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TBK1 (NM_013254) Human Untagged Clone
CAT＃: SC111251
TBK1 (untagged)-Human TANK-binding kinase 1 (TBK1)
CNY 5,344.00
| Cited in 2 publications. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | FTDALS4; IIAE8; NAK; T2K |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF sequence for NM_013254 edited
ATGCAGAGCACTTCTAATCATCTGTGGCTTTTATCTGATATTTTAGGCCAAGGAGCTACT GCAAATGTCTTTCGTGGAAGACATAAGAAAACTGGTGATTTATTTGCTATCAAAGTATTT AATAACATAAGCTTCCTTCGTCCAGTGGATGTTCAAATGAGAGAATTTGAAGTGTTGAAA AAACTCAATCACAAAAATATTGTCAAATTATTTGCTATTGAAGAGGAGACAACAACAAGA CATAAAGTACTTATTATGGAATTTTGTCCATGTGGGAGTTTATACACTGTTTTAGAAGAA CCTTCTAATGCCTATGGACTACCAGAATCTGAATTCTTAATTGTTTTGCGAGATGTGGTG GGTGGAATGAATCATCTACGAGAGAATGGTATAGTGCACCGTGATATCAAGCCAGGAAAT ATCATGCGTGTTATAGGGGAAGATGGACAGTCTGTGTACAAACTCACAGATTTTGGTGCA GCTAGAGAATTAGAAGATGATGAGCAGTTTGTTTCTCTGTATGGCACAGAAGAATATTTG CACCCTGATATGTATGAGAGAGCAGTGCTAAGAAAAGATCATCAGAAGAAATATGGAGCA ACAGTTGATCTTTGGAGCATTGGGGTAACATTTTACCATGCAGCTACTGGATCACTGCCA TTTAGACCCTTTGAAGGGCCTCGTAGGAATAAAGAAGTGATGTATAAAATAATTACAGGA AAGCCTTCTGGTGCAATATCTGGAGTACAGAAAGCAGAAAATGGACCAATTGACTGGAGT GGAGACATGCCTGTTTCTTGCAGTCTTTCTCGGGGTCTTCAGGTTCTACTTACCCCTGTT CTTGCAAACATCCTTGAAGCAGATCAGGAAAAGTGTTGGGGTTTTGACCAGTTTTTTGCA GAAACTAGTGATATACTTCACCGAATGGTAATTCATGTTTTTTCGCTACAACAAATGACA GCTCATAAGATTTATATTCATAGCTATAATACTGCTACTATATTTCATGAACTGGTATAT AAACAAACCAAAATTATTTCTTCAAATCAAGAACTTATCTACGAAGGGCGACGCTTAGTC TTAGAACCTGGAAGGCTGGCACAACATTTCCCTAAAACTACTGAGGAAAACCCTATATTT GTAGTAAGCCGGGAACCTCTGAATACCATAGGATTAATATATGAAAAAATTTCCCTCCCT AAAGTACATCCACGTTATGATTTAGACGGGGATGCTAGCATGGCTAAGGCAATAACAGGG GTTGTGTGTTATGCCTGCAGAATTGCCAGTACCTTACTGCTTTATCAGGAATTAATGCGA AAGGGGATACGATGGCTGATTGAATTAATTAAAGATGATTACAATGAAACTGTTCACAAA AAGACAGAAGTTGTGATCACATTGGATTTCTGTATCAGAAACATTGAAAAAACTGTGAAA GTATATGAAAAGTTGATGAAGATCAACCTGGAAGCGGCAGAGTTAGGTGAAATTTCAGAC ATACACACCAAATTGTTGAGACTTTCCAGTTCTCAGGGAACAATAGAAACCAGTCTTCAG GATATCGACAGCAGATTATCTCCAGGTGGATCACTGGCAGACGCATGGGCACATCAAGAA GGCACTCATCCGAAAGACAGAAATGTAGAAAAACTACAAGTCCTGTTAAATTGCATGACA GAGATTTACTATCAGTTCAAAAAAGACAAAGCAGAACGTAGATTAGCTTATAATGAAGAA CAAATCCACAAATTTGATAAGCAAAAACTGTATTACCATGCCACAAAAGCTATGACGCAC TTTACAGATGAATGTGTTAAAAAGTATGAGGCATTTTTGAATAAGTCAGAAGAATGGATA AGAAAGATGCTTCATCTTAGGAAACAGTTATTATCGCTGACTAATCAGTGTTTTGATATT GAAGAAGAAGTATCAAAATATCAAGAATATACTAATGAGTTACAAGAAACTCTGCCTCAG AAAATGTTTACAGCTTCCAGTGGAATCAAACATACCATGACCCCAATTTATCCAAGTTCT AACACATTAGTAGAAATGACTCTTGGTATGAAGAAATTAAAGGAAGAGATGGAAGGGGTG GTTAAAGAACTTGCTGAAAATAACCACATTTTAGAAAGGTTTGGCTCTTTAACCATGGAT GGTGGCCTTCGCAACGTTGACTGTCTTTAG >OriGene 5' read for NM_013254 unedited
ATTTTGTAATACGACTCACTTATAGGGCGGCCGCGAATTCGCACGAGGCCTCGTGCCGAA TTCGGCACGAGGCCCGCCGGCGGTGGCGCGGCGGAGACCCGGCTGGTATAACAAGAGGAT TGCCTGATCCAGCCAAGATGCAGAGCACTTCTAATCATCTGTGGCTTTTATCTGATATTT TAGGCCAAGGAGCTACTGCAAATGTCTTTCGTGGAAGACATAAGAAAACTGGTGATTTAT TTGCTATCAAAGTATTTAATAACATAAGCTTCCTTCGTCCAGTGGATGTTCAAATGAGAG AATTTGAAGTGTTGAAAAAACTCAATCACAAAAATATTGTCAAATTATTTGCTATTGAAG AGGAGACAACAACAAGACATAAAGTACTTATTATGGAATTTTGTCCATGTGGGAGTTTAT ACACTGTTTTAGAAGAACCTTCTAATGCCTATGGACTACCAGAATCTGAATTCTTAATTG TTTTGCGAGATGTGGTGGGTGGAATGAATCATCTACGAGAGAATGGTATAGCGCACCGTG ATATCAAGCCAGGAAATATCATGCGTGTTATAGGGGAAGATGGACAGTCTGTGTACAAAC TCACAGATTTTGGTGCAGCTAGAGAATTACAAGATGATGAGCAGTTTGTTTCTCTGTATG GCACAGAAGAATATTTGCACCCTGATATGTATGAGAGAGCAGTGCTAAGAAAGATCATCA GAAGAATATGGAGCACCAGTTGATCTTTGGAGCATTGGGGTAACATTTTACCATGCAGCT ACTGCATCACTGCCATTTACACCCTTTGGAGGGCCTCGTAGGAATAAAGAAGTGATGTTT AAAATATTTACAGAAAAGCCCTTTGGTGCAAAATCTGAAGACCAGAAGCATAAT >OriGene 3' read for NM_013254 unedited
CCGGCCGCAATCTAGGATCGAGTTTTTTTTTTTTTTTTTTCTTTACATTAAAATTGAGAA ATTTATTTTTTTCCATGAAATAGTAAGCAGAATTAAAGAAATATACAGCTTAAAACAGTT GAAATGACCTTAGAATTTTAATGACAATTACACATTTATGGCCAAAGGAAAAAAATGAAT AGTTTTTAATAATGAATTCACTTTAAAATGTTTGCTTAATAATTCATCTGAAATTACATG GATACAAGGATAACTGGGATCTGGGCACCTTGTAAAATAAAATAATGCCACTTTATCCTT CTCAAAAAAATTGTTATCCCAGTATAACAGTGGTGCGGTTCTGCTCCCCACTCACAGTAG CCACCGTTCTACCATTTACAAACGTGTCAAGTCAGTCTTCCTGATTTGTAAGGATGCCTA TTTTGGTTCCACTTAAAAATATTTCCAGTAGGCGGTCAGAGAAAATAACTTATTTAGCCC CACTCAGAGTAGAGGATCAGTATGTCAACATATTGGTCGGTCATGGCTTTCTTCTCGTGA TCACTGAGGTCAAATTTCCTCATATAATTATAAATGTTAAAAGATAAAATTACATCTTCA CAGCAGCCAAAAATTTGNATATTTTTTATGTATTTACAATATTGTACATATTTACACGAC CACATCAAATACTGAATTGTAGAAACAAGTGACTATCTATAAAGGCATTCATTTAATGCC CAAGCGTTATTTTCTTGTGCAAACGGAAACTTTTCTTAAACTTCTATTAAAAAGCTAAGA CAGTCAACGTTGCGAAGGCCACATCCATGGTTAAAGAGCCAAACCCTTTCTAAATGTGTT ATTTTCAGCAAGTTCTTTAACCACCCTTCCATCTCTTTCTTTAATTNCTCATACCAAGAT CCATTNTACTAAGTGGTAAAACTTGATAATGGGGGCATGGTATGTTGATCCCTGGAACTG AACATTTTT |
| Restriction Sites | NotI-NotI |
| ACCN | NM_013254 |
| Insert Size | 2880 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_013254.2, NP_037386.1 |
| RefSeq Size | 2982 bp |
| RefSeq ORF | 2190 bp |
| Locus ID | 29110 |
| UniProt ID | Q9UHD2 |
| Domains | pkinase, TyrKc, S_TKc |
| Protein Families | Druggable Genome, Protein Kinase |
| Protein Pathways | Cytosolic DNA-sensing pathway, RIG-I-like receptor signaling pathway, Toll-like receptor signaling pathway |
| Gene Summary | The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. [provided by RefSeq, Oct 2010] |
Citations (2)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Evaluating TBK1 as a Therapeutic Target in Cancers with Activated IRF3
,Muvaffak, A;Pan, Q;Yan, H;Fernandez, R;Lim, J;Dolinski, B;Nguyen, TT;Strack, P;Wu, S;Chung, R;Zhang, W;Hulton, C;Ripley, S;Hirsch, H;Nagashima, K;Wong, KK;Janne, PA;Seidel-Dugan, C;Zawel, L;Kirschmeier, PT;Middleton, RE;Morris, EJ;Wang, Y;,
Mol. Cancer Res. April 2014
,PubMed ID 24752990
[TBK1]
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Copy number variations on chromosome 12q14 in patients with normal tension glaucoma
,John H. Fingert, Alan L. Robin, Jennifer L. Stone, Ben R. Roos, Lea K. Davis, Todd E. Scheetz, Steve R. Bennett, Thomas H. Wassink, Young H. Kwon, Wallace L.M. Alward, Robert F. Mullins, Val C. Sheffield, and Edwin M. Stone,
Hum. Mol. Genet., Jun 2011; 20: 2482 - 2494
[TBK1]
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Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC205238 | TBK1 (Myc-DDK-tagged)-Human TANK-binding kinase 1 (TBK1) |
CNY 5,344.00 |
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| RC205238L1 | Lenti ORF clone of Human TANK-binding kinase 1 (TBK1), Myc-DDK-tagged |
CNY 7,744.00 |
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| RC205238L2 | Lenti ORF clone of Human TANK-binding kinase 1 (TBK1), mGFP tagged |
CNY 7,744.00 |
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| RC205238L3 | Lenti ORF clone of Human TANK-binding kinase 1 (TBK1), Myc-DDK-tagged |
CNY 7,744.00 |
|
| RC205238L4 | Lenti ORF clone of Human TANK-binding kinase 1 (TBK1), mGFP tagged |
CNY 7,744.00 |
|
| RG205238 | TBK1 (tGFP-tagged) - Human TANK-binding kinase 1 (TBK1) |
CNY 6,944.00 |
|
| SC323338 | TBK1 (untagged)-Kinase deficient mutant (K38M) of Human TANK-binding kinase 1 (TBK1) |
CNY 5,344.00 |
