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Kinesin Heavy Chain 2 (KIF2A) (NM_004520) Human Untagged Clone
CAT＃: SC117315
KIF2A (untagged)-Human kinesin heavy chain member 2A (KIF2A), transcript variant 1
CNY 4,984.00
| Cited in 4 publications. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | CDCBM3; HK2; KIF2 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_004520 edited
GAATTCGGCACGAGGTCCCTCGGCCCGCTGCTGCTGCTCCAGATGAGGTGATGGCAACGG CCAACTTCGGCAAGATCCAGATCGGGATTTACGTGGAGATCAAGCGCAGCGATGGCCGAA TACATCAAGCAATGGTAACATCTTTAAATGAAGATAATGAAAGTGTAACTGTTGAATGGA TAGAAAATGGAGATACAAAAGGCAAAGAGATTGACCTGGAGAGCATCTTTTCACTTAACC CTGACCTTGTTCCTGATGAAGAAATTGAACCCAGTCCAGAAACACCTCCACCTCCAGCAT CCTCAGCCAAAGTAAACAAAATTGTAAAGAATCGACGGACTGTAGCTTCTATTAAGAATG ACCCTCCTTCAAGAGATAATAGAGTGGTTGGTTCAGCACGTGCACGGCCCAGTCAATTTC CTGAACAGTCTTCCTCTGCACAACAGAATGGTAGTGTTTCAGATATATCTCCAGTTCAAG CTGCAAAAAAGGAATTTGGACCCCCTTCACGTAGAAAATCTAATTGTGTGAAAGAAGTAG AAAAACTGCAAGAAAAACGAGAGAAAAGGAGATTGCAACAGCAAGAACTTAGAGAAAAAA GAGCCCAGGACGTTGATGCTACAAACCCAAATTATGAAATTATGTGTATGATCAGAGACT TTAGAGGAAGTTTGGATTATAGACCATTAACAACAGCAGATCCTATTGATGAACATAGGA TATGTGTGTGTGTAAGAAAACGACCACTCAATAAAAAAGAAACTCAAATGAAAGATCTTG ATGTAATCACAATTCCTAGTAAAGATGTTGTGATGGTACATGAACCAAAACAAAAAGTAG ATTTAACAAGGTACCTAGAAAACCAAACATTTCGTTTTGATTATGCCTTTGATGACTCAG CTCCTAATGAAATGGTTTACAGGTTTACTGCTAGACCACTAGTGGAAACTATATTTGAAA GGGGAATGGCTACATGCTTTGCTTATGGGCAGACTGGAAGTGGAAAAACTCATACTATGG GTGGTGACTTTTCAGGAAAGAACCAAGATTGTTCTAAAGGAATTTATGCATTAGCAGCTC GAGATGTCTTTTTAATGCTAAAGAAGCCAAACTATAAGAAGCTAGAACTTCAAGTATATG CAACCTTCTTTGAAATTTATAGTGGAAAGGTGTTTGACTTGCTAAACAGGAAAACAAAAT TAAGAGTTCTAGAAGATGGAAAACAGCAGGTTCAAGTGGTGGGATTACAGGAACGGGAGG TCAAATGTGTTGAAGATGTACTGAAACTCATTGACATAGGCAACAGTTGCAGAACATCCG GTCAAACATCTGCAAATGCACATTCATCTCGGAGCCATGCAGTGTTTCAGATTATTCTTA GAAGGAAAGGAAAACTACATGGCAAATTTTCTCTCATTGATTTGGCTGGAAATGAAAGAG GAGCTGATACTTCCAGTGCGGACAGGCAAACTAGGCTTGAAGGTGCTGAAATTAATAAAA GCCTTTTAGCACTCAAGGAGTGCATCAGAGCCTTAGGTAGAAATAAACCTCATACTCCTT TCCGTGCAAGTAAACTCACTCAGGTGTTAAGAGATTCTTTCATAGGTGAAAACTCTCGTA CCTGCATGATTGCCACAATCTCTCCAGGAATGGCATCCTGTGAAAATACTCTTAATACAT TAAGATATGCAAATAGAGTAAAGGAGTTTGGAATTAGTCCATCAGACATTCCCTTCTCAC AGGGTAGTGGCAGTCGCCCTGATCTCTCTCCTTCTTATGAATATGACGACTTTTCTCCTT CAGTTACCAGGGTCAAAGAATTGACTGTAGATCCAACTGCTGCTGGTGATGTTCGTCCAA TAATGCACCATCCACCAAACCAGATTGATGACTTAGAGACACAGTGGGGTGTGGGGAGTT CCCCTCAGAGAGATGATCTAAAACTTCTTTGTGAACAAAATGAAGAAGAAGTCTCTCCAC AGTTGTTTACTTTCCACGAAGCTGTTTCACAAATGGTAGAAATGGAAGAACAAGTTGTAG AAGATCACAGGGCAGTGTTCCAGGAATCTATTCGGTGGTTAGAAGATGAAAAGGCCCTCT TAGAGATGACTGAAGAAGTAGATTATGATGTCGATTCATATGCTACACAACTTGAAGCTA TTCTTGAGCAAAAAATAGACATTTTAACTGAACTGCGGGATAAAGTGAAATCTTTCCGTG CAGCTCTACAAGAGGAGGAACAAGCCAGCAAGCAAATCAACCCGAAGAGACCCCGTGCCC TTTAAACCGGCATTTGCTGCTAAAGGATACCCAGAACCCTCACTACTGTAACATACAACG GTTCAGCTGTAAGGGCCATTTGAAAGTTTGGAATTTTAAGTGTCTGTGGAAAATGTTTTG TCCTTCACCTGAATTACATTTCAATTTTGTGAAACACTCTTTTGTCTACAAAATGCTTCT AGTCCAGGAGGCACAACCAAGAACTGGGATTAATGAAGCATTTTGTTTCATTTACACAAA TAGTGATTTACTTTTGGAGATCCTTGTCAGTTTTATTTTCTATTTGATGAAGTAAGACTG TGGACTCAATCCAGAGCCAGATAGTAGGGGGAAGCCACAGCATTTCCTTTTAACTCAGTT CAATTTTTGTAGTGAGACTGAGCAGTTTTAAATCCTTTGCGTGCATGCATACCTCATCAG TGATTGTACATACCTTGCCCACTCCTAGAGACAGCTGTGCTCACCTTTTCCTGCTTTGTG CCTTGATTAAGGCTACTGACCCTAAATTTCTGAAGCACAGCCAAGAAAAATTACATTCCT TGTCATTGTAAATTACCTTTGTGTGTACATTTTTACTGTATTTGAGACATTTTTTGTGTG TGACTAGTTAATTTTGCAGGATGTGCCATATCATTGAACGGAACTAAAGTCTGTGACAGT GGATATAGCTGCTGGACCATTCCATCTTATATGTAAAGAAATCTGGAATTATTATTTTAA AACCATATAACATGTGATTATAATTTTTCTTAGCATTTTCTTTGTAAAGAACTACAATAT AAACTAGTTGGTGTATAATAAAAAGTAATGAAATTCAAAAAAAAAAAAAAAAAACTCGAC >OriGene 5' read for NM_004520 unedited
AATACGACTCACTATAGGGCGGCCGCGAATTCGGCACGAGGTCCCTCGGCCCGCTGCTGC TGCTCCAGATGAGGTGATGGCAACGGCCAACTTCGGCAAGATCCAGATCGGGATTTACGT GGAGATCAAGCGCAGCGATGGCCGAATACATCAAGCAATGGTAACATCTTTAAATGAAGA TAATGAAAGTGTAACTGTTGAATGGATAGAAAATGGAGATACAAAAGGCAAAGAGATTGA CCTGGAGAGCATCTTTTCACTTAACCCTGACCTTGTTCCTGATGAAGAAATTGAACCCAG TCCAGAAACACCTCCACCTCCAGCATCCTCAGCCAAAGTAAACAAAATTGTAAAGAATCG ACGGACTGTAGCTTCTATTAAGAATGACCCTCCTTCAAGAGATAATAGAGTGGTTGGTTC AGCACGTGCACGGCCCAGTCAATTTCCTGAACAGTCTTCCTCTGCACAACAGAATGGTAG TGTTTCAGATATATCTCCAGTTCAAGCTGCAAAAAAGGAATTTGGACCCCCTTCACGTAA CTAAATCTAATTGTGTGAAAGAAGTAGAAAAACTGCAAGAAAAACGAGAGAAAAGGAGAA TTGCACAGCAAGAACTTAGAGAANAAAGAGCCCAGGACGTTGATGCTACANACCCAAATT ATGAAATTATGTGTATGATCAGAGACTNTAGAGGAAAGTTTGATTATAGACCATTNACCA CAGCAGATCCTATTGATGAACATANGATATGTGNTGTGTGTAAGAAAACCGACCCACTCA TANNAAAGAAACTCAAATGAAAAGATCTTGATGTAATCACAATTCCTAGTAAAGATGTNG NGATGGTCCATGAACCCAAACAAAAGTAGATTTACAGGTACCTANAAAACCACCATTTCG TTTGATTATGCTTTGAGACTCACTCCTATGAATGGNTT >OriGene 3' read for NM_004520 unedited
TTGGACCGCGNGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTGAATTTCATTAC TTTTTATTATACACCAACTAGTTTATATTGTAGTTCTTTACAAAGAAAATGCTAAGAAAA ATTATAATCACATGTTATATGGTTTTAAAATAATAATTCCAGATTTCTTTACATATAAGA TGGAATGGTCCAGCAGCTATATCCACTGTCACAGACTTTAGTTCCGTTCAATGATATGGC ACATCCTGCAAAATTAACTAGTCACACACAAAAAATGTCTCAAATACAGTAAAAATGTAC ACACAAAGGTAATTTACAATGACAAGGAATGTAATTTTTCTTGGCTGTGCTTCAGAAATT TAGGGTCAGTAGCCTTAATCAAGGCACAAAGCAGGAAAAGGTGAGCACAGCTGTCTCTAG GAGTGGGCAAGGTATGTACAATCACTGATGAGGTATGCATGCACGCAAAGGATTTAAAAC TGCTCAGTCTCACTACAAAAATTGAACTGAGTTAAAAGGAAATGCTGTGGCTTCCCCCTA CTATCTGGCTCTGGATTGAGTCCACAGTCTTACTTCATCAAATAGAAAATAAAACTGACA AGGATCTCCAAAAGTAAATCACTATTTGTGTAAATGAAACAAAATGCTTCATTAATCCCA GTTCTTGGTTGTGCCTCCTGGACTAGAAGCATTTTGTAGACAAAAGAGTGTTTCACAAAA TTGAAATGTAATTCAGGTGAAGGACAAAACATTTTCCACAGACACTTAAAATTCCAAACT TTCAAATGGNCCCTTACAGCTGAACCGTTGTATGTTACAGTAGTGAAGGGGTCTGGGTAT CCTTTAGCAGCAAATGCCGGNTTAAAGGGCACGGNNGTCTCTTNCGGNNTGNNATTGCTG CTGGGCTGTTCCTCCTT |
| Restriction Sites | NotI-NotI |
| ACCN | NM_004520 |
| Insert Size | 3200 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_004520.1, NP_004511.1 |
| RefSeq Size | 2905 bp |
| RefSeq ORF | 2040 bp |
| Locus ID | 3796 |
| UniProt ID | O00139 |
| Domains | kinesin |
| Protein Families | Druggable Genome |
| Gene Summary | The protein encoded by this gene is a plus end-directed motor required for normal mitotic progression. The encoded protein is required for normal spindle activity during mitosis and is necessary for normal brain development. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011] Transcript Variant: This variant (1) lacks an alternate in-frame exon compared to variant 2. The resulting isoform (1) has the same N- and C-termini but is shorter compared to isoform 2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
Citations (4)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
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Conditional switching of KIF2A mutation provides new insights into cortical malformations pathogeny
,Gilet, J;Ivanova, E;Trofimova, D;Rudolf, G;Meziane, H;Broix, L;Drouot, N;Courraud, J;Skory, V;Voulleminot, P;Osipenko, M;Bahi-Buisson, N;Yalcin, B;Birling, MC;Hinckelmann, MV;Kwok, BH;Allingham, JS;Chelly, J;,
Hum. Mol. Genet.
,PubMed ID 31919497
[KIF2A]
|
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Ciliogenesis and cell cycle alterations contribute to KIF2A-related malformations of cortical development
,Broix, L;Asselin, L;Silva, CG;Ivanova, EL;Tilly, P;Gilet, JG;Lebrun, N;Jagline, H;Muraca, G;Saillour, Y;Drouot, N;Reilly, ML;Francis, F;Benmerah, A;Bahi-Buisson, N;Belvindrah, R;Nguyen, L;Godin, JD;Chelly, J;Hinckelmann, MV;,
Hum. Mol. Genet.2017
,PubMed ID 29077851
[KIF2A]
|
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A patient with lissencephaly, developmental delay, and infantile spasms, due to de novo heterozygous mutation of KIF2A
,Tian, G;Cristancho, AG;Dubbs, HA;Liu, GT;Cowan, NJ;Goldberg, EM;,
Molecular Genetics & Genomic Medicine
,PubMed ID 27896282
[KIF2A]
|
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Mutations in TUBG1, DYNC1H1, KIF5C and KIF2A cause malformations of cortical development and microcephaly
,Karine Poirier, Nicolas Lebrun, Loic Broix, Guoling Tian, Yoann Saillour, + et al.,
Nature Genetics doi:10.1038/ng.2613
,PubMed ID 23603762
[KIF2A]
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Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC205132 | KIF2A (Myc-DDK-tagged)-Human kinesin heavy chain member 2A (KIF2A), transcript variant 1 |
CNY 4,976.00 |
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| RC205132L3 | Lenti ORF clone of Human kinesin heavy chain member 2A (KIF2A), transcript variant 1, Myc-DDK-tagged |
CNY 9,310.00 |
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| RC205132L4 | Lenti ORF clone of Human kinesin heavy chain member 2A (KIF2A), transcript variant 1, mGFP tagged |
CNY 9,310.00 |
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| RG205132 | KIF2A (tGFP-tagged) - Human kinesin heavy chain member 2A (KIF2A), transcript variant 1 |
CNY 8,170.00 |
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| SC318185 | KIF2A (untagged)-Human kinesin heavy chain member 2A (KIF2A), transcript variant 1 |
CNY 13,590.00 |
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