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TIMP1 (NM_003254) Human Untagged Clone
CAT＃: SC118082
TIMP1 (untagged)-Human TIMP metallopeptidase inhibitor 1 (TIMP1)
CNY 2,400.00
CNY 2,950.00
| Cited in 3 publications. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | CLGI; EPA; EPO; HCI; TIMP; TIMP-1 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC118082 sequence for NM_003254 edited (data generated by NextGen Sequencing)
ATGGCCCCCTTTGAGCCCCTGGCTTCTGGCATCCTGTTGTTGCTGTGGCTGATAGCCCCC AGCAGGGCCTGCACCTGTGTCCCACCCCACCCACAGACGGCCTTCTGCAATTCCGACCTC GTCATCAGGGCCAAGTTCGTGGGGACACCAGAAGTCAACCAGACCACCTTATACCAGCGT TATGAGATCAAGATGACCAAGATGTATAAAGGGTTCCAAGCCTTAGGGGATGCCGCTGAC ATCCGGTTCGTCTACACCCCCGCCATGGAGAGTGTCTGCGGATACTTCCACAGGTCCCAC AACCGCAGCGAGGAGTTTCTCATTGCTGGAAAACTGCAGGATGGACTCTTGCACATCACT ACCTGCAGTTTCGTGGCTCCCTGGAACAGCCTGAGCTTAGCTCAGCGCCGGGGCTTCACC AAGACCTACACTGTTGGCTGTGAGGAATGCACAGTGTTTCCCTGTTTATCCATCCCCTGC AAACTGCAGAGTGGCACTCATTGCTTGTGGACGGACCAGCTCCTCCAAGGCTCTGAAAAG GGCTTCCAGTCCCGTCACCTTGCCTGCCTGCCTCGGGAGCCAGGGCTGTGCACCTGGCAG TCCCTGCGGTCCCAGATAGCCTGA Clone variation with respect to NM_003254.2 372 t=>c >OriGene 5' read for NM_003254 unedited
GGTAACATCTTGGATTTTGTAATCACGACTTACTATNAGGGCGGCACGCGCAATTCGGCA CGAGGCCCAGCGCCCAGAANAAACACCAGAANAACCCACCATGGCCCCCTTTGAGCCCCT GGCTTCTGGCATCCTGTTGTTGCTGTGGCTGATAGCCCCCAGCAGGGCCTGCACCTGTGT CCCACCCCACCCACAGACGGCCTTCTGCAATTCCGACCTCGTCATCAGGGCCAAGTTCGT GGGGACACCAGAAGTCAACCAGACCACCTTATACCAGCGTTATGAGATCAAGATGACCAA GATGTATAAAGGGTTCCAAGCCTTAGGGGATGCCGCTGACATCCGGTTCGTCTACACCCC CGCCATGGAGAGTGTCTGCGGATACTTCCACAGGTCCCACAACCGCAGCGAGGAGTTTCT CATTGCTGGAAAACTGCAGGATGGACTCTTGCACATCACTACCTGCAGTTTCGTGGCTCC CTGGAACAGCCTGAGCTTAGCTCAGCGCCGGGGCTTCACCAAGACCTACACTGTTGGCTG TGAGGAATGCACAGTGTTTCCCTGTTTATCCATCCCCTGCAAACTGCAGAGTGGCACTCA TTGCTTGTGGACGGACCAGCTCCTCCAAGGCTCTGAAAAGGGCTTCCAGTCCCGTCACCT TGCCTGCCTGCCTCGGGAGCCAGGGCTGTGCACCTGGCAGTCCCTGCGGTCCCAGATAGC CTGAATCCTGCCCGGAGTGGAAGCTGAAGCCTGCACAGTGTCCACCCTGTTCCCACTCCC ATCTTTCTTNCCCGGACAATGAATANAGAGTTACCACCCAGCAAAAAAAAAAAAAAAAAA CTCGACTCTAGATTGCGGCCCGCGTCATAGCTGTTTCCTGAACAGACCCNGGNTGA >OriGene 3' read for NM_003254 unedited
CCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTTGCTGGGTGGTAACTCTTTATTTC ATTGTCCGGAAGAAAGAGGGAGTGGGAACAGGGTGGACACTGTGCAGGCTTCAGCTTCCA CTCCGGGCAGGATTCAGGCTATCTGGGACCGCAGGGACTGCCAGGTGCACAGCCCTGGCT CCCGAGGCAGGCAGGCAAGGTGACGGGACTGGAAGCCCTTTTCAGAGCCTTGGAGGAGCT GGTCCGTCCACAAGCAATGAGTGCCACTCTGCAGTTTGCAGGGGATGGATAAACAGGGAA ACACTGTGCATTCCTCACAGCCAACAGTGTAGGTCTTGGTGAAGCCCCGGCGCTGAGCTA AGCTCAGGCTGTTCCAGGGAGCCACGAAACTGCAGGTAGTGATGTGCAAGAGTCCATCCT GCAGTTTTCCAGCAATGAGAAACTCCTCGCTGCGGTTGTGGGACCTGTGGAAGTATCCGC AGACACTCTCCATGGCGGGGGTGTAGACCAACCGGATGTCANCGGCATCCCCTAAGGCTT GGAACCCTTTATACATCTTGGCCATCTTGATCTCATAACGCTGGTATAAGGTGGTCTGGT TGACTTCTGGTGTCCCCACAAACTTGGCCCTGATGACCAGGTCCGAACTGCCACAACGCC GCCTGTGGGTGGCGCGGGACACAGGTGCAAGCCCTGCTGGGGGCTATCAACCCCCGCAAC CCAAGATGCCAAACCCAGGGGCTCAAAGGGGCTCTGGGGGGTTCCCCTGTGCTTTCTTGG ACGCTGGCTCCGGCCAACCCCGGGCCCGCCACANCCAGCCGATTCAAAATCCCGACGGTT TCTAAACAAGTTCCGTTTATATAACTTCCCAGTACCCCCCCCCCCCATCGCCCCACGGGC GCGGTCTTCGAATTCCGACAACACTGTTCCCTTGGCCCCACAAACCCCCTGGTCTTCAGG GTCGCCCCTCTCAT |
| Restriction Sites | NotI-NotI |
| ACCN | NM_003254 |
| Insert Size | 624 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_003254.2, NP_003245.1 |
| RefSeq Size | 931 bp |
| RefSeq ORF | 624 bp |
| Locus ID | 7076 |
| UniProt ID | P01033 |
| Domains | NTR |
| Protein Families | Druggable Genome, Secreted Protein |
| Gene Summary | This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. [provided by RefSeq, Jul 2008] |
Citations (3)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
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Intrinsic dynamics study identifies two amino acids of TIMP-1 critical for its LRP-1-mediated endocytosis in neurons
,Verzeaux, L;Belloy, N;Thevenard-Devy, J;Devy, J;Ferracci, G;Martiny, L;Dedieu, S;Dauchez, M;Emonard, H;Etique, N;Devarenne-Charpentier, E;,
Sci Rep
,PubMed ID 28710453
[TIMP1]
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|
Posttranslational regulation of tissue inhibitor of metalloproteinase-7 by calcium-dependent vesicular exocytosis
,Dranoff, JA;Bhatia, N;Fausther, M;,
Physiological Reports DOI: 10.1002/phy2.125
[TIMP1]
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Hyaluronan Synthase 2 (HAS2) Promotes Breast Cancer Cell Invasion by Suppression of Tissue Metalloproteinase Inhibitor 1 (TIMP-1)
,Berit Bernert, Helena Porsch, and Paraskevi Heldin,
J. Biol. Chem., Dec 2011; 286: 42349 - 42359.
[TIMP1]
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Resources
Other Versions
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| RC201548 | TIMP1 (Myc-DDK-tagged)-Human TIMP metallopeptidase inhibitor 1 (TIMP1) |
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| RC201548L1 | Lenti ORF clone of Human TIMP metallopeptidase inhibitor 1 (TIMP1), Myc-DDK-tagged |
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| RC201548L2 | Lenti ORF clone of Human TIMP metallopeptidase inhibitor 1 (TIMP1), mGFP tagged |
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| RC201548L3 | Lenti ORF clone of Human TIMP metallopeptidase inhibitor 1 (TIMP1), Myc-DDK-tagged |
CNY 5,890.00 |
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| RC201548L4 | Lenti ORF clone of Human TIMP metallopeptidase inhibitor 1 (TIMP1), mGFP tagged |
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| RG201548 | TIMP1 (tGFP-tagged) - Human TIMP metallopeptidase inhibitor 1 (TIMP1) |
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