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PTPN12 (NM_002835) Human Untagged Clone
CAT＃: SC118362
PTPN12 (untagged)-Human protein tyrosine phosphatase, non-receptor type 12 (PTPN12), transcript variant 1
CNY 2,950.00
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | PTP-PEST; PTPG1 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF sequence for NM_002835 edited
GCGGCCGCGAATTCGGCACGAGGGCCGGGGGGACGCGGGAGGATGGAGCAAGTGGAGATC CTGAGGAAATTCATCCAGAGGGTCCAGGCCATGAAGAGTCCTGACCACAATGGGGAGGAC AACTTCGCCCGGGACTTCATGCGGTTAAGAAGATTGTCTACCAAATATAGAACAGAAAAG ATATATCCCACAGCCACTGGAGAAAAAGAAGAAAATGTTAAAAAGAACAGATACAAGGAC ATACTGCCATTTGATCACAGCCGAGTTAAATTGACATTAAAGACTCCTTCACAAGATTCA GACTATATCAATGCAAATTTTATAAAGGGCGTCTATGGGCCAAAAGCATATGTAGCAACT CAAGGACCTTTAGCAAATACAGTAATAGATTTTTGGAGGATGATATGGGAGTATAATGTT GTGATCATTGTAATGGCCTGCCGAGAATTTGAGATGGGAAGGAAAAAATGTGAGCGCTAT TGGCCTTTGTATGGAGAAGACCCCATAACGTTTGCACCATTTAAAATTTCTTGTGAGGAT GAACAAGCAAGAACAGACTACTTCATCAGGACACTCTTACTTGAATTTCAAAATGAATCT CGTAGGCTGTATCAGTTTCATTATGTGAACTGGCCAGACCATGATGTTCCTTCATCATTT GATTCTATTCTGGACATGATAAGCTTAATGAGGAAATATCAAGAACATGAAGATGTTCCT ATTTGTATTCATTGCAGTGCAGGCTGTGGAAGAACAGGTGCCATTTGTGCCATAGATTAT ACGTGGAATTTACTAAAAGCTGGGAAAATACCAGAGGAATTTAATGTATTTAATTTAATA CAAGAAATGAGAACACAAAGGCATTCTGCAGTACAAACAAAGGAGCAATATGAACTTGTT CATAGAGCTATTGCCCAACTGTTTGAAAAACAGCTACAACTATATGAAATTCATGGAGCT CAGAAAATTGCTGATGGAGTGAATGAAATTAACACTGAAAACATGGTCAGCTCCATAGAG CCTGAAAAACAAGATTCTCCTCCTCCAAAACCACCAAGGACCCGCAGTTGCCTTGTTGAA GGGGATGCTAAAGAAGAAATACTGCAGCCACCGGAACCTCATCCAGTGCCACCCATCTTG ACACCTTCTCCCCCTTCAGCTTTTCCAACAGTCACTACTGTGTGGCAGGACAATGATAGA TACCATCCAAAGCCAGTGTTGCATATGGTTTCATCAGAACAACATTCAGCAGACCTCAAC AGAAACTATAGTAAATCAACAGAACTTCCAGGGAAAAATGAATCAACAATTGAACAGATA GATAAAAAATTGGAACGAAATTTAAGTTTTGAGATTAAGAAGGTCCCTCTCCAAGAGGGA CCAAAAAGTTTTGATGGGAACACACTTTTGAATAGGGGACATGCAATTAAAATTAAATCT GCTTCACCTTGTATAGCTGATAAAATCTCTAAGCCACAGGAATTAAGTTCAGATCTAAAT GTCGGTGATACTTCCCAGAATTCTTGTGTGGACTGCAGTGTAACACAATCAAACAAAGTT TCAGTTACTCCACCAGAAGAATCCCAGAATTCAGACACACCTCCAAGGCCAGACCGCTTG CCTCTTGATGAGAAAGGACATGTAACGTGGTCATTTCATGGACCTGAAAATGCCATACCC ATACCTGATTTATCTGAAGGCAATTCCTCAGATATCAACTATCAAACTAGGAAAACTGTG AGTTTAACACCAAGTCCTACAACACAAGTTGAAACACCTGATCTTGTGGATCATGATAAC ACTTCACCACTCTTCAGAACACCCCTCAGTTTTACTAATCCACTTCACTCTGATGACTCA GACTCAGATGAAAGAAACTCTGATGGTGCTGTGACCCAGAATAAAACTAATATTTCAACA GCAAGTGCCACAGTTTCTGCTGCCACTAGTACTGAAAGCATTTCTACTAGGAAAGTATTG CCAATGTCCATTGCTAGACATAATATAGCAGGAACAACACATTCAGGTGCTGAAAAAGAT GTTGATGTTAGTGAAGATTCACCTCCTCCCCTACCTGAAAGAACTCCTGAATCGTTTGTG TTAGCAAGTGAACATAATACACCTGTAAGATCGGAATGGAGTGAACTTCAAAGTCAGGAA CGATCTGAACAAAAAAAGTCTGAAGGCTTGATAACCTCTGAAAATGAGAAATGTGATCAT CCAGCGGGAGGTATTCACTATGAAATGTGCATAGAATGTCCACCTACTTTCAGTGACAAG AGAGAACAAATATCAGAAAATCCAACAGAAGCCACAGATATTGGTTTTGGTAATCGATGT GGAAAACCCAAAGGACCAAGAGATCCACCTTCAGAATGGACATGATTCAAGGAGCTAGAA GACACTTTAAGTTATACTGGAAAATTCAGGTGCCACTGAAAGCCAGATTTATAGTATTCC ATCTTTAATATGTGGGACTAACAGCAGTGTAGATTGTTACCTTAATATTTTTTGCTGGGA CCATCTACCTGCCTTATACTACACTTAGGAAAAAGTATTACATATGGTTTATTTTGAAAC TTCAAGTATTATTGCCTTAATGTCTCTTAACCCTGTTACACGCTGCTTGTAGACATGTTA ATATAGTAATACCTTTATGATATATTGAGTTTAAAGACTACTCTTTTTCTGTTTTATCAT GTATGCATTATTTTGTATATGTACAGGGCAAGTAGGTATATAATTTGATAAAGTTGCAAT TGA >OriGene 5' read for NM_002835 unedited
GTTCGCATTTGTATACGACTCCTATAGGGCGGCCGCGATTCGGCACGAGGGCCGGGGGGA CGCGGGAGGATGGAGCAAGTGGAGATCCTGAGGAAATTCATCCAGAGGGTCCAGGCCATG AAGAGTCCTGACCACAATGGGGAGGACAACTTCGCCCGGGACTTCATGCGGTTAAGAAGA TTGTCTACCAAATATAGAACAGAAAAGATATATCCCACAGCCACTGGAGAAAAAGAAGAA AATGTTAAAAAGAACAGATACAAGGACATACTGCCATTTGATCACAGCCGAGTTAAATTG ACATTAAAGACTCCTTCACAAGATTCAGACTATATCAATGCAAATTTTATAAAGGGCGTC TATGGGCCAAAAGCATATGTAGCAACTCAAGGACCTTTAGCAAATACAGTAATAGATTTT TGGAGGATGATATGGGAGTATAATGTTGTGATCATTGTAATGGCCTGCCGAGAATTTGAG ATGGGAAGGAAAAAATGTGAGCGCTATTGGCCTTTGTATGGAGAAGACCCCATAACGTTT GCACCATTTAAAATTTCTTGTGAGGATGAACAAGCAAGAACAGACTACTTCATCAGGACA CTCTTACTTGAATTTCAAAATGAATCTCGTAGGCTGTATCAGTTTCATTATGTGAACTGG CCAGACCATGATGTTCCTTCATCATTTGATTCTATTCTGGACATGATAAGCTTAATGAGG AAATATCAAGAACATGAAGATGTTCCTATNTGTATTCATTGCAGTGCAGGCTGTGGAAGA ACAGGTGCCATTTGTGCCATAGATTATACGTGGAAATTACTANAAGCTGGGAAAATACCA GAGGAATTTAATGTATTTAANTTAATACCAGAAATGAGAACACAAGGCATCCTGCAGTAC CAACCAAGGAGCATATGAN >OriGene 3' read for NM_002835 unedited
GACCGCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTCACTGTAAAACTGTTT GTTTTTTTTAATGACAGGTCAAATATCCTGAACACATACATGTATTTTGATAGTCTTCTA ATCCCACTTGAGTTCAAATATTAAAGAAACACACACAAGCTAAGAGAATTCAATATTGTT CCAAGGCACTTACTGAATCTCTGACTAGATGAAAACAGGAACAATTAGGATGAACAATTA GACTGTATATAATATAAAAATAACTTTTTGCTTACAATTTACAAAATTATTATTACAATC TTTGATCTCTGATAACCTGCAAAGCTGGCTGCATGAATCCAGCAAGTTTAAAATTCAGAA ACTATTTTCTAAAACTCCAGGGCAAATAATTTACAAATAAAGTACACAAAGATTTAGACC ATGCAGAAATTTCTTACATCTTCTGTTAATAATATTTCAATTGCAACTTTATCAAATTAT ATACCTACTTGCCCTGTACATATACAAAATAATGCATACATGATAAAACAGAAAAAGAGT AGTCCTTAAACTCAATATATCATAAAGGTATTACTATATTAACATGTCTACAAGCAGCGT GTAACAGGGTTAAGAGACATTAAGGCAATAATACTTGAAGTTTCAAAATAAACCATATGT AATACTTTTTCCTAAGTGTAGTATAAGGCAGGTAGATGGTCCCAGCAAAAAATATTAAGG TAACAATCTACACTGCTGTTAGTCCCACATATTAAAGATGGAATACTATAAATCTGGCTT TCAGTGGCACCTGAATTTCCAGTATAACTTAAAGGGTCTTCTAGCTCCCTGATCATGTCC ATTCTGAAAGTGGATCTCTGGGTCCTTGGGGTTTTCACATCGATTACAAAACCAATATCT GTGCTTCTGTTGGGATTTCTGAATTT |
| Restriction Sites | NotI-NotI |
| ACCN | NM_002835 |
| Insert Size | 2930 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_002835.2, NP_002826.2 |
| RefSeq Size | 3161 bp |
| RefSeq ORF | 2343 bp |
| Locus ID | 5782 |
| UniProt ID | Q05209 |
| Domains | Y_phosphatase, PTPc_motif |
| Protein Families | Druggable Genome, Phosphatase |
| Gene Summary | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008] Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). |
Documents
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| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC207952 | PTPN12 (Myc-DDK-tagged)-Human protein tyrosine phosphatase, non-receptor type 12 (PTPN12), transcript variant 1 |
CNY 3,990.00 |
|
| RC207952L1 | Lenti ORF clone of Human protein tyrosine phosphatase, non-receptor type 12 (PTPN12), transcript variant 1, Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC207952L2 | Lenti ORF clone of Human protein tyrosine phosphatase, non-receptor type 12 (PTPN12), transcript variant 1, mGFP tagged |
CNY 5,890.00 |
|
| RC207952L3 | Lenti ORF clone of Human protein tyrosine phosphatase, non-receptor type 12 (PTPN12), transcript variant 1, Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC207952L4 | Lenti ORF clone of Human protein tyrosine phosphatase, non-receptor type 12 (PTPN12), transcript variant 1, mGFP tagged |
CNY 5,890.00 |
|
| RG207952 | PTPN12 (tGFP-tagged) - Human protein tyrosine phosphatase, non-receptor type 12 (PTPN12), transcript variant 1 |
CNY 4,370.00 |
