FRMD8 (NM_031904) Human Untagged Clone
CAT#: SC107202
FRMD8 (untagged)-Human FERM domain containing 8 (FRMD8)
CNY 3,656.00
Cited in 1 publication. |
Product images
![](https://cdn.origene.com/img/defaults-img.jpg)
Specifications
Product Data | |
Type | Human Untagged Clone |
Tag | Tag Free |
Synonyms | FKSG44; iTAP |
Vector | pCMV6-XL6 |
E. coli Selection | Ampicillin (100 ug/mL) |
Mammalian Cell Selection | None |
Sequence Data |
>OriGene ORF within SC107202 sequence for NM_031904 edited (data generated by NextGen Sequencing)
ATGGACGGGACAGAAGGCAGTGCCGGGCAGCCCGGCCCCGCTGAGCGATCCCACCGAAGC AGCGTGTCCTCCGTGGGAGCCCGAGCGGCTGACGTGCTGGTATACCTAGCGGATGACACG GTGGTGCCCCTGGCTGTGGAGAACCTGCCCTCGCTCAGTGCCCATGAGCTGCACCGCGCT GTCCGCGAGGTCCTGCAGCTTCCAGACATCGCCCTGGATGTCTTCGCGCTCTGGCTGGTC TCCCCTCTGCTGGAGGTGCAGCTGAAACCCAAGCACCAGCCCTACAAGCTGGGACGCCAG TGGCCGGAGCTGCTGCTGCGCTTCACCAGTGCCCCAGATGATGACGTGGCCATGGATGAG CCTTTCCTGCAGTTCCGAAGGAACGTGTTCTTCCCAAAGCGGCGGGAGCTCCAGATCCAT GACGAGGAGGTCCTGCGGCTGCTCTATGAGGAGGCCAAGGGCAACGTGCTGGCTGCACGG TACCCGTGCGACGTGGAGGACTGCGAGGCTCTGGGCGCCCTGGTGTGCCGCGTGCAGCTT GGGCCCTACCAGCCCGGCCGGCCGGCAGCCTGCGACCTGAGGGAGAAGCTGGACTCCTTC CTCCCTGCCCACCTCTGTAAGCGGGGCCAGAGTCTCTTTGCTGCCCTCCGGGGCCGTGGG GCCAGGGCCGGGCCGGGCGAGCAGGGCCTGCTGAACGCCTACCGCCAGGTGCAGGAGGTC AGCAGCGACGGCGGGTGCGAGGCCGCCCTGGGCACCCACTACCGCGCCTATCTCCTCAAG TGCCACGAGCTGCCGTTTTATGGGTGTGCCTTCTTCCACGGTGAGGTTGACAAGCCGGCC CAAGGCTTTTTGCACCGGGGTGGGCGCAAGCCAGTTTCTGTGGCCATCAGTCTGGAAGGC GTGCACGTCATCGATAGCAGAGAGAAGCATGTCCTGCTGGGCCTGCGCTTCCAGGAGCTG TCGTGGGACCACACCTCCCCCGAGGAGGAGGAGCCCATCTTGTGGCTGGAGTTCGACGGG GACAGCGAGGGCACACCTGTCAACAAGCTCCTCAAGATCTACTCCAAGCAGGCCGAACTG ATGAGCAGTCTCATTGAGTACTGCATCGAACTGAGCCAGGTGGCGGAGCCCGCAGGCCCC CAGGACAGTGCGACTGGCTCGCCCTCGGACCCCAGCTCCTCACTGGCTCCTGTTCAGCGC CCCAAGCTGCGGAGGCAGGGCAGTGTGGTGTCCAGCCGGATCCAGCATCTCTCCACCATC GACTACGTGGAGGACGGCAAGGGGATCAGGCGAGTGAAGCCGAAGCGCACCACATCCTTC TTCAGCCGGCAGCTGTCCTTGGGCCAGGGGAGCTACACCGTGGTGCAGCCCGGCGACAGC CTGGAGCAGGGCTGA Clone variation with respect to NM_031904.3 339 c=>t;1121 c=>t >OriGene 5' read for NM_031904 unedited
TCCCCCGCCCCGTTGNCGCAAAGGGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCA GAGCTCATTTAGGTGACACTATAGAATACAAGCTACTTGTTCTTTTTGCAGCGGCCGCGA ATTCGGCACGAGGGCTGCGTCCTTAGCGGGAGCCCGAGTGCGGGCGGTGGCGGGCTTGGC GGCGGGGCAGGATTCCAGGCAGGAGCCTTGCCTCTCAGGTGGCGGGCTCTGCGACCCTGC GAGATGGACGGGACAGAAGGCAGTGCCGGGCAGCCCGGCCCCGCTGAGCGATCCCACCGA AGCAGCGTGTCCTCCGTGGGAGCCCGAGCGGCTGACGTGCTGGTATACCTAGCGGATGAC ACGGTGGTGCCCCTGGCTGTGGAGAACCTGCCCTCGCTCAGTGCCCATGAGCTGCACCGC GCTGTCCGCGAGGTCCTGCAGCTTCCAGACATCGCCCTGGATGTCTTCGCGCTCTGGCTG GTCTCCCCTCTGCTGGAGGTGCAGCTGAAACCCAAGCACCAGCCCTACAAGCTGGGACGC CAGTGGCCGGAGCTGCTGCTGCGCTTCACCAGTGCCCCAGATGATGACGTGGCCATGGAT GAGCCTTTCCTGCAGTTCCGAAGGAACGTGTTCTTCCCAAAGCGGCGGGAGCTCCAGATC CATGACGAGGAGGTCCTGCGGCTGCTCTATGAGGAGGCCAAGGGCAACGTGCTGGCTGCA CGGTACCCGTGCGACGTGGAGGACTGCGAGGCTCTGGGCGCCCTGGTGTGCCGCGTGCAG CTTGGGCCCCTACAGCCGGCCGGGCCGCAGCCTGCGACCTGAGGGAGAAGCTGGNACTCT TNCTCCCTGCCCACCTCTGTTAGCGGGGCCAGAGTCTCTTTGCTGCCCCTCGGGGCCGTG GGCCAGGGCGGGCCCGGCGGCAGGGCCTGCTGAACGCTACCGCCAAGTGCAGAGTCAGCA CGAC >OriGene 3' read for NM_031904 unedited
TTTAAAACCCTTTNNTTTTTGTTAGAAACTGTTTTTAATAAGTCACATGATACAAAAGAA TGAGAACATTCAAAGAATGAGTAAAATACTGCTTTGTCCCAAAGGACAAGCAGAAAATGT TAAGGCACAACGGATGCTCAGAAAACGTAAGCAGCTGAAGGGAAAACACATCATCTGTGT TCTTCTTACACACACACTCCAACCCATCACACGAACACACCCTCGCCCGCCCATCAGAGA AGAATTCGCCTGGAATCAGCTGGGGGCGGTGGCTCACGCCTATAATCCCAGCACTTTGGG AGGTTGAGGCGGGCAGATCATGAGGTCAGGAGTTCACGACCAGCCTGACCAACATGGTGA AACCCTATCTCTACTAAAAATACAAAAATCAGCGGGGCCTGGTGGCATGCACCTGTAATC CCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAGACAGAGGTTGCAGTGAGCCGA GATGCGCCACTGCACTCCTGCCTGGGCAACAGAGCAAGACTCCGTCTCAAAAAAAAATAA AAAAATAAAAAAAATAAAATCACCTGGAATCAAAGCAGCAGGGACAGCCTGCGCTGGAGC CGCCAGAACAGGCAGGCGGGCAGCTCCGCAAGACCGAGCAACTCCAGNACGGGAGACGAG GACTGGCAGCTGACATGACCCCTGTGACCAGGACATTTCCAAAGACTGGGGGGCCCCTCC CCAAGCCTCTTTCTTTCCGCCCATTATTTTAACAAAATTCCATGCCTGGCCAGATGGCAA GCCCTACCCTCGGAAACACCTGGGCCCCATTTCCCAAGCCTACCAAGAGGGAAGGAAGGG TGGG |
Restriction Sites | NotI-NotI |
ACCN | NM_031904 |
Insert Size | 4000 bp |
OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
Reference Data | |
RefSeq | NM_031904.2, NP_114110.1 |
RefSeq Size | 3693 bp |
RefSeq ORF | 1395 bp |
Locus ID | 83786 |
UniProt ID | Q9BZ67 |
Domains | B41 |
Gene Summary | Promotes the cell surface stability of iRhom1/RHBDF1 and iRhom2/RHBDF2 and prevents their degradation via the endolysosomal pathway. By acting on iRhoms, involved in ADAM17-mediated shedding of TNF, amphiregulin/AREG, HBEGF and TGFA from the cell surface (PubMed:29897333, PubMed:29897336). Negatively regulates Wnt signaling, possibly by antagonizing the recruitment of AXIN1 to LRP6 (PubMed:19572019).[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). |
Citations (1)
The use of this cDNA Clones has been cited in the following citations: |
---|
FRMD8 promotes inflammatory and growth factor signalling by stabilising the iRhom/ADAM17 sheddase complex
,null,
eLife
,PubMed ID 29897336
[FRMD8]
|
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Other Versions
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RC207879 | FRMD8 (Myc-DDK-tagged)-Human FERM domain containing 8 (FRMD8) |
CNY 3,656.00 |
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RC207879L3 | Lenti ORF clone of Human FERM domain containing 8 (FRMD8), Myc-DDK-tagged |
CNY 5,890.00 |
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RC207879L4 | Lenti ORF clone of Human FERM domain containing 8 (FRMD8), mGFP tagged |
CNY 5,890.00 |
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RG207879 | FRMD8 (tGFP-tagged) - Human FERM domain containing 8 (FRMD8) |
CNY 5,256.00 |