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SLUG (SNAI2) (NM_003068) Human Untagged Clone
CAT＃: SC118205
SNAI2 (untagged)-Human snail homolog 2 (Drosophila) (SNAI2)
CNY 3,600.00
| Cited in 5 publications. |
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | SLUG; SLUGH; SLUGH1; SNAIL2; WS2D |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_003068 edited
GAATTCGGCACGAGGAGGAGCCGGGTGACTTCAGAGGCGCCGGCCCGTCCGTCTGCCGCA CCTGAGCACGGCCCCTGCCCGAGCCTGGCCCGCCGCGATGCTGTAGGGACCGCCGTGTCC TCCCGCCGGACCGTTATCCGCGCCGGGCGCCCGCCAGACCCGCTGGCAAGATGCCGCGCT CCTTCCTGGTCAAGAAGCATTTCAACGCCTCCAAAAAGCCAAACTACAGCGAACTGGACA CACATACAGTGATTATTTCCCCGTATCTCTATGAGAGTTACTCCATGCCTGTCATACCAC AACCAGAGATCCTCAGCTCAGGAGCATACAGCCCCATCACTGTGTGGACTACCGCTGCTC CATTCCACGCCCAGCTACCCAATGGCCTCTCTCCTCTTTCCGGATACTCCTCATCTTTGG GGCGAGTGAGTCCCCCTCCTCCATCTGACACCTCCTCCAAGGACCACAGTGGCTCAGAAA GCCCCATTAGTGATGAAGAGGAAAGACTACAGTCCAAGCTTTCAGACCCCCATGCCATTG AAGCTGAAAAGTTTCAGTGCAATTTATGCAATAAGACCTATTCAACTTTTTCTGGGCTGG CCAAACATAAGCAGCTGCACTGCGATGCCCAGTCTAGAAAATCTTTCAGCTGTAAATACT GTGACAAGGAATATGTGAGCCTGGGCGCCCTGAAGATGCATATTCGGACCCACACATTAC CTTGTGTTTGCAAGATCTGCGGCAAGGCGTTTTCCAGACCCTGGTTGCTTCAAGGACACA TTAGAACTCACACGGGGGAGAAGCCTTTTTCTTGCCCTCACTGCAACAGAGCATTTGCAG ACAGGTCAAATCTGAGGGCTCATCTGCAGACCCATTCTGATGTAAAGAAATACCAGTGCA AAAACTGCTCCAAAACCTTCTCCAGAATGTCTCTCCTGCACAAACATGAGGAATCTGGCT GCTGTGTAGCACACTGAGTGACGCAATCAATGTTTACTCGAACAGAATGCATTTCTTCAC TCCGAAGCCAAATGACAAATAAAGTCCAAAGGCATTTTCTCCTGTGCTGACCAACCAAAT AATATGTATAGACACACACACATATGCACACACACACACACACACCCACAGAGAGAGAGC TGCAAGAGCATGGAATTCATGTGTTTAAAGATAATCCTTTCCATGTGAAGTTTAAAATTA CTATATATTTGCTGATGGCTAGATTGAGAGAATAAAAGACAGTAACCTTTCTCTTCAAAG ATAAAATGAAAAGCACATTGCATCTTTTCTTCCTAAAAAAATGCAAAGATTTACATTGCT GCCAAATCATTTCAACTGAAAAGAACAGTATTGCTTTGTAATAGAGTCTGTAATAGGATT TCCCATAGGAAGAGATCTGCCAGACGCGAACTCAGGTGCCTTAAAAAGTATTCCAAGTTT ACTCCATTACATGTCGGTTGTCTGGTTGCCATTGTTGAACTAAAGCCTTTTTTTGATTAC CTGTAGTGCTTTAAAGTATATTTTTAAAAGGGAGGAAAAAAATAACAAGAACAAAACACA GGAGAATGTATTAAAAGTATTTTTGTTTTGTTTTGTTTTTGCCAATTAACAGTATGTGCC TTGGGGGAGGAGGGAAAGATTAGCTTTGAACATTCCTGGCGCATGCTCCATTGTCTTACT ATTTTAAAACATTTTAATAATTTTTGAAAATTAATTAAAGATGGGAATAAGTGCAAAAGA GGATTCTTACAAATTCATTAATGTACTTAAACTATTTCAAATGCATACCACAAATGCAAT AATACAATACCCCTTCCAAGTGCCTTTTTAAATTGTATAGTTGATGAGTCAATGTAAATT TGTGTTTATTTTTATATGATTGAATGAGTTCTGTATGAAACTGAGATGTTGTCTATAGCT ATGTCTATAAACAACCTGAAGACTTGTGAAATCAATGTTTCTTTTTTAAAAAACAATTTT CAAGTTTTTTTTACAATAAACAGTTTTGATTTAAAAAAAAAAAAAAAAAACTCGAC >OriGene 5' read for NM_003068 unedited
GTCAGAATTTGTATACGACTCATATAGGGCGGCCGCGATTCGGCACGAGGAGGAGCCGGG TGACTTCAGAGGCGCCGGCCCGTCCGTCTGCCGCACCTGAGCACGGCCCCTGCCCGAGCC TGGCCCGCCGCGATGCTGTAGGGACCGCCGTGTCCTCCCGCCGGACCGTTATCCGCGCCG GGCGCCCGCCAGACCCGCTGGCAAGATGCCGCGCTCCTTCCTGGTCAAGAAGCATTTCAA CGCCTCCAAAAAGCCAAACTACAGCGAACTGGACACACATACAGTGATTATTTCCCCGTA TCTCTATGAGAGTTACTCCATGCCTGTCATACCACAACCAGAGATCCTCAGCTCAGGAGC ATACAGCCCCATCACTGTGTGGACTACCGCTGCTCCATTCCACGCCCAGCTACCCAATGG CCTCTCTCCTCTTTCCGGATACTCCTCATCTTTGGGGCGAGTGAGTCCCCCTCCTCCATC TGACACCTCCTCCAAGGACCACAGTGGCTCAGAAAGCCCCATTAGTGATGAAGAGGAAAG ACTACAGTCCAAGCTTTCAGACCCCCATGCCATTGAAGCTGAAAAGTTTCAGTGCAATTT ATGCAATAAGACCTATTCAACTTTTTCTGGGCTGGCCAAACATAAGCAGCTGCACTGCGA TGCCCAGTCTAGAAAATCTTTCAGCTGTAAATACTGTGACAAGGAATATGTGAGCCTGGG CGCCCTGAAGATGCATATTCGGACCCACACATTACCTTGTGTTTGCAAGATCTGCGGNCA GGCGTTTTCCAGACCCTGGTTGCTTCAAGACACATTAGAACTCACACGGNGGAGAAGCCT TTTTCTTGCNCCTCACTGCACAGAGCATTTGCAGACAGGTCAAATCTGAGGGCTCATCTG CAGACCCATTNCTGATGTAAGAAATACCAGTGCANAAACTGCTNCCACACCT >OriGene 3' read for NM_003068 unedited
GCGGCACGCAATCTAGAATCGAGTTTTTTTTTTTTTTTTTTAAATCAAAACTGTTTATTG TAAAAAAAACTTGAAAATTGTTTTTTAAAAAAAAAACATTGATTTCACAAGTCTTCAGGT TGTTTATAGACATAGCTATAGACAACATCTCAGTTTCATACAGAACTCATTCAATCATAT AAAAATAAACACAAATTTACATTGACTCATCAACTATACAATTTAAAAAGGCACTTGGAA GGGGTATTGTATTATTGCATTTGTGGTATGCATTTGAAATAGTTTAAGTACATTAATGAA TTTGTAAGAATCCTCTTTTGCACTTATTCCCATCTTTAATTAATTTTCAAAAATTATTAA AATGTTTTAAAATAGTAAGACAATGGAGCATGCGCCAGGAATGTTCAAAGCTAATCTTTC CCTCCTCCCCCAAGGCACATACTGTTAATTGGCAAAAACAAAACAAAACAAAAATACTTT TAATACATTCTCCTGAGTTTTGTTCTTGTTATTTTTTTCCTCCCTTTTAAAAATATACTT TAAAGCACTACAGGTAATCAAAAAAAGGCTTTAGTTCAACAATGGCAACCAGACAACCGA CATGTAATGGAGTAAACTTGGAATACTTTTTAAGGCACCTGAGTTCGCGTCTGGCAGATC TCTTCCTATGGGAAATCCTATTACAGACTCTATTACAAAGCAATACTGTTCTTTTCAGTT GAAATGATTTGGCAGCAATGTAAATCTTTGCATTNTTTTAGGAAGAAAAAGATGCATGTG CTTTTCATTTTATCTTTGAAGAGAAAGTTACTGTNCTTTATTCTCTCAATCTAGCCATCA GCAAATATATAGTAATTTTAAACTTACATGGGAAGGGATATCTTAACACATGAAATTCAT GCTCTGCAGCTCTCTTCTGGGGNNGGNGNGNGGGGGNGGGCATATGGGGGGNGNCTATCA TATTATTGGGTGGNCANACAGGAAAA |
| Restriction Sites | NotI-NotI |
| ACCN | NM_003068 |
| Insert Size | 1900 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_003068.3, NP_003059.1 |
| RefSeq Size | 2101 bp |
| RefSeq ORF | 807 bp |
| Locus ID | 6591 |
| UniProt ID | O43623 |
| Domains | zf-C2H2 |
| Protein Families | Druggable Genome, Transcription Factors |
| Protein Pathways | Adherens junction |
| Gene Summary | This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects. [provided by RefSeq, Jul 2008] |
Citations (5)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
SNAILs promote G1 phase in selected cancer cells
,Wu, YL;Xue, JX;Zhou, L;Deng, L;Shang, YN;Liu, F;Mo, XM;Lu, Y;,
Int. J. Oncol.
,PubMed ID 26352801
[SNAI2]
|
|
IMP3 expression is associated with epithelial-mesenchymal transition in breast cancer
,null,
International Journal of Clinical and Experimental Pathology
,PubMed ID 25031719
[SNAI2]
|
|
IMP3 expression is associated with epithelial-mesenchymal transition in breast cancer
,Su, P;Hu, J;Zhang, H;Li, W;Jia, M;Zhang, X;,
National Library of Medicine
[SNAI2]
|
|
Integrated Proteomics and Genomics Analysis Reveals a Novel Mesenchymal to Epithelial Reverting Transition in Leiomyosarcoma through Regulation of Slug
,Jilong Yang, James A. Eddy, Yuan Pan, Andrea Hategan, Ioan Tabus, Yingmei Wang, David Cogdell, Nathan D. Price, Raphael E. Pollock, Alexander J. F. Lazar, Kelly K. Hunt, Jonathan C. Trent, and Wei Zhang,
Mol. Cell. Proteomics, Nov 2010; 9: 2405 - 2413
[SNAI2]
|
|
Endothelial progenitor cells undergo an endothelial-to-mesenchymal transition-like process mediated by TGFßRI
,Marta Díez, Melina M. Musri, Elisabet Ferrer, Joan A. Barberà, and Víctor I. Peinado,
Cardiovasc Res, Aug 2010; 10.1093/cvr/cvq236
[SNAI2]
|
Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC202365 | SNAI2 (Myc-DDK-tagged)-Human snail homolog 2 (Drosophila) (SNAI2) |
CNY 2,400.00 |
|
| RC202365L1 | Lenti ORF clone of Human snail homolog 2 (Drosophila) (SNAI2), Myc-DDK-tagged |
CNY 4,800.00 |
|
| RC202365L2 | Lenti ORF clone of Human snail homolog 2 (Drosophila) (SNAI2), mGFP tagged |
CNY 4,800.00 |
|
| RC202365L3 | Lenti ORF clone of Human snail homolog 2 (Drosophila) (SNAI2), Myc-DDK-tagged |
CNY 4,800.00 |
|
| RC202365L4 | Lenti ORF clone of Human snail homolog 2 (Drosophila) (SNAI2), mGFP tagged |
CNY 4,800.00 |
|
| RG202365 | SNAI2 (tGFP-tagged) - Human snail homolog 2 (Drosophila) (SNAI2) |
CNY 4,000.00 |
