAAACTTGTAGCCACACTCGGT GCACTCAAACTTTCTCACCCCCTTGTGCCGTCTGACGTGCCACGCAATTGCTCCACGGCT GCAAGAAGGAGAACACCGTGGGGGATCATGCANGAGCCCCGGGACCCTCGAGGAAACCCA ACANGAAGTTGGGACAAGCACCAAGGGGAGGGACCAGTTGTTTACAAGTGCTGCAAAGCC CTGCCAAGCTCTCCAGTGCCCCCCAAGGGTACTACTGGACAGGACACCCCTGTCTTCCAA GCAGGGCCACTCTTAACTCTACCATGTGGGGCAACAAAGAAGTTACAAGCCAAAAAGGGA CGTTTCCTCCTAAAAACCCTCCAATCGGATGAGCCAGGAATGCTTTTCCAGGCCCCCCCA GTACCTTTTAAGGCCTGCCGCAATATTGGCAAATGGGGGCCCGGCCTCCGGATGGCGCTC
Restriction Sites	NotI-NotI
ACCN	AF318381
Insert Size	2800 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	AF318381.1, AAL55888.1
RefSeq Size	2479 bp
RefSeq ORF	399 bp
Locus ID	3104
Protein Families	Transcription Factors
Gene Summary	Telomere-binding protein that acts as a regulator of telomere length (PubMed:28500257, PubMed:28082411). Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat (PubMed:28500257, PubMed:28082411). Preferentially binds to telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents the accumulation of aberrantly long telomeres (PubMed:28082411). Also acts as a transcription regulator that binds to promoter regions (PubMed:7969177, PubMed:24382891, PubMed:28500257). Regulates expression of a small subset of genes, including MTFP1 (PubMed:28500257). Regulates expression the J and/or S elements in MHC II promoter (PubMed:7969177). Acts as a negative regulator of cell proliferation by specifically activating expression of ARF, a tumor suppressor isoform of CDKN2A (PubMed:24382891).[UniProtKB/Swiss-Prot Function]

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