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CXCR4 (NM_003467) Human Untagged Clone
CAT＃: SC117951
CXCR4 (untagged)-Human chemokine (C-X-C motif) receptor 4 (CXCR4), transcript variant 2
CNY 5,488.00
| Cited in 3 publications. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | CD184; D2S201E; FB22; HM89; HSY3RR; LAP-3; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM; WHIMS |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_003467 edited
GAATTCGGCACGAGGGCCGAGGGCCTGAGTGCTCCAGTAGCCACCGCATCTGGAGAACCA GCGGTTACCATGGAGGGGATCAGTATATACACTTCAGATAACTACACCGAGGAAATGGGC TCAGGGGACTATGACTCCATGAAGGAACCCTGTTTCCGTGAAGAAAATGCTAATTTCAAT AAAATCTTCCTGCCCACCATCTACTCCATCATCTTCTTAACTGGCATTGTGGGCAATGGA TTGGTCATCCTGGTCATGGGTTACCAGAAGAAACTGAGAAGCATGACGGACAAGTACAGG CTGCACCTGTCAGTGGCCGACCTCCTCTTTGTCATCACGCTTCCCTTCTGGGCAGTTGAT GCCGTGGCAAACTGGTACTTTGGGAACTTCCTATGCAAGGCAGTCCATGTCATCTACACA GTCAACCTCTACAGCAGTGTCCTCATCCTGGCCTTCATCAGTCTGGACCGCTACCTGGCC ATCGTCCACGCCACCAACAGTCAGAGGCCAAGGAAGCTGTTGGCTGAAAAGGTGGTCTAT GTTGGCGTCTGGATCCCTGCCCTCCTGCTGACTATTCCCGACTTCATCTTTGCCAACGTC AGTGAGGCAGATGACAGATATATCTGTGACCGCTTCTACCCCAATGACTTGTGGGTGGTT GTGTTCCAGTTTCAGCACATCATGGTTGGCCTTATCCTGCCTGGTATTGTCATCCTGTCC TGCTATTGCATTATCATCTCCAAGCTGTCACACTCCAAGGGCCACCAGAAGCGCAAGGCC CTCAAGACCACAGTCATCCTCATCCTGGCTTTCTTCGCCTGTTGGCTGCCTTACTACATT GGGATCAGCATCGACTCCTTCATCCTCCTGGAAATCATCAAGCAAGGGTGTGAGTTTGAG AACACTGTGCACAAGTGGATTTCCATCACCGAGGCCCTAGCTTTCTTCCACTGTTGTCTG AACCCCATCCTCTATGCTTTCCTTGGAGCCAAATTTAAAACCTCTGCCCAGCACGCACTC ACCTCTGTGAGCAGAGGGTCCAGCCTCAAGATCCTCTCCAAAGGAAAGCGAGGTGGACAT TCATCTGTTTCCACTGAGTCTGAGTCTTCAAGTTTTCACTCCAGCTAACACAGATGTAAA AGACTTTTTTTTATACGATAAATAACTTTTTTTTAAGTTACACATTTTTCAGATATAAAA GACTGACCAATATTGTACAGTTTTTATTGCTTGTTGGATTTTTGTCTTGTGTTTCTTTAG TTTTTGTGAAGTTTAATTGACTTATTTATATAAATTTTTTTTTGTTTCATATTGATGTGT GTCTAGGCAGGACCTGTGGCCAAGTTCTTAGTTGCTGTATGTCTCGTGGTAGGACTGTAG AAAAGGGAACTGAACATTCCAGAGCGTGTAGTGAATCACGTAAAGCTAGAAATGATCCCC AGCTGTTTATGCATAGATAATCTCTCCATTCCCGTGGAACGTTTTTCCTGTTCTTAAGAC GTGATTTTGCTGTAGAAGATGGCACTTATAACCAAAGCCCAAAGTGGTATAGAAATGCTG GTTTTTCAGTTTTCAGGAGTGGGTTGATTTCAGCACCTACAGTGTACAGTCTTGTATTAA GTTGTTAATAAAAGTACATGTTAAACTTAAAAAAAAAAAAAAAAAACTCGAC >OriGene 5' read for NM_003467 unedited
TTACTATTTGTATACGACTCACTATAGGGNNCGGCCGCGCAATTCGGCACGAGGGCCGAG GGCCTGAGTGCTCCAGTAGCCACCGCATCTGGAGAACCAGCGGTTACCATGGAGGGGATC AGTATATACACTTCAGATAACTACACCGAGGAAATGGGCTCAGGGGACTATGACTCCATG AAGGAACCCTGTTTCCGTGAAGAAAATGCTAATTTCAATAAAATCTTCCTGCCCACCATC TACTCCATCATCTTCTTAACTGGCATTGTGGGCAATGGATTGGTCATCCTGGTCATGGGT TACCAGAAGAAACTGAGAAGCATGACGGACAAGTACAGGCTGCACCTGTCAGTGGCCGAC CTCCTCTTTGTCATCACGCTTCCCTTCTGGGCAGTTGATGCCGTGGCAAACTGGTACTTT GGGAACTTCCTATGCAAGGCAGTCCATGTCATCTACACAGTCAACCTCTACAGCAGTGTC CTCATCCTGGCCTTCATCAGTCTGGACCGCTACCTGGCCATCGTCCACGCCACCAACAGT CAGAGGCCAAGGAAGCTGTTGGCTGAAAAGGTGGTCTATGTTGGCATCTGGATCCCTGCC CTCCTGCTGACTATTCCCGACTTCATCTTTGCCAACGTCAGTGAGGCAGATGACAGATAT ATCTGTGACCGCTCCTACCCCATGACTTGTGGGTGTTTGTGTTCCAGTTTCAGCACATAA TGGTTTGGCCTTATCCTGCCTTGTTATGGCCATCCTGTCCTGCTATTGCATTATCATCTC CAAGCTGTTACATTCCAGGGGCCACAGAAAGCGCAAGCCCCTCAAGACCACAGGCATCCT CATCCTTGCTTTTTTCGCCTGTGGCTGGCTTACTACATTGGGTACAGGATTGACTCCTTA ATCCTCTGGAAAAATCAACCAAGGGGTGAG >OriGene 3' read for NM_003467 unedited
TGGACCGCGGGCCGCAATCTANAGTCGAGTTTTTTTTTTTTTTTTTTAAGTTTAACATGT ACTTTTATTAACAACTTAATACAAGACTGTACACTGTAGGTGCTGAAATCAACCCACTCC TGAAAACTGAAAAACCAGCATTTCTATACCACTTTGGGCTTTGGTTATAAGTGCCATCTT CTACAGCAAAATCACGTCTTAAGAACAGGAAAAACGTTCCACGGGAATGGAGAGATTATC TATGCATAAACAGCTGGGGATCATTTCTAGCTTTACGTGATTCACTACACGCTCTGGAAT GTTCAGTTCCCTTTTCTACAGTCCTACCACGAGACATACAGCAACTAAGAACTTGGCCAC AGGTCCTGCCTAGACACACATCAATATGAAACAAAAAAAAATTTATATAAATAAGTCAAT TAAACTTCACAAAAACTAAAGAAACACAAGACAAAAATCCAACAAGCAATAAAAACTGTA CAATATTGGTCAGTCTTTTATATCTGAAAAATGTGTAACTTAAAAAAAAGTTATTTATCG TATAAAAAAAAGTCTTTTACATCTGTGTTAGCTGGAGTGAAAACTTGAAGACTCAGACTC AGTGGAAACAGATGAATGTCCACCTCGCTTTCCTTTGGAGAGGATCTTGAGGCTGGACCC TCTGCTCACAGAGGTGAGTGCGTGCTGGGCAAAGGTTTTAAATTTGGCTCCAAGGAAAGC ATAGAGGATGGGGTTCAGACAACAGTGGAAGAAAGCTAAGCCCCTCGTGATGGAAATCCA CTTGTGCACAGGGTTCTCAAACTCACACCCTTGCTTGATGATTCCCAGNAGGATGAAGGA GTCAATGCTGATCCCAATGTANTAAGGCAGCCAACCAGCGAAAAAGCCAGGATGAAGATG ACTGTGGTCTTGAG |
| Restriction Sites | NotI-NotI |
| ACCN | NM_003467 |
| Insert Size | 1720 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_003467.2, NP_003458.1 |
| RefSeq Size | 1691 bp |
| RefSeq ORF | 1059 bp |
| Locus ID | 7852 |
| UniProt ID | P61073 |
| Domains | 7tm_1 |
| Protein Families | Druggable Genome, ES Cell Differentiation/IPS, GPCR, Transmembrane |
| Protein Pathways | Axon guidance, Chemokine signaling pathway, Cytokine-cytokine receptor interaction, Endocytosis, Leukocyte transendothelial migration |
| Gene Summary | This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 3. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform c. |
Citations (3)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
CXCR4 HAS THE POTENTIAL TO ENHANCE BONE FORMATION IN OSTEOPENIC RATS
,Sanghani, A;Osagie-Clouard, L;Samizadeh, S;Coathup, MJ;Kalia, P;DiSilvio, L;Blunn, G;,
Tissue Eng Part A
,PubMed ID 29882473
[CXCR4]
|
|
Osteoporosis and ageing affects the migration of stem cells and this is ameliorated by transfection with CXCR4
,Sanghani-Kerai, A;Coathup, M;Samazideh, S;Kalia, P;Silvio, LD;Idowu, B;Blunn, G;,
Bone Joint Res
,PubMed ID 28576885
[CXCR4]
|
|
CXCR4 Antagonists: A Screening Strategy for Identification of Functionally Selective Ligands
,Castaldo, C;Benicchi, T;Otrocka, M;Mori, E;Pilli, E;Ferruzzi, P;Valensin, S;Diamanti, D;Fecke, W;Varrone, M;Porcari, V;,
J Biomol Screen
,PubMed ID 24632660
[CXCR4]
|
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC202069 | CXCR4 (Myc-DDK-tagged)-Human chemokine (C-X-C motif) receptor 4 (CXCR4), transcript variant 2 |
CNY 5,488.00 |
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| RC202069L1 | Lenti ORF clone of Human chemokine (C-X-C motif) receptor 4 (CXCR4), transcript variant 2, Myc-DDK-tagged |
CNY 7,888.00 |
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| RC202069L2 | Lenti ORF clone of Human chemokine (C-X-C motif) receptor 4 (CXCR4), transcript variant 2, mGFP tagged |
CNY 5,890.00 |
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| RC202069L3 | Lenti ORF clone of Human chemokine (C-X-C motif) receptor 4 (CXCR4), transcript variant 2, Myc-DDK-tagged |
CNY 7,888.00 |
|
| RC202069L4 | Lenti ORF clone of Human chemokine (C-X-C motif) receptor 4 (CXCR4), transcript variant 2, mGFP tagged |
CNY 7,888.00 |
|
| RG202069 | CXCR4 (tGFP-tagged) - Human chemokine (C-X-C motif) receptor 4 (CXCR4), transcript variant 2 |
CNY 7,088.00 |
