United States
Germany
Japan
United Kingdom
China
TGF beta 2 (TGFB2) (NM_003238) Human Untagged Clone
CAT＃: SC118070
TGFB2 (untagged)-Human transforming growth factor, beta 2 (TGFB2), transcript variant 2
CNY 5,488.00
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | G-TSF; LDS4; TGF-beta2 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_003238 edited
GAATTCGGCACGAGGGTCTCTTTTTTTCCCCATCTCATTGCTCCAAGAATTTTTTTCTTC TTACTCGCCAAAGTCAGGGTTCCCTCTGCCCGTCCCGTATTAATATTTCCACTTTTGGAA CTACTGGCCTTTTCTTTTTAAAGGAATTCAAGCAGGATACGTTTTTCTGTTGGGCATTGA CTAGATTGTTTGCAAAAGTTTCGCATCAAAAACAAACAACAACAACAAAAAACCAAACAA CTCTCCTTGATCTATACTTTGAGAATTGTTGATTTCTTTTTTTTATTCTGACTTTTAAAA ACAACTTTTTTTTCCACTTTTTTAAAAAATGCACTACTGTGTGCTGAGCGCTTTTCTGAT CCTGCATCTGGTCACGGTCGCGCTCAGCCTGTCTACCTGCAGCACACTCGATATGGACCA GTTCATGCGCAAGAGGATCGAGGCGATCCGCGGGCAGATCCTGAGCAAGCTGAAGCTCAC CAGTCCCCCAGAAGACTATCCTGAGCCCGAGGAAGTCCCCCCGGAGGTGATTTCCATCTA CAACAGCACCAGGGACTTGCTCCAGGAGAAGGCGAGCCGGAGGGCGGCCGCCTGCGAGCG CGAGAGGAGCGACGAAGAGTACTACGCCAAGGAGGTTTACAAAATAGACATGCCGCCCTT CTTCCCCTCCGAAAATGCCATCCCGCCCACTTTCTACAGACCCTACTTCAGAATTGTTCG ATTTGACGTCTCAGCAATGGAGAAGAATGCTTCCAATTTGGTGAAAGCAGAGTTCAGAGT CTTTCGTTTGCAGAACCCAAAAGCCAGAGTGCCTGAACAACGGATTGAGCTATATCAGAT TCTCAAGTCCAAAGATTTAACATCTCCAACCCAGCGCTACATCGACAGCAAAGTTGTGAA AACAAGAGCAGAAGGCGAATGGCTCTCCTTCGATGTAACTGATGCTGTTCATGAATGGCT TCACCATAAAGACAGGAACCTGGGATTTAAAATAAGCTTACACTGTCCCTGCTGCACTTT TGTACCATCTAATAATTACATCATCCCAAATAAAAGTGAAGAACTAGAAGCAAGATTTGC AGGTATTGATGGCACCTCCACATATACCAGTGGTGATCAGAAAACTATAAAGTCCACTAG GAAAAAAAACAGTGGGAAGACCCCACATCTCCTGCTAATGTTATTGCCCTCCTACAGACT TGAGTCACAACAGACCAACCGGCGGAAGAAGCGTGCTTTGGATGCGGCCTATTGCTTTAG AAATGTGCAGGATAATTGCTGCCTACGTCCACTTTACATTGATTTCAAGAGGGATCTAGG GTGGAAATGGATACACGAACCCAAAGGGTACAATGCCAACTTCTGTGCTGGAGCATGCCC GTATTTATGGAGTTCAGACACTCAGCACAGCAGGGTCCTGAGCTTATATAATACCATAAA TCCAGAAGCATCTGCTTCTCCTTGCTGCGTGTCCCAAGATTTAGAACCTCTAACCATTCT CTACTACATTGGCAAAACACCCAAGATTGAACAGCTTTCTAATATGATTGTAAAGTCTTG CAAATGCAGCTAAAATTCTTGGAAAAGTGGCAAGACCAAAATGACAATGATGATGATAAT GATGATGACGACGACAACGATGATGCTTGTAACAAGAAAACATAAGAGAGCCTTGGTTCA TCAGTGTTAAAAAATTTTTGAAAAGGCGGTACTAGTTCAGACACTTTGGAAGTTTGTGTT CTGTTTGTTAAAACTGGCATCTGACACAAAAAATGTTGAAGGCCTTATTCTACATTTCAC CTACTTTGTAAGTGAGAGAGACAAGAAGCAAATTTTTTTTAAAGAAAAAAATAAACACTG GAAGAATTTATTAGTGTTAATTATGTGAACAACGACAACAACAACAACAACAACAAACAG GAAAATCCCATTAAGTGGAGTTGCTGTACGTACCGTTCCTATCCCGCGCCTCACTTGATT TTTCTGTATTGCTATGCAATAGGCACCCTTCCCATTCTTACTCTTAGAGTTAACAGTGAG TTATTTATTGTGTGTTACTATATAATGAACGTTTCATTGCCCTTGGAAAATAAAACAGGT GTATAAAGTGGAGACCAAATACTTTGCCAGAAACTCATGGATGGCTTAAGGAACTTGAAC TCAAACGAGCCAGAAAAAAAGAGGTCATATTAATGGGATGAAAACCCAAGTGAGTTATTA TATGACCGAGAAAGTCTGCATTAAGATAAAGACCCTGAAAACACATGTTATGTATCAGCT GCCTAAGGAAGCTTCTTGTAAGGTCCAAAAACTAAAAAGCCTGTTAATAAAAGAAACTTT CAGTCAGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACTCGAC >OriGene 5' read for NM_003238 unedited
TCAGAATTTTGTAATACGACTCACTTATAGGGCGGCCGCGAATTCGCACGAGGGTCTCTT TTTTTCCCCATCTCATTGCTCCAANAATTTTTTTCTTCTTACTCGCCAAAGTCAGGGTTC CCTCTGCCCGTCCCGTATTAATATTTCCACTTTTGGAACTACTGGCCTTTTCTTTTTAAA GGAATTCAAGCAGGATACGTTTTTCTGTTGGGCATTGACTAGATTGTTTGCAAAAGTTTC GCATCAAAAACAAACAACAACAACAAAAAACCAAACAACTCTCCTTGATCTATACTTTGA GAATTGTTGATTTCTTTTTTTTATTCTGACTTTTAAAAACAACTTTTTTTTCCACTTTTT TAAAAAATGCACTACTGTGTGCTGAGCGCTTTTCTGATCCTGCATCTGGTCACGGTCGCG CTCAGCCTGTCTACCTGCAGCACACTCGATATGGACCAGTTCATGCGCAAGAGGATCGAG GCGATCCGCGGGCAGATCCTGAGCAAGCTGAAGCTCACCAGTCCCCCAGAAGACTATCCT GAGCCCGAGGAAGTCCCCCCGGAGGTGATTTCCATCTACAACAGCACCAGGGACTTGCTC CAGGAGAAGGCGAGCCGGAGGGCGGCCGCCTGCGAGCGCGAGAGGAGCGACGAAGAGTAC TACGCCAAGGAGGTTTACAAAATAGACATGCCGCCCTTCTTCCCCTCCGAAAATGCCATC CCGCCCACTTTCTACAGACCCTACTTCAGAATTGTTCGATTTGACGTCTCAGCAATGGAG AAAGATGCTTNNCAATTNGTGAAAGCAGAGTTCAGAAGTCTTTCGTTTGCAGAAACCCAA AGCCAGAGTGCCCTGACAACGNNATGAGCTATATCAGATTCTCAAGTCCAAAAGATTACA TNTNCAACCAGCGCTCATNGCAGNNAAGTGTGAAAACAGACAGAAGCGATGGCTTCCN >OriGene 3' read for NM_003238 unedited
GAACCGGCGGCCGCAATCTAGGATCGAGNTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT TTTTCTGACTGAAAGTTTCTTTTATTAACAGGCTTTTTAGTTTTTGGACCTTACAAAAAG CTTCCTTAGGCAGCTGATACATAACATGTGTTTTCAGGGTCTTTATCTTAATGCAAACTT TCTCGGTCATATAATAACTCACTTGGGTTTTCATCCCATTAATATGACCTCTTTTTTTCT GGCTCGTTTGAGTTCAAGTTCCTTAAGCCATCCATGAGTTTCTGGCAAAGTATTTGGTCT CCACTTTATACACCTGTTTTATTTTCCAAGGGCAATGAAACGTTCATTATATAGTAACAC ACAATAAATAACTCACTGTTAACTCTAAAAGTAAAAATGGGAAGGGTGCCTATTGCATAG CAATACAGAAAAATCAAGTGAGGCGCGGGATAGGAACGGTACGTACAGCAACTCCACTTA ATGGGATTTTCCTGTTTGTTGTTGTTGCTGTTGTTGCCGTTGTTCACATAATTAACACTA ATAAATTCTTCCAGTGTTTATTTTTTTCTTTAAAAAAAATTTGCTTCTTGTCTCTCTCAC TTACAAAGTAGGTGAAATGTACAATAAGGCCTTTAACATTTTTTTGTGTCAGACGCCAGT TTTACCAAACAGAACACAAACTTCCAAAGTGTCTGAACTAGTACCGCCTTTTCAAAAATT TCTTACACCTGAGAACCAAGCTCTCTATGTTTTCTTGTTACAAGCACATCGGTGCCGGCC GCCTCATCATAATCATATCATTGCCATTTTGCCCTTGCCACTTTTCCAAGAATTTTAGCT GCTTTTGCAAGACTTCCAATCATATAGAAAAGCTGTTCATCCTTGGTGTTTTGCCATGTA CTAAAAATGGTAGAGGTTTAATCTTGGCCCGCACAAGAAAACCAAGCTTTGGATTATGAT TTAATACCCAAGACCTGTGTGCCGAAGTTGAAT |
| Restriction Sites | NotI-NotI |
| ACCN | NM_003238 |
| Insert Size | 2290 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_003238.1, NP_003229.1 |
| RefSeq Size | 1695 bp |
| RefSeq ORF | 1245 bp |
| Locus ID | 7042 |
| UniProt ID | P61812 |
| Domains | TGFb_propeptide, TGF-beta |
| Protein Families | Druggable Genome, Secreted Protein, Transmembrane |
| Protein Pathways | Cell cycle, Chronic myeloid leukemia, Colorectal cancer, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM), MAPK signaling pathway, Pancreatic cancer, Pathways in cancer, Renal cell carcinoma, TGF-beta signaling pathway |
| Gene Summary | This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. Disruption of the TGF-beta/SMAD pathway has been implicated in a variety of human cancers. A chromosomal translocation that includes this gene is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. Mutations in this gene may be associated with Loeys-Dietz syndrome. This gene encodes multiple isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016] Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region compared to variant 1. The resulting isoform (2) is shorter than isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC212624 | TGFB2 (Myc-DDK-tagged)-Human transforming growth factor, beta 2 (TGFB2), transcript variant 2 |
CNY 5,488.00 |
|
| RC212624L1 | Lenti ORF clone of Human transforming growth factor, beta 2 (TGFB2), transcript variant 2, Myc-DDK-tagged |
CNY 7,888.00 |
|
| RC212624L2 | Lenti ORF clone of Human transforming growth factor, beta 2 (TGFB2), transcript variant 2, mGFP tagged |
CNY 5,890.00 |
|
| RC212624L3 | Lenti ORF clone of Human transforming growth factor, beta 2 (TGFB2), transcript variant 2, Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC212624L4 | Lenti ORF clone of Human transforming growth factor, beta 2 (TGFB2), transcript variant 2, mGFP tagged |
CNY 5,890.00 |
|
| RG212624 | TGFB2 (tGFP-tagged) - Human transforming growth factor, beta 2 (TGFB2), transcript variant 2 |
CNY 7,088.00 |
其它TGF beta 2产品
