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Adenylosuccinate Lyase (ADSL) (NM_000026) Human Untagged Clone
CAT＃: SC110822
ADSL (untagged)-Human adenylosuccinate lyase (ADSL), transcript variant 1
CNY 3,656.00
| Cited in 1 publication. |
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CNY 1,999.00
CNY 2,700.00
热销推荐Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | AMPS; ASASE; ASL |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>NCBI ORF sequence for NM_000026, the custom clone sequence may differ by one or more nucleotides
ATGGCGGCTGGAGGCGATCATGGTTCGCCCGACAGCTACCGCTCACCTCTTGCCTCCCGCTATGCCAGCC CGGAGATGTGCTTCGTGTTTAGCGACAGGTATAAATTCCGGACATGGCGGCAGCTGTGGCTGTGGCTGGC GGAGGCCGAGCAGACATTGGGTTTGCCTATCACAGATGAACAAATCCAGGAGATGAAATCAAACCTGGAG AACATCGACTTCAAGATGGCAGCTGAGGAAGAGAAACGTTTACGACATGATGTGATGGCTCACGTGCACA CATTTGGCCACTGCTGTCCAAAAGCTGCAGGCATTATTCACCTTGGTGCTACTTCTTGCTATGTTGGAGA CAATACTGACTTGATTATTCTTAGAAATGCACTTGACCTGCTTTTGCCAAAGCTTGCCAGAGTGATCTCT CGGCTTGCCGACTTTGCTAAGGAACGAGCCAGTCTACCCACATTAGGTTTCACACATTTCCAGCCTGCAC AGCTGACCACAGTTGGGAAACGTTGCTGTCTTTGGATTCAGGATCTTTGCATGGATCTCCAGAACTTGAA GCGTGTCCGAGATGACCTGCGCTTCCGGGGAGTAAAGGGTACCACTGGCACTCAGGCCAGTTTCCTGCAG CTCTTTGAGGGAGATGACCATAAGGTAGAGCAGCTTGACAAGATGGTGACAGAAAAGGCAGGATTTAAGA GAGCTTTCATCATCACAGGGCAGACATATACACGAAAAGTGGATATTGAAGTACTGTCTGTGCTGGCTAG CTTGGGGGCATCAGTGCACAAGATTTGCACCGACATACGCCTCCTGGCAAACCTCAAGGAGATGGAGGAA CCCTTTGAAAAACAGCAGATTGGCTCAAGTGCGATGCCATATAAGCGGAATCCCATGCGTTCAGAACGTT GCTGCAGTCTTGCCCGCCACCTGATGACCCTTGTCATGGACCCGCTACAGACAGCATCTGTCCAGTGGTT TGAACGCACACTGGATGATAGTGCCAACCGACGGATCTGTTTGGCCGAGGCATTTCTTACCGCAGATACT ATATTGAATACGCTGCAGAACATTTCTGAAGGATTGGTCGTGTACCCCAAAGTAATTGAACGGCGCATTC GGCAAGAGCTGCCTTTCATGGCCACAGAGAACATCATCATGGCCATGGTCAAAGCTGGAGGTAGCCGCCA GGATTGCCATGAGAAAATCAGAGTGCTTTCTCAGCAGGCAGCTTCTGTGGTTAAGCAGGAAGGGGGTGAC AATGACCTCATAGAGCGTATCCAGGTTGATGCCTACTTCAGTCCCATTCACTCCCAGTTGGATCATTTAC TGGATCCTTCTTCTTTCACTGGTCGTGCCTCCCAGCAGGTGCAGAGATTCTTAGAAGAGGAGGTGTATCC CCTGTTAAAACCATATGAAAGCGTGATGAAGGTGAAAGCAGAATTATGTCTGTAG >OriGene 5' read for NM_000026 unedited
CGTCAGATTTGAACTCGACTCATATAGGCGGCCGCTNAATCGGCACGAGGCCTCGTGCCG AATTCGGCACGAGGCAGGGTTGGGATGGCGGCTGGAGGCGATCATGGTTCGCCCGACAGC TACCGCTCACCTCTTGCCTCCCGCTATGCCAGCCCGGAGATGTGCTTCGTGTTTAGCGAC AGGTATAAATTCCGGACATGGCGGCAGCTGTGGCTGTGGCTGGCGGAGGCCGAGCAGACA TTGGGTTTGCCTATCACAGATGAACAAATCCAGGAGATGAAATCAAACCTGGAGAACATC GACTTCAAGATGGCAGCTGAGGAAGAGAAACGTTTACGACATGATGTGATGGCTCACGTG CACACATTTGGCCACTGCTGTCCAAAAGCTGCAGGCATTATTCACCTTGGTGCTACTTCT TGCTATGTTGGAGACAATACTGACTTGATTATTCTTAGAAATGCACTTGACCTGCTTTTG CCAAAGCTTGCCAGAGTGATCTCTCGGCTTGCCGACTTTGCTAAGGAACGAGCCAGTCTA CCCACATTAGGTTTCACACATTTCCAGCCTGCACAGCTGACCACAGTTGGGAAACGTTGC TGTCTTTGGATTCAGGATCTTTGCATGGATCTCCAGAACTTGAAGCGTGTCCGAGATGAC CTGCGCTTCCGGGGAGTAAAGGGTACCACTGGCACTCAGGCCAGTTTCCTGCAGCTCTTT GAGGGAGATGACCATAANGTAGAGCAGCTTGACTAGATGGTGACAGACAAGGCAGGATTT TAGAGAGCTTTCATCATCACAGGGCAGACATATACACGAAAAGTGGATAATGCAGTACTG TCTGTGCTGGCTAGCTTGNGGNCATCAGTGCACAGATTTGCACTGACTACCCCTCTGCCA AACTCAGGAGATGTAGCACCCTTTGAC >OriGene 3' read for NM_000026 unedited
TCGACATATACAATGATTTTCGTTTAATTCTCTTCCAACTCTACATACATAATTCTGCTT TCACCTTCATCACGCTTTCATATGGTTTTAACAGGGGATACACCTCCTCTTCTAAGAATC TCTGCACCTGCTGGGAGGCACGACCAGTGAAAGAAGAAGGATCCAGTAAATGATCCAACT GGGAGTGAATGGGACTGAAGTAGGCATCAACCTGGATACGCTCTATGAGGTCATTGTCAC CCCCTTCCTGCTTAACCACAGAAGCTGCCTGCTGAGAAAGCACTCTGATTTTCTCATGGC AATCCTGGCGGCTACCTCCAGCTTTGACCATGGCCATGATGATGTTCTCTGTGGCCATGA AAGGCAGCTCTTGCCGAATGCGCCGTTCAATTACTTTGGGGTACACGACCAATCCTTCAG AAATGTTCTGCAGCGTATTCAATATAGTATCTGCGGTAAGAAATGCCTCGGCCAAACAGA TCCGTCGGTTGGCACTATCATCCAGTGTGCGTTCAAACCACTGGACAGATGCTGTCTGTA GCGGGTCCATGACAAGGGTCATCATGTGGCGGGCAAGACTGCAGCAACGTTCTGAACGCA TGGGATTCCGCTTATATGGCATCGCACTTGAGCCAATCTGCTGTTTTTCAAAGGGTTCCT CCATCTNCTTGAGGTTGCCAGGAGGCGTATGTCGGTGCAAATCTTGTGCACTGATGCCCC CAAGCTAGCCAGCACAGACAGTACTTAATATCCACTTTCCTGTATATGTCTGCCCTGTGA TGATGATAGCTCTCTTTAATCCTGCCTTTTCTGTCACCATCTTGTCAAGCTGCTCTACCT TATGGTCATTTCCCTAAAGGACTGCAAGAAACTGGCCCTGATGCCATTGTTTCCCTTTTC TCCCAGGATCGCAGTTATCTCCGGCACGCTTAATGTCTGGAAATCCTCCAAATTCCTGAT CCAAACACGTACGTTCCAACTGGGGCACN |
| Restriction Sites | NotI-NotI |
| ACCN | NM_000026 |
| Insert Size | 1650 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_000026.1, NP_000017.1 |
| RefSeq Size | 1692 bp |
| RefSeq ORF | 1455 bp |
| Locus ID | 158 |
| UniProt ID | P30566 |
| Domains | lyase_1 |
| Protein Families | Druggable Genome |
| Protein Pathways | Alanine, aspartate and glutamate metabolism, Metabolic pathways, Purine metabolism |
| Gene Summary | The protein encoded by this gene belongs to the lyase 1 family. It is an essential enzyme involved in purine metabolism, and catalyzes two non-sequential reactions in the de novo purine biosynthetic pathway: the conversion of succinylaminoimidazole carboxamide ribotide (SAICAR) to aminoimidazole carboxamide ribotide (AICAR) and the conversion of adenylosuccinate (S-AMP) to adenosine monophosphate (AMP). Mutations in this gene are associated with adenylosuccinase deficiency (ADSLD), a disorder marked with psychomotor retardation, epilepsy or autistic features. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015] Transcript Variant: This variant (1) represents the predominant transcript and encodes the longest isoform (a). |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Modulation of de novo purine biosynthesis leads to activation of AMPK and results in improved glucose handling and insulin sensitivity
,Sadasivan, SK;Vasamsetti, B;Singh, J;,
Journal of Diabetes &Metabolic Disorders 13 . April 2014
[ADSL]
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Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC200524 | ADSL (Myc-DDK-tagged)-Human adenylosuccinate lyase (ADSL), transcript variant 1 |
CNY 3,656.00 |
|
| RC200524L3 | Lenti ORF clone of Human adenylosuccinate lyase (ADSL), transcript variant 1, Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC200524L4 | Lenti ORF clone of Human adenylosuccinate lyase (ADSL), transcript variant 1, mGFP tagged |
CNY 5,890.00 |
|
| RG200524 | ADSL (tGFP-tagged) - Human adenylosuccinate lyase (ADSL), transcript variant 1 |
CNY 5,256.00 |
|
| SC320633 | ADSL (untagged)-Human adenylosuccinate lyase (ADSL), transcript variant 1 |
CNY 3,656.00 |
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