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Thimet Oligopeptidase (THOP1) (NM_003249) Human Untagged Clone
CAT＃: SC118078
THOP1 (untagged)-Human thimet oligopeptidase 1 (THOP1)
CNY 5,056.00
| Cited in 1 publication. |
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | EP24.15; MEPD_HUMAN; MP78; TOP |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC118078 sequence for NM_003249 edited (data generated by NextGen Sequencing)
ATGAAGCCCCCCGCAGCCTGTGCAGGAGACATGGCGGACGCAGCATCTCCGTGCTCTGTG GTAAACGACCTGCGGTGGGACCTGAGTGCCCAGCAGATAGAGGAGCGCACCAGGGAGCTC ATCGAGCAGACCAAGCGCGTGTATGACCAGGTTGGCACCCAGGAGTTTGAGGACGTGTCC TACGAGAGCACGCTCAAGGCGCTGGCCGATGTGGAGGTCACCTACACAGTTCAGAGGAAT ATCCTTGACTTCCCCCAGCATGTTTCCCCCTCCAAGGACATCCGGACAGCCAGCACAGAG GCCGACAAGAAGCTCTCTGAGTTCGACGTGGAGATGAGCATGAGGGAGGACGTGTACCAG AGGATCGTGTGGCTCCAGGAGAAAGTTCAGAAGGACTCACTGAGGCCCGAGGCTGCGCGG TACCTGGAGCGGCTAATCAAGCTGGGCCGGAGAAATGGGCTTCACCTCCCCAGAGAGACT CAGGAAAACATCAAACGCATCAAGAAGAAGCTGAGCCTTCTGTGCATCGACTTCAACAAG AACCTGAACGAGGACACGACCTTCCTGCCCTTCACGCTCCAGGAGCTAGGAGGGCTCCCC GAGGACTTTCTGAACTCCCTGGAGAAGATGGAGGACGGCAAGTTGAAGGTCACCCTCAAG TACCCCCATTACTTCCCCCTCCTGAAGAAATGCCACGTGCCTGAGACCAGGAGGAAAGTG GAGGAGGCCTTCAACTGCCGGTGCAAGGAGGAGAACTGCGCTATCCTCAAGGAGCTGGTG ACGCTGCGGGCCCAGAAGTCCCGCCTGCTGGGGTTCCACACGCACGCCGACTATGTCCTG GAGATGAACATGGCCAAGACCAGCCAGACCGTGGCCACCTTCCTAGATGAGCTGGCGCAG AAGCTGAAGCCCCTGGGGGAGCAGGAGCGTGCGGTGATTCTGGAGCTGAAGCGTGCGGAG TGCGAGCGCCGGGGCCTGCCCTTCGACGGCCGCATCCGTGCCTGGGACATGCGCTACTAC ATGAACCAGGTGGAGGAGACGCGCTACTGCGTGGACCAGAACCTGCTCAAGGAGTACTTC CCCGTGCAGGTGGTCACGCACGGGCTGCTGGGCATCTACCAGGAGCTCCTGGGGCTGGCC TTCCACCACGAGGAGGGCGCCAGTGCCTGGCATGAGGACGTGCGGCTCTACACCGCGAGG GACGCGGCCTCGGGGGAGGTGGTCGGCAAGTTCTACCTGGACCTGTACCCGCGGGAAGGA AAGTACGGGCACGCGGCCTGCTTTGGCCTGCAGCCCGGCTGCCTGCGGCAGGATGGGAGC CGCCAGATCGCCATCGCGGCCATGGTGGCCAACTTCACCAAGCCCACAGCCGACGCGCCC TCGCTGCTGCAGCATGACGAGGTGGAGACCTACTTCCATGAGTTTGGCCACGTGATGCAC CAGCTCTGCTCCCAGGCGGAGTTCGCCATGTTCAGCGGGACCCACGTGGAGCGGGACTTT GTGGAGGCGCCGTCGCAGATGCTGGAGAACTGGGTGTGGGAGCAGGAGCCGCTGCTGCGG ATGTCGCGGCACTACCGCACAGGCAGCGCCGTGCCCCGGGAGCTCCTGGAGAAGCTCATT GAGTCCCGGCAGGCCAACACAGGCCTCTTCAACCTGCGCCAGATCGTCCTCGCCAAGGTG GACCAGGCCCTGCACACGCAGACGGACGCAGACCCCGCCGAGGAGTATGCGCGGCTCTGC CAGGAGATCCTCGGGGTCCCGGCCACGCCAGGAACCAACATGCCTGCAACCTTCGGCCAT CTGGCAGGTGGCTACGACGCCCAGTACTACGGGTACCTGTGGAGCGAGGTGTATTCCATG GACATGTTCCACACGCGCTTCAAGCAGGAGGGTGTCCTGAACAGCAAGGTTGGCATGGAT TACAGAAGCTGCATCCTGAGACCCGGCGGTTCCGAGGATGCCAGCGCCATGCTGAGGCGC TTCCTGGGCCGTGACCCCAAGCAGGACGCCTTCCTCCTGAGCAAGGGGCTGCAGGTCGGG GGCTGCGAGCCCGAGCCGCAGGTCTGCTGA Clone variation with respect to NM_003249.3 >OriGene 5' read for NM_003249 unedited
ATTTTGTAATACGACTTACTATAGGGCGGCCGCGCAATTCGCACGAGGGGCGGCGGGCCC CTTGGTCCTCAGGCGGCCGTGGCGGCGGTGGCGGCGGTTGGGCCGAGGCAGGCGGCCTCA GTGGCCGAGGTGGCTGGACGCGTAGCAGGTGGAAGGAGGGAGGGAGCCGCAGGCGCAGAC CCACCCGCCATGAAGCCCCCCGCAGCCTGTGCAGGAGACATGGCGGACGCAGCATCTCCG TGCTCTGTGGTAAACGACCTGCGGTGGGACCTGAGTGCCCAGCAGATAGAGGAGCGCACC AGGGAGCTCATCGAGCAGACCAAGCGCGTGTATGACCAGGTTGGCACCCAGGAGTTTGAG GACGTGTCCTACGAGAGCACGCTCAAGGCGCTGGCCGATGTGGAGGTCACCTACACAGTT CAGAGGAATATCCTTGACTTCCCCCAGCATGTTTCCCCCTCCAAGGACATCCGGACAGCC AGCACAGAGGCCGACAAGAAGCTCTCTGAGTTCGACGTGGAGATGAGCATGAGGGAGGAC GTGTACCAGAGGATCGTGTGGCTCCAGGAGAAAGTTCAGAAGGACTCACTGAGGCCCGAG GCTGCGCGGTACCTGGAGCGGCTAATCAAGCTGGGCCGGAGAAATGGGCTTCACCTCCCC AGAGAGACTCAGGANAACATCAAACGCATCAAGAAGAAGCTGAGCCTTCTGTGCATCGAC TTCAACAAGAACCTGAACGAGGACACGACCTTCCTGCCCTTCACGCTCCAGGAGCTAGGA GGGCTCCCCGAGGACTTTCTGAAACTCCTGGAGAAGATGGNAGACNGGCAGNTGAAGGTC ACCCNTTCAGTACCCCATTACTTTCCCCTNNCTGAGAAATGCCACGTGCCTGAGACCAGN NNAGAAGTGGNAGAGGCCCTTCACTGNCCNGTGCAGGGAGAGACTGCGCTTNCTCAGGAG CTGTGACGCTCNGNCCAAAGTCCGCTGCTGGGT >OriGene 3' read for NM_003249 unedited
CGCGGCCGCAATCTAGNATCGAGTTTTTTTTTTTTTTTTTTCTGTTTCCTTTTAATGACC TCATTTCAAAAAAAAGCCGTCTCCTGACAAGGGACGTTTCCCAGAGAGGAGACGTGTTAG TGCAACAAAGACCAGGCCCTGGCAGCCACGAAAGCCCTCCAGATGCCTTGAGGACGCCGT CTCTAGCCGGGTGGGCCACGACCGGGTGGGGACAGACAATGACAAGAGGCAAGACAGCCG CTCAGCCACCCTGCCAGTCCCAGGCACTGTGCCAGAGCCTGCCCCATCCTGTGCCGGGGG CTAAGGCACCAGGGCGGCGGGAGCGCAGGCCAGACTGGGCAGTCGCAGTGCCAGGCCTCA GCAGACCTGCGGCTCGGGCTCGCAGCCCCCGACCTGCAGCCCCTTGCTCAGGAGGAAGGC GTCCTGCTTGGGGTCACCGGCCCAGGAAGCGCCTCAGCATGGCGCTGGCATCCTCGGAAC CGCCGGGTCTCAGGATGCAGCTTCTGTAATCCATGCCAACCTTGCTGTTCAGGACACCCT CCTGCTTGAAGCGCGTGTGGAACATGTNCATGGAATACACCTCGCTCCACAGGTACCCGT AGCACTGCGCGTCGTACCCACCTGCCAGATTGGCCGAAGCTGCAGGCATGCTGGTTCCTG GCGTGCCCGGGACCCNGAGGATCTCCTGCCAGAGCCGCGCATACTCCTCGGTGGGGTCTG CGCCCGTTTGCGTGTGCAAGGCCTGATCCACCTGGCCGAGGACAACCTGGCGCACGTTGA AAAAGCCTGTTGTTGCCCGCCCGGACTCATTGAGCTTCTCCAGAACCTACCGGGGCAAGG TCCTGCCTGGGCGGTAATGCCGCAACTTCCGCATCAAGGGTTCCTTGGTCCCAACCCCAG TTTCTCACAATTGTGGGAAGCGGCCTCACACAAAG |
| Restriction Sites | NotI-NotI |
| ACCN | NM_003249 |
| Insert Size | 2680 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_003249.3, NP_003240.1 |
| RefSeq Size | 2568 bp |
| RefSeq ORF | 2070 bp |
| Locus ID | 7064 |
| UniProt ID | P52888 |
| Domains | Peptidase_M3 |
| Protein Families | Druggable Genome, Protease |
| Protein Pathways | Renin-angiotensin system |
| Gene Summary | The protein encoded by this gene is a kininase that uses zinc as a cofactor. The encoded oligopeptidase cleaves cytosolic peptides, making them unavailable for display on antigen-presenting cells. This protein also cleaves neuropeptides under 20 aa in length and can degrade beta-amyloid precursor protein to amyloidogenic peptides. [provided by RefSeq, Nov 2015] |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Kinin B2 Receptor-Mediated Bradykinin Internalization and Metalloendopeptidase EP24.15-Dependent Intracellular Bradykinin Degradation
,Caroline Sandén, Johan Enquist, Sara H. Bengtson, Heiko Herwald, and L. M. Fredrik Leeb-Lundberg,
J. Pharmacol. Exp. Ther., Jul 2008; 326: 24 - 32.
[THOP1]
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Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC201738 | THOP1 (Myc-DDK-tagged)-Human thimet oligopeptidase 1 (THOP1) |
CNY 5,048.00 |
|
| RC201738L3 | Lenti ORF clone of Human thimet oligopeptidase 1 (THOP1), Myc-DDK-tagged |
CNY 7,700.00 |
|
| RC201738L4 | Lenti ORF clone of Human thimet oligopeptidase 1 (THOP1), mGFP tagged |
CNY 7,448.00 |
|
| RG201738 | THOP1 (tGFP-tagged) - Human thimet oligopeptidase 1 (THOP1) |
CNY 6,648.00 |
|
| SC324358 | THOP1 (untagged)-Human thimet oligopeptidase 1 (THOP1) |
CNY 5,056.00 |
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