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SM22 alpha (TAGLN) (NM_003186) Human Untagged Clone
CAT＃: SC118118
TAGLN (untagged)-Human transgelin (TAGLN), transcript variant 2
CNY 2,400.00
CNY 2,950.00
| Cited in 1 publication. |
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | SM22; SM22-alpha; SMCC; TAGLN1; WS3-10 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC118118 sequence for NM_003186 edited (data generated by NextGen Sequencing)
ATGGCCAACAAGGGTCCTTCCTATGGCATGAGCCGCGAAGTGCAGTCCAAAATCGAGAAG AAGTATGACGAGGAGCTGGAGGAGCGGCTGGKGGAGTGGATCATAGTGCAGTGTGGCCCT GATGTGGGCCGCCCAGACCGTGGGCGCTTGGGCTTCCAGGTCTGGCTGAAGAATGGCGTG ATTCTGAGCAAGCTGGTGAACAGCCTGTACCCTGATGGCTCCAAGCCGGTGAAGGTGCCC GAGAACCCACCCTCCATGGTCTTCAAGCAGATGGAGCAGGTGGCTCAGTTCCTGAAGGCG GCTGAGGACTATGGGGTCATCAAGACTGACATGTTCCAGACTGTTGACCTCTTTGAAGGC AAAGACATGGCAGCAGTGCAGAGGACCCTGATGGCTTTGGGCAGCTTGGCAGTGACCAAG AATGATGGGCACTACCGTGGAGATCCCAACTGGTTTATGAAGAAAGCGCAGGAGCATAAG AGGGAATTCACAGAGAGCCAGCTGCAGGAGGGAAAGCATGTCATTGGCCTTCAGATGGGC AGCAACAGAGGGGCCTCCCAGGCCGGCATGACAGGCTACGGACGACCTCGGCAGATCATC AGTTAG Clone variation with respect to NM_003186.3 92 t=>k >OriGene 5' read for NM_003186 unedited
TAGGGCGGACAAGCCATTCGGCACGAGGCACAAGTCTTCACTCCTTCCTGCGAGCCCTGA GGAAGCCTTCTTTCCCCAGACATGGCCAACAAGGGTCCTTCCTATGGCATGAGCCGCGAA GTGCAGTCCAAAATCGAGAAGAAGTATGACGAGGAGCTGGAGGAGCGGCTGGTGGAGTGG ATCATATTGTTGTGTGGCCCTGATGTGGGCCGCCCAGACCGTGGGCGCTTGGGCTTCCAG GTCTGGCTGAAGAATGGCGTGATTCTGAGCAAGCTGGTGAACAGCCTGTACCCTGATGGC TCCAAGCCGGTGAAGGTGCCCGAGAACCCACCCTCCATGGTCTTCAAGCAGATGGAGCAG GTGGCTCAGTTCCTGAAGGCGGCTGAGGACTATGGGGTCATCAAGACTGACATGTTCCAG ACTGTTGACCTCTTTGAAGGCAAAGACATGGCAGCAGTGCAGAGGACCCTGATGGCTTTG GGCAGCTTGGCAGTGACCAAGAATGATGGGCACTACCGTGGAGATCCCAACTGGTTTATG AAGAAAGCGCAGGAGCATAAGAGGGAATTCACAGAGAGCCAGCTGCAGGAGGGAAAGCAT GTCATTGGCCTTCAGATGGGCAGCAACAGAGGGGCCTCCCAGGCCGGCATGACAGGCTAC GGACGACCTCGGCAGATCATCAGTTAGAGCGGAGAGGGGCTAGCCTGAGCCCGGCCCTCC CCCAGCTCCTTGGCTGCAGCCATCCCGCTTAGCCTGCCTCACCCACACCCGTGTGGTACC TTCAGCCCTGGCCAAGNNCTTGAGCTCTGTCACTGAGCAATGGTAACTGACCCTGGGCAG CTCCTCCCTGTGCCCCCAGNCTCAGCCCAACTTCTTACCCGAAGCATCACA >OriGene 3' read for NM_003186 unedited
GGCCGCAATCTANAGTCGAGTTTTTTTTTTTTTTTTTTGAAAAAAGATGATTTTTTTTTT TTTTTTTTGAGTTCCAACCCCAAAAATATTCCAGGACAAGATAGGGGGCAGGCTGGGCTG GTTCTTCTTCAATGGGCTTTTGCCGCCAAGGAGGACAGTGGACTTGGCCCACATCCAGGC TACCCCCAGCCCGCTTCTCCCCTGCTTAACCCAGGGAGGAGACAGTAAAGGTGATGGGGG CAGCCGGGAGGGAGGGGCCAAGGCAGTGATGCTTTCGGGTAAAAAGTTGGGCTGAGGCTG GGGGCACAGGGAGGAGCTGCCCAGGTGCAGTTACCATTGCTCAGTGACAGAGCCTCAAAG CTTGGCCAGGGCTGAAGGTACCACACGGGTGTGGGTGAGGCAGGCTAAACGGGATGGCTG CAGCCAAGGAGCTGGGGGAGGGCCGGGCTCAAGGCTAGCCCTCTCCGCTCTAACTGATGA TCTGCCGAGGTCGTCCGTAGCCTGTCATGCCGGCCTGGGAGGCCCCTCTGTTGCTGCCCA TCTGAAGGCCAATGACATGCTTTCCCTCCTGCAGCTGGCTCTCTGTGAATTCCCTCTTAT GCTCCTGCGCTTTCTTCATAAACCAGTTGGGATCTCCACGGTAGTGCCCATCATTCTTGG TCACCTGCCAGCTGGCCAAAGCCATCAGGGTCCTCTGCACTGCTGCCATGTCTTTGCCTT CAAAAGGTCAACAGTTTGGAACATGGCAGTCTTGATGACCCCATATTCCTCAACCCGCCT TCAGGAACTGAGCCCCCCGGCTCCAACTGCCTGGAGAACATGGGAGGGTGGGTTCCTTGG GCACCTATCCGGGCTTGAGACCATAAGGGGTACAGCGTGGTCACCCAAGTTGGGCTAAAA ATTACGCCCACTCTCTCAACCCCGAACCTGTGAAGCCCAATGCCCCCACGGGTTTGGGCC GCGCCCACTAAGGGGCACACCGGGCTTTGGATTCCTTCACACACCCCGCTTTCACGTGTC CTCTGCTAAA |
| Restriction Sites | NotI-NotI |
| ACCN | NM_003186 |
| Insert Size | 1050 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_003186.3, NP_003177.2 |
| RefSeq Size | 1177 bp |
| RefSeq ORF | 606 bp |
| Locus ID | 6876 |
| UniProt ID | Q01995 |
| Domains | calponin, CH |
| Gene Summary | This gene encodes a shape change and transformation sensitive actin-binding protein which belongs to the calponin family. It is ubiquitously expressed in vascular and visceral smooth muscle, and is an early marker of smooth muscle differentiation. The encoded protein is thought to be involved in calcium-independent smooth muscle contraction. It acts as a tumor suppressor, and the loss of its expression is an early event in cell transformation and the development of some tumors, coinciding with cellular plasticity. The encoded protein has a domain architecture consisting of an N-terminal calponin homology (CH) domain and a C-terminal calponin-like (CLIK) domain. Mice with a knockout of the orthologous gene are viable and fertile but their vascular smooth muscle cells exhibit alterations in the distribution of the actin filament and changes in cytoskeletal organization. [provided by RefSeq, Aug 2017] Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
SM22α suppresses cytokine-induced inflammation and the transcription of NF-κB inducing kinase (Nik) by modulating SRF transcriptional activity in vascular smooth muscle cells
,Dai, X;Thiagarajan, D;Fang, J;Shen, J;Annam, NP;Yang, Z;Jiang, H;Ju, D;Xie, Y;Zhang, K;Tseng, YY;Yang, Z;Rishi, AK;Li, HJ;Yang, M;Li, L;,
PLoS ONE
,PubMed ID 29284006
[TAGLN]
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Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC215789 | TAGLN (Myc-DDK-tagged)-Human transgelin (TAGLN), transcript variant 2 |
CNY 2,400.00 |
|
| RC215789L1 | Lenti ORF clone of Human transgelin (TAGLN), transcript variant 2, Myc-DDK-tagged |
CNY 4,800.00 |
|
| RC215789L2 | Lenti ORF clone of Human transgelin (TAGLN), transcript variant 2, mGFP tagged |
CNY 5,890.00 |
|
| RC215789L3 | Lenti ORF clone of Human transgelin (TAGLN), transcript variant 2, Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC215789L4 | Lenti ORF clone of Human transgelin (TAGLN), transcript variant 2, mGFP tagged |
CNY 5,890.00 |
|
| RG215789 | TAGLN (tGFP-tagged) - Human transgelin (TAGLN), transcript variant 2 |
CNY 4,000.00 |
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