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XPC (NM_004628) Human Untagged Clone
CAT＃: SC117234
XPC (untagged)-Human xeroderma pigmentosum, complementation group C (XPC), transcript variant 1
CNY 10,336.00
| Cited in 1 publication. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | p125; RAD4; XP3; XPCC |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC117234 sequence for NM_004628 edited (data generated by NextGen Sequencing)
ATGGCTCGGAAACGCGCGGCCGGCGGGGAGCCGCGGGGACGCGAACTGCGCAGCCAGAAA TCCAAGGCCAAGAGCAAGGCCCGGCGTGAGGAGGAGGAGGAGGATGCCTTTGAAGATGAG AAACCCCCAAAGAAGAGCCTTCTCTCCAAAGTTTCACAAGGAAAGAGGAAAAGAGGCTGC AGTCATCCTGGGGGTTCAGCAGATGGTCCAGCAAAAAAGAAAGTGGCCAAGGTGACTGTT AAATCTGAAAACCTCAAGGTTATAAAGGATGAAGCCCTCAGCGATGGGGATGACCTCAGG GACTTTCCAAGTGACCTCAAGAAGGCACACCATCTGAAGAGAGGGGCTACCATGAATGAA GACAGCAATGAAGAAGAGGAAGAAAGTGAAAATGATTGGGAAGAGGTTGAAGAACTTAGT GAGCCTGTGCTGGGTGACGTGAGAGAAAGTACAGCCTTCTCTCGATCTCTTCTGCCTGTG AAGCCAGTGGAGATAGAGATTGAAACGCCAGAGCAGGCGAAGACAAGAGAAAGAAGTGAA AAGATAAAACTGGAGTTTGAGACATATCTTCGGAGGGCGATGAAACGTTTCAATAAAGGG GTCCATGAGGACACACACAAGGTTCACCTTCTCTGCCTGCTAGCAAATGGCTTCTATCGA AATAACATCTGCAGCCAGCCAGATCTGCATGCTATTGGCCTGTCCATCATCCCAGCCCGC TTTACCAGAGTGCTGCCTCGAGATGTGGACACCTACTACCTCTCAAACCTGGTGAAGTGG TTCATTGGAACATTTACAGTTAATGCAGAACTTTCAGCCAGTGAACAAGATAACCTGCAG ACTACATTGGAAAGGAGATTTGCTATTTACTCTGCTCGAGATGATGAGGAATTGGTCCAT ATATTCTTACTGATTCTCCGGGCTCTGCAGCTCTTGACCCGGCTGGTATTGTCTCTACAG CCAATTCCTCTGAAGTCAGCAACAGCAAAGGGAAAGAAACCTTCCAAGGAAAGATTGACT GCGGATCCAGGAGGCTCCTCAGAAACTTCCAGCCAAGTTCTAGAAAACCACACCAAACCA AAGACCAGCAAAGGAACCAAACAAGAGGAAACCTTTGCTAAGGGCACCTGCAGGCCAAGT GCCAAAGGGAAGAGGAACAAGGGAGGCAGAAAGAAACGGAGCAAGCCCTCCTCCAGCGAG GAAGATGAGGGCCCAGGAGACAAGCAGGAGAAGGCAACCCAGCGACGTCCGCATGGCCGG GAGCGGCGGGTGGCCTCCAGGGTGTCTTATAAAGAGGAGAGTGGGAGTGATGAGGCTGGC AGCGGCTCTGATTTTGAGCTCTCCAGTGGAGAAGCCTCTGATCCCTCTGATGAGGATTCC GAACCTGGCCCTCCAAAGCAGAGGAAAGCCCCCGCTCCTCAGAGGACAAAGGCTGGGTCC AAGAGTGCCTCCAGGACCCATCGTGGGAGCCATCGTAAGGACCCAAGCTTGCCAGCGGCA TCCTCAAGCTCTTCAAGCAGTAAAAGAGGCAAGAAAATGTGCAGCGATGGTGAGAAGGCA GAAAAAAGAAGCATAGCTGGTATAGACCAGTGGCTAGAGGTGTTCTGTGAGCAGGAGGAA AAGTGGGTATGTGTAGACTGTGTGCACGGTGTGGTGGGCCAGCCTCTGACCTGTTACAAG TACGCCACCAAGCCCATGACCTATGTGGTGGGCATTGACAGTGACGGCTGGGTCCGAGAT GTCACACAGAGGTACGACCCAGTCTGGATGACAGTGACCCGCAAGTGCCGGGTTGATGCT GAGTGGTGGGCCGAGACCTTGAGACCATACCAGAGCCCATTTATGGACAGGGAGAAGAAA GAAGACTTGGAGTTTCAGGCAAAACACATGGACCAGCCTTTGCCCACTGCCATTGGCTTA TATAAGAACCACCCTCTGTATGCCCTGAAGCGGCATCTCCTGAAATATGAGGCCATCTAT CCCGAGACAGCTGCCATCCTTGGGTATTGTCGTGGAGAAGCGGTCTACTCCAGGGATTGT GTGCACACTCTGCATTCCAGAGACACGTGGCTGAAGAAAGCAAGAGTGGTGAGGCTTGGA GAAGTACCCTACAAGATGGTGAAAGGCTTTTCTAACCGTGCTCGGAAAGCCCGACTTGCT GAGCCCCAGCTGCGGGAAGAAAATGACCTGGGCCTGTTTGGCTACTGGCAGACAGAGGAG TATCAGCCCCCAGTGGCCGTGGACGGGAAGGTGCCCCGGAACGAGTTTGGGAATGTGTAC CTCTTCCTGCCCAGCATGATGCCTATTGGCTGTGTCCAGCTGAACCTGCCCAATCTACAC CGCGTGGCCCGCAAGCTGGACATCGACTGTGTCCAGGCCATCACTGGCTTTGATTTCCAT GGCGGCTACTCCCATCCCGTGACTGATGGATACATCGTCTGCGAGGAATTCAAAGACGTG CTCCTGACTGCCTGGGAAAATGAGCAGGCAGTCATTGAAAGGAAGGAGAAGGAGAAAAAG GAGAAGCGGGCTCTAGGGAACTGGAAGTTGCTGGCCAAAGGTCTGCTCATCAGGGAGAGG CTGAAGCGTCGCTACGGGCCCAAGAGTGAGGCAGCAGCTCCCCACACAGATGCAGGAGGT GGACTCTCTTCTGATGAAGAGGAGGGGACCAGCTCTCAAGCAGAAGCGGCCAGGATACTG GCTGCCTCCTGGCCTCAAAACCGAGAAGATGAAGAAAAGCAGAAGCTGAAGGGTGGGCCC AAGAAGACCAAAAGGGAAAAGAAAGCAGCAGCTTCCCACCTGTTCCCATTTGAGAAGCTG TGA Clone variation with respect to NM_004628.4 2061 g=>a;2815 c=>a >OriGene 5' read for NM_004628 unedited
AATCCGGCGCCCGTTGCCGCATTGGGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGC AGAGCTCGTTTAGTGAACCGTCAGAATTTTGTAATACGACTCACTATAGGGCGGCCGCGA ATTCGGCACGAGGCCCAGACAAGCAACATGGCTCGGAAACGCGCGGCCGGCGGGGAGCCG CGGGGACGCGAACTGCGCAGCCAGAAATCCAAGGCCAAGAGCAAGGCCCGGCGTGAGGAG GAGGAGGAGGATGCCTTTGAAGATGAGAAACCCCCAAAGAAGAGCCTTCTCTCCAAAGTT TCACAAGGAAAGAGGAAAAGAGGCTGCAGTCATCCTGGGGGTTCAGCAGATGGTCCAGCA AAAAAGAAAGTGGCCAAGGTGACTGTTAAATCTGAAAACCTCAAGGTTATAAAGGATGAA GCCCTCAGCGATGGGGATGACCTCAGGGACTTTCCAAGTGACCTCAAGAAGGCACACCAT CTGAAGAGAGGGGCTACCATGAATGAAGACAGCAATGAAGAAGAGGAAGAAAGTGAAAAT GATTGGGAAGAGGTTGAAGAACTTAGTGAGCCTGTGCTGGGTGACGTGAGAGAAAGTACA GCCTTCTCTCGATCTCTTCTGCCTGTGAAGCCAGTGGAGATAGAGATTGAAACGCCAGAG CAGGCGAAGACCAGAGGAAGAAGTGAAAAGATAAAACTGGAGTTGGAGACATATCTTCGG AGGGCGATGAAACGTTTCATAAAGGGGTCCATGAGGACACACCACAAGTTACCTTTCTTG GCTGCTAGCAAAGGGGTTCTATCGAATAACATCTGCAGCCAGCCAGATCTGCATGCTATT GGCCTGGCCATTATCCCAGCCCGTTTTCACAGATGCTGCCTCGAGAGGTGAACACCTATA CCCTTAAACCGGGGGAAGGGTTCATG >OriGene 3' read for NM_004628 unedited
GGTAATCTATGNACGCGGCCGCATTCTAGATCGAGTTTTTTTTTTTTTTTTTTTTTAGAT AAATGCTTTATTATTTTCTCAAAATGTTATAAAAGTCATTTCTCCTTAGTACAGAGAGCT TTATACATTTTATCTAGTAATGAATACAATCTAGTTTAACACTGATCTATTTTACTAACA TTTCCTTAATTTTCAATTCGTATTTTTCCTTTTCTTTCCTGATTTTAGCTTTTTTTAGGC TTCTGTCACCACAAAATGTTACTTGGAAAACTAGATCCCAGCAGATGACCTGTACTTCTC TGCTCTCTCCCCTACTGCAAAGAGGCAGTGAGGGCAGCATTAGTAAGCCTGACTCAGGGG AAGGTAAGTGGCCTGCAGAGAAATGGTCCTAGGTCCGCAACCGAGGCGAGTGAACTTGTC GGACAGATGAAGACTCTAACTGGAAGAAACGATCAGCGCATTCACGGATGCACCACCATC CAGAAATCTCCCGGTGGCTTCCATACAAAAACTGATGTTTCTAAAGATGGAAAGAACAGG TCTAGGAGGCAGAAGAGTATCTCCTAGCAAAGTGTTCTGTAGCTCAAAGGGTGAGTGGGC TTTGGTAGCAAAAAGCTTTGAAGGCTTCACCCTGGGTGAATCTGACAAGGGCTGGAGCCA GACGGGACCTGCAGCACCTCCTCAGCTTGGCCTCGTCTCCCCTGACCCCGCCTCCGTGCA TGCTGCCTCAGTTTGCCTTCTCAGCAGAGAAGCCCCCACCACCAGGGGCTGGGCATGCCC AGGGCAGGTGTGGGGCCTGTAGTGGGGCAGCAGCAACTGGTGGGGTGCCCCTCTAGTGGG CGCTCAGCTCACAGCTTCTCAAATGGGGACCAGGTGGGAAGCTGCTGNCTTTCTTTTTCC TTTTGGGTCTTCTTGGGGCCC |
| Restriction Sites | NotI-NotI |
| ACCN | NM_004628 |
| Insert Size | 4000 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_004628.3, NP_004619.2 |
| RefSeq Size | 3714 bp |
| RefSeq ORF | 2823 bp |
| Locus ID | 7508 |
| UniProt ID | Q01831 |
| Domains | Rad4 |
| Protein Families | Druggable Genome |
| Protein Pathways | Nucleotide excision repair |
| Gene Summary | The protein encoded by this gene is a key component of the XPC complex, which plays an important role in the early steps of global genome nucleotide excision repair (NER). The encoded protein is important for damage sensing and DNA binding, and shows a preference for single-stranded DNA. Mutations in this gene or some other NER components can result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2017] Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Phosphorylation of xeroderma pigmentosum group C regulates ultraviolet-induced DNA damage repair
,Shah, P;Zhao, B;Qiang, L;He, YY;,
Nucleic Acids Res.
,PubMed ID 29660033
[XPC]
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Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC204483 | XPC (Myc-DDK-tagged)-Human xeroderma pigmentosum, complementation group C (XPC), transcript variant 1 |
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| RC204483L1 | Lenti-ORF clone of XPC (Myc-DDK-tagged)-Human xeroderma pigmentosum, complementation group C (XPC), transcript variant 1 |
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| RC204483L2 | Lenti-ORF clone of XPC (mGFP-tagged)-Human xeroderma pigmentosum, complementation group C (XPC), transcript variant 1 |
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| RC204483L3 | Lenti-ORF clone of XPC (Myc-DDK-tagged)-Human xeroderma pigmentosum, complementation group C (XPC), transcript variant 1 |
CNY 9,030.00 |
|
| RC204483L4 | Lenti-ORF clone of XPC (mGFP-tagged)-Human xeroderma pigmentosum, complementation group C (XPC), transcript variant 1 |
CNY 12,728.00 |
|
| RG204483 | XPC (tGFP-tagged) - Human xeroderma pigmentosum, complementation group C (XPC), transcript variant 1 |
CNY 11,928.00 |
