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HSD11B1 (NM_005525) Human Untagged Clone
CAT＃: SC109325
HSD11B1 (untagged)-Human hydroxysteroid (11-beta) dehydrogenase 1 (HSD11B1), transcript variant 1
CNY 2,400.00
CNY 2,950.00
| Cited in 1 publication. |
Product images
CNY 6,281.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | 11-beta-HSD1; 11-DH; CORTRD2; HDL; HSD11; HSD11B; HSD11L; SDR26C1 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC109325 sequence for NM_005525 edited (data generated by NextGen Sequencing)
ATGGCTTTTATGAAAAAATATCTCCTCCCCATTCTGGGGCTCTTCATGGCCTACTACTAC TATTCTGCAAACGAGGAATTCAGACCAGAGATGCTCCAAGGAAAGAAAGTGATTGTCACA GGGGCCAGCAAAGGGATCGGAAGAGAGATGGCTTATCATCTGGCGAAGATGGGAGCCCAT GTGGTGGTGACAGCGAGGTCAAAAGAAACTCTACAGAAGGTGGTATCCCACTGCCTGGAG CTTGGAGCAGCCTCAGCACACTACATTGCTGGCACCATGGAAGACATGACCTTCGCAGAG CAATTTGTTGCCCAAGCAGGAAAGCTCATGGGAGGACTAGACATGCTCATTCTCAACCAC ATCACCAACACTTCTTTGAATCTTTTTCATGATGATATTCACCATGTGCGCAAAAGCATG GAAGTCAACTTCCTCAGTTACGTGGTCCTGACTGTAGCTGCCTTGCCCATGCTGAAGCAG AGCAATGGAAGCATTGTTGTCGTCTCCTCTCTGGCTGGGAAAGTGGCTTATCCAATGGTT GCTGCCTATTCTGCAAGCAAGTTTGCTTTGGATGGGTTCTTCTCCTCCATCAGAAAGGAA TATTCAGTGTCCAGGGTCAATGTATCAATCACTCTCTGTGTTCTTGGCCTCATAGACACA GAAACAGCCATGAAGGCAGTTTCTGGGATAGTCCATATGCAAGCAGCTCCAAAGGAGGAA TGTGCCCTGGAGATCATCAAAGGGGGAGCTCTGCGCCAAGAAGAAGTGTATTATGACAGC TCACTCTGGACCACTCTTCTGATCAGAAATCCATGCAGGAAGATCCTGGAATTTCTCTAC TCAACGAGCTATAATATGGACAGATTCATAAACAAGTAG Clone variation with respect to NM_005525.3 >OriGene 5' read for NM_005525 unedited
ACGAGGAGNAAGTGTGATGAAACATAAGTAAAGCAAATGCCCGAGGGAGAGAGAGAGAAG AGAAGAAAAATATAAAAGAACATCAATAAAAAGAAGTCAGATTTGTTCGAAATCTTGAGG AGTCTTCAGGCCAGCTCCCTGTCGGATGGCTTTTATGAAAAAATTTTTTTCCCCATTCTG GGGCTCTTCATGGCCTACTACTACTATTCTGCAAACGAGGAATTCAGACCAGATATGCTC CAAGGAAATAAAGTGATTGTCACAGGGGCCAGCAAAGGGATCGGAAGATAGATGGCTTAT CATCTGGCGAATATGGGAGCCCATGTGGTGGTGACAGCGAGGTCAAAAGAAACTCTACAG AAGGTGGTATCCCACTGCCTGGAGCTTGGAGCAGCCTCAGCACACTACATTGCTGGCACC ATGGAAGACATGACCTTCGCAGAGCAATTTGTTGCCCAAGCAGGAAAGCTCATGGGAGGA CTAGACATGCTCATTCTCAACCACATCACCAACACTTCTTTGAATCTTTTTCATGATGAT ATTCACCATGTGCGCAAAAGCATGGAAGTCAACTTCCTCAGTTACGTGGTCCTGACTGTA GCTGCCTTGCCCATGCTGAAGCAGAGCAATGGAAGCATTGTTGTCGTCTCCTCTCTGGCT GGGAAAGTGGCTTATCCAATGGTTGCTGCCTATTCTGCAAGCAAGTTTGCTTTGGATGGG TTCTTCTCCTCCTCAGAAAGGATATTCAGTGTCCCAGGTCAAGGATCAATCACTCTCTGG GTTCTTGGCCTCATAGACACCAGAACAGCCCTGAAAGCAGTTTCT >OriGene 3' read for NM_005525 unedited
GGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTCATTTGTACAGTTTATGGTTTT AAAGAAACCATCCTGAATAAGCTCAAGTTATAGCTACCAGTTATGAATTTATAAAGTTTA TGTGACCTTTATTATAATTAATATTGTATTAATCATCACATATTATTATATATAAGATAT AAATTTAATATAACTATCTGGTAATTATACCTATGTTTACTAACAATTTTACAACTGCTG GCTGCAGCGGTGCATGACATTCATTATTATTACATTTCCATTTTGCAAATGTTAAAGGAA CTCCTTCCATTTGTCAGGTGTGACCCATGACTTGCATGTCTCTGGGGACACTCTGGGAAG ATGTCTTCATAGATAAGAGCTCAGATAAACATGAGACAGAACAGTCCCAAAATCCCTCAG CATGCCCAGCCCTCAGGGAGTTCCTACTTGTTTATGAATCTGTCCATATTATAGCTCGTT GAGTAGAGAAATTCCAGGATCTTCCTGCATGGATTTCTGATCAGAAGAGTGGTCCAGAGT GAGCTGTCATAATACACTTCTTCTTGGCGCAGAGCTCCCCCTTTGATGATCTCCAGGGCA CATTCCTCCTTTGGAGCTGCTTGCATATGGACTATCCCAGAAACTGCCTTCATGGCTGTT TCTGTGTCTATGAGGCCAAGAACACAGAGAGTGATTGATACATTGACCCTGGACACTGAA TATTCCTTTCTGATGGAGGAGAAGAACCCATNCCAAGCAAACTTGCTTGCAGAATAGGCA GCAACCCATTGGATAAGCCACTTTCCCAGCCAGNAGANAGACGACAAACCATGCTTCATT GCTCTGCTTCAGCATGGGCAAGGCAGCTACAGTCAGGAACACNNGTACTGAGAAAGTGAC TTCCATGCTTTGCGCCATGGTGAATATCCTCTGAAAGATCCAAGAGTGTGTGATGGGTGA AAATGACTGCTATCCTCCATGACTTCTGTT |
| Restriction Sites | NotI-NotI |
| ACCN | NM_005525 |
| Insert Size | 1400 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_005525.2, NP_005516.1 |
| RefSeq Size | 1405 bp |
| RefSeq ORF | 879 bp |
| Locus ID | 3290 |
| UniProt ID | P28845 |
| Domains | adh_short |
| Protein Families | Druggable Genome, Transmembrane |
| Protein Pathways | Androgen and estrogen metabolism, C21-Steroid hormone metabolism, Metabolic pathways |
| Gene Summary | The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Mutations in this gene and H6PD (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)) are the cause of cortisone reductase deficiency. Alternate splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, May 2011] Transcript Variant: This variant (1) represents the predominant transcript. Variants 1, 2 and 3 encode the same protein. |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Identification of a tumor-promoter cholesterol metabolite in human breast cancers acting through the glucocorticoid receptor
,Voisin, M;de Medina, P;Mallinger, A;Dalenc, F;Huc-Claustre, E;Leignadier, J;Serhan, N;Soules, R;Ségala, G;Mougel, A;Noguer, E;Mhamdi, L;Bacquié, E;Iuliano, L;Zerbinati, C;Lacroix-Triki, M;Chaltiel, L;Filleron, T;Cavaillès, V;Al Saati, T;Rochaix, P;Duprez-Paumier, R;Franchet, C;Ligat, L;Lopez, F;Record, M;Poirot, M;Silvente-Poirot, S;,
Proc. Natl. Acad. Sci. U.S.A.
,PubMed ID 29078321
[HSD11B1]
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Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC203109 | HSD11B1 (Myc-DDK-tagged)-Human hydroxysteroid (11-beta) dehydrogenase 1 (HSD11B1), transcript variant 1 |
CNY 3,600.00 |
|
| RC203109L1 | Lenti ORF clone of Human hydroxysteroid (11-beta) dehydrogenase 1 (HSD11B1), transcript variant 1, Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC203109L2 | Lenti ORF clone of Human hydroxysteroid (11-beta) dehydrogenase 1 (HSD11B1), transcript variant 1, mGFP tagged |
CNY 5,890.00 |
|
| RC203109L3 | Lenti ORF clone of Human hydroxysteroid (11-beta) dehydrogenase 1 (HSD11B1), transcript variant 1, Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC203109L4 | Lenti ORF clone of Human hydroxysteroid (11-beta) dehydrogenase 1 (HSD11B1), transcript variant 1, mGFP tagged |
CNY 6,000.00 |
|
| RG203109 | HSD11B1 (tGFP-tagged) - Human hydroxysteroid (11-beta) dehydrogenase 1 (HSD11B1), transcript variant 1 |
CNY 5,200.00 |
|
| SC321065 | HSD11B1 (untagged)-Human hydroxysteroid (11-beta) dehydrogenase 1 (HSD11B1), transcript variant 1 |
CNY 2,400.00 |
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