Amyloid Precursor Protein (APP) (NM_000484) Human Untagged Clone
CAT#: SC111589
APP (untagged)-Human amyloid beta (A4) precursor protein (APP), transcript variant 1
CNY 8,472.00
Cited in 2 publications. |
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
Product Data | |
Type | Human Untagged Clone |
Tag | Tag Free |
Synonyms | AAA; ABETA; ABPP; AD1; alpha-sAPP; APPI; CTFgamma; CVAP; PN-II; PN2; preA4 |
Vector | pCMV6-XL5 |
E. coli Selection | Ampicillin (100 ug/mL) |
Mammalian Cell Selection | None |
Sequence Data |
>OriGene sequence for NM_000484 edited
CTCTGAGCCCCGCCGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAG CACGCGGAGGAGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAG CAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCG ATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTA CCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGA CTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAA ACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTG CAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGG GGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGT GAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGG ATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAG AAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGA GGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGAT GCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGG AGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAA GAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAA CCCTACGAAGAAGCCACAGAGAGAACCACCAGCATTGCCACCACCACCACCACCACCACA GAGTCTGTGGAAGAGGTGGTTCGAGAGGTGTGCTCTGAACAAGCCGAGACGGGGCCGTGC CGAGCAATGATCTCCCGCTGGTACTTTGATGTGACTGAAGGGAAGTGTGCCCCATTCTTT TACGGCGGATGTGGCGGCAACCGGAACAACTTTGACACAGAAGAGTACTGCATGGCCGTG TGTGGCAGCGCCATGTCCCAAAGTTTACTCAAGACTACCCAGGAACCTCTTGCCCGAGAT CCTGTTAAACTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAG ACACCTGGGGATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCC AAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAAGAGGCAGAACGTCAAGCA AAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAA TCTTTGGAACAGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGA GTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGGAGAACTACATCACCGCTCTG CAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAGAAGTATGTCCGCGCA GAACAGAAGGACAGACAGCACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGATCCC AAGAAAGCCGCTCAGATCCGGTCCCAGGTTATGACACACCTCCGTGTGATTTATGAGCGC ATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAGGAGATTCAGGAT GAAGTTGATGAGCTGCTTCAGAAAGAGCAAAACTATTCAGATGACGTCTTGGCCAACATG ATTAGTGAACCAAGGATCAGTTACGGAAACGATGCTCTCATGCCATCTTTGACCGAAACG AAAACCACCGTGGAGCTCCTTCCCGTGAATGGAGAGTTCAGCCTGGACGATCTCCAGCCG TGGCATTCTTTTGGGGCTGACTCTGTGCCAGCCAACACAGAAAACGAAGTTGAGCCTGTT GATGCCCGCCCTGCTGCCGACCGAGGACTGACCACTCGACCAGGTTCTGGGTTGACAAAT ATCAAGACGGAGGAGATCTCTGAAGTGAAGATGGATGCAGAATTCCGACATGACTCAGGA TATGAAGTTCATCATCAAAAATTGGTGTTCTTTGCAGAAGATGTGGGTTCAAACAAAGGT GCAATCATTGGACTCATGGTGGGCGGTGTTGTCATAGCGACAGTGATCGTCATCACCTTG GTGATGCTGAAGAAGAAACAGTACACATCCATTCATCATGGTGTGGTGGAGGTTGACGCC GCTGTCACCCCAGAGGAGCGCCACCTGTCCAAGATGCAGCAGAACGGCTACGAAAATCCA ACCTACAAGTTCTTTGAGCAGATGCAGAACTAGACCCCCGCCACAGCAGCCTCTGAAGTT GGACAGCAAAACCATTGCTTCACTACCCATCGGTGTCCATTTATAGAATAATGTGGGAAG AAACAAACCCGTTTTATGATTTACTCATTATCGCCTTTTGACAGCTGTGCTGTAACACAA GTAGATGCCTGAACTTGAATTAATCCACACATCAGTAATGTATTCTATCTCTCTTTACAT TTTGGTCTCTATACTACATTATTAATGGGTTTTGTGTACTGTAAAGAATTTAGCTGTATC AAACTAGTGCATGAATAGATTCTCTCCTGATTATTTATCACATAGCCCCTTAGCCAGTTG TATATTATTCTTGTGGTTTGTGACCCAATTAAGTCCTACTTTACATATGCTTTAAGAATC GATGGGGGATGCTTCATGTGAACGTGGGAGTTCAGCTGCTTCTCTTGCCTAAGTATTCCT TTCCTGATCACTATGCATTTTAAAGTTAAACATTTTTAAGTATTTCAGATGCTTTAGAGA GATTTTTTTTCCATGACTGCATTTTACTGTACAGATTGCTGCTTCTGCTATATTTGTGAT ATAGGAATTAAGAGGATACACACGTTTGTTTCTTCGTGCCTGTTTTATGTGCACACATTA GGCATTGAGACTTCAAGCTTTTCTTTTTTTGTCCACGTATCTTTGGGTCTTTGATAAAGA AAAGAATCCCTGTTCATTGTAAGCACTTTTACGGGGCGGGTGGGGAGGGGTGCTCTGCTG GTCTTCAATTACCAAGAATTCTCCAAAACAATTTTCTGCAGGATGATTGTACAGAATCAT TGCTTATGACATGATCGCTTTCTACACTGTATTACATAAATAAATTAAATAAAATAAAAA AAAAAAAAAAAAA >OriGene 5' read for NM_000484 unedited
TACGACTCACTATAGGGCGGCCGCGAATTCGGCACGAGGCTCTGAGCCCCGCCGCCGCGC TCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGGAGCGTGCGCGG GGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCAC TCGCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTG CTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGC CTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTC CAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAA GGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAA GCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGNGCCGCAAGCAGTGCAAGACC CATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTT CTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGGATGTNTNGCGAAACTC ATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATG ACTACGGCATGTTGCTGCCCTGCGGNATTGACAGTNCCGAGGTGACAGTTCTGGGCGCCT GCCCCTGCCTGNAGAAAGCGACATGCGGCTCCCGCTGTGCGGCACGAGATGCCCACGCAG CCTGCCGCCCCGTCCTACTCTCCCTTACCCCGTTCTCTCCCCCTCCCCCCCCCTCCTCCC GCCCCCCCCCCGTCTTTATTACGCGTCCTCCTCTCTCCCTGCATCGTCGTTCCTGGCTGT ACCCCCCCATCTCACCCACTTCGGCCTTCCTCCG >OriGene 3' read for NM_000484 unedited
CCATCGNGANNGATGGCAACTTCCCAGGTTCAGGAAAGCACTGGGGCAGGGTCACAGGGC TGCCACCCGGGTTCTGTTCAGGAAAACAGCTATGACCGCGGCCGCAATCTAGAGTCGAGT TTTTTTTTTTTTTTTTTATTTTATTTAATTTATTTATGTAATACAGTGTAGAAAGCGATC ATGTCATAAGCAATGATTCTGTACAATCATCCTGCAAAAAATTGTTTTGGAGAATTCTTG GTAATTGAAGACCAGCAGAGCACCCCTCCCCACCCGCCCCGTAAAAGTGCTTACAATGAA CAGGGATTCTTTTCTTTATCAAAGACCCAAAGATACGTGGACAAAAAAAGAAAAGCTTGA AGTCTCAATGCCTAATGTGTGCACATAAAACAGGCACGAAGAAACAAACGTGTGTATCCT CTTAATTCCTATATCACAAATATAGCAGAAGCAGCAATCTGTACAGTAAAATGCAGTCAT GGAAAAAAAATCTCTCTAAAGCATCTGAAATACTTAAAAATGTTTAACTTTAAAATGCAT AGTGATCAGGAAAGGAATACTTAGGCAAGAGAAGCAGCTGAACTCCCACGTTCACATGAA GCATCCCCCATCGATTCTTAAAGCATATGTAAAGTAAGACTTAATTGGGTCACACACCAC AAGAATAATATACAACTGGCTAAGGGGCTATGTGATAAATAATCAGGAAAGAATCCTTTC CTGCCCTAGTTTGATACAGCTAAATTCTTTACGGTCACCAAACCCTTTTTTTATTGTTTT TTGAGCCCAATTGTAAGGGGGGGTGGAATCCCTTCCGGGTGTGTGGTTCCATTCAGGGTT AGCTTTTTTTTGTTTTCACTCCCTCTGCCCATGGCGNTTTTGTGTAACCCTAAAAAGGGC GTTTTCTTCCCCCTTTTTCTTTGAGGGCCCAAAGA |
Restriction Sites | NotI-NotI |
ACCN | NM_000484 |
Insert Size | 3600 bp |
OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | The ORF of this clone has been fully sequenced and found to be a perfect match to NM_000484.2. |
Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
Reference Data | |
RefSeq | NM_000484.2, NP_000475.1 |
RefSeq Size | 3641 bp |
RefSeq ORF | 2313 bp |
Locus ID | 351 |
UniProt ID | P05067 |
Domains | Beta-APP, KU, A4_EXTRA |
Protein Families | Druggable Genome, Transmembrane |
Protein Pathways | Alzheimer's disease |
Gene Summary | This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2014] Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a, also known as PreA4 770). |
Citations (2)
The use of this cDNA Clones has been cited in the following citations: |
---|
Excess APP O-glycosylation by GalNAc-T6 decreases Aβ production.
,null,
Journal of biochemistry
,PubMed ID 28053144
[APP]
|
Quantification of protein interaction in living cells by two-photon spectral imaging with fluorescent protein fluorescence resonance energy transfer pair devoid of acceptor bleed-through.
,null,
Cytometry. Part A : the journal of the International Society for Analytical Cytology
,PubMed ID 22076866
[APP]
|
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Other Versions
SKU | Description | Size | Price |
---|---|---|---|
RC221339 | APP (Myc-DDK-tagged)-Human amyloid beta (A4) precursor protein (APP), transcript variant 1 |
CNY 8,456.00 |
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RC221339L1 | Lenti ORF clone of Human amyloid beta (A4) precursor protein (APP), transcript variant 1, Myc-DDK-tagged |
CNY 10,856.00 |
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RC221339L2 | Lenti ORF clone of Human amyloid beta (A4) precursor protein (APP), transcript variant 1, mGFP tagged |
CNY 10,856.00 |
|
RC221339L3 | Lenti ORF clone of Human amyloid beta (A4) precursor protein (APP), transcript variant 1, Myc-DDK-tagged |
CNY 7,700.00 |
|
RC221339L4 | Lenti ORF clone of Human amyloid beta (A4) precursor protein (APP), transcript variant 1, mGFP tagged |
CNY 10,856.00 |
|
RG221339 | APP (tGFP-tagged) - Human amyloid beta (A4) precursor protein (APP), transcript variant 1 |
CNY 10,056.00 |
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