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Beta Arrestin 2 (ARRB2) (NM_004313) Human Untagged Clone
CAT＃: SC108950
ARRB2 (untagged)-Human arrestin, beta 2 (ARRB2), transcript variant 1
CNY 5,488.00
| Cited in 4 publications. |
Product images
热销推荐Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | ARB2; ARR2; BARR2 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_004313 edited
GAATTCGGCACGAGGTGGCAGCGGGCGAGGAGGCTGCGAGCGAGCCGCGAACCGAGCGGG CGGCGGGCGCGCGCACCATGGGGGAGAAACCCGGGACCAGGGTCTTCAAGAAGTCGAGCC CTAACTGCAAGCTCACCGTGTACTTGGGCAAGCGGGACTTCGTAGATCACCTGGACAAAG TGGACCCTGTAGATGGCGTGGTGCTTGTGGACCCTGACTACCTGAAGGACCGCAAAGTGT TTGTGACCCTCACCTGCGCCTTCCGCTATGGCCGTGAAGACCTGGATGTGCTGGGCTTGT CCTTCCGCAAAGACCTGTTCATCGCCACCTACCAGGCCTTCCCCCCGGTGCCCAACCCAC CCCGGCCCCCCACCCGCCTGCAGGACCGGCTGCTGAGGAAGCTGGGCCAGCATGCCCACC CCTTCTTCTTCACCATACCCCAGAATCTTCCATGCTCCGTCACACTGCAGCCAGGCCCAG AGGATACAGGAAAGGCCTGCGGCGTAGACTTTGAGATTCGAGCCTTCTGTGCTAAATCAC TAGAAGAGAAAAGCCACAAAAGGAACTCTGTGCGGCTGGTGATCCGAAAGGTGCAGTTCG CCCCGGAGAAACCCGGCCCCCAGCCTTCAGCCGAAACCACACGCCACTTCCTCATGTCTG ACCGGTCCCTGCACCTCGAGGCTTCCCTGGACAAGGAGCTGTACTACCATGGGGAGCCCC TCAATGTAAATGTCCACGTCACCAACAACTCCACCAAGACCGTCAAGAAGATCAAAGTCT CTGTGAGACAGTACGCCGACATCTGCCTCTTCAGCACCGCCCAGTACAAGTGTCCTGTGG CTCAACTCGAACAAGATGACCAGGTATCTCCCAGCTCCACATTCTGTAAGGTGTACACCA TAACCCCACTGCTCAGTGACAACCGGGAGAAGCGGGGTCTCGCCCTGGATGGGAAACTCA AGCACGAGGACACCAACCTGGCTTCCAGCACCATCGTGAAGGAGGGTGCCAACAAGGAGG TGCTGGGAATCCTGGTGTCCTACAGGGTCAAGGTGAAGCTGGTGGTGTCTCGAGGCGGGG ATGTCTCTGTGGAGCTGCCTTTTGTTCTTATGCACCCCAAGCCCCACGACCACATCCCCC TCCCCAGACCCCAGTCAGCCGCTCCGGAGACAGATGTCCCTGTGGACACCAACCTCATTG AATTTGATACCAACTATGCCACAGATGATGACATTGTGTTTGAGGACTTTGCCCGGCTTC GGCTGAAGGGGATGAAGGATGACGACTATGATGATCAACTCTGCTAGGAAGCGGGGTGGG AAGAAGGGAGGGGATGGGGTTGGGAGAGGTGAGGGCAGGATTAAGATCCCCACTGTCAAT GGGGGATTGTCCCAGCCCCTCTTCCCTTCCCCTCACCTGGAAGCTTCTTCAACCAATCCC TTCACACTCTCTCCCCCATCCCCCCAAGATACACACTGGACCCTCTCTTGCTGAATGTGG GCATTAATTTTTTGACTGCAGCTCTGCTTCTCCAGCCCCGCCGTGGGTGGCAAGCTGTGT TCATACCTAAATTTTCTGGAAGGGGACAGTGAAAAGAGGAGTGACAGGAGGGAAAGGGGG AGACAAAACTCCTACTCTCAACCTCACACCAACACCTCCCATTATCACTCTCTCTGCCCC CATTCCTTCAAGAGGAGACCCTTTGGGGACAAGGCCGTTTCTTTGTTTCTGAGCATAAAG AAGAAAATAAATCTTTTACTAAGAAAAAAAAAAAAAAAAAAACTCGAC >OriGene 5' read for NM_004313 unedited
TGTCAGAAATTTTGTATACGAACTCACTATAGGGCGGCCGCGATTCGGCACGAGGTGGCA GCGGGCGAGGAGGCTGCGAGCGAGCCGCGAACCGAGCGGGCGGCGGGCGCGCGCACCATG GGGGAGAAACCCGGGACCAGGGTCTTCAAGAAGTCGAGCCCTAACTGCAAGCTCACCGTG TACTTGGGCAAGCGGGACTTCGTAGATCACCTGGACAAAGTGGACCCTGTAGATGGCGTG GTGCTTGTGGACCCTGACTACCTGAAGGACCGCAAAGTGTTTGTGACCCTCACCTGCGCC TTCCGCTATGGCCGTGAAGACCTGGATGTGCTGGGCTTGTCCTTCCGCAAAGACCTGTTC ATCGCCACCTAACCAGGCCTTCCCCCCCGGTGCCCAACCCACCCCGGCCCCCCACCCGCC TGCAGGACCGGCTGCTGAGGAAGCTGGGCCAGCATGCCCACCCCTTCTTCTTCACCATAC CCCAGAATCTTCCATGCTCCGTCACACTGCAGCCAGGCCCAGAGGATACAGGAAAGGCCT GCGGCGTAGACTTTGAGATTCGAGCCTTCTGTGCTAAATCACTAGAAGAGAAAAGCCACA AAAGGAACTCTGTGCGGCTGGTGATCCGAAAGGTGCAGTTCGCCCCGGAGAAACCCGGCC CCCAGCCTTCAGCCGAAACCACACGCCACTTCCTCATGTCTGACCGGTCCCTGCACCTCG AGGCTTCCCTGGACAGGGAGCTGTACTACCATGGNGAGCCCCTCATGTANATGTCCACGT CACCAACAACTCCACCAAGACCGTNCAGAAGATCANAGTCTCTGTGAGACAGTACGCCGA CATCTGCCTCTTCAGCACCGCCCAGTACAAGTGTCCTGTGGCTCAACTCGAACAGAATGA CCAGTATCTCCCCAGCTCCATA >OriGene 3' read for NM_004313 unedited
GCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTTCTTAGTAAAAGATTTATTTTTC TTCTTTATGCTCAGAAACAAAGAAACGGCCTTGTCCCCAAAGGGTCTCCTCTTGAAGGAA TGGGGGCAGAGAGAGTGATAATGGGAGGTGTTGGTGTGAGGTTGAAAGTAGGAGTTTTGT CTCCCCCTTTCCCTCCTGTCACTCCTCTTTTCACTGTCCCCTTCCAGAAAATTTAGGTAT GAACACAGCTTGCCACCCACGGCGGGGCTGGAGAAGCAGAGCTGCAGTCAAAAAATTAAT GCCCACATTCAGCAAGAGAGGGTCCAGTGTGTATCTTGGGGGGATGGGGGAGAGAGTGTG AAGGGATCTGGTTTGAAGAAGCTTCCAGGTGAGGGGAAGGGAAGAGGGGCTGGGACAATC CCCCATTGACAGTGGGGATCTTAATCCTGCCCTCACCTCTCCCAACCCCATCCCCTCCCT TCTTCCCACCCCGCTTCCTAGCAGAGTTGATCATCATAGTCGTCATCCTTCATCCCCTTC AGCCGAAGCCGGGCAAAGTCCTCAAACACAATGTCATCATCTGTGGCATAGTTGGTATCA AATTCAATGAGGTTTGGTGTCCACAGGGACATCTGTCTCCGGAGCGGCTGACTGGGGTCT GAGGATGGGGNATGCTGGTCNTGGGGGCTGGGGGTGCATAANAACAAAGGCATCTGCCAG AGACATCCCCGCCTCGAGACACACAAGTTTAACCTAGACCCTGTAAGACACCAGGATTCC CAGCACTTCCTTGNTGGCACCCTNCTCACGATGGTGCTGGAAGCCAGGTTGGTGTCCTCG AGCTTGAGTTTGCATTCAGGGCGATACCCCGCTCTCCCGGTTGCACTGGCCATGGGGGTT GGGGGTCCCCTACAAATTGGGAGCGGGAATCCCGGCATCTTGTCAATTGACCCAGGCCTT GTCCTGGCGGGCGAAGA |
| Restriction Sites | NotI-NotI |
| ACCN | NM_004313 |
| Insert Size | 1880 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_004313.3, NP_004304.1 |
| RefSeq Size | 1936 bp |
| RefSeq ORF | 1230 bp |
| Locus ID | 409 |
| UniProt ID | P32121 |
| Domains | arrestin |
| Protein Families | Druggable Genome |
| Protein Pathways | Chemokine signaling pathway, Endocytosis, MAPK signaling pathway, Olfactory transduction |
| Gene Summary | Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012] Transcript Variant: This variant (1) uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 3. The resulting isoform (1) lacks an alternate internal segment compared to isoform 3. |
Citations (4)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
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Overexpression of β-Arrestins inhibits proliferation and motility in triple negative breast cancer cells
,Bostanabad, SY;Noyan, S;Dedeoglu, BG;Gurdal, H;,
Scientific reports
,PubMed ID 33452359
[ARRB2]
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Cross Talk between Phosphatidylinositol 3-Kinase and Cyclic AMP (cAMP)-Protein Kinase A Signaling Pathways at the Level of a Protein Kinase B/ß-Arrestin/cAMP Phosphodiesterase 4 Complex
,Elisa Bjørgo, Silje A. Solheim, Hilde Abrahamsen, George S. Baillie, Kim M. Brown, Torunn Berge, Klaus Okkenhaug, Miles D. Houslay, and Kjetil Taskén,
Mol. Cell. Biol., Apr 2010; 30: 1660 - 1672
[ARRB2]
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Crosstalk between PI3-Kinase and cAMP-Protein Kinase A signaling pathways at the level of a Protein Kinase B/{beta}-arrestin/cAMP phosphodiesterase-4 complex
,Elisa Bjørgo, Silje A. Solheim, Hilde Abrahamsen, George S. Baillie, Kim M. Brown, Torunn Berge, Klaus Okkenhaug, Miles D. Houslay, and Kjetil Taskén,
Mol. Cell. Biol., Jan 2010; 10.1128/MCB.00696-09
[ARRB2]
|
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Site-specific cleavage of GPCR-engaged Beta-arrestin: Influence of the AT1 receptor conformation on scissile site selection
,ChangWoo Lee, Sumantha Bhatt, Anita Shukla, Russell W. Desnoyer, Satya P. Yadav, Mijin Kim, Sei-Heon Jang, and Sadashiva S. Karnik,
J. Biol. Chem., Aug 2008; 283: 21612 - 21620
[ARRB2]
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Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC201168 | ARRB2 (Myc-DDK-tagged)-Human arrestin, beta 2 (ARRB2), transcript variant 1 |
CNY 5,488.00 |
|
| RC201168L1 | Lenti ORF clone of Human arrestin, beta 2 (ARRB2), transcript variant 1, Myc-DDK-tagged |
CNY 7,888.00 |
|
| RC201168L2 | Lenti ORF clone of Human arrestin, beta 2 (ARRB2), transcript variant 1, mGFP tagged |
CNY 7,888.00 |
|
| RC201168L3 | Lenti ORF clone of Human arrestin, beta 2 (ARRB2), transcript variant 1, Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC201168L4 | Lenti ORF clone of Human arrestin, beta 2 (ARRB2), transcript variant 1, mGFP tagged |
CNY 7,888.00 |
|
| RG201168 | ARRB2 (tGFP-tagged) - Human arrestin, beta 2 (ARRB2), transcript variant 1 |
CNY 7,088.00 |
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